|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Decreased levels of plasma adiponectin associated with increased risk of colorectal cancer显示文摘AIM:To investigate the association between adiponectin levels and risk of colorectal adenoma and cancer (early and advanced).METHODS: A cross-sectional study in a cohort of hospital-based patients was conducted between January 2004 and March 2006 at Yamagata University Hospital. Male subjects, who had colorectal tumors detected by endoscopic examination, were enrolled according to inclusion and exclusion criteria. Based on the T factor of the TNM system, intraepithelial carcinoma and submucosally invasive carcinoma were def ined as early cancer, and invasion into the muscularis propria or deeper was defined as advanced cancer. The plasma levels of glucose, insulin, total cholesterol, triglyceride, high sensitivity C-reactive protein, insulin like growth factor (IGF)-1, IGF binding protein-3, adiponectin, leptin, and resistin were measured. Each factor level was designated low or high, and the risk of adenoma or cancer was estimated by univariate and multivariate logistic regression analysis.RESULTS: We enrolled 124 male subjects (47 with adenoma, 34 with early cancer, 17 with advanced cancer, and 26 without tumors as controls). In patients with adenoma, high triglyceride and low adiponectin were associated with a significant increase in the odds ratio (OR) by univariate analysis. Only a low adiponectin level was related to increased adenoma risk, with an adjusted OR for low level (<11 μg/mL) to high (≥11 μg/mL) of 5.762 (95% confidence interval (CI):1.683-19.739, P=0.005). In the patients with early cancer, high body mass index, high triglyceride, and low adiponectin were associated with a significant increase in OR in univariate analysis. Imultivariate analysis, only low adiponectin was significantly associated with early cancer, with an adjusted OR of 4.495 (95% CI:1.090-18.528, P=0.038). However, in patients with advanced cancer, low adiponectin was not recognized as a significant risk factor for advanced cancer.CONCLUSION: A decreased level of adiponectin is strongly associated with an increased risk of colorectal adenoma and early cancer. These data call for further investigation, including a controlled prospective study. | Sayaka Otake Hiroaki Takeda Shoichiro Fujishima Tadahisa Fukui Tomohiko Orii Takeshi Sato Yu Sasaki Shoichi Nishise Sumio Kawata | 2010 | World Journal of Gastroenterology2010，16，10： | 14 |
| 2 | Does Helicobacter pylori eradication therapy for peptic ulcer prevent gastric cancer?显示文摘AIM:To investigate the effects of Helicobacter pylori (H pylori)eradication therapy for treatment of peptic ulcer on the incidence of gastric cancer. METHODS:A multicenter prospective cohort study was conducted between November 2000 and December 2007 in Yamagata Prefecture,Japan.The study included patients with H pylori-positive peptic ulcer who decided themselves whether to receive H pylori eradication(eradication group)or conventional antacid therapy(non-eradication group).Incidence of gastric cancer in the two groups was determined based on the results of annual endoscopy and questionnaire surveys,as well as Yamagata Prefectural Cancer Registry data,and was compared between the two groups and by results of H pylori therapy.RESULTS:A total of 4133 patients aged between 13 and 91 years(mean 52.9 years)were registered,and 56 cases of gastric cancer were identified over a mean follow-up of 5.6 years.The sex-and age-adjusted incidence ratio of gastric cancer in the eradication group, as compared with the non-eradication group,was 0.58 (95%CI:0.28-1.19)and ratios by follow-up period(<1 year,1-3 years,>3 years)were 1.16(0.27-5.00),0.50 (0.17-1.49),and 0.34(0.09-1.28),respectively.Longer follow-up tended to be associated with better prevention of gastric cancer,although not to a