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| 1 | Boron neutron capture therapy for vulvar melanoma and genital extramammary Paget’s disease with curative responses显示文摘Background:Although the most commonly recommended treatment for melanoma and extramammary Paget’s disease(EMPD)of the genital region is wide surgical excision of the lesion,the procedure is highly invasive and can lead to functional and sexual problems.Alternative treatments have been used for local control when wide local exci-sion was not feasible.Here,we describe four patients with genital malignancies who were treated with boron neutron capture therapy(BNCT).Methods:The four patients included one patient with vulvar melanoma(VM)and three with genital EMPD.They underwent BNCT at the Kyoto University Research Reactor between 2005 and 2014 using para-boronophenylalanine as the boron delivery agent.They were irradiated with an epithermal neutron beam between the curative tumor dose and the tolerable skin/mucosal doses.Results:All patients showed similar tumor and normal tissue responses following BNCT and achieved complete responses within 6 months.The most severe normal tissue response was moderate skin erosion during the first 2 months,which diminished gradually thereafter.Dysuria or contact pain persisted for 2 months and resolved com-pletely by 4 months.Conclusions:Treating VM and EMPD with BNCT resulted in complete local tumor control.Based on our clinical expe-rience,we conclude that BNCT is a promising treatment for primary VM and EMPD of the genital region. | Junichi Hiratsuka Nobuhiko Kamitani Ryo Tanaka Eisaku Yoden Ryuji Tokiya Minoru Suzuki Rolf F.Barth Koji Ono | 2018 | Cancer Communications2018，38，1： | 10 |
| 2 | 硼中子俘获治疗外阴黑色素瘤和生殖器乳腺外Paget病的疗效显示文摘背景与目的尽管目前对生殖器区的黑色素瘤和乳腺外Paget病(extramammary Paget’s disease,EMPD)最常推荐的治疗方法是广泛性手术切除病变,但该方法侵害性极高并可导致功能性和性方面的问题。当扩大局部切除术不可行的情况下,替代疗法已被用于进行局部控制。本研究描述了4例接受硼中子俘获治疗(boron neutron capture therapy,BNCT)的生殖器恶性肿瘤患者。方法 4例患者中包括1例外阴黑色素瘤(vulvar melanoma,VM)和3例生殖器EMPD患者。他们于2005至2014年间在Kyoto大学研究堆接受了对二羟基硼酰苯丙氨酸作为硼携带剂的BNCT治疗。他们接受了介于治愈性肿瘤剂量和可耐受的皮肤/黏膜剂量之间的超热中子束照射。结果所有患者在BNCT治疗后均表现出相似的肿瘤和正常组织反应,并在6个月内达到完全缓解。最严重的正常组织反应前2个月内出现,随后逐渐减弱的中度皮肤糜烂,排尿困难或接触性疼痛持续2个月,完全解决需4个月。结论 BNCT治疗VM和EMPD后局部肿瘤得到完全控制。根据我们的临床经验,我们认为BNCT是治疗生殖器区原发性VM和EMPD的一种有前景的方法。 | Junichi Hiratsuka Nobuhiko Kamitani Ryo Tanaka Eisaku Yoden Ryuji Tokiya Minoru Suzuki Rolf F.Barth Koji Ono | 2018 | 癌症2018，37，7： | 3 |
| 3 | Prospective trial of combined transcatheter arterial chemoembolization and three-dimensional conformal radiotherapy for portal vein tumor thrombus in patients with unresectable hepatocellular carcinoma显示文摘 | Kazunari Yamada Kenta Izaki Koji Sugimoto Hiroshi Mayahara Yoshitaka Morita Eisaku Yoden Shinichi Matsumoto Toshinori Soejima Kazuro Sugimura | 2003 | International Journal of Radiation Oncology, Biology, Physics2003，，1： | 3 |
| 4 | Whole-breast radiotherapy with shorter fractionation schedules following breast-conserving surgery: short-term morbidity and preliminary outcomes显示文摘 | Osamu Fujii Jyunichi Hiratsuka Naomi Nagase Ryuji Tokiya Eisaku Yoden Hiroshi Sonoo Nobutaka Murashima Shigemichi Iha Yoshinari Imajyo | 2008 | Breast Cancer2008，，1： | 2 |
