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| 1 | A novel phenol-bound pectic polysaccharide from Decalepis hamiltonii with multi-step ulcer preventive activity显示文摘AIM: To investigate H+, K+-ATPase inhibition, anti-H pylori , antioxidant, and the in vivo antiulcer potential of a pectic polysaccharide from Swallow root (Decalepis hamiltonii; SRPP). METHODS: SRPP, with known sugar composition [rhamnose: arabinose: xylose: galactose in the ratio of 16:50:2:32 (w/w), with 141 mg/g of uronic acid] was examined for anti-ulcer potency in vivo against swim/ ethanol stress-induction in animal models. Ulcer index, antioxidant/antioxidant enzymes, H+, K+-ATPase and gastric mucin levels were determined to assess the anti- ulcer potency. Anti-H pylori activity was also determined by viable colony count and electron microscopic studies. RESULTS: SRPP, containing phenolics at 0.12 g GAE/g, prevented stress-induced gastric ulcers in animal models by 80%-85%. Down regulation of gastric mucin 2-3 fold, antioxidant/antioxidant enzymes and upregulation of 3 fold of H+, K+-ATPase in ulcerous animals were normalized upon treatment with SRPP. Histopathological analysis revealed protection to the disrupted gastric mucosal layer and epithelial glands. SRPP also inhibited H+, K+-ATPase in vitro, at an IC50 of 77 μg/mL as opposed to that of 19.3 μg/mL of Lansoprazole and H pylori growth at Minimum Inhibitory Concentration (MIC) of 150 μg/mL. In addition, free radical scavenging (IC50-40 μg/mL) and reducing power (3200 U/g) activities were also observed. CONCLUSION: SRPP, with defined sugar composition and phenolics, exhibited multi-potent free radical scavenging, antioxidant, anti-H pylori, inhibition of H+, K+-ATPase and gastric mucosal protective activities. In addition, SRPP is non-toxic as opposed to other known anti-ulcer drugs, and therefore may be employed as a potential alternative for ulcer management. | BM Srikanta MN Siddaraju Shylaja M Dharmesh | 2007 | World Journal of Gastroenterology2007，13，39： | 6 |
| 2 | 柚皮苷改善束缚性应激引起的小鼠生化指标及行为变化的一氧化氮调节机制(英文)显示文摘目的:研究柚皮苷对束缚性应激引起的小鼠生化指标改变、行为变化及线粒体功能紊乱的影响。方法:将小鼠按照体质量随机分组,分别给予不同药物治疗14 d。在第15天让所有小鼠接受束缚性应激刺激6 h,然后在接受各种不同的行为测试后处死。取小鼠的大脑匀浆进行各种生化指标测量和线粒体功能分析。结果:6 h的急性束缚性应激刺激能显著改变小鼠的行为(焦虑和记忆),引起生化指标变化和线粒体功能紊乱。用柚皮苷预处理(50或100 mg/kg口服)14 d则能显著减轻急性束缚性应激刺激引起的小鼠行为和生化指标变化以及线粒体功能紊乱(P<0.05);而使用一氧化氮的前体左旋精氨酸预处理(50 mg/kg腹腔注射)可以拮抗柚皮苷的保护效应(P<0.05)。此外,采用左旋精氨酸甲酯预处理(5 mg/kg腹腔注射)则导致柚皮苷的保护效应增强。结论:柚皮苷对束缚性应激刺激引起的小鼠行为和生化指标变化以及线粒体功能紊乱的保护作用与氮能神经通路有关。 | Gollapalle L.Viswanatha Hanumanthappa Shylaja K.Sadashiva Sandeep Rao Yathiraj Ashwini V.Ramaiah Santhosh Kumar C.Gangadharaiah Mohan Venkate Gowda Sunil M.Venkateshappa Sarvesh Kumar Subbanna Rajesh | 2011 | 中西医结合学报2011，9，11： | 3 |
| 3 | Effects of Ir electrodes on Barium Strontium Titanate thin-film capacitors for hight-density memory application 显示文摘 | Chen Tung-Sheng Katakam Shylaja | 1999 | IEEE Transactions on Electron Devices1999，46，12： | 1 |
| 4 | Lobe-specific increases in malondialdehyde DNA adduct formation in the livers of mice following infection with Helicobacter hepaticus显示文摘 | Rajinder S Chiara L Shylaja J | 2001 | Carcinogenesis2001，22，8： | 1 |
| 5 | Inhibition of DNA adduct formation of PhIP I female F344 rat by dietary conjugated linoleic acid 显示文摘 | Shylaja J Ying -hua He Randall J | 1998 | Nutrition and Cancer1998，32，2： | 1 |
