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| 1 | Savage Concurrent Expression of MYC and BCL2 in Diffuse Large B-Cell Lymphoma Treated With Rituximab Plus Cyclophos- phamide, Doxorubicin, Vincristine, and Prednisone 显示文摘 | Johnson NA Graham WS Kerry J | 2012 | J Clin Oneol2012，30，： | 1 |
| 2 | Compliance with SEP-1 guidelines is associated with improved outcomes for septic shock but not for severe sepsis显示文摘Background: In 2018, the Centers for Medicaid and Medicare Services (CMS) issued a protocol for the treatment of sepsis. This bundle protocol, titled SEP-1 is a multicomponent 3 h and 6 h resuscitation treatment for patients with the diagnosis of either severe sepsis or septic shock. The SEP-1 bundle includes antibiotic administration, fluid bolus, blood cultures, lactate measurement, vasopressors for fluid-refractory hypotension, and a reevaluation of volume status. We performed a retrospective analysis of patients diagnosed with either severe sepsis or septic shock comparing mortality outcomes based on compliance with the updated SEP-1 bundle at a rural community hospital. Methods: Mortality outcome and readmission data were extracted from an electronic medical records database from January 1, 2019, to June 30, 2020. International Classification of Diseases (ICD)-10 codes were used to identify patients with either severe sepsis or septic shock. Once identified, patients were separated into four populations: patients with severe sepsis who met SEP-1, patients with severe sepsis who failed SEP-1, patients with septic shock who met SEP-1, and patients with septic shock who failed SEP-1. A patient who met bundle criteria (SEP-1 criteria) received each component of the bundle in the time allotted. Using chi-squared test of homogeneity, mortality outcomes for population proportions were investigated. Two sample proportion summary hypothesis test and 95% confidence intervals (CI) determined significance in mortality outcomes. Results: Out of our 1122 patient population, 437 patients qualified to be measured by CMS criteria. Of the 437 patients, 195 met the treatment bundle and 242 failed the treatment bundle. Upon comparing the two groups, we found the probable difference in mortality rate between the met(14.87%) and failed bundle(27.69%) groups to be significant(95% CI: 5.28-20.34, P = 0.0013). However, the driving force of this result lies in the subgroup of patients with severe sepsis with septic shock, which show a higher mortality rate compared to the subgroup with just severe sepsis. The difference was within the range of 3.31% to 29.71%. Conclusion: This study shows that with septic shock obtained a benefit, decreased mortality, when the SEP-1 bundle was met. However, meeting the SEP-1 bundle had no benefit for patients who had the diagnosis of severe sepsis alone. The significant difference in mortality, found between the met and failed bundle groups, is primarily due to the number of patients with septic shock, and whether or not those patients with septic shock met or failed the bundle. | Shelly NBSloan Nate Rodriguez Thomas Seward Lucy Sare Lukas Moore Greg Stahl Kerry Johnson Scott Goade Robert Arnce | 2022 | Journal of Intensive Medicine2022，2，3： | 1 |
| 3 | Congestive heart failure and sepsis:a retrospective study of hospitalization outcomes from a rural hospital in Southwest Missouri显示文摘Background:Sepsis is the leading cause of death in hospitalized patients and significant effort has been made to facilitate early diagnosis and management.However,aggressive treatment can have negative effects,especially in patients with unstable volume status,such as those with congestive heart failure.Methods:We used electronic medical records to perform a retrospective study looking at hospital outcomes in patients from Southwest Missouri who were admitted with sepsis and had a comorbid diagnosis of hypertensive heart failure.Our primary outcome was in-hospital mortality.Results:We studied a total of 184 patients with the diagnosis of hypertensive heart failure with sepsis,and 348 patients with the diagnosis of sepsis that served as the baseline group.There was a total of 37(20%)deaths in the hypertensive heart failure group and a total of 94(27%)deaths in the baseline group.Conclusion:Our study showed no significant difference between the baseline group and those with hypertensive heart disease with heart failure. | Alexandra Skovran Mason Hinke Shelly N.B.Sloan Greg Stahl Kerry Johnson Scott Goade Robert Arnce | 2022 | Emergency and Critical Care Medicine2022，2，3： | 1 |
| 4 | Syncope Predicts the Outcome of Cardiomyopathy Patients显示文摘 | Brian Olshansky Jeanne E. Poole George Johnson Jill Anderson Anne S. Hellkamp Douglas Packer Daniel B. Mark Kerry L. Lee Gust H. Bardy | 2008 | Journal of the American College of Cardiology2008，，13： | 1 |