| 5 | Preparation of aluminum nitride powder from aluminum polynuclear complexes显示文摘 | Hashimoto N Yoden H Nomura K | 1991 | J AmCeramSoc1991，74，12： | 1 |
| 6 | Negative MRI findings with invasive cervical biopsy may indicate stage I A cervical carcinoma 显示文摘 | Fujiwara K Yoden E Asakawa T et a1 | 2000 | Gynecol Oncol2000，79，3： | 1 |
| 7 | Sintering Behavior of Fine Aluminum Nitride Powder Synthesized from Alu- minum Polynuclear Complexes 显示文摘 | Hashimoto N Yoden H Deki S | 1992 | J Am Ceram Soc1992，75，8： | 1 |
| 8 | Sintering behavior of fine aluminum nitride powder syn- thesized from aluminum polynuclear complexes 显示文摘 | Hashimoto Noboru Yoden Hiroyoshi Deki Shigehito | 1992 | Journal American Ceramic Society1992，75，8： | 1 |
| 9 | Hypothyroidism after radiotherapy to the neck显示文摘 | Yoden E Soejima T Maruta T | 2004 | Nippon Igaku Hoshasen Gakkai Zasshi2004，64，3： | 1 |
| 10 | Thoracoscopic surgery combined with a supraclavicular approach for removing superior mediastinal tumor 显示文摘 | Akashi A Ohashi S Yoden Y | 1997 | Surg Endosc1997，11，1： | 1 |
| 11 | Neoadjuvant eoncurrent chemoradiotherapy followed by definitive high-dose radiotherapy or surgery for operable thoracic esophageal carcinoma显示文摘 | MurakamiM Kuroda Y OkamotoY Kono K Yoden E Kusumi F | 1998 | Int J Radiat Oncol Biol Phys1998，40，： | 1 |
| 12 | Sintering Behavior of line Aluminu,Nitridefrom Aluminum Pdynuclear,Complexes显示文摘 | Hashimoto n Yoden H Deki S | 1992 | J AM Ceramic Soc1992，75，8： | 1 |
| 13 | Hypothyroidism after radiotherapy to the neck显示文摘 | Yoden E Maruta T Soejima T | 2001 | Int J Radiat Oncol Biol Phys2001，49，2： | 1 |
| 14 | Sintering behavior of fine aluminum nitride powder synthesized from aluminum polynuclear complexes显示文摘 | HASHIMOTO N YODEN H DEKII S | 1992 | J Am Ceram Soc1992，75，8： | 1 |
| 15 | Sintering behavior of fine aluminum nitride powder synthesized from aluminum polynuclear complexes显示文摘 | Hashimoto N Yoden H Deki S | 1992 | Journal of American Ceramic Society1992，75，8： | 1 |
| 16 | Sintering Behavior of Fine Aluminum Nitride Powder Synthesized from Aluminum Polynuclear Complexes显示文摘 | Hashimoto N Yoden H Deki S | 1992 | J Am Ceram Soc1992，75，8： | 1 |
| 17 | Florid endocervival glandular hyperplasica with pyloric gland metaplasia : a radiologic pitfall 显示文摘 | Yoden E Mikami Y Fujiwara K | 2001 | J Comput Assist Tomogr2001，25，1： | 1 |
| 18 | Fluorescence formation from hydroperoxides of phosphatidylcholine with amino compounds显示文摘 | Lio T Yoden K | 1988 | Lipids1988，23，： | 1 |
| 19 | Negative MRI findings with invasive cervical biopsy may indicate stage Ⅰ A cervical carcinoma 显示文摘 | Fujiwara K Yoden E Asakawa T | 2000 | Gynecol Oncol2000，79，3： | 1 |
| 20 | Fluorescence formation and heme degradation at different stages of lipid peroxidation显示文摘 | Iio T Yoden K | 1987 | Life Sciences1987，40，27： | 1 |
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