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| 1 | Prognosis of metastatic splenic hilum lymph node in patients with gastric cancer after total gastrectomy and splenectomy显示文摘AIM:To clarify the significance of combined resection of the spleen to dissect the No.10 lymph node(LN). METHODS:We studied 191 patients who had undergone total gastrectomy with splenectomy,excluding non-curative cases,resection of multiple gastric cancer, and those with remnant stomach cancer.Various clinico-pathological factors were evaluated for any independent contributions to No.10 LN metastasis,usingχ 2 test. Significant factors were extracted for further analysis, carried out using a logistic regression method.Furthermore,lymph node metastasis was evaluated for any independent contribution to No.10 LN metastasis,using the same methods.The cumulative survival rate was calculated using the Kaplan-Meier method.The significance of any difference between the survival curves was determined using the Cox-Mantel test,and any difference was considered significant at the 5%level. RESULTS:From the variables considered to be potentially associated with No.10 LN metastasis,age, depth,invasion of lymph vessel,N factor,the numberof lymph node metastasis,Stage,the number of sites, and location were found to differ significantly between those with metastasis(the Positive Group)and those without(the Negative Group).A logistic regression analysis showed that the localization and Stage were significant parameters for No.10 LN metastasis.There was no case located on the lesser curvature in the Posi-tive Group.The numbers of No.2,No.3,No.4sa,No. 4sb,No.4d,No.7,and No.11 LN metastasis were each found to differ significantly between the Positive Group and the Negative Group.A logistic regression analysis showed that No.4sa,No.4sb,and No.11 LN metastasis were each a significant parameter for No.10 LN metastasis.There was no significant difference in survival curves between the Positive Group and the Negative Group. CONCLUSION:Splenectomy should be performed to dissect No.10 LN for cases which have No.4sa,No. 4sb or No.11 LN metastasis.However,in cases where the tumor is located on the lesser curvature,splenectomy can be omitted. | Keishiro Aoyagi Kikuo Kouhuji Motoshi Miyagi Takuya Imaizumi Junya Kizaki Kazuo Shirouzu | 2010 | World Journal of Hepatology2010，2，2： | 26 |
| 2 | Characteristics and prognosis of synchronous multiple early gastric cancer显示文摘AIM:To assess the clinicopathologic characteristics,risk factors,and prognosis for synchronous multiple early gastric cancer(SMGC).METHODS:A total of 146 patients with SMGC and1194 patients with single gastric cancer who had undergone gastrectomy between 1989 and 2008 were retrospectively analyzed to determine their clinicopathologic characteristics and postoperative survival.Tumors were classified into groups on the basis of location and histology.Smoking habits were evaluated using the Brinkman index.Clinical and pathological factors were compared using either Fisher’s exact test or Pearson’sχ2test.Logistic regression analysis was performed to identify independent risk factors.Survival rate was calculated using the Kaplan-Meier method.RESULTS:SMGCs accounted for 10.9%of gastric cancer cases and occurred predominantly in elderly male patients with a family history of gastric cancer who were both smokers and drinkers.These tumors were typically macroscopically elevated and histologically differentiated.There were no significant differences between SMGC and single gastric cancer patients with respect to tumor location,tumor size,lymph node metastasis,the number of metastatic lymph nodes,venous invasion,or tumor stage(P=0.052,P=0.347,P=0.595,P=0.805,P=0.559,and P=0.408,respectively).Further,there was no significant difference in postoperative survival between the patient groups(P=0.200).Of the 146SMGC patients,a single patient had remnant cancer.CONCLUSION:A careful preoperative endoscopy is necessary for patients who are at high risk of SMGC,and minimally invasive treatment may be indicated in some cases. | Taro Isobe Kousuke Hashimoto Junya Kizaki Naotaka Murakami Keishiro Aoyagi Kikuo Koufuji Yoshito Akagi Kazuo Shirouzu | 2013 | World Journal of Gastroenterology2013，19，41： | 17 |
