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14篇 您的检索式:作者名="Kashir"
    题名 作者 年代 出处 被引量
1A numerical study on the effects of H2 addition in non-premixed turbulent combustion of C3Hs-H2-N2 mixture using a steady flamelet approach显示文摘KASHIR B TABEJAMAAT S 2013International Journal of Hydrogen Energy2013,38,23:1
2Oocyte activation, phospholipase C zeta and human infertility 显示文摘Kashir J Heindryckx B Jones C 2010Hum Reprod Update2010,16,6:1
3Oocyte activation, phospholipase C zeta and human infertility 显示文摘Kashir J Heindryckx B Jones C 2010Hum Reprod Update2010,16,6:1
4Oocyte activation, phospholipase C zeta and human infertility 显示文摘Kashir J Heindryckx I3 Jones C 2010Hum Reprod Update2010,16,6:1
5Oocyte activation,phospholipase C zeta and human infertility显示文摘Kashir J Heindiyckx B Jones C 2010Human reproduction update2010,16,6:1
6Loss of activity mutations in phospholipase C zeta (PLC)abolishes calcium oscillatory ability of human recombinant protein in mouse oocytes显示文摘Kashir J Jones C Lee HC 2011Human reproduction2011,26,12:1
7Comparative biology of sperm factors and fertilization induced calcium signals across the animal kingdom显示文摘Kashir J Deguchi R Jones C 2013Molecular reproduction and development2013,80,10:1
8Oocyte activation, phospholipase C zeta and human infertility 显示文摘Kashir J Heindryckx B Jones 0 2010Human Reprod Update2010,16,6:1
9A maternally inherited autosomal point mutation in human phospholipase C zeta(PLCζ)leads to male infertility显示文摘Kashir J Konstantinidis M Jones C 0,,01:1
10Comparative biology of sperm factors and fertilization‐induced calcium signals across the animal kingdom显示文摘Junaid Kashir Ryusaku Deguchi Celine Jones Kevin Coward Stephen A. Stricker 2013Mol Reprod Dev2013,,10:1
11Characterization of two heterozygous mutations of the oocyte activation factor phospholipase C zeta (PLCζ) from an infertile man by use of minisequencing of individual sperm and expression in somatic cells显示文摘Junaid Kashir Michalis Konstantinidis Celine Jones Bjorn Heindryckx Petra De Sutter John Parrington Dagan Wells Kevin Coward 2012Fertility and Sterility2012,,2:1
12Effects of cryopreservation and density-gradient washing on phospholipase C zeta concentrations in human spermatozoa显示文摘Junaid Kashir Ariane Heynen Celine Jones Claire Durrans Jo Craig Joaquín Gadea Karen Turner John Parrington Kevin Coward 2011Reproductive BioMedicine Online2011,,2:1
13Advancing male age differentially alters levels and localization patterns of PLCzeta in sperm and testes from different mouse strains显示文摘Sperm-specific phospholipase C zeta(PLCζ)initiates intracellular calcium(Ca2+)transients which drive a series of concurrent events collectively termed oocyte activation.Numerous investigations have linked abrogation and absence/reduction of PLCζwith forms of male infertility in humans where oocyte activation fails.However,very few studies have examined potential relationships between PLCζand advancing male age,both of which are increasingly considered to be major effectors of male fertility.Initial efforts in humans may be hindered by inherent PLCζvariability within the human population,alongside a lack of sufficient controllable repeats.Herein,utilizing immunoblotting,immunofluorescence,and quantitative reverse transcription PCR(qRT-PCR)we examined for the first time PLCζprotein levels and localization patterns in sperm,and PLCζmRNA levels within testes,from mice at 8 weeks,12 weeks,24 weeks,and 36 weeks of age,from two separate strains of mice,C57BL/6(B6;inbred)and CD1(outbred).Collectively,advancing male age generally diminished levels and variability of PLCζprotein and mRNA in sperm and testes,respectively,when both strains were examined.Furthermore,advancing male age altered the predominant pattern of PLCζlocalization in mouse sperm,with younger mice exhibiting predominantly post-acrosomal,and older mice exhibiting both post-acrosomal and acrosomal populations of PLCζ.However,the specific pattern of such decline in levels of protein and mRNA was strain-specific.Collectively,our results demonstrate a negative relationship between advancing male age and PLCζlevels and localization patterns,indicating that aging male mice from different strains may serve as useful models to investigate PLCζin cases of male infertility and subfertility in humans.Junaid Kashir Bhavesh V Mistry Maha Adel Gumssani Muhammad Rajab Reema Abu-Dawas Falah AlMohanna Michail Nomikos Celine Jones Raed Abu-Dawud Nadya Al-Yacoub Kevin Coward F Anthony Lai Abdullah M Assiri 2021Asian Journal of Andrology2021,23,2:0
14COVID-19: cross-immunity of viral epitopes may influence severity of infection and immune response显示文摘A recent study published in Science by Shrock et al.1 examined how responses to COVID-19 severity differed amongst patients with different prior viral exposure history,finding notable correlations between both.Such serological profiling provides a window into differential viral responses amongst patients with diverse outcomes,potentially mediating improved therapeutics and vaccines for SARS-CoV-2.Junaid Kashir Khaled AlKattan Ahmed Yaqinuddin 2021Signal Transduction and Targeted Therapy2021,6,4:0
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