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| 1 | Benefits of early postoperative jejunal feeding in patients undergoing duodenohemipancreatectomy显示文摘瞄准:学习早手术后的肠内的营养是否减少复杂并发症的发生或改进营养的地位追随者 duodenohemipancreatectomy (DHP ) 。方法:我们学习了为一个 peri-ampullary 团经历了 DHP 的 39 个病人。23 个病人收到了全部的父母营养然后开始有在手术后的白天(邮政部门) 之间的营养的口头的吸入 7 和 14 [晚手术后的肠内的营养(LPEN ) 组] 。十六个病人开始有肠内的在手术以后整个空肠造口术导管日子喂[早手术后的肠内的营养(EPEN ) 组] 。在早手术后的阶段的复杂并发症和实验室数据的发生在在 LPEN 和 EPEN 组之间的比较被学习。结果:在 EPEN 组的白朊和全部的蛋白质的浆液层次比在 LPEN 组的那些显著地高。身体团索引的损失显著地作为与 LPEN 组相比在 EPEN 组被压制。在操作比在 LPEN 组在 EPEN 组更快显著地被恢复以后,淋巴细胞计数立即减少了。EPEN 组显著地比 LPEN 组显示出手术后的胰腺的管,以及住院的显著地更短的长度的更少发生。在在二个组之间的另外的手术后的复杂并发症的发生没有有效差量,例如推迟的胃的倒空,外科的地点感染,胆管炎,和小肠阻塞。结论:EPEN 是为为一个 peri-ampullary 团经历了 DHP 的病人的一个安全、有益的机会。 | Takehiro Okabayashi Michiya Kobayashi Isao Nishimori Tekeki Sugimoto Toyokazu Akimori Tsutomu Namikawa Ken Okamoto Saburo Onishi Keijiro Araki | 2006 | World Journal of Gastroenterology2006，12，1： | 23 |
| 2 | STI571 (Glivec) suppresses the expression of vascular endothelial growth factor in the gastrointestinal stromal tumor cell line,GIST-T1显示文摘AIM:To estimate whether STI571 inhibits the expressionof vascular endothelial growth factor(VEGF)in thegastrointestinal stromal tumor(GIST)cells.METHODS:We used GIST cell line,GIST-T1.It hasa heterogenic 57-bp deletion in exon 11 to produce amutated c-KIT,which results in constitutive activationof c-KIT.Cells were treated with/without STI571 orstem cell factor(SCF).Transcription and expression ofVEGF were determined by RT-PCR and flow cytometryor Western blotting,respectively.Activated c-KIT wasestimated by immunoprecipitation analysis.Cell viabilitywas determined by MTT assay.RESULTS:Activation of c-KIT was inhibited bySTI571 treatment.VEGF was suppressed at both thetranscriptional and translational levels in a temporal anddose-dependent manner by STI571.SCF upregulatedthe expression of VEGF and it was inhibited by STI571.STI571 also reduced the cell viability of the GIST-T1cells,as determined by MTT assay.CONCLUSION:Activation of c-KIT in the GIST-T1regulated the expression of VEGF and it was inhibited bySTI571.STI571 has antitumor effects on the GIST cellswith respect to not only the inhibition of cell growth,butalso the suppression of VEGF expression. | Toufeng Jin Hajime Nakatani Takahiro Taguchi Takumi Nakano Takehiro Okabayashi Takeki Sugimoto Michiya Kobayashi Keijiro Araki | 2006 | World Journal of Gastroenterology2006，12，5： | 14 |
| 3 | Pharmacokinetic study of paclitaxel in malignant ascites from advanced gastric cancer patients显示文摘瞄准:由于源于先进胃的癌症的腹膜炎 carcinomatosa 与腹水在病人在它的静脉内的管理以后在血浆和腹水检验 paclitaxel 集中。方法:有腹水的二个病人在这研究由于源于胃的癌症的腹膜炎 carcinomatosa 被包括。在血浆和腹水的 paclitaxel 集中为 72 h 被调查以防 1 和 168 h 以防 2 在静脉内的管理以后。结果:在血浆的 paclitaxel 集中在管理以后立即达到顶点,在 24 h 以内在 0.1 微摩尔(85 ng/mL ) 的阀值价值下面由快速的减少列在后面。相反,在腹水的 paclitaxel 集中在管理以后为 24 h 逐渐地增加了到与在血浆发现的水平一致的水平。在 24 h 以后,在腹水和血浆的 paclitaxel 的水平变得类似,与被维持直到 72 h 追随者管理的最佳的水平。结论:在腹水的 paclitaxel 的集中在静脉内的管理以后为多达 72 h 为癌症房间的治疗在最佳的水平以内被维持。Paclitaxel 是为胃的癌症的恶意的腹水的治疗的有希望的药。 | Michiya Kobayashi Junichi Sakamoto Tsutomu Namikawa Ken Okamoto Takehiro Okabayashi Kengo Ichikawa Keijiro Araki | 2006 | World Journal of Gastroenterology2006，12，9： | 14 |
| 4 | Diagnostic evaluation of acute pancreatitis in two patients with hypertriglyceridemia显示文摘We present two diagnostically challenging cases of acute pancreatitis with hypertriglyceridemia accompanied with chylomicronemia caused with a deficiency of lipoprotein lipase and with the presence of type V hyperlipidemia.Both cases suffered from acute abdomen following the ingestion of fatty food and revealed the increase in parameters of inflammation without significant elevation of serum amylase levels. The imaging examination of ultrasonography could not detect significant findings of acute pancreatitis and a computer tomography scan eventually confirmed the findings of acute pancreatitis. Both cases responded to a low fat diet and administration of a