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| 1 | A Novel Approach for QoS Prediction Based on Bayesian Combinational Model显示文摘As an important factor in evaluating service,QoS(Quality of Service) has drawn more and more concerns with the rapid increasing of Web services. However,due to the great volatility of services in Mobile Internet environments,such as internet of vehicles,Web services often do not work as announced and thus cause unacceptable problems. QoS prediction can avoid failure before it takes place,which is considered a more effective way to assure quality. However,Current QoS prediction approaches neither consider the highly dynamic of Web services,nor maintain good prediction performance all the time. Consequently we propose a novel Bayesian combinational model to predict QoS by continuously adjusting credit values of the basic models so as to keep good prediction accuracy. QoS attributes such as response time,throughput and reliability are used to validate the proposed model. Experimental results show that the model can provide stable prediction results in Mobile Internet environments. | Pengcheng Zhang Yingtao Sun Hareton Leung Meijun Xu Wenrui Li | 2016 | China Communications2016，13，11： | 3 |
| 2 | Preparation and stability investigation of tamsulosin hydrochloride sustained release pellets containing acrylic resin polymers with two different techniques显示文摘The objective of this study was to prepare tamsulosin hydrochloride-sustained release(TSH-SR)pellets which showed good release stability with frame-controlled method.TSH was added to Eudragit~?NE30D and Eudragit~?L30D-55 polymers to form drug-loaded inner core.Afterwards,enteric Eudragit~?L30D-55 polymer was modified on the surface of it to the final product.Dissolution studies showed that TSH-SR pellets were more stable during the coating process,different curing temperatures and storage conditions compared with TSH pellets produced by film-controlled technique.Appearances and glass transition temperatures(Tgs)of free films and surface morphologies observed by scanning electron microscopy(SEM)of blank sustained release pellets prepared by different ratios of Eudragit~?NE30D and Eudragit~?L30D-55 further indicated that temperature and relative humidity(RH)were the key factors when Eudragit~?NE30D blended with Eudragit~?L30D-55 were applied to sustained/controlled release preparations.In addition,SEM identified the surface morphologies of TSH-SR pellets before and after dissolution,which showed intact surface structure and great correlation with release curve respectively. | Rui Fan Yinghua Sun Bing Li Ruyi Yang Wenrui Ma Jin Sun | 2017 | Asian Journal of Pharmaceutical Sciences2017，12，2： | 2 |
| 3 | Liver proteome analysis of adaptive response in rat immediately after partial hepatectomy显示文摘 | SUN Yanwei DENG Xinyu LI Wenrui | 2007 | Proteomics2007，7，23： | 1 |
| 4 | An Algorithmic Approach to Finding Factorial Designs with Generalized Minimum Aberration显示文摘 | Fasheng Sun Min-Qian Liu Wenrui Hao | 2009 | Journal of Complexity2009，，25： | 1 |
| 5 | Measurement of alkaline phosphatase isoenzymes in individual mouse bone marrow fibroblast cells based on capillary electroresis with on-capillary enzyme-catalyzed reaction and electrochemical detection显示文摘 | Sun Xuemei Jin Wenrui Li Dong | 2004 | Elcetrophoresis2004，25，： | 1 |
| 6 | Therapeutic application of chick early amniotic fluid: effective rescue of acute myocardial ischemic injury by intravenous administration显示文摘Myocardial regeneration has been considered a promising option for the treatment of adult myocardial injuries.Previously,a chick early amniotic fluid(ceAF)preparation was shown to contain growth-related factors that pro-moted embryonic growth and cellular proliferation,though the nature of the components within ceAF were not fully defined.Here we tested whether this ceAF preparation is similarly effective in the promotion of myocardial regen-eration,which could provide an alternative therapeutic for intervening myocardial injury.In this study,a myocardial ischemic injury model was established in adult mice and pigs by multiple research entities,and we were able to show that ceAF can efficiently rescue damaged cardiac tissues and markedly improve cardiac function in both experimental models through intravenous administration.ceAF administration increased cell proliferation and improved angio-genesis,likely via down-regulation of Hippo-YAP signaling.Our data suggest that ceAF administration can effectively rescue ischemic heart injury,providing the key functional information for the further development of ceAF for use in attenuating myocardial injury. | Baiping Cui Yufan Zheng Xiang Gao Lihong Zhang Borui Li Jia Chen Xinyan Zhou Mengyuan Cai Wenrui Sun Yuting Zhang Keejong Chang Jiayi Xu Fuyin Zhu Yan Luo Tao Sun Jin Qian Ning Sun | 2022 | Cell Regeneration2022，11，1： | 0 |
