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| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 2 | Application of methods for identifying broiler chicken gut bacterial species linked with increased energy metabolism显示文摘 | Valeria A T Kathy O K Maylene Loo Robert J H | 2008 | Applied and Environmental Microbiology2008，74，3： | 1 |
| 3 | Use of a Mycoplasma hyopneumoniae nested polymerase chain reaction test to determine the optimal sampling sites in swine 显示文摘 | KATHY T K TSUNGDA H ERIC R S | 2002 | Vet Diagn Invest2002，14，： | 1 |
| 4 | In situ detection of Australian gill-associated virus with a yellow head virus gene probe显示文摘 | Kathy F- J T Kirsten M S Leigh O | 2002 | Aquaculture2002，205，： | 1 |
| 5 | Lipid-raft-dependent Coxsackievirus B4 internalization and rapid targeting to the Golgi显示文摘 | Kathy T Martha T | 2004 | Virology2004，326，1： | 1 |
| 6 | Uranium depositional controls at the Prairie Flats surficial uranium deposit, Summerland,British Columbia 显示文摘 | Kathy T Roger B | 2002 | Environmental Geology2002，40，： | 1 |
| 7 | Uranium depositional controls at the Prairie Flats surficial uranium deposit, Summerland British Columbia显示文摘 | Kathy T Roger B | 2002 | Environmental Geology2002，40，： | 1 |
| 8 | Nanostructure of liquid crystalline matrix determines in vitro sustained release and in vivn oral absorption kinetics for hydrophilic model drugs 显示文摘 | KATHY WY NGUYEN TH HANLEY T | 2009 | Int J Pharm2009，365，12： | 1 |
| 9 | Using Rats as a Research Model for the Study of Endometriosis显示文摘 | Sharpe T Kathy L | 2002 | Annals of the New York Academy of Sciences2002，955，： | 1 |
| 10 | Semibatch absorption and regeneration studies for CO2 capture by aqueous ammonia显示文摘 | YEH JAMES T RESNIK KEVIN P KATHY RYGLE | 2005 | Fuel Processing Technology2005，86，15： | 1 |
| 11 | Semi-batch absorption and regeneration studies for CO2 capture by aqueous ammonia显示文摘 | James T Y Kevin P R Kathy R | 2005 | Fuel Processing Technology2005，86，1415： | 1 |
| 12 | Bioequivalence among three methods of administering pantoprozole granules in healthy subjects显示文摘 | BRINDA T KATHY W ARIE K | 2009 | Am J Health Syst Pharm2009，66，21： | 1 |
| 13 | Proanthocyanidin biosynthesis in plants-purification of legume leucoanthocyanidin reductase and molecular cloning of its cDNA 显示文摘 | Gregory J Tanner Kathy T Francki Sharon Abrahams | 2003 | Journal of Biological Chemistry2003，278，31： | 1 |
| 14 | Radiotherapy plus chemotherapy with or without surgical resection for stage III non-small-cell lung cancer: a phase III randomised controlled trial显示文摘 | Kathy S Albain R Suzanne Swann Valerie W Rusch Andrew T Turrisi Frances A Shepherd Colum Smith Yuhchyau Chen Robert B Livingston Richard H Feins David R Gandara Willard A Fry Gail Darling David H Johnson Mark R Green Robert C Miller Joanne Ley Willliam T | 2009 | The Lancet . 2009 (9687)2009，，9687： | 1 |
| 15 | A multicenter comparison of intraaortic balloon pump utilization in isolated coronary artery bypass graft surgery显示文摘 | Roger J.F Baskett Gerald T O’Connor Gregory M Hirsch William A Ghali Kathy Sabadosa Jeremy R Morton Cathy S Ross Felix Hernandez William C Nugent Stephen J Lahey Donato A Sisto Lawrence J Dacey John D Klemperer Robert E Helm Andrew Maitland | 2003 | The Annals of Thoracic Surgery2003，，6： | 1 |
| 16 | The contrast sensitivity of human color vision to red-green and blue-yellow chromatic gratings显示文摘 | Kathy T Mullen | 1985 | J Physiol1985，359，： | 1 |
| 17 | Semi-batch absorption and regeneration studies for CO2 capture by aqueous ammonia 显示文摘 | James T Yeh Kevin P Resnik Kathy Rygle | 2005 | Fuel Processing Technology2005，86，1415： | 1 |
| 18 | First report of Spring viremia of carp virus (SVCV) in wild common carp in North America显示文摘 | Audrey L D Craig R Kathy T K | 2004 | J Aquatic Animal Health2004，16，： | 1 |
| 19 | Solubilization of manganese dioxide-bound copper by naturally occurring organic compounds 显示文摘 | Kathy L Godtfredsen and Stone A T | 1994 | Environ SciTechnol1994，28，： | 1 |
| 20 | The peroxisome proliferators - activated receptor gamma ligand rosiglitazone delays the onset of inflammatory bowel disease in mice with interleukin 10 deficiency 显示文摘 | Lytle C Tod T Kathy T | 2005 | Inflamm Bowel Dis2005，11，： | 1 |
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