cholecystokinin receptor antagonist, exhibiting a relief of abdominal symptoms. As in the present cases with acute abdomen following the ingestion of fatty food, the identification of serum hypertriglyceridemia and an abdominal computer tomography scan might be useful in establishing the diagnosis of acute pancreatitis and in developing the therapeutic regimen, when hypertriglyceridemia interferes with the evaluation of pancreatic enzyme activities and ultrasound examination provides poor pancreatic visualization. | Yoshifumi Okura KozoHayashi TetsujiShingu GoroKajiyama Yoshiyuki Nakashima Keijiro Saku | 2004 | World Journal of Gastroenterology2004，10，24： | 12 |
| 5 | 早胃的癌症用的程度的诊断灵活光谱成像颜色改进显示文摘 The demarcation line between the cancerous lesion and the surrounding area could be easily recognized with flexible spectral imaging color enhancement (FICE) system compared with conventional white light images. The characteristic f inding of depressed-type early gastric cancer (EGC) in most cases was revealed as reddish lesions distinct from the surrounding yellowish non-cancerous area without magnification. Conventional endoscopic images provide little information regarding depressed lesions located in the tangential line, but FICE produces higher color contrast of such cancers. Histological f indings in depressed area with reddish col- or changes show a high density of glandular structure and an apparently irregular microvessel in intervening parts between crypts, resulting in the higher color con- trast of FICE image between cancer and surrounding area. Some depressed cancers are shown as whitish lesion by conventional endoscopy. FICE also can pro- duce higher color contrast between whitish cancerous lesions and surrounding atrophic mucosa. For nearly flat cancer, FICE can produce an irregular structuralpattern of cancer distinct from that of the surrounding mucosa, leading to a clear demarcation. Most elevated-type EGCs are detected easily as yellowish lesions with clearly contrasting demarcation. In some cases, a partially reddish change is accompanied on the tumor surface similar to depressed type cancer. In addition, the FICE system is quite useful for the detection of minute gastric cancer, even without magnif ication. These new contrasting images with the FICE system may have the potential to increase the rate of detection of gastric cancers and screen for them more effectively as well as to determine the extent of EGC. | Hiroyuki Osawa Hironori Yamamoto Yoshimasa Miura Mitsuyo Yoshizawa Keijiro Sunada Kiichi Satoh Kentaro Sugano | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，8： | 11 |
| 6 | High-density lipoprotein and atherosclerosis: Roles of lipid transporters显示文摘Various previous studies have found a negative cor-relation between the risk of cardiovascular events and serum high-density lipoprotein(HDL) cholesterol levels. The reverse cholesterol transport, a pathway of choles-terol from peripheral tissue to liver which has several potent antiatherogenic properties. For instance, the particles of HDL mediate to transport cholesterol from cells in arterial tissues, particularly from atherosclerotic plaques, to the liver. Both ATP-binding cassette trans-porters(ABC) A1 and ABCG1 are membrane cholesterol transporters and have been implicated in mediating cholesterol effluxes from cells in the presence of HDL and apolipoprotein A-I, a major protein constituent of HDL. Previous studies demonstrated that ABCA1 and ABCG1 or the interaction between ABCA1 and ABCG1 exerted antiatherosclerotic effects. As a therapeutic approach for increasing HDL cholesterol levels, much focus has been placed on increasing HDL cholesterol levels as well as enhancing HDL biochemical functions. HDL therapies that use injections of reconstituted HDL, apoA-I mimetics, or full-length apoA-I have shown dramatic effectiveness. In particular, a novel apoA-I mi-metic peptide, Fukuoka University ApoA-I Mimetic Pep-tide, effectively removes cholesterol via specific ABCA1 and other transporters, such as ABCG1, and has an an-tiatherosclerotic effect by enhancing the biological func-tions of HDL without changing circulating HDL choles-terol levels. Thus, HDL-targeting therapy has significant atheroprotective potential, as it uses lipid transporter-targeting agents, and may prove to be a therapeutic tool for atherosclerotic cardiovascular diseases. | Yoshinari Uehara Keijiro Saku | 2014 | World Journal of Cardiology2014，6，10： | 10 |