| 6 | Inhibition of Helicobacter pylori growth and its cytotoxicity by 2-hydroxy 4-methoxy benzaldehyde of Decalepis hamiltonii (Wight & Arn); a new functional attribute显示文摘 | Belagihalli M. Srikanta Mysore A. Harish Nayaka Shylaja M. Dharmesh | 2011 | Biochimie2011，，4： | 1 |
| 7 | Inhibition of Aldose Reductase from CataractedEye Lenses by Finger Millet(Eleusine Coracana)Polyphenols显示文摘 | Chethan S Dharmesh Shylaja M Malleshi NagappaG | 2008 | Bioorganic&Medicinal Chemis-try2008，16，10： | 1 |
| 8 | Effects of Ir electrodes on Barium Strontium Titanate thin-film capacitors for hight-density memory application显示文摘 | Chen Tung-Sheng Katakam Shylaja Lee Jian-hung | 1999 | IEEE Transac-tions on Electron Devices1999，46，： | 1 |
| 9 | Antioxidant and cytotoxic effect of oxidized lutein in human cervical carcinoma cells (HeLa)显示文摘 | Rangaswamy Lakshminarayana Upparahalli V. Sathish Shylaja M. Dharmesh Vallikannan Baskaran | 2010 | Food and Chemical Toxicology2010，，7： | 1 |
| 10 | Inhibition of DNA adduct formation of PhIP I female F344 rat by dietary conjugated linoleic acid显示文摘 | SHYLAJA J YING-HUA H E RANDALL J | 1998 | Nutrition and cancer1998，32，2： | 1 |
| 11 | Portal-large terminase interactions of the bacteriophage T4 DNA packaging machine implicate a molecular lever mechanism for coupling ATPase to DNA translocation显示文摘 | Shylaja H Victor P Bonnie D | 2012 | Journal of Virology2012，86，8： | 1 |
| 12 | Free and bound phenolic antioxidants in amla ( Emblica officinalis ) and turmeric ( Curcuma longa )显示文摘 | G. Suresh Kumar Harish Nayaka Shylaja M. Dharmesh P.V. Salimath | 2006 | Journal of Food Composition and Analysis2006，，5： | 1 |
| 13 | Conjunctival inclusion cysts following small incision cataract surgery Indian 显示文摘 | Shylaja NS Dayananda M Dakshayini S | 2010 | Ophthalmol2010，58，5： | 1 |
| 14 | Determination of lunar surface ages from crater frequency- size distribution显示文摘 | Shylaja B S | | 0，，06： | 1 |
| 15 | Inhibition of Aldose Reductase from Cataracted Eye Lenses by Finger Millet ( Eleusine coracana) Polyphenols 显示文摘 | Chethan S Dharmesh Shylaja M Malleshi Nagappa G | 2008 | Bioorganic & Medicinal Chemistry2008，16，10： | 1 |
| 16 | Different abilities of certain succulent plants in removing CO2 from the indoor environment of a hospital显示文摘 | Raza S H Shylaja G | 1995 | Environment International1995，21，4： | 1 |
| 17 | Determination of lunar surface ages from crater frequency-size distribution显示文摘 | Shylaja B S | 2005 | Journal of Earth System Science2005，114，6： | 1 |
| 18 | Preemptiverotor blade damage identification by blade tiptiming method显示文摘 | Gum Siddhartha S Shylaja S Kumar Sunil | 2014 | Journal of Engineering for GasTurbines & Power2014，136，7： | 1 |
| 19 | The Structure of the Phage T4 DNA Packaging Motor Suggests a Mechanism Dependent on Electrostatic Forces显示文摘 | Siyang Sun Kiran Kondabagil Bonnie Draper Tanfis I. Alam Valorie D. Bowman Zhihong Zhang Shylaja Hegde Andrei Fokine Michael G. Rossmann Venigalla B. Rao | 2008 | Cell2008，，7： | 1 |
| 20 | De-velopment of ELISA {or the detection of Ralstonia so lanacearum in tomato: its application in seed health testing显示文摘 | Rajeshwari N Shylaja M D Krishnappa M | 1998 | World journal of Microbiology and Bio- technology1998，14，5： | 1 |
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