significant extent.No significant difference in incidence of gastric cancer was observed between patients with successful eradication therapy(32/2451 patients,1.31%)and those with treatment failure(11/639 patients,1.72%).Among patients with duodenal ulcer,which is known to be more prevalent in younger individuals,the incidence of gastric cancer was significantly less in those with successful eradication therapy(2/845 patients,0.24%)than in those with treatment failure(3/216 patients,1.39%). CONCLUSION:H pylori eradication therapy for peptic ulcer patients with a mean age of 52.9 years at registration did not significantly decrease the incidence of gastric cancer. | Katsuhiro Mabe Mikako Takahashi Haruhumi Oizumi Hideaki Tsukuma Akiko Shibata Kazutoshi Fukase Toru Matsuda Hiroaki Takeda Sumio Kawata | 2009 | World Journal of Gastroenterology2009，15，34： | 10 |
| 3 | Programmed cell death-1 inhibitor-related sclerosing cholangitis:A systematic review显示文摘BACKGROUND Programmed cell death-1(PD-1)inhibitor has been indicated for many types of malignancies.However,these inhibitors also cause immune-related adverse events.Hepatobiliary disorder is a phenotype of immune-related adverse event affecting 0%–4.5%of patients treated with PD-1 inhibitors.Recent studies have reported PD-1 inhibitor-related sclerosing cholangitis(SC);however,the associated clinical and pathological features are unclear.AIM To evaluate the clinical and pathological features of PD-1 inhibitor-related SC through a systematic review of the literature.METHODS The review,conducted using electronic databases in PubMed,was restricted to the period from January 2014 to September 2019 and focused on case reports/series on PD-1 inhibitor-related SC published in English.We scanned the references of the selected literature to identify any further relevant studies.Six cases previously studied by us,including three that have not yet been published,were included in this review.RESULTS Thirty-one PD-1 inhibitor-related SC cases were evaluated.Median age of patients was 67 years(range,43–89),with a male to female ratio of 21:10.The main disease requiring PD-1 inhibitor treatment was non-small cell lung cancer.Agents that caused PD-1 inhibitor-related SC were nivolumab(19 cases),pembrolizumab(10 cases),avelumab(1 case),and durvalumab(1 case).The median number of cycles until PD-1 inhibitor-related SC onset was 5.5(range,1–27).Abdominal pain or discomfort(35.5%,11/31)was the most frequent symptom.Blood serum tests identified liver dysfunction with a notable increase in biliary tract enzymes relative to hepatic enzymes,and a normal level of serum immunoglobulin G4.Biliary dilation without obstruction(76.9%,20/26),diffuse hypertrophy of the extrahepatic biliary tract(90.5%,19/21),and multiple strictures of the intrahepatic biliary tract(30.4%,7/23)were noted.In 11/23(47.8%)cases,pathological examination indicated that CD8+T cells were the dominant inflammatory cells in the bile duct or peribiliary tract.Although corticosteroids were mainly used for PD inhibitor-related SC treatment,the response rate was 11.5%(3/26).CONCLUSION Some clinical and pathological features of PD-1 inhibitor-related SC were revealed.To establish diagnostic criteria for PD-1 inhibitor-related SC,more cases need to be evaluated. | Takumi Onoyama Yohei Takeda Taro Yamashita Wataru Hamamoto Yuri Sakamoto Hiroki Koda Soichiro Kawata Kazuya Matsumoto Hajime Isomoto | 2020 | World Journal of Gastroenterology2020，26，3： | 7 |
| 4 | 气体燃料发动机的高性能气门座圈材料开发显示文摘烧结材料广泛用于气门座圈(VSI)。当用于气体燃料(LPG,CNG)发动机时,由于环境干燥,VSI磨损量增大。介绍了气体燃料发动机用的,两种新开发的高性能VSI材料。为增高耐磨性,这些材料应用的新工艺是,高性能硬质颗粒和固体润滑剂新分布方法。 | Hideaki Kawata Kunio Maki | 2011 | 粉末冶金技术2011，29，1： | 5 |