| 7 | Systematic review of laparoscopic vs open surgery for colorectal cancer in elderly patients显示文摘AIM: To verify the safety and validity of laparoscopic surgery for the treatment of colorectal cancer in elderly patients.METHODS: A meta-analysis was performed of a systematic search of studies on an electronic database. Studies that compared laparoscopic colectomy(LAC) in elderly colorectal cancer patients with open colectomy(OC) were retrieved, and their short and long-term outcomes compared. Elderly people were defined as 65 years old or more. Inclusion criteria were set at: Resection of colorectal cancer, comparison between laparoscopic and OC and no significant difference in backgrounds between groups.RESULTS: Fifteen studies were identified for analysis. LAC was performed on 1436 patients, and OC performed on 1810 patients. In analyses of short-term outcomes, operation time for LAC was longer than for OC(mean difference = 34.4162, 95%CI: 17.8473-50.9851, P < 0.0001). The following clinical parameters were lower in LAC than in OC: Amount of estimated blood loss(mean difference =-93.3738, 95%CI:-132.3437 to-54.4039, P < 0.0001), overall morbidity(OR = 0.5427, 95%CI: 0.4425-0.6655, P < 0.0001), incisional surgical site infection(OR = 0.6262, 95%CI: 0.4310-0.9097, P = 0.0140), bowel obstruction and ileus(OR = 0.6248, 95%CI: 0.4519-0.8638, P = 0.0044) and cardiovascular complications(OR = 0.4767, 95%CI: 0.2805-0.8101, P = 0.0062). In analyses of long-term outcomes(median follow-up period: 36.4 mo in LAC, 34.3 mo in OC), there was no significant difference in overall survival(mean difference = 0.8321, 95%CI: 0.5331-1.2990, P = 0.4187) and disease specific survival(mean difference = 1.0254, 95%CI: 0.6707-1.5675, P = 0.9209). There was also no significant difference in the number of dissected lymph nodes(mean difference =-0.1360, 95%CI:-4.0553-3.7833, P = 0.9458).CONCLUSION: LAC in elderly colorectal cancer patients had benefits in short-term outcomes compared with OC except operation time. The long-term outcomes and oncological clearance of LAC were similar to that of OC. These results support the assertion that LAC is an effective procedure for elderly patients with colorectal cancer. | Shoichi Fujii Mitsuo Tsukamoto Yoshihisa Fukushima Ryu Shimada Koichi Okamoto Takeshi Tsuchiya Keijiro Nozawa Keiji Matsuda Yojiro Hashiguchi | 2016 | World Journal of Gastrointestinal Oncology2016，8，7： | 10 |
| 8 | Metastatic bone cancer as a recurrence of early gastric cancer - characteristics and possible mechanisms显示文摘The surgical outcome of most early gastric cancer (EGC)is usually satisfactory. Some cases show bone metastasis even though the depth of cancer invasion is confined to the mucosa. The most frequent site for recurrence of EGC is the liver. Cases of EGC with bone metastasis are reviewed to clarify the clinicopathological characteristics of EGC giving rise to bone metastasis. Possible mechanisms and risk factors underlying this rare condition are proposed.Forty-six cases of bone metastasis from EGC are reviewed from published reports and meeting proceedings in Japan.This investigation suggests that risk factors for bone metastasis from EGC include depressed-type signet-ring cell carcinoma, poorly differentiated carcinoma, and/or the likely involvement of lymph node metastasis, even though the cancer is confined to the gastric mucosa. The risk factors do not include recurrence of EGC in the liver. We speculate that the mechanism of bone metastasis from EGC is via lymphatic channels and systemic circulation. Postoperative follow-up of cases should consider the development of bone metastasis from EGC. We propose the use of elevated alkaline phosphatase levels for the detection of bone metastasis and recommend bone scintigraphy in positive cases. | Michiya Kobayashi Takehiro Okabayashi Takeshi Sano Keijiro Araki | 2005 | World Journal of Gastroenterology2005，11，36： | 9 |
