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| 1 | Comparison of DWI and PET/CT in evaluation of lymph node metastasis in uterine cancer显示文摘AIM: To investigate diffusion-weighted imaging (DWI) and positron emission tomography and computed tomography (PET/CT) with Ⅳ contrast for the preoperative evaluation of pelvic lymph node (LN) metastasis in uterine cancer. METHODS: Twenty-five patients with endometrial or cervical cancer who underwent both DWI and PET/CT before pelvic lymphadenectomy were included in this study. For area specific analysis, LNs were divided into eight regions: both common iliac, external iliac, internal iliac areas, and obturator areas. The classification for malignancy on DWI was a focally abnormal signal intensity in a location that corresponded to the LN chains on the T1WI and T2WI. The criterion for malignancy on PET/CT images was increased tracer uptake by the LN.RESULTS: A total of 36 pathologically positive LN areas were found in 9 patients. With DWI, the sensitivity, specificity, positive predictive value, negative predictive value and accuracy for detecting metastatic LNs on an LN area-by-area analysis were 83.3%, 51.2%, 27.3%, 93.3% and 57.0%, respectively, while the corresponding values for PET/CT were 38.9%, 96.3%, 70.0%, 87.8% and 86.0%. Differences in sensitivity, specificity and accuracy were significant (P < 0.0005). CONCLUSION: DWI showed higher sensitivity and lower specificity than PET/CT. Neither DWI nor PET/CT were sufficiently accurate to replace lymphadenectomy. | Kazuhiro Kitajima Erena Yamasaki Yasushi Kaji Koji Murakami Kazuro Sugimura | 2012 | World Journal of Radiology2012，4，5： | 16 |
| 2 | Immunoglobulin G4-related gastrointestinal diseases, are they immunoglobulin G4-related diseases?显示文摘In immunoglobulin G4(IgG4)-related disease(RD),organ enlargement or nodular lesions consisting of abundant infiltration of lymphocytes and IgG4-positive plasma cells and fibrosis are seen in various organs.Although infiltration of many IgG4-positive plasma cells is detected in the gastric and colonic mucosa and major duodenal papilla of patients with autoimmune pancreatitis,it cannot be diagnosed as a gastrointestinal lesion involved in IgG4-RD,because none of the following is observed in these lesions:a mass-like formation;dense fibrosis;or obliterative phlebitis.Based on our review of the literature,there appear to be two types of IgG4-related gastrointestinal disease.One is a gastrointestinal lesion showing marked thickening of the wall of the esophagus and stomach,consisting of dense fibrosis with abundant infiltration of IgG4-positive plasma cells,which usually show submucosal spreading.The other is an IgG4-related pseudotumor occurring in gastrointestinal regions such as the stomach,colon,and major duodenal papilla,showing polypoid or mass-like lesions.Most solitary IgG4-related gastrointestinal lesions that are not associated with other IgG4-RD appear to be difficult to diagnose.It is of utmost importance to rule out malignancy.However,these lesions may respond to steroid therapy.To avoid unnecessary resection,IgG4-related gastrointestinal diseases should be considered in the differential diagnosis. | Satomi Koizumi Terumi Kamisawa Sawako Kuruma Taku Tabata Kazuro Chiba Susumu Iwasaki Yuka Endo Go Kuwata Koichi Koizumi Tooru Shimosegawa Kazuichi Okazaki Tsutomu Chiba | 2013 | World Journal of Gastroenterology2013，19，35： | 12 |
| 3 | Safety and efficacy of metallic stent for unresectable distal malignant biliary obstruction in elderly patients显示文摘AIM To study the safety of insertion of metallic stents in elderly patients with unresectable distal malignant biliary obstruction.METHODS Of 272 patients with unresectable distal malignant biliary obstruction, 184 patients under the age of 80 were classified into Group A, and 88 subjects aged 80 years or more were classified into Group B. The safety of metallic stent insertion, metal stent patency period, and the obstruction rate were examined in each group.RESULTS In Group B, patients had a significantly worse per-formance status, high blood pressure, heart disease, cerebrovascular