| 3 | Molecular targeting therapy using bevacizumab for peritoneal metastasis from gastric cancer显示文摘AIM: To clarify the significance of vascular endothelial growth factor(VEGF) in peritoneal metastasis from gastric cancer, using the gastric cancer cell line MKN-45 compared with the high potential peritoneal dissemination gastric cancer cell line MKN-45 P. METHODS: The supernatant of culture medium of MKN-45 cells or MKN-45 P cells was collected and the concentrations were measured of various cytokines, matrix metalloproteinases, growth factor and angiogenic factors, including VEGF. We performed an initial pilot study to explore whether bevacizumab, a humanized monoclonal antibody against VEGF, had any suppressive effect on the peritoneal dissemination from gastric cancer in an experimental nude mouse modelof peritoneal metastasis. RESULTS: The concentrations of interleukin-6(IL-6), IL-8, VEGF and matrix metalloproteinase-2 protein in the culture supernatant were each significantly higher than each of those for MKN-45. In the in vivo study, the volume of ascites and the mitotic index were significantly lower in the therapy group than in the nontherapy group. The survival curve of the therapy group was significantly higher than that of the non-therapy group. These results suggested that VEGF was correlated with peritoneal metastasis from gastric cancer. CONCLUSION: Findings suggested that bevacizumab for inhibiting VEGF could suppress peritoneal dissemination from gastric cancer. | Keishiro Aoyagi Kikuo Kouhuji Motoshi Miyagi Junya Kizaki Taro Isobe Kousuke Hashimoto Kazuo Shirouzu | 2013 | World Journal of Critical Care Medicine2013，2，4： | 12 |
| 4 | Molecular targeting to treat gastric cancer显示文摘Trastuzumab that targets human epidermal growth factor receptor 2(HER2) protein is the only approved molecular targeting agent for treating gastric cancer in Japan and the outcomes have been favorable. However,trastuzumab is effective for only 10% to 20% of the population with gastric cancer that expresses HER2 protein. Molecular targeting therapy with bevacizumab against vascular endothelial growth factors(VEGF) and with cetuximab and panitumumab against the epidermal growth factors pathway that have been approved for treating colorectal cancer are not considered effective for treating gastric cancer according to several clinical trials. However,ramucirumab that targets VEGF receptor-2 prolonged overall survival in a large phase Ⅲ clinical trial and it might be an effective molecular targeting therapy for gastric cancer. The significance of molecular targeting therapy for gastric cancer remains controversial. A large-scale randomized clinical trial of novel molecular targeting agents with which to treat gastric cancer is needed. | Keishiro Aoyagi Kikuo Kouhuji Junya Kizaki Taro Isobe Kousuke Hashimoto Kazuo Shirouzu | 2014 | World Journal of Gastroenterology2014，20，38： | 5 |
| 5 | Quality of life after total vs distal gastrectomy with Rouxen-Y reconstruction: Use of the Postgastrectomy Syndrome Assessment Scale-45显示文摘AIM To investigate the detrimental impact of loss of reservoir capacity by comparing total gastrectomy(TGRY) and distal gastrectomy with the same Rouxen-Y(DGRY) reconstruction. The study was conducted using an integrated questionnaire, the Postgastrectomy Syndrome Assessment Scale(PGSAS)-45, recently developed by the Japan Postgastrectomy Syndrome Working Party.METHODS The PGSAS-45 comprises 8 items from the Short Form-8, 15 from the Gastrointestinal Symptom Rating Scale, and 22 newly selected items. Uni-and multivariate analysis was performed on 868 questionnaires completed by patients who underwent either TGRY(n = 393) or DGRY(n = 475) for stage I gastric cancer(52 institutions). Multivariate analysis weighed of six explanatory variables, including the type of gastrectomy(TGRY/DGRY), interval after surgery, age, gender, surgical approach(laparoscopic/open), and whether the celiac branch of the vagus nerve was preserved/divided on the quality of