| 5 | CONSTRUCTION OF A GENOMIC DNA LIBRARY WITH ATA VECTOR AND ITS APPLICATION IN CLONING OF THE PHYTOENE SYNTHASE GENE FROM THE CYANOBACTERIUM SPIRULINA PLATENSIS M-135显示文摘An efficient and simple method for constructing a genomic DNA library using a TAcloning vector is presented. It is based on the sonicative cleavage of genomic DNA and modification offragment ends with Taq DNA polymerase, followed by ligation using a TA vector. This method was ap-plied for cloning of the phytoene synthase gene crtB from Spirulina platensis. This method is useful whengenomic DNA cannot be efficiently digested with restriction enzymes, a problem often encountered duringthe construction of a genomic DNA library of cyanobacteria. | Yoshikazu Kawata Shin-ichi Yano Hiroyuki Kojima(Osaka Mational Research Institute. Agency of Industrial Science and Technology, Ikeda, Osaka 563, Japan) | 1998 | Chinese Journal of Oceanology and Limnology1998，16，S1： | 5 |
| 6 | 耐热/耐磨烧结合金发展趋势显示文摘粉末冶金的一个特殊优势是合金设计自由度高,因此,烧结合金广泛用于耐热与耐磨零件。主要产品对象是气门导管、阀座圈(VSI)及发动机排气系统的零件。近年来,为回应环境问题,发动机的使用性能在不断提高,这些零件的使用环境随之越益严苛,因此,就日益要求改进材料的耐磨性与其它性能。论述了近年来耐热/耐磨烧结材料的技术发展趋势,特别着重于材料发展趋势。 | Hideaki Kawata Kunio Maki 韩凤麟 | 2011 | 粉末冶金技术2011，29，5： | 4 |
| 7 | Endoscopic and biopsy diagnoses of superficial, nonampullary, duodenal adenocarcinomas显示文摘AIM: To investigate the accuracy of endoscopic or biopsy diagnoses of superficial nonampullary duodenal epithelial tumors(NADETs).METHODS:Clinicopathological data were reviewed for84 superficial NADETs from 74 patients who underwent surgery or endoscopic resection between September2002 and August 2014 at a single prefectural cancer center.Superficial NADETs were defined as lesions confined to the mucosa or submucosa.Demographic and clinicopathological data were retrieved from charts,endoscopic and pathologic reports.Endoscopic reports included endoscopic diagnosis,location,gross type,diameter,color,and presence or absence of biopsy.Endoscopic diagnoses were made by an endoscopist in charge of the examination before biopsy specimens were obtained.Endoscopic images were obtained using routine,front-view,high-resolution video endoscopy,and chromoendoscopy with indigocarmine was performed for all lesions.Endoscopic images were reviewed by at least two endoscopists to assess endoscopic findings indicative of carcinoma.Preoperative diagnoses based on endoscopy and biopsy findings were compared with histological diagnoses of resected specimens.Sensitivity,specificity,and accuracy were assessed for endoscopic diagnosis and biopsy diagnosis.RESULTS:The majority(81%)of the lesions were located in the second portion of the duodenum.The median lesion diameter was 14.5 mm according to final histology.Surgery was performed for 49 lesions from 39 patients,and 35 lesions from 35 patients were endoscopically resected.Final histology confirmed 65carcinomas,15 adenomas,and 3 hyperplasias.A finaldiagnosis of duodenal carcinoma was made for 91%(52/57)of the lesions diagnosed as carcinoma by endoscopy and 93%(42/45)of the lesions diagnosed as carcinoma by biopsy.The sensitivity,specificity,and accuracy of endoscopic diagnoses were 80%,72%,and 78%,respectively,whereas those of biopsy diagnoses were 72%,80%,and 74%,respectively.Preoperative diagnoses of carcinomas were made in88%(57/65)of the carcinoma lesions via endoscopy or biopsy.Endoscopic findings associated with carcinoma were red color,depression,and mixed-type morphology.CONCLUSION:Preoperative endoscopy and biopsy showed similar accuracies in the diagnosis of carcinoma in patients with superficial NADETs. | Naomi Kakushima Hideyuki Kanemoto Keiko Sasaki Noboru Kawata Masaki Tanaka Kohei Takizawa Kenichiro Imai Kinichi Hotta Hiroyuki Matsubayashi Hiroyuki Ono | 2015 | World Journal of Gastroenterology2015，21，18： | 3 |