| 9 | Clinical outcomes of enteroscopy using the double-balloon method for strictures of the small intestine显示文摘AIM: To evaluate the clinical outcome of enteroscopy, using the double-balloon method, focusing on the involvement of neoplasms in strictures of the small intestine.METHODS: Enteroscopy, using the double-balloon method, was performed between December 1999 and December 2002 at Jichi Medical School Hospital, Japan and strictures of the small intestine were found in 17 out of 62 patients. These 17 consecutive patients were subjected to analysis.RESULTS: The double-balloon enteroscopy contributed to the diagnosis of small intestinal neoplasms found in 3out of 17 patients by direct observation of the strictures as well as biopsy sampling. Surgical procedures were chosen for these three patients, while balloon dilation was chosen for the strictures in four patients diagnosed with inflammation without involvement of neoplasm.CONCLUSION: Double-balloon enteroscopy is a useful method for the diagnosis and treatment of strictures in the small bowel. | Keijiro Sunada Hironori Yamamoto Hiroto Kita Tomonori Yano Hiroyuki Sato Yoshikazu Hayashi Tomohiko Miyata Yutaka Sekine Akiko Kuno Michiko Iwamoto Hirohide Ohnishi Kenichi Ido Kentaro Sugano | 2005 | World Journal of Gastroenterology2005，11，7： | 6 |
| 10 | Non-steroidal anti-inflammatory drug-induced small bowel injuries identified by double-balloon endoscopy显示文摘AIM: To clarify clinical features of the NSAID-induced small bowel lesions using a new method of endoscopy.METHODS: This is a retrospective study and we analyzed seven patients with small bowel lesions while taking NSAIDs among 61 patients who had undergone doubleballoon endoscopy because of gastro-intestinal bleeding or anemia between September 2000 and March 2004, at Jichi Medical School Hospital in Japan. Neither conventional EGD nor colonoscopy revealed any lesions of potential bleeding sources including ulcerations. Double-balloon endoscopy was carried out from oral approach in three patients, from anal approach in three patients, and from both approaches in one patient.RESULTS: Ulcers or erosions were observed in the ileum in six patients and in the jejunum in one patient, respectively.The ulcers were multiple in all the patients with different features from tiny punched out ulcers to deep ulcerations with oozing hemorrhage or scar. All the patients recovered uneventfully and had full resolution of symptoms after suspension of the drug.CONCLUSION: NSAIDs can induce injuries in the small bowel even in patients without any lesions in both the stomach and colon. | Yoshikazu Hayashi Hironori Yamamoto Hiroto Kita Keijiro Sunada Hiroyuki Sato Tomonori Yano Michiko Iwamoto Yutaka Sekine Tomohiko Miyata Akiko Kuno Takaaki Iwaki Yoshiyuki Kawamura Hironari Ajibe Kenichi Ido Kentaro Sugano | 2005 | World Journal of Gastroenterology2005，11，31： | 6 |
| 11 | Periostin as a Novel Factor Responsible for Ventricular Dilation显示文摘 | Naruto Katsuragi Ryuichi Morishita Noriko Nakamura Tayehito Ochiai Yoshiaki Taniyama Yasuhiro Hasegawa Kayoko Kawashima Yasufumi Kaneda Toshio Ogihara Keijiro Sugimura | 2004 | Circulation2004，，13： | 2 |
| 12 | Clinical outcomes of double-balloon endoscopy for the diagnosis and treatment of small-intestinal diseases显示文摘 | Hironori Yamamoto Hiroto Kita Keijiro Sunada Yoshikazu Hayashi Hiroyuki Sato Tomonori Yano Michiko Iwamoto Yutaka Sekine Tomohiko Miyata Akiko Kuno Hironari Ajibe Kenichi Ido Kentaro Sugano | 2004 | Clinical Gastroenterology and Hepatology2004，，11： | 2 |