disease, and dementia; besides the rate of patients orally administered antiplatelet drugs or anticoagulants tended to be higher(P < 0.05). Metallic stents were successfully inserted in all patients. The median patency period was 265.000 ± 26.779(1-965) d; 252.000 ± 35.998(1-618) d in Group A and 269.000 ± 47.885(1-965) d in Group B, with no significant difference between the two groups. Metallic stent obstruction occurred in 82 of the 272(30.15%) patients; in 53/184(28.80%) patients in Group A and in 29/88(32.95%) of those in Group B, showing no significant difference between the two groups. Procedural accidents due to metal stent insertion occurred in 24/272(8.8%) patients; in 17/184(9.2%) of patients in Group A and in 7/88(8.0%) of those in Group B, with no significant difference between the two groups, either.CONCLUSION These results suggested that metallic stents can be safely inserted to treat unresectable distal malignant biliary obstruction even in elderly patients aged 80 years or more. | Yuji Sakai Tomohisa Iwai Kenji Shimura Katsushige Gon Kazuya Koizumi Masashi Ijima Kazuro Chiba Seigo Nakatani Harutoshi Sugiyama Toshio Tsuyuguchi Terumi Kamisawa Iruu Maetani Mitsuhiro Kida | 2018 | World Journal of Gastroenterology2018，24，1： | 4 |
| 4 | Clinical diagnostic criteria of autoimmune pancreatitis: revised proposal显示文摘 | Kazuichi Okazaki Shigeyuki Kawa Terumi Kamisawa Satoru Naruse Shigeki Tanaka Isao Nishimori Hirotaka Ohara Tetsuhide Ito Seiki Kiriyama Kazuro Inui Tooru Shimosegawa Masaru Koizumi Koichi Suda Keiko Shiratori Koji Yamaguchi Taketo Yamaguchi Masanori Sugiy | 2006 | Journal of Gastroenterology2006，，7： | 3 |
| 5 | Erythropoietin -induced proliferation of gastric mucosal cells显示文摘瞄准:在胃的标本上分析红细胞生成素受体的本地化并且用一个猪的胃的上皮的房间文化模型在正常胃的上皮的增长上描绘红细胞生成素的效果。方法:红细胞生成素受体被 RT-PCR,西方的弄污和 immunohistochermistry 检测。有教养的胃的粘膜房间上的红细胞生成素的生长刺激效果被 ELISA 用 bromodeoxyuridine (BrdU ) 决定。结果:红细胞生成素受体在有教养的猪的胃的粘膜上皮细胞上被检测。红细胞生成素受体也在胃的粘膜上皮的底组织化学地被检测。BrdU 试金由红细胞生成素的管理在有教养的猪的胃的粘膜上皮细胞的生长潜力表明了剂量依赖者增加,以及这些效果被反的管理禁止 -- 红细胞生成素抗体(P<0.01 ) 。结论:这些调查结果显示红细胞生成素有一个潜力增殖经由红细胞生成素的胃的粘膜上皮受体。 | Kazuro Itoh Yoshio Sawasaki Kyoko Takeuchi Shingo Kato Nobuhiro Imai Yoichiro Kato Noriyuki Shibata Makio Kobayashi Yoshiyuki Moriguchi Masato Higuchi Fumio Ishihata Yushi Sudoh Soichiro Miura | 2006 | World Journal of Gastroenterology2006，12，2： | 3 |
| 6 | Prospective trial of combined transcatheter arterial chemoembolization and three-dimensional conformal radiotherapy for portal vein tumor thrombus in patients with unresectable hepatocellular carcinoma显示文摘 | Kazunari Yamada Kenta Izaki Koji Sugimoto Hiroshi Mayahara Yoshitaka Morita Eisaku Yoden Shinichi Matsumoto Toshinori Soejima Kazuro Sugimura | 2003 | International Journal of Radiation Oncology, Biology, Physics2003，，1： | 3 |
| 7 | Hypothyroidism in patients with autoimmune pancreatitis显示文摘AIM To examine thyroid function and clinical features of hypothyroidism in autoimmune pancreatitis(AIP) patients.METHODS We examined thyroid function in 77 patients with type 1 AIP(50 males, 27 females; median age 68 years, range 33-85) diagnosed according to the Japanese diagnostic criteria for AIP 2011. We compared clinical and serological findings between patients with and without various categories of hypothyroidism. The change in hypothyroidism after steroid therapy was also examined. RESULTS Eight patients(10%) had hypothyroidism of 6 patients had subclinical hypothyroidism with a normal serum free thyroxine(FT4) and high thyroid stimulating hormone(TSH) level, and 2 patients had central hypothyroidism with low serum free triiodothyronine(FT3), FT4 and TSH levels. A significant goiter of the thyroid was not observed in any patient. There were no significant differences in age; male to female ratio; serum concentrations of IgG and IgG 4-related disease(IgG4-RD); presence of antithyroglobulin antibody, antinuclear antigen or rheumatoid factor; or presence of extrapancreatic lesions between the 6 patients with subclinical hypothyroidism and patients with euthyroidism. After steroid therapy, both subclinical and central hypothyroidism improved with improvement of the AIP.CONCLUSION Hypothyroidism was observed in 8(10%) of 77 AIP patients and was subclinical in 6 patients and central in 2 patients. Further studies are necessary to clarify whether this subclinical hypothyroidism is another manifestation of IgG4-RD. | Ryoko Shimizuguchi Terumi Kamisawa Yuka Endo Masataka Kikuyama Sawako Kuruma Kazuro Chiba Taku Tabata Satomi Koizumi | 2018 | World Journal of Gastrointestinal Pharmacology and Therapeutics2018，9，2： | 3 |
