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| 1 | Rhubarb extract partially improves mucosal integrity in chemotherapy-induced intestinal mucositis显示文摘AIM To investigate the effects of orally gavaged aqueous rhubarb extract(RE) on 5-fluorouracil(5-FU)-induced intestinal mucositis in rats. METHODS Female Dark Agouti rats(n = 8/group) were gavaged daily(1 mL) with water, high-dose RE(HDR; 200 mg/kg) or low-dose RE(LDR; 20mg/kg) for eight days. Intestinal mucositis was induced(day 5) with 5-FU(150 mg/kg) via intraperitoneal injection. Intestinal tissue samples were collected for myeloperoxidase(MPO) activity and histological examination. Xenopus oocytes expressing aquaporin 4 water channels were prepared to examine the effect of aqueous RE on cell volume, indicating a potential mechanism responsible for modulating net fluid absorption and secretion in the gastrointestinal tract. Statistical significance was assumed at P < 0.05 by one-way ANOVA. RESULTS B o d y w e i g h t w a s s i g n i f i c a n t l y r e d u c e d i n r a t s administered 5-FU compared to healthy controls(P < 0.01). Rats administered 5-FU significantly increased intestinal MPO levels(≥ 307%; P < 0.001), compared to healthy controls. However, LDR attenuated this effect in 5-FU treated rats, significantly decreasing ileal MPO activity(by 45%; P < 0.05), as compared to 5-FU controls. 5-FU significantly reduced intestinal mucosal thickness(by ≥ 29% P < 0.001) as compared to healthy controls. LDR significantly increased ileal mucosal thickness in 5-FU treated rats(19%; P < 0.05) relative to 5-FU controls. In xenopus oocytes expressing AQP4 water channels, RE selectively blocked water influx into the cell, induced by a decrease in external osmotic pressure. As water efflux was unaltered by the presence of extracellular RE, the directional flow of water across the epithelial barrier, in the presence of extracellular RE, indicated that RE may alleviate water loss across the epithelial barrier and promote intestinal health in chemotherapy-induced intestinal mucositis.CONCLUSION In summary, low dose RE improves selected parameters of mucosal integrity and reduces ileal inflammation, manifesting from 5-FU-induced intestinal mucositis. | Juliana E Bajic Georgina L Eden Lorrinne S Lampton Ker Y Cheah Kerry A Lymn Jinxin V Pei Andrea J Yool Gordon S Howarth | 2016 | World Journal of Gastroenterology2016，22，37： | 3 |
| 2 | Oral simvastatin treatment in relapsing-remitting multiple sclerosis显示文摘 | Vollmer T ker L Durkalski V | 2004 | Lancet2004，363，9421： | 1 |
| 3 | Molecular standardization of mating type terminology in the Gibberella fujikuroi species complex显示文摘 | Kerényi Z Zeller K Hornok L | 1999 | Applied and Environmental Microbiology1999，65，9： | 1 |
| 4 | Serum uric acid and cardiovascular disease:recent developments,where do they leave us显示文摘 | Ker JF Krishnan E Chen L | | 0，，8： | 1 |
| 5 | Dig显示文摘 | Ker M D Deng C K and Huang J L SID Tech | 2005 | 288-2912005，，： | 1 |
| 6 | Progress Report:Construction of Centennial Heritage Gardens underway!显示文摘 | Ker L | 1990 | Newsletter of the Idaho Botanical Garden1990，，3： | 1 |
| 7 | 显示文摘 | Fang J S Hsu T P Ker M L | 2007 | J Phys Chem Solids2007，07，： | 1 |
| 8 | First report of cylindrospermopsin production by two cyanobacteria(Dolichospermummendotae and Chrysosporumovalisporum)in Lake Iznik,Turkey显示文摘 | Akcaalan R K?ker L O?uz A | 2014 | Toxins2014，6，11： | 1 |
| 9 | A retrospective analysis and review of an institution 's experience with the complications of cranioplasty 显示文摘 | Lee L Ker J Quah BL | 2013 | Br J Neurosurg2013，27，： | 1 |
| 10 | Red cell distribution width as a novel prognostic marker in heart failure: Data from the CHARM program and the duke databank 显示文摘 | Fel ker G M All en L A Pocock S J | 2007 | J Am Coil Cardiol2007，50，1： | 1 |
| 11 | Tracking and balance control of ball and plate system显示文摘 | Ker C Ch L Wang R | 2007 | J of the Chinese Institute of Engineers2007，30，3： | 1 |
| 12 | Development of microbial populations in the anaerobic hydrolysis of grass silage for methane production 显示文摘 | Wang H Vuorela M Ker/inen A L | 2010 | FEMS Microbiology Ecology2010，72，3： | 1 |
| 13 | Biochemical andbiological characteristics of cross-reacting material 197(CRM197),a non-toxic mutant of diphtheria toxin:Use as a conjugationprotein in vaccines and other potential clinicalapplications显示文摘 | Br- ker M Costantino P De Tora L | 2011 | Biologicals2011，39，4： | 1 |
| 14 | Genome sequence of the Thermotoga thermarum type strain (LA3T) from an African solfataric spring 显示文摘 | G?ker M Spring?S Scheuner C Anderson I Zeytun A Nolan M Lucas S Tice H Del Rio TG Cheng JF Han C Tapia R Goodwin LA Pitluck S Liolios K Mavromatis K Pagani I Ivanova N Mikhailova N Pati A Chen A Palaniappan K Land M Hauser L Chang YJ Jeffries CD Rohde M Detter JC Woyke T Bristow J Eisen JA Markowitz V Hugenholtz P Kyrpides NC Klenk HP Lapidus A | 2014 | Stand Genomic Sci2014，9，3： | 1 |
| 15 | Evaluation of properties of Ta-Ni amorphous thin film for copper metallization in integrated circuits显示文摘 | Fanga J S Hsub T P Ker M L | 2008 | J Phys Chem Solids2008，69，23： | 1 |
| 16 | Glomerular filtration rate estimation using cystatin C alone or combined with creatinine as a confirmatory test显示文摘 | Fan L h ker LA Rossert J | 2014 | NephrolDialTransplant2014，29，6： | 1 |
| 17 | Design of charge pump circuit with consideration of gate-oxide reliability in low-voltage CMOS process 显示文摘 | Ker M D Chen S L Tsai C S | 2006 | Electronics IEEE Journals of Solid-State Circuits2006，41，： | 1 |
| 18 | Molecular mechanisms of auxin action显示文摘 | WAL KER L ESTELL EM | 1998 | Curr Opin Plant Biol1998，1，5： | 1 |
| 19 | Outcomes of chronic subdural hematoma drainage in nonagenarians and centenarians: a multicenter study 显示文摘 | Lee L Ker J Ng HY | 2015 | J Neurosurg2015，10，： | 1 |
| 20 | A pulsed field gradient Spin-Echo method for diffusion measurements in the presence of internal gradients显示文摘 | S(φ)rland G H Aksnes D Gjerd(a)ker L | 1999 | J Magn Reson1999，137，： | 1 |
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