life(QOL).RESULTS The patients who underwent TGRY experienced the poorer QOL compared to DGRY in the 15 of 19 main outcome measures of PGSAS-45. Moreover, multiple regression analysis indicated that the type of gastrectomy, TGRY, most strongly and broadly impaired the postoperative QOL among six explanatory variables. CONCLUSION The results of the present study suggested that TGRY had a certain detrimental impact on the postoperative QOL, and the loss of reservoir capacity could be a major cause. | Masazumi Takahashi Masanori Terashima Hiroshi Kawahira Eishi Nagai Yoshikazu Uenosono Shinichi Kinami Yasuhiro Nagata Masashi Yoshida Keishiro Aoyagi Yasuhiro Kodera Koji Nakada | 2017 | World Journal of Gastroenterology2017，23，11： | 3 |
| 6 | Characteristics and prognosis of gastric cancer in young patients显示文摘 | Taro Isobe Kousuke Hashimoto Junya Kizaki Motoshi Miyagi Keishiro Aoyagi Kikuo Koufuji Kazuo Shirouzu | 2013 | Oncology Reports2013，，1： | 2 |
| 7 | Expression of CD133 in the cytoplasm is associated with cancer progression and poor prognosis in gastric cancer显示文摘 | Kousuke Hashimoto Keishiro Aoyagi Taro Isobe Kikuo Kouhuji Kazuo Shirouzu | 2014 | Gastric Cancer2014，，1： | 2 |
| 8 | Comparative analysis of socio-economic and environmental performances for Chinese EIPs: case studies in Baotou, Suzhou, and Shanghai显示文摘 | ZHANG H Y KEISHIRO H HELMUT Y | 2009 | Sustainability Science2009，4，2： | 1 |
| 9 | Characterization of the gene for Δ1-pyrroline-5-carboxylate synthetase and correlation between the expression of the gene and salt tolerance in Oryza sativa L.显示文摘 | Yumiko Igarashi Yoshu Yoshiba* Yukika Sanada Kazuko Yamaguchi-Shinozaki Keishiro Wada Kazuo Shinozaki | 1997 | Plant Molecular Biology1997，，5： | 1 |
| 10 | Effect of polymer size on the polyeletrolyte-surfactant in- teraction 显示文摘 | Liu Jun Noboru Takisawa Keishiro Shirahama | 1997 | Journal of Physical Chemistry1997，101，38： | 1 |
| 11 | Preparation and properties of inhalable nanocomposite particles for treatment of lung cancer显示文摘 | Keishiro Tomoda Takumi Ohkoshi Keiji Hirota Ganeshchandra S. Sonavane Takehisa Nakajima Hiroshi Terada Masahito Komuro Kenji Kitazato Kimiko Makino | 2009 | Colloids and Surfaces B: Biointerfaces2009，，2： | 1 |
| 12 | Fluctuation in Ig levels(IgG and IgM)of chicken during aging显示文摘 | SHIMURA Keishiro | 1975 | Mie Igaku1975，19，1： | 1 |
| 13 | Index- profile design for low-loss crossed multimode waveguide for optical printed circuit board 显示文摘 | Takaaki Ishigure Keishiro Shitanda Yutaro Oizmi | 2015 | Optics Express2015，23，22： | 1 |
| 14 | Enzymatic synthesis of α- arbutin by α-anomer-selective glucosylation of hydroquinone using lyophilized cells of Xanthomonas campestris WU-9701 显示文摘 | Kurosu J Sato T Keishiro Y | 2002 | J Biosci Bioeng2002，93，3： | 1 |
| 15 | Clinicopathological significance of hypoxia-inducible factor-1 alpha(HIF-1α)expression in gastric cancer显示文摘 | Taro I Keishiro A Kikuo K | 2013 | International journal of clinical oncology2013，18，2： | 1 |
| 16 | Enzymatic synthesis of α-arbutin by α - anomer- selective glucosylatian of hydroquinone using lyophilized cells of Xanthomonas campestris WU- 9701 显示文摘 | JUN K TOSHIYUKI S KEISHIRO Y | 2002 | J Biosclence and Bioengineering2002，93，3： | 1 |
| 17 | Effect of labeled derivatives of podophyllotoxin on cell cycle and macromolecular synthsis in hu- man lymphoid leukemia Molt 4B ceils 显示文摘 | Wang JZ Hideki T Keishiro S | 1998 | Acta Pharrnacol Sin1998，19，6： | 1 |
| 18 | Tracking environmental innovations and policy regulations in Japan: Case studies on dioxin emissions and electric home appliances recycling 显示文摘 | Yabar H Michinori Uwasu Keishiro Hara | 2013 | Journal of Cleaner Production2013，44，： | 1 |
| 19 | Suppressive effect of bevacizumab on peritoneal dissemination from gastric cancer in a peritoneal metastasis model显示文摘 | Takuya Imaizumi Keishiro Aoyagi Motoshi Miyagi Kazuo Shirouzu | 2010 | Surgery Today2010，，9： | 1 |
| 20 | Pulsed dry methane reforming in plasma- enhanced catalytic reaction 显示文摘 | SEIGO K KEISHIRO T YUTARO I | 2015 | Catalysis Today2015，256，： | 1 |
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