| 8 | Additional gene therapy with Ad5CMV- p53 enhanced the efficacy of radiotherapy in human prostate cancer cells显示文摘 | Ryohei Sasaki Toshiro Shirakawa Zhu Jun Zhang Akira Tamekane Akira Matsumoto Kazuro Sugimura Masafumi Matsuo Sadao Kamidono Akinobu Gotoh | 2001 | International Journal of Radiation Oncology Biology Physics2001，，5： | 1 |
| 9 | Optimal mother wavelet selection for Lamb wave analyses 显示文摘 | LI Fu-cai MENG Guang KAGEYAMA Kazuro | 2009 | Journal of Intelligent Material Systems and Structures2009，20，10： | 1 |
| 10 | A RecA-mediated exon profiling method显示文摘 | Yuki H Shiro F Kazuro S | 2006 | Nucleic Acids Res2006，34，13： | 1 |
| 11 | Study on the curing process for carbon/epoxy composites to reduce thermal residual stress显示文摘 | Seong S K Hideaki M Kazuro K | 2012 | Composites Part A: Applied Science and Manufacturing2012，43，8： | 1 |
| 12 | Increased expression of galectin-3 in primary gastric cancer and themetastatic lymph nodes显示文摘 | Junichi Miyazaki Ryota Hokari Shingo Kato Yoshikazu Tsuzuki Atushi Kawaguchi Shigeaki Nagao Kazuro Itoh Soichiro Miura | 2002 | Oncology Reports2002，，6： | 1 |
| 13 | Evaluation of the efficacy and safety of biapenem against pneumonia in the elderly and a study on its pharmacokinetics显示文摘 | Fumi Karino Naoko Deguchi Hibiki Kanda Miki Ohe Keiichi Kondo Mitsuhiro Tada Takashige Kuraki Nobuhiro Nishimura Hidehiko Moriyama Kazuro Ikawa Norifumi Morikawa Takeshi Isobe | 2013 | Journal of Infection and Chemotherapy2013，，1： | 1 |
| 14 | Vibration and damping prediction of laminates with constrained viscoelastic layers-numerical analysis by a multiplayer higher-order-deformable finite element and experimental observations显示文摘 | Kohji S Kazuro K Isao K | 2003 | Mechanics of Advanced Materials and Structures2003，10，1： | 1 |
| 15 | Transthoracic CT-guided biopsy with multiplanar reconstruction image improves diagnostic accuracy of solitary pulmonary nodules显示文摘 | Yoshiharu Ohno Hiroto Hatabu Daisuke Takenaka Masatake Imai Chiho Ohbayashi Kazuro Sugimura | 2003 | European Journal of Radiology2003，，2： | 1 |
| 16 | Performance of Integrated FDG-PET/Contrast-enhanced CT in the Diagnosis of Recurrent Pancreatic Cancer: Comparison with Integrated FDG-PET/Non-contrast-enhanced CT and Enhanced CT显示文摘 | Kazuhiro Kitajima Koji Murakami Erena Yamasaki Yasushi Kaji Mitsugi Shimoda Keiichi Kubota Narufumi Suganuma Kazuro Sugimura | 2010 | Molecular Imaging and Biology2010，，4： | 1 |
| 17 | Increased Expression of Long Pentraxin PTX3 in Inflammatory Bowel Diseases显示文摘 | Shingo Kato Mitsuko Ochiai Tomoya Sakurada Shino Ohno Kyoko Miyamoto Mina Sagara Masataka Ito Kyoko Takeuchi Junko Imaki Kazuro Itoh Koji Yakabi | 2008 | Digestive Diseases and Sciences2008，，7： | 1 |
| 18 | Performance of integrated FDG–PET/contrast-enhanced CT in the diagnosis of recurrent ovarian cancer: comparison with integrated FDG–PET/non-contrast-enhanced CT and enhanced CT显示文摘 | Kazuhiro Kitajima Koji Murakami Erena Yamasaki Yasushi Domeki Yasushi Kaji Ichio Fukasawa Noriyuki Inaba Narufumi Suganuma Kazuro Sugimura | 2008 | European Journal of Nuclear Medicine and Molecular Imaging2008，，8： | 1 |
| 19 | Correlation between suspended particles in the environmental air and causes ofdisease among inhabitants:Cross-sectional studies using thevital statistics and air pollution data in Japan显示文摘 | Kazuro Iwaia Shoichi Mizunob Yoji Miyasakac | 2005 | Environmental Research2005，，99： | 1 |
| 20 | Correlation between vori- conazole through plasma concentration and hepatotoxicity in pa- tients with different CYP2CI9 genotypes 显示文摘 | Kazuaki M Kazuro I kazu ko A | 2009 | Int J Antimicrob Agents2009，34，1： | 1 |
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