| 13 | Clinicopathological study of cardiac tamponade due to pericardial metastasis originating from gastric cancer显示文摘AIM: To review the cases reported in the literature,examined their clinicopathological features, and evaluated the efficacy of different therapeutic modalities for this rare condition.METHODS: A search of the MEDLINE database revealed 16 cases of pericarditis carcinomatosa (PC)originating from GC reported in the literature between1982 and 2005. Additional detailed data were obtained from the authors of these studies for subsequent clinicopathological investigation. We have also described about a case study from our own clinic.RESULTS: The mean age of cases with pericarditis carcinomatosa originating from GC was 54 years.Females were diagnosed at a younger age (46.3 years)compared to males (58 years). The mean survival period after diagnosis was 4.5 mo. No statistical differences in the length of survival time were found between different therapeutic modalities, such as drainage, and local and/or systemic chemotherapy after drainage. However,three cases who underwent systemic chemotherapy survived for more than 10 mo. Cases that developed metachronous cardiac tamponade for more than 2years after the diagnosis of GC generally survived for a longer period of time, although this was not statistically significant. Multivariate analysis revealed that low levels of carcinoembryonic antigen (CEA), and CEA and/or cancer antigen 19-9 (CA 19-9) were associated with longer survival.CONCLUSION: Cases with low levels of CEA, and CEA and/or CA 19-9 should undergo systemic chemotherapy with or without local chemotherapy after drainage. | Michiya Kobayashi Takehiro Okabayashi Ken Okamoto Tsutomu Namikawa Keijiro Araki | 2005 | World Journal of Gastroenterology2005，11，44： | 2 |
| 14 | Double-balloon endoscopy: past, present, and future显示文摘 | Keijiro Sunada Hironori Yamamoto | 2009 | Journal of Gastroenterology2009，，1： | 2 |
| 15 | Double‐balloon endoscopy in clinical practice: Where are we now?显示文摘 | Emanuele Rondonotti Keijiro Sunada Tomonori Yano Silvia Paggi Hironori Yamamoto | 2012 | Digestive Endoscopy2012，，4： | 2 |
| 16 | Success rate of curative endoscopic mucosal resection with circumferential mucosal incision assisted by submucosal injection of sodium hyaluronate显示文摘 | Hironori Yamamoto Hiroshi Kawata Keijiro Sunada Kiichi Satoh Yoshinari Kaneko Kenichi Ido Kentaro Sugano | 2002 | Gastrointestinal Endoscopy2002，，4： | 2 |
| 17 | Nonsurgical management of small-bowel polyps in Peutz–Jeghers syndrome with extensive polypectomy by using double-balloon endoscopy显示文摘 | Hirotsugu Sakamoto Hironori Yamamoto Yoshikazu Hayashi Tomonori Yano Tomohiko Miyata Naoyuki Nishimura Hakuei Shinhata Hiroyuki Sato Keijiro Sunada Kentaro Sugano | 2011 | Gastrointestinal Endoscopy2011，，2： | 2 |
| 18 | Circulating miR-200c Levels Significantly Predict Response to Chemotherapy and Prognosis of Patients Undergoing Neoadjuvant Chemotherapy for Esophageal Cancer显示文摘 | Koji Tanaka Hiroshi Miyata Makoto Yamasaki Keijiro Sugimura Tsuyoshi Takahashi Yukinori Kurokawa Kiyokazu Nakajima Shuji Takiguchi Masaki Mori Yuichiro Doki | 2013 | Annals of Surgical Oncology2013，，3： | 2 |
| 19 | Local recurrence after rectal endoscopic submucosal dissection: a case of tumor cell implantation显示文摘 | Takashi Inoue Hisao Fujii Fumikazu Koyama Tadashi Nakagawa Kazuaki Uchimoto Shinji Nakamura Takeshi Ueda Naoto Nishigori Keijiro Kawasaki Shinsaku Obara Takayuki Nakamoto Yoshiyuki Nakajima | 2014 | Clinical Journal of Gastroenterology2014，，1： | 1 |
| 20 | Time Path in Innovation,Imitation,and Growth:the case of the motorcycle industry in postwar Japan显示文摘 | Yamamura Eiji Tetsushi Sonobe and Keijiro Otsuka | 2005 | Journal of Evolutionary2005，，15： | 1 |
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