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2篇 您的检索式:作者名="Keejong Chang"
    题名 作者 年代 出处 被引量
1Effective generation of transgenic pigs and mice by linker based sperm-mediated gene transfer显示文摘Keejong Chang Jin Qian Meisheng Jiang 2002BMC Biotechnology2002,2,:1
2Therapeutic application of chick early amniotic fluid: effective rescue of acute myocardial ischemic injury by intravenous administration显示文摘Myocardial regeneration has been considered a promising option for the treatment of adult myocardial injuries.Previously,a chick early amniotic fluid(ceAF)preparation was shown to contain growth-related factors that pro-moted embryonic growth and cellular proliferation,though the nature of the components within ceAF were not fully defined.Here we tested whether this ceAF preparation is similarly effective in the promotion of myocardial regen-eration,which could provide an alternative therapeutic for intervening myocardial injury.In this study,a myocardial ischemic injury model was established in adult mice and pigs by multiple research entities,and we were able to show that ceAF can efficiently rescue damaged cardiac tissues and markedly improve cardiac function in both experimental models through intravenous administration.ceAF administration increased cell proliferation and improved angio-genesis,likely via down-regulation of Hippo-YAP signaling.Our data suggest that ceAF administration can effectively rescue ischemic heart injury,providing the key functional information for the further development of ceAF for use in attenuating myocardial injury.Baiping Cui Yufan Zheng Xiang Gao Lihong Zhang Borui Li Jia Chen Xinyan Zhou Mengyuan Cai Wenrui Sun Yuting Zhang Keejong Chang Jiayi Xu Fuyin Zhu Yan Luo Tao Sun Jin Qian Ning Sun 2022Cell Regeneration2022,11,1:0
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