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| 1 | Overexpression of HSP27 and HSP70 is associated with decreased survival among patients with esophageal adenocarcinoma显示文摘BACKGROUND Overexpression of heat shock proteins(HSPs) is associated with several malignancies and contributes to the development, progression, and metastasis of cancer, in addition to the inhibition of cellular death. In recent years, there has been active research into using HSP inhibitors in several malignancies. Due to the poor prognosis of esophageal adenocarcinoma(EAC), it would be valuable to find new biomarkers for the development of cancer treatments.AIM To evaluate the expressions of HSP27 and HSP70 and their effect on survival in EAC.METHODS Immunohistochemical analyses and evaluations of HSP27 and HSP70 expression were performed on all available samples from 93 patients diagnosed with EACbetween 1990 and 2007 at two university hospitals. Fifteen cases with Barrett's metaplasia and 5 control cases from the same patient population were included in the analysis. HSP expression was quantitatively assessed and classified as high or low. Kaplan-Meier analyses and Cox regression models adjusting for age and sex as well as tumor site, stage, and grade were used to evaluate the effect on survival.RESULTS Tumor stage and surgical treatment were the main prognostic factors. High HSP27 expression in cancer cases was a strong negative predictive factor, with a mean survival of 23 mo compared to the 49 mo in cases with a low expression(P= 0.018). The results were similar for HSP70, with a poorer survival of 17 mo in cases with high HSP70 expression, in contrast to 40 mo(P = 0.006) in cases with a low expression. A Cox regression survival analysis was performed, adjusting for possible confounding factors, and higher HSP27 and HSP70 expressions remained an independent negative prognostic factor. The HSPs' correlation with survival was not affected by cancer treatments. When the analysis was adjusted for all factors, the odds ratios for HSP27 and HSP70 were 3.3(CI: 1.6–6.6, P =0.001) and 2.2(CI: 1.2–3.9, P = 0.02), respectively.CONCLUSION HSP27 and HSP70 overexpression is associated with poor survival in EAC, which is, to the best of our knowledge, reported for the first time. | Henna K S?derstr?m Juha T Kauppi Niku Oksala Timo Paavonen Leena Krogerus Jari R?s?nen Tuomo Rantanen | 2019 | World Journal of Clinical Cases2019，7，3： | 7 |
| 2 | Overlap Syndrome of Asthma and COPD Predicts Low Quality of Life显示文摘 | Paula Kauppi Henna Kupiainen Ari Lindqvist Lauri Tammilehto Maritta Kilpel? inen Vuokko L. Kinnula Tari Haahtela Tarja Laitinen | 2011 | Journal of Asthma2011，，3： | 2 |
| 3 | Small-molecule inhibitors specifically targeting type III secretion显示文摘 | Nordfelth R Kauppi A M Norberg H A | 2005 | Infect Immun2005，73，5： | 1 |
| 4 | Structure of an aromaticring-hydroxylating dioxygenase-naphthalene 1,2-dioxygenase显示文摘 | Kauppi B Lee K Carredano E | 1998 | Structure1998，6，： | 1 |
| 5 | The threedimensional structures of antagonistic and agonistic forms of the glucocorticoid receptor ligand-binding domain: RU-486 induces a transconformation that leads to active antagonism 显示文摘 | Kauppi B Jakob C Farnegardh M | 2003 | J Biol Chem2003，278，22： | 1 |
| 6 | The climatic impacts of land surface change and carbon management, and the implications for climate-change mitigation policy显示文摘 | Gregg Marland Roger A. Pielke Mike Apps Roni Avissar Richard A. Betts Kenneth J. Davis Peter C. Frumhoff Stephen T. Jackson Linda A. Joyce Pekka Kauppi John Katzenberger Kenneth G. MacDicken Ronald P. Neilson John O. Niles Dev dutta S. Niyogi Richard J. N | 2003 | Climate Policy2003，，2： | 1 |
| 7 | Long-term smoking increases the need for acute care among asthma patients:a case control study显示文摘 | Kauppi P Kupiainen H Lindqvist A | 2014 | BMC Pulm Med2014，14，1： | 1 |
| 8 | Rheumatoid atlantoaxial subluxation can be prevented by intensive use of traditional disease modifying antirheumatic drugs显示文摘 | Kauppi MJ Neva MH Laiho K | | 0，，8： | 1 |
| 9 | High- Speed milling of advanced materials 显示文摘 | Nieminen I Paro J Kauppi | 1996 | Journal of Materials Processing Technology1996，56，14： | 1 |
| 10 | Biomass and carbon budget of European forests, 1971 to 1990 显示文摘 | KAUPPI P E MIELIKAINEN K KUUSELA K | 1992 | Science1992，256，： | 1 |
| 11 | Accumulation of airborn elements from vehicles in transplanted lichens in urban sites 显示文摘 | GARTY J KAUPPI M KAUPPI A | 1996 | Journal of Environmental Quality1996，25，2： | 1 |
| 12 | Trees as carbon sinks and sources in the European Union 显示文摘 | J Liski T Karjalainen A Pussinen G-J Nabuurs P Kauppi | 2000 | Environmental Science & Policy2000，，3： | 1 |
| 13 | Structure of an aromatic ring- hydroxylating dioxygenase- naphthalene 1, 2- dioxygenase显示文摘 | Kauppi B Lee K Carredano E | 1998 | Structure1998，6，： | 1 |
| 14 | Fall-related risk factors and heel quantitative ultrasound in the assessment of hip fracture risk : a 10-year follow-up of a nationally representative adult popu- lation sample 显示文摘 | Kauppi M Stenholm S Impivaara O | 2014 | Osteoporos Int2014，25，6： | 1 |
| 15 | The three-dimensional structures of antagonistic and agonistic forms of the glueocortieoid receptor ligand-binding domain显示文摘 | Kauppi B Jakob C Famegardh M | 2003 | J Biol Chem2003，278，22： | 1 |
| 16 | Overlap syndrome of asthma and COPD predicts low quality of life 显示文摘 | Kauppi P Kupiainen H Lindqvist A | 2011 | J Asthma2011，48，3： | 1 |
| 17 | Attempt tomodel laboratory scale diffusion and retardation data显示文摘 | HOLTTAP SIITARI KAUPPI M HAKANEN M | 2001 | J ContamHydrol2001，47，： | 1 |
| 18 | Design and function of novel superplasticizers for more durable high performance concrete (superplast project)显示文摘 | Yves F. Houst Paul Bowen Fran?ois Perche Annika Kauppi Pascal Borget Laurent Galmiche Jean-Fran?ois Le Meins Fran?oise Lafuma Robert J. Flatt Irene Schober Phil F.G. Banfill David S. Swift Bernt O. Myrvold Berit G. Petersen K?re Reknes | 2008 | Cement and Concrete Research2008，，10： | 1 |
| 19 | Probing the effect of superplasticizer adsorption on the surface forces u?sing the colloidal probe AFM technique显示文摘 | Kauppi A Andersson K M Bergstrom L | 2005 | Cern Concr Res2005，35，1： | 1 |
| 20 | A large and persistent carbon sink in the world’s forests 显示文摘 | Pan YD Birdsey RA Fang JY Houghton R Kauppi PE Kurz WA Phillips OL Shvidenko A Lewis SL Canadell JG Giais P Jackson RB Pacala SW McGuire A Piao SL Rautiainen A Sitch S Hayes D | 2011 | Science2011，333，： | 1 |
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