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| 1 | Simultaneous determination of ezetimibe and simvastatin in rat plasma by stable-isotope dilution LC-ESI-MS/MS and its application to a pharmacokinetic study显示文摘A simple,sensitive and specilic liquid ehromatography-tandem mass spectrometry method was developed for simultaneous quantification of ezetimibe and simvastatin in rat plasma.The deuterium isotopes:ezetimibe d_4 and simvastatin d_6 were used as internal standards for ezetimibe and simvastatin,respectively.MS/MS detection involved a switch of electron spray ionization mode from negative to positive at retention time 3.01 min.Samples were extracted from plasma by liquid-liquid extraction using tertiary butyl methyl ether.Chromatographic separation was achieved with Agilent Eclipse XBD-C_(18) column using mobile phase that consisted of a mixture of ammonium acetate(pH4.5:10 mM)-acetonilrile(25:75 v/v).The method was linear and validated over the concentration range of 0.2-40.0 ng/mL for simvastatin and 0.05-15.0 ng/mL for ezetimibe.The transitions selected were mlz 408.3→271.1 and mlz 4I2.0→ 275.10 for ezetimibe and ezetimibe d_4.and mlz 419.30→ 285.20 and mlz 425.40 →199.20 for simvastatin and simvastatin d_6.Intra- and inter-batch precisions for ezetimibe were 1.6-14.8%and 2.1-13.4%;and for simvastatin 0.94-9.56%and0.79-12%.respectively.The proposed method was sensitive,selective,precise and accurate for the quantification of ezetimibe and simvastatin simultaneously in rat plasma.The method was successfully applied to a pharmacokinetic study by oral co-administration of ezetimibe and simvastatin in SD rats. | Sireesha R.Karanam Prakash Katakam Babu R.Chandu Nagiat T.Hwisa Shanta K.Adiki | 2014 | Journal of Pharmaceutical Analysis2014，4，4： | 4 |
| 2 | Multilayer 3D Chirality and Its Synthetic Assembly显示文摘3D chirality of sandwich type of organic molecules has been discovered.Te key element of this chirality is characterized by three layers of structures that are arranged nearly in parallel fashion with one on top and one down from the center plane.Individual enantiomers of these molecules have been fully characterized by spectroscopies with their enantiomeric purity measured by chiral HPLC.Te absolute confguration was unambiguously assigned by X-ray difraction analysis.Tis is the frst multilayer 3D chirality reported and is anticipated to lead to a new research area of asymmetric synthesis and catalysis and to have a broad impact on chemical,medicinal,and material sciences in future. | Guanzhao Wu Yangxue Liu Zhen Yang Nandakumar Katakam Hossein Rouh Sultan Ahmed Daniel Unruh Kazimierz Surowiec Guigen Li | 2019 | Research2019，，1： | 3 |
| 3 | Myocardial pre-conditioning against ischemia-reperfusion injury is abolished in Zucker obese rats with insulin resistance显示文摘 | Katakam PV Jordan JE Snipes JA | | 0，，2： | 1 |
| 4 | Effects of Ir electrodes on Barium Strontium Titanate thin-film capacitors for hight-density memory application 显示文摘 | Chen Tung-Sheng Katakam Shylaja | 1999 | IEEE Transactions on Electron Devices1999，46，12： | 1 |
| 5 | Streptozotocin (STZ) mediates acute upregulation of serum and pancreatic osteopontin (OPN) : a novel islet--protective effect of OPN through inhibition of STZ-- induced nitric oxide production显示文摘 | A K Katakam G Chipitsyna Q Gong | 2005 | Journal of Endocrinology2005，187，： | 1 |
| 6 | Multi-layer 3D chirality:new synthesis,AIE and computational studies显示文摘New synthesis of multi-layer 3 D chiral molecules has been developed under novel conditions to give better outcomes.The aggregation-induced emission(AIE),UV irradiation/excitation,charge transfer(CT)and local excited(LE)ππ*transitions have been investigated on a representative individual enantiomer of pseudo C_2 asymmetry which was made possibly by differentiating moieties on phosphorous on N-phosphonyl ring of chiral sandwich framework.Meanwhile,a new tandem C–N/C–C coupling reaction was unexpectedly rendered providing a novel access to special benzo[a]carbazoles. | Yangxue Liu Guanzhao Wu Zhen Yang Hossein Rouh Nandakumar Katakam Sultan Ahmed Daniel Unruh Zhonghua Cui Hans Lischka Guigen Li | 2020 | Science China Chemistry2020，63，5： | 1 |
| 7 | Streptozotocin (STZ) mediates acute upregulation of serum and pancreatic osteopontin(OPN):a novel islet-protective effect of OPN through inhibition of STZ-induced nitric oxide production显示文摘 | Katakam AK Chipitsyna G Vancha AR | 2005 | Endocrinology2005，187，9： | 1 |