| 7 | Activation of Pancreatic Acinar FXR Protects against Pancreatitis via Osginl-Mediated Restoration of Efficient Autophagy显示文摘Pancreatitis is the leading cause of hospitalization in gastroenterology,and no medications are available for treating this disease in current clinical practice.FxR plays an anti-inflammatory role in diverse inflammatory diseases,while its function in pancreatitis remains unknown.In this study,we initially observed a marked increase of nuclear FXR in pancreatic tissues of human patients ithpancratis eleting theFXRinpancreati acinar cels FXRicnara/a)ledto moreseverepancreatitis in mousemodels of caerulein-induced acute and chronic pancreatitis,while the FXR agonist GW4064 significantly attenuated pancreatitis in caerulein or arginine-induced acute pancreatitis and caerulein-induced chronic pancreatitis.FXR deletion impaired the viability and stress responses of pancreatic exocrine organoids(PEOs)in vitro.Utilizing RNA-seq and ChIP-seq of PEOs,we identified Osginl as a direct target of FxR in the exocrine pancreas,which was also increasingly expressed in human pancreatitis tissues compared to normal pancreatic tissues.Pancreatic knockdown of Osgin1 by AAV-pan abolished the therapeutic effects of FXR activation on pancreatitis,whereas pancreatic overexpression of Osginl effectively alleviated caerulein-induced pancreatitis.Mechanistically,we found that the FXR-OSGINl axis stimulated autophagic flux in the pancreatic tissues and cell lines,which was considered as the intrinsic mechanisms through which FXR-OSGINI protecting against pancreatitis.Our results highlight the protective role of the FXR-OSGIN1 axis in pancreatitis and provided a new target for the treatment of this disease. | Yufan Zheng Wenrui Sun Zhengyang Wang Jiaying Liu Cong Shan Chenxi He Borui Li Xiao Hu Wenjia Zhu Liyan Liu Fei Lan Changtao Jiang Chao Zhao Xiaobo Li Ning Sun | 2023 | Research2023，，1： | 0 |
| 8 | Advances in Research on Hypoglycemic Functions of Polysaccharides from Medicinal and Edible Plants显示文摘Plant polysaccharides have an excellent hypoglycemic effect through various ways such as promoting insulin secretion,improving insulin resistance,regulating related enzyme activities,improving sugar,protein and fat metabolism,promoting hepatic glycogen synthesis,inhibiting gluconeogenesis,and improving immune system function and resistance.At present,more than 200 polysaccharides derived from traditional Chinese medicines have been reported,and most of them are isolated and purified from plants.With the deepening of research on plant polysaccharides,more and more attention has been paid to the development of safe and economical natural hypoglycemic products.This paper first introduced the hypoglycemic effects of Folium Mori polysaccharides,Cucurbita moschata polysaccharides,Momordica charantia polysaccharides,Dioscoreae Rhizoma polysaccharides and Camellia sinensis O.Kuntze polysaccharides.Besides,it discussed the utilization ways of hypoglycemic plant polysaccharides,and the prospects of applying polysaccharide hypoglycemic effect to diabetes treatment,so as to provide reference for the research and utilization of plant polysaccharide hypoglycemic effects and the development of natural hypoglycemic foods. | Xiaohan ZHANG Chenghui ZHANG Wenrui YU Wanru XUE Tong TONG Jialin SUN Xuqiao FENG | 2018 | Medicinal Plant2018，9，6： | 0 |
| 9 | Predict Blood Pressure by Photoplethysmogram with the Fluid-Structure Interaction Modeling显示文摘Blood pressure(BP)has been identified as one of the main factors in cardiovascular disease and other related diseases.Then how to accurately and conveniently measure BP is important to monitor BP and to prevent hypertension.This paper proposes an efficient BP measurement model by integrating a fluid-structure interaction model with the photoplethysmogram(PPG)signal and developing a data-driven computational approach to fit two optimization parameters in the proposedmodel for each individual.The developed BPmodel has been validated on a public BP dataset and has shown that the average prediction errors among the root mean square error(RMSE),the mean absolute error(MAE),the systolic blood pressure(SBP)error,and the diastolic blood pressure(DBP)error are all below 5mmHg for normal BP,stage I,and stage II hypertension groups,and,prediction accuracies of the SBP and the DBP are around 96%among those three groups. | Jianhong Chen Wenrui Hao Pengtao Sun Lian Zhang | 2022 | Communications in Computational Physics2022，31，4： | 0 |
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