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| 1 | Anticancer effect of linalool via cancer-specific hydroxyl radical generation in human colon cancer显示文摘AIM To investigate the anticancer mechanisms of the monoterpenoid alcohol linalool in human colon cancer cells.METHODS The cytotoxic effect of linalool on the human colon cancer cell lines and a human fibroblast cell line was examined using the WST-8 assay. The apoptosisinducing effect of linalool was measured using the terminal deoxynucleotidyl transferase d UTP nickend labeling assay and flow cytometry with Annexin V. Oxidative stress was investigated by staining for diphenyl-1-pyrenylphosphine, which is a cellular lipid peroxidation marker, and electron spin resonance spectroscopy. Sixteen SCID mice xenografted with human cancer cells were randomized into 3 groups for in vivo analysis: control and low-dose and high-dose linalool groups. The control group was administered tap water orally every 3 d. The linalool treatment groups were administered 100 or 200 μg/kg linalool solution orally for the same period. All mice were sacrificed under anesthesia 21 d after tumor inoculation, and tumors and organs were collected for immunohistochemistry using an anti-4-hydroxynonenal antibody. Tumor weights were measured and compared between groups. RESULTS Linalool induced apoptosis of cancer cells in vitro, following the cancer-specific induction of oxidative stress, which was measured based on spontaneous hydroxyl radical production and delayed lipid peroxidation. Mice in the high-dose linalool group exhibited a 55% reduction in mean xenograft tumor weight compared with mice in the control group(P < 0.05). In addition, tumor-specific lipid peroxidation was observed in the in vivo model.CONCLUSION Linalool exhibited an anticancer effect via cancerspecific oxidative stress, and this agent has potential for application in colon cancer therapy. | Kenichi Iwasaki Yun-Wen Zheng Soichiro Murata Hiromu Ito Ken Nakayama Tomohiro Kurokawa Naoki Sano Takeshi Nowatari Myra O Villareal Yumiko N Nagano Hiroko Isoda Hirofumi Matsui Nobuhiro Ohkohchi | 2016 | World Journal of Gastroenterology2016，22，44： | 5 |
| 2 | Causes of encephalitis and differences in their clinical presentations in England: a multicentre, population-based prospective study显示文摘 | Julia Granerod Helen E Ambrose Nicholas WS Davies Jonathan P Clewley Amanda L Walsh Dilys Morgan Richard Cunningham Mark Zuckerman Ken J Mutton Tom Solomon Katherine N Ward Michael PT Lunn Sarosh R Irani Angela Vincent David WG Brown Natasha S Crowcroft | 2010 | The Lancet Infectious Diseases2010，，12： | 2 |
| 3 | Hemagglutinins in fungus extracts and their blood group specificity显示文摘 | Ren Y Tamiko N | 1996 | Experimental and Clinical Immunogenetics1996，12，4： | 1 |
| 4 | Differential geometrical conditions between geodesic curves and ruled surfaces显示文摘 | Ayyildiz N A Cken C Yucesan A | 2002 | Balkan Journal of Geometry and Its Applications2002，7，1： | 1 |
| 5 | Increase glutathione hiosynthesis plays a role in nickel tolerance in thlaspi nickel hyperaecumulas显示文摘 | John L F Michael W P Ken N | 2004 | The Plant Cell2004，16，： | 1 |
| 6 | A unique technique of laser-induced breakdown spectroscopy using transversely excited atmospheric CO2 laser for the sensitive analysis of powder samples 显示文摘 | Ali K Hideaki N Ken F | 2011 | Current Applied Physics2011，11，3： | 1 |
| 7 | 显示文摘 | KEN T TAKESHI S KEIICHI N | 2007 | J Org Chem2007，7，： | 1 |
| 8 | Antioxidant activity of hot water extract from the fruit of the Doum palm, Hyphaene thebaica 显示文摘 | Hsu B Coupar I M Ken N | 2006 | Food Chemistry2006，98，2： | 1 |
| 9 | Effect of side methyl groups of polymer glycol on elongation - induced crystallization behavior of polyurethane elastomers显示文摘 | KEN K SADAHARU N MUTSUHISA F | 2004 | Pol- ymer2004，45，24： | 1 |
| 10 | Morphological characterization of Apis cerana in the Yunnan Province of China 显示文摘 | TAN Ken FUCHS S KOENIGER N | 2003 | Apidologie2003，34，6： | 1 |
| 11 | Mechanism of the conversion of xanthine dehydrogenase to xanthine oxidase:identification of the two cysteine disulfide bonds and crystal structure of a non-convertible rat liver xanthine dehydrogenase mutant显示文摘 | Tomoko N Ken O Yuko K | 2005 | J Biol Chem2005，280，24： | 1 |
| 12 | Increased glutathione biosynthesis plays a role in nickel tolerance in thlaspi nickel hyperaccumulators显示文摘 | John L F Michael W P Ken N | 2004 | The Plant Cell2004，16，： | 1 |
| 13 | Enzymic hydrolysis of lignin-carbohydrate complexes isolated from kraft pulp显示文摘 | Ken K Y Wong Shinso Yokota John N Saddler | 1996 | Journal of Wood Chemistry and Technology1996，16，2： | 1 |
| 14 | Mitochondrial DNA diversity of Chinese Apis cerana 显示文摘 | TAN Ken WARRIT N SMITH D R | 2007 | Apidologie2007，38，3： | 1 |
| 15 | Predictive factors of TIMI-3 flow before pereutaneous coronary intervention in facilitated percutaneous coronary intervention for acute myocardial infarction显示文摘 | IKUYOSHI W KEN N SHIGEMASA T | 2006 | Int Heart J2006，47，： | 1 |
| 16 | Hysteroscopic appearance of the mid-secretary endometrium relationship to early phase pregnancy outcome after implantation显示文摘 | Hitoshi M Ken N Keji K | 2000 | Hum Reprod2000，15，10： | 1 |
| 17 | Improved algorithm for estimating pulse repetition intervals显示文摘 | Ken I N Massaaki K | 2000 | IEEE Trans on Aerospace and Electronic Systems2000，36，2： | 1 |
| 18 | Effect of casein genotype on milk performance in Japanese shorthorn cow 显示文摘 | Nakayarna O Mistsyji O Ken N | 1995 | Animal Science and Technology1995，66，8： | 1 |
| 19 | Early-life-stage toxicity in offspring from exposed parent medaka, oryzias latipes, to mixtures of tributyltin and polychlorinated biphenyls显示文摘 | Kei N Yuji O Ken N | 2005 | Environ Toxicol Pharmacol2005，24，3： | 1 |
| 20 | Clinicoradiologic features of vertebrobasilar dolichoectasia in stroke patients显示文摘 | Yoshikazu N Takehisa H Ken I | 2010 | Journal of Stroke and Cerebrovascular Disease2010，，： | 1 |
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