| 8 | Osteopontin protects the islets and beta-cells from interleukin-1beta-mmediated cytotoxicity through negative feedback regulation of nitric oxide显示文摘 | Arafat HA Katakam AK Chipitsyna G | 2007 | Endocrinology2007，148，2： | 1 |
| 9 | Metformin improves vascular function in insulin-resistant rats 显示文摘 | Katakam PV Ujhelyi MR Hoenig M | 2000 | Hypertension2000，35，11： | 1 |
| 10 | endothelium-med-iated relax-ation in coronary arteries from insulin-resistant rats 显示文摘 | Katakam P Ujhelyi MR | 1999 | J Vasc Res1999，36，5： | 1 |
| 11 | Acute treat- ment with rosuvastatin protects insulin resistant (C57BL/6J ob/ob) mice against transient cerebral ischemia显示文摘 | Mayanagi K Katakam P V Gaspar T | 2008 | J Cereb Blood Flow Metab2008，28，12： | 1 |
| 12 | Systemic administration of diazoxide induces delayed preconditioning against transient focal cerebral ischemia in rats显示文摘 | Mayanagi K Gaspar T Katakam PV | 2007 | Brain Research2007，1168，： | 1 |
| 13 | In vitro–in vivo studies of the quantitative effect of calcium,multivitamins and milk on single dose ciprofloxacin bioavailability显示文摘Ciprofloxacin, commonly used in India as an anti-microbial for prolonged use in chronic and non-specific indications, may affect the bioavailability of the drug. The drug prescribed is commonly taken with multivitamins, calcium and milk. A simple and reliable analytical methodology obtaining a correlation with in vivo urinary excretion studies using UV and HPLC and in vitro dissolution studies(IVIVC) has shown a significant increase in elimination rate of ciprofloxacin co-administered with multivitamins,calcium and milk. Appreciable IVIVC results proved that dissolution studies could serve as an alternative to in vivo bioavailability and also support bio-waivers. | Baishakhi Dey Prakash Katakam Fathi H.Assaleh Babu Rao Chandu Shanta Kumari Adiki Analava Mitra | 2015 | Journal of Pharmaceutical Analysis2015，5，6： | 1 |
| 14 | Enhanced endothelin-1 response and receptor expression in small mesenteric arteries of insulin-resistant rats显示文摘 | Katakam PV Pollock JS Pollock DM | 2001 | Am J Physiol Heart Circ Physical2001，280，： | 1 |
| 15 | Endothelial dysfunction precedes hypertension in diet-induced insulin resistance 显示文摘 | Ujhelyi MR Hoenig ME | 1998 | Am J Physiol1998，275，3： | 1 |
| 16 | Metformin improves vascular function in insulin-resistance rats 显示文摘 | Ujhelyi MR Hoenig M | 2000 | Hypertension2000，35，11： | 1 |
| 17 | Metformin Improves Vascular Function in Insulin-Resistant Rats显示文摘 | Prasad V. G. Katakam Michael R. Ujhelyi Margarethe Hoenig Allison W. Miller | 2000 | Hypertension: Journal of the American Heart Association ( Part )2000，，1： | 1 |
| 18 | Enantioselective assembly of multi-layer 3D chirality显示文摘The first enantioselective assembly of sandwich-shaped organo molecules has been achieved by conducting dual asymmetric Suzuki-Miyaura couplings and nine other reactions.This work also presents the first fully C-C anchored multi-layer 3D chirality with optically pure enantiomers.As confirmed by X-ray diffraction analysis that this chiral framework is featured by a unique C2-symmetry in which a nearly parallel fashion consisting of three layers:top,middle and bottom aromatic rings.Unlike the documented planar or axial chirality,the present chirality shows its top and bottom layers restrict each other from free rotation,i.e.,this multi-layer 3D chirality would not exist if either top or bottom layer is removed.Nearly all multi-layered compounds showed strong luminescence of different colors under UV irradiation,and several randomly selected samples displayed aggregation-induced emission(AIE)properties.This work is believed to have broad impacts on chemical,medicinal and material sciences including optoelectronic materials in future. | Guanzhao Wu Yangxue Liu Zhen Yang Tao Jiang Nandakumar Katakam Hossein Rouh Liulei Ma Yao Tang Sultan Ahmed Anis URahman Hongen Huang Daniel Unruh Guigen Li | 2020 | National Science Review2020，7，3： | 1 |
| 19 | Osteopontin Protects the Isletsand-Cells from Interleukin-1?-Mediated Cytotoxicity through Negative Feedback Regulation of Nitric Oxide显示文摘 | Arafat H Katakam A Chipitsyna G | 2007 | Endocrinology2007，148，2： | 1 |
| 20 | Fe-based amorphous coatings on AISI 4130 structural steel for corrosion resistance显示文摘 | Katakam S Santhanakrishnan S Dahotre N B | 2012 | JOM2012，64，6： | 1 |
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