| 8 | Role of the preoperative usefulness of the pathological diagnosis of pancreatic diseases显示文摘Pancreatic cancer is the fifth leading cause of cancer death and has the lowest survival rate of any solid cancer.Endoscopic ultrasound-guided fine-needle aspiration biopsy(EUS-FNA) is currently capable of providing a cytopathological diagnosis of pancreatic malignancies with a higher diagnostic power,with a sensitivity and specificity of 85%-89% and 98%-99%,compared to pancreatic juice cytology(PJC),whose sensitivity and specificity are only 33.3%-93% and 83.3%-100%.However,EUS-FNA is not effective in the cases of carcinoma in situ and minimally invasive carcinoma because both are undetectable by endoscopic ultrasonography,although PJC is able to detect them.As for the frequency of complications such as post endoscopic retrograde cholangiopancreatography pancreatitis,EUS-FNA is safer than PJC.To diagnose pancreatic cancer appropriately,it is necessary for us to master both procedures so that we can select the best methods of sampling tissues while considering the patient's safety and condition. | Kazuya Matsumoto Yohei Takeda Takumi Onoyama Soichiro Kawata Hiroki Kurumi Masaru Ueki Norimasa Miura Hajime Isomoto | 2016 | World Journal of Gastrointestinal Oncology2016，8，9： | 2 |
| 9 | Fatty acid-binding protein 7 triggersα-synuclein oligomerization in glial cells and oligodendrocytes associated with oxidative stress显示文摘We previously show that fatty acid-binding protein 3(FABP3)triggersα-synuclein(Syn)accumulation and induces dopamine neuronal cell death in Parkinson disease mouse model.But the role of fatty acid-binding protein 7(FABP7)in the brain remains unclear.In this study we investigated whether FABP7 was involved in synucleinopathies.We showed that FABP7 was co-localized and formed a complex with Syn in Syn-transfected U251 human glioblastoma cells,and treatment with arachidonic acid(100 M)significantly promoted FABP7-induced Syn aggregation,which was associated with cell death.We demonstrated that synthetic FABP7 ligand 6 displayed a high affinity against FABP7 with Kd value of 209 nM assessed in 8-anilinonaphthalene-1-sulfonic acid(ANS)assay;ligand 6 improved U251 cell survival via disrupting the FABP7–Syn interaction.We showed that activation of phospholipase A2(PLA2)by psychosine(10 M)triggered oligomerization of endogenous Syn and FABP7,and induced cell death in both KG-1C human oligodendroglia cells and oligodendrocyte precursor cells(OPCs).FABP7 ligand 6(1 M)significantly decreased Syn oligomerization and aggregation thereby prevented KG-1C and OPC cell death.This study demonstrates that FABP7 triggersα-synuclein oligomerization through oxidative stress,while FABP7 ligand 6 can inhibit FABP7-induced Syn oligomerization and aggregation,thereby rescuing glial cells and oligodendrocytes from cell death. | An Cheng Yi-fei Wang Yasuharu Shinoda Ichiro Kawahata Tetsunori Yamamoto Wen-bin Jia Hanae Yamamoto Tomohiro Mizobata Yasushi Kawata Kohji Fukunaga | 2022 | Acta Pharmacologica Sinica2022，43，3： | 2 |
| 10 | Silver hierarchical structures grown on microstructured silicon in chip for microfluidic integrated catalyst and SERS detector显示文摘In this Letter, silver(Ag) hierarchical nanostructures grown on black silicon(BS) are used as the catalyst and a surface-enhanced Raman scattering(SERS) detector integrated in a microfluid. The BS is fabricated via femtosecond laser ablation in an atmosphere of sulfur hexafluoride, and then hydrogenated with hydrofluoric acid. As formed, the BS substrate directly acts as a reducing template to grow silver hierarchical nano-structures.Particularly, Ag-BS composite micro/nano-structures can be in-situ constructed in silicon-based microchannels.These structures simultaneously serve as integrated catalytic reactors and a SERS substrate for sensing. The sensitivity is tested to be as low as 10-8mol∕L using Rhodamine 6G. | 闫兆旭 李春昊 骆杨 赵纪红 杨海 Prabhat Verma Satoshi Kawata | 2015 | Chinese Optics Letters2015，13，10： | 2 |
| 11 | Successful En-Bloc Resection of Large Superficial Tumors in the Stomach and Colon Using Sodium Hyaluronate and Small-Caliber-Tip Transparent Hood显示文摘 | H. Yamamoto H. Kawata K. Sunada A. Sasaki K. Nakazawa T. Miyata Y. Sekine T. Yano K. Satoh K. Ido K. Sugano | 2003 | Endoscopy2003，，08： | 2 |