| 5 | Environmental contamination because of multidrug-resistant Acinetobacter baumannii surrounding colonized or infected patients显示文摘 | Kerri A. Thom J. Kristie Johnson Mary S. Lee Anthony D. Harris | 2011 | AJIC: American Journal of Infection Control2011，，9： | 1 |
| 6 | In vitro C ytotoxic Properties of Crude Polar Extracts of Plants Sourced from Australia显示文摘Background:Numerous commercial pharmaceuticals-including anticancer,antiviral,and antidiabetic drugs have been developed from traditional plant-derived medicines.There are approximately 25,000 species of flora occurring in Australia,which are adapted to a range of harsh environments,and hence a plethora of novel compounds are still awaiting research in the context of their medicinal properties.Objective:The current study therefore aimed to develop a systematic protocol for screening plants with potential cytotoxicity.Many studies have found polar compounds such as to be the bioactive components responsible for the therapeutic effects.Methods:The total phenolic content(TPC)and antioxidant capacity(FRAP)of methanolic extracts of selected plants was first determined.A high correlation between the TPC values and FRAP values of the plant polar extracts were evident.Cell viability of the cancer cell lines were assessed using the MTS assay.Results:Cells subjected to Pittosporum angustifolium Lodd.Extracts at concentration of 250μg/mL showed no viable cells,comparable to cisplatin(a chemotherapy medication)used as a positive control(10μg/mL).Some promising inhibitory effects were also seen with Murrya koenigii flower and leaves at concentration of 250μg/mL,with only 43.46%and 63.88%cell viability,respectively.In contrast,extracts of Citrus hystrix(leaves)and Sygyz-ium australe(stamen)showed higher percentage cell viabilities(around 82-93%)at same concentrations.The phenolic profile of P.angustifolium B extracts demonstrating greater peak intensity and dominant peaks were tentatively identified as chlorogenic acid,p-coumaric acid,caffeic acid,t-ferulic acid and rutin.Conclusion:The Australian species P.angustifolium extract was the most cytotoxic against HeLa and HT29 cells comparing to the other plant extracts tested.A HPLC profile of the P.angustifolium extract also showed an array of promising therapeutic phenolic compounds.Future work will aim to fractionate and isolate novel compounds from this species and test their bioactivity. | Janice Mani Joel Johnson Holly Hosking Kerry Walsh Paul Neilsen Mani Naiker | 2022 | Clinical Complementary Medicine and Pharmacology2022，2，1： | 0 |
| 7 | Elite,transformable haploid inducers in maize显示文摘The introduction of alleles into commercial crop breeding pipelines is both time consuming and costly.Two technologies that are disrupting traditional breeding processes are doubled haploid(DH)breeding and genome editing(GE).Recently,these techniques were combined into a GE trait delivery system called HI-Edit(Haploid Inducer-Edit).In HI-Edit,the pollen of a haploid inducer line is reprogrammed to deliver GE traits to any variety,obviating recurrent selection.For HI-Edit to operate at scale,an efficient transformable HI line is needed,but most maize varieties are recalcitrant to transformation,and haploid inducers are especially difficult to transform given their aberrant reproductive behaviors.Leveraging marker assisted selection and a three-tiered testing scheme,we report the development of new Iodent and Stiff Stalk maize germplasm that are transformable,have high haploid induction rates,and exhibit a robust,genetically-dominant anthocyanin native trait that may be used for rapid haploid identification.We show that transformation of these elite‘‘HI-Edit”lines is enhanced using the BABYBOOM and WUSCHEL morphogenetic factors.Finally,we evaluate the HI-Edit performance of one of the lines against both Stiff Stalk and non-Stiff Stalk testers.The strategy and results of this study should facilitate the development of commercially scalable HI-Edit systems in diverse crops. | Brent Delzer Dawei Liang David Szwerdszarf Isadora Rodriguez Gonzalo Mardones Sivamani Elumalai Francine Johnson Samson Nalapalli Rachel Egger Erin Burch Kerry Meier Juan Wei Xiujuan Zhang Huaping Gui Huaibing Jin Huan Guo Kun Yu Yubo Liu Becky Breitinger Ana Poets Jason Nichols Wan Shi David Skibbe Qiudeng Que Timothy Kelliher | 2024 | The Crop Journal2024，12，1： | 0 |
| 8 | 为何汽车制造商需要关注HTML5显示文摘不只是在汽车业,在平板电脑、尤其是智能手机等其他没备上,制造商们为了满足消费者对内容和服务的需求,纷纷部署了令人眼花缭乱的各种技术。HTML5是一项非专有且被普遍采用的标准,并在广泛的部署中证明了其价值所在。如果有什么能在现在和未来帮助汽车制造商在合理的成本条件下满足车载伉色、娱乐系统中的用户所需,那就非HTML5莫属了。 | Andy Gryc Kerry Johnson | 2012 | 世界电子元器件2012，，1： | 0 |
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