| 12 | Stability of pyrrolidone derivatives against γ-ray irradiation显示文摘To evaluate the stability of N-alkylated pyrrolidone derivatives(NRPs),which are supposed to be used as precipitants for U(VI) and Pu(IV,VI) species in HNO 3 media,under irradiation environment,some candidate NRPs were irradiated by γ-ray.Irradiation to HNO 3 solutions up to 6 mol dm 3(= M) containing 2 M N-n-butyl-2-pyrrolidone(NBP),one of NRPs with lower hydrophobicity,has revealed that the residual ratios of NBP in the samples of HNO 3 up to 3 M decreased identically and linearly.Approximately 20% of NBP was found to be degraded after the irradiation at 1 MGy.It was also found that the decrease in the precipitation ratio of UO 2 2+(P.R.,%) was gentle and that the P.R.values were relatively in accordance with the residual ratios of NBP.On the other hand,the degradation of the samples irradiated in 6 M HNO 3 was found more distinguished.It was proposed from the analyses of degraded compounds that the degradation of NBP in HNO 3 by γ-ray irradiation started from the cleavage of the pyrrolidone ring by the addition of oxygen atom originating from HNO 3,followed by the formation of chain compounds by the successive addition of oxygen,leading to the generation of oxalic acid and acetic acid.The stability of other NRPs in 3 M HNO 3 was evaluated to be nearly identical with that of NBP except lower P.R.values of the samples containing NRPs with higher hydrophobicity irradiated at more than 0.5 MGy. | NOGAMI Masanobu SUGIYAMA Yuichi KAWASAKI Takeshi HARADA Masayuki KAWATA Yoshihisa MORITA Yasuji KIKUCHI Toshiaki IKEDA Yasuhisa | 2012 | Science China Chemistry2012，55，9： | 2 |
| 13 | A particle swarm optimization for reactive power and voltage control considering voltage security assessment显示文摘 | Hirotaka Yoshida Kenichi Kawata | 2000 | IEEE Trans on Power Systems2000，15，4： | 2 |
| 14 | Success rate of curative endoscopic mucosal resection with circumferential mucosal incision assisted by submucosal injection of sodium hyaluronate显示文摘 | Hironori Yamamoto Hiroshi Kawata Keijiro Sunada Kiichi Satoh Yoshinari Kaneko Kenichi Ido Kentaro Sugano | 2002 | Gastrointestinal Endoscopy2002，，4： | 2 |
| 15 | Surface plasmon coupled fluorescence in deep-ultraviolet excitation by Kretschmann configuration显示文摘我们与表面电浆子刺激报导 CdSe 量点的荧光的试验性的示范在深紫外(深 -- 紫外) 区域。表面电浆子回声在深 -- 紫外被铝激动在 Kretschmann-Raether 几何学的薄电影。就铝的氧化厚度而言,反射的事件角度依赖的试验性的结果与夫累X尔理论显示出好同意。有 19 nm 厚的铝和 5 nm 厚的氧化铝的表面电浆子回声为 266 nm 刺激在 48 度的事件角度激动。在这部铝电影上涂的 CdSe 量点的荧光被表面电浆子刺激观察。 | Atsushi Ono Masakazu Kikawada Wataru Inami Yoshimasa Kawata | 2014 | Frontiers of physics2014，9，1： | 2 |
| 16 | Characteristics of Patients With Nonalcoholic Steatohepatitis Who Develop Hepatocellular Carcinoma显示文摘 | Kohichiroh Yasui Etsuko Hashimoto Yasuji Komorizono Kazuhiko Koike Shigeki Arii Yasuharu Imai Toshihide Shima Yoshihiro Kanbara Toshiji Saibara Takahiro Mori Sumio Kawata Hirofumi Uto Shiro Takami Yoshio Sumida Toshinari Takamura Miwa Kawanaka Takeshi Oka | 2011 | Clinical Gastroenterology and Hepatology2011，，5： | 2 |
| 17 | Three-dimensional optical data storage using photochromic materials 显示文摘 | Kawata S Kawata Y | 2000 | Chem Rev2000，100，： | 1 |
| 18 | Laser-scan fluorescence microscope with annular excitation显示文摘 | AR IMOTO R KAWATA S | 1990 | Optik1990，86，1： | 1 |
| 19 | E5531,A synthetic non-toxin lipid A derivate blicks the immunbiological activities of liopolysaccharide显示文摘 | Bristol J R Rossignol D P | 1999 | Br J Pharmacol1999，127，4： | 1 |
| 20 | Characterization of the hemorrhagic reaction caused by Vibrio vulnificus metatlopre - tease, a member of the hemolysin family 显示文摘 | MIYOSHI D L NAKAZAWA H KAWATA K | 1998 | Infect Immune1998，66，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员