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| 1 | Second-look arthroscopic evaluation of the articular cartilage after primary single-bundle and double-bundle anterior cruciate ligament reconstructions显示文摘在前面的十字形的系带( ACL ) reconstruction.No 报告关于比较变化在以后的软骨被出版了以后,背景几报告显示出关节的软骨退化的前进单个捆( SB )并且这研究的双捆( DB ) ACL reconstructions.The 目的是在 SB 和 DB ACL 以后评估关节的软骨变化由收到了 arthroscopic ACL 重建的 99 个病人回顾地是的秒看 arthroscopy.Methods | WANG Hai-jun AO Ying-fang CHEN Lian-xu GONG Xi WANG Yong-jian MA Yong LEUNG Kevin Kar Ming YU Jia-kuo | 2011 | Chinese Medical Journal2011，，21： | 12 |
| 2 | A review of microfluidic approaches for investigating cancer extravasation during metastasis显示文摘Metastases,or migration of cancers,are common and severe cancer complications.Although the 5-year survival rates of primary tumors have greatly improved,those of metastasis remain below 30%,highlighting the importance of investigating specific mechanisms and therapeutic approaches for metastasis.Microfluidic devices have emerged as a powerful platform for drug target identification and drug response screening and allow incorporation of complex interactions in the metastatic microenvironment as well as manipulation of individual factors.In this work,we review microfluidic devices that have been developed to study cancer cell migration and extravasation in response to mechanical(section‘Microfluidic investigation of mechanical factors in cancer cell migration’),biochemical(section‘Microfluidic investigation of biochemical signals in cancer cell invasion’),and cellular(section‘Microfluidic metastasis-on-a-chip models for investigation of cancer extravasation’)signals.We highlight the device characteristics,discuss the discoveries enabled by these devices,and offer perspectives on future directions for microfluidic investigations of cancer metastasis,with the ultimate aim of identifying the essential factors for a‘metastasis-on-a-chip’platform to pursue more efficacious treatment approaches for cancer metastasis. | Yu-Heng Vivian Ma Kevin Middleton Lidan You Yu Sun | 2018 | Microsystems & Nanoengineering2018，4，1： | 4 |
| 3 | Apparent relationships between anthropogenic factors and climate change indicators and POPs deposition in a lacustrine system显示文摘Climate change and anthropogenic activities are expected to impact the environmental behaviors and fates of persistent organic pollutants(POPs), however, quantitative studies on these combined factors are scarce. In this study, dichlorodiphenyltrichloroethane(DDTs), polycyclic aromatic hydrocarbons(PAHs), and polychlorinated biphenyls(PCBs)were used as examples to identify how and when those factors may be related to the deposition of POPs in the sediment of Lake Chaohu, China, using generalized additive models(GAMs). Three historical trends of DDT, PAH, and PCB deposition were delineated in a dated sediment core encompassing ~100 years of historical record: a steady state or gradually increasing stage, a rapidly increasing stage, and a declining stage. The GAM results showed that aquatic total phosphorus(TP) concentrations and regional GDP(anthropogenic factors) were dominant contributors to POP accumulation rates in the lake sediment. The fitted relationships between air temperature and sedimentary DDT and PAH concentrations were linear and negative, while a positive linear relationship was found for PCBs, suggesting that Lake Chaohu may have become a net source for DDTs and PAHs, and a sink for PCBs, under a progressively warming climate. | Hanxiao Zhang Shouliang Huo Kevin M. Yeager Chaocan Li Beidou Xi Jingtian Zhang Zhuoshi He Chunzi Ma | 2019 | Journal of Environmental Sciences2019，31，9： | 4 |
| 4 | A new multi-parallel-beam collimators with improved sensitivity for SPECT显示文摘In this paper, a new design of multi-parallel-beam (MPB) collimators with projection multiplexing is proposed. In the MPB system, two different oblique parallel channels are introduced in a conventional parallel-beam collimator. The sensitivity of the single photon emission computed tomography (SPECT) system is improved by allowing projection overlapping. Comparative simulation studies were performed in the MPB collimators, general purpose parallel-beam (GPPB) collimators and high sensitivity parallel-beam (HSPB) collimators. In the simulation, attenuation, scattering and the impact of detector response were neglected. Simulation results show that the sensitivity is improved for the MPB collimator comparing with parallel-beam collimator. The behavior of spatial resolution is only different near the front face of the collimators and approaches that of the GPPB with increasing depth. Proper pre-filtering is helpful for the image reconstruction in the MPB collimators. Comparing with the HSPB collimator, the MPB can achieve a similar sensitivity and better resolution. The simulation ot the U87 cells, and their expression levels were higher in the 10 Gy group than in the 0 Gy group. The differential gene expression in DCX-U87 cells before and after radiation is helpful for future investigations into the mechanisms of radiation therapy in neurogliocytoma cells. | MA Jiayi ZHAO Jingwu SHI Xiaodong ZHANG Kevin HUANG Runshen | 2012 | Nuclear Science and Techniques2012，23，2： | 3 |
| 5 | Development and evaluation of corrosion resistant coating for expandable rock bolt against highly corrosive ground conditions显示文摘Expandable rock bolts are widely used in hard rock mines as an efficient ground control product.However, capacity and service life can be significantly reduced if the metallic body is subjected to corrosion.In some hard rock mines in the U.S., highly corrosive ground conditions exist, and it has been reported that inflatable rock bolts have corroded within a few months after installation.To provide mining industry a cost-effective inflatable bolt and combat the corrosion issues, Jennmar Corporation, Inc.,and its subsidiary Keystone Mining Services, LLC(KMS), analyzed corroded bolt samples, identified root causes, evaluated properties of various coating materials, and developed a new inflatable rock bolt,Python M3^(TM), that is protected with an innovative PyFlexU2^(TM)coating.The new generation Python M3^(TM) features improved steel chemistry for reliable performance, modified profile for better inflation, and surface preparation and coating application.The PyFlexU2^(TM)is impervious to liquid and air, durable, and UV resistant.With a flexible, adhesive, and highly corrosion-resistant undercoating, and a very hard sacrificial surface coating, the PyFlexU2^(TM)coating system provides the Python M3^(TM)superior protection against chemical corrosion and physical scratch damage.The under-coating has exceptional flexibility and adhesion to prevent coating micro-cracks or fractures after bolt inflation and possesses excellent corrosion resistance to acids(pH < 3), alkalis(p H > 11), fuels, and salt solvents.The corrosion and scratch resistant PyFlexU2^(TM)coating offers very effective bolt protection for extra longevity in highly corrosive environments.The Python M3^(TM)coated with PyFlexU2^(TM)has been tested in the most challenging conditions,including laboratory corrosion tests in extreme acidic and basic solvents, rock slurry, and borehole scratch insertion tests.With demonstrated corrosion and scratch resistance, the product has been greatly welcomed by hard rock mines in the West and is currently installed in large scale.This paper identifies the root causes of the bolt corrosion, discusses the analysis process, and details laboratory and underground tests carried out on the Python M3^(TM)coated with PyFlexU2^(TM).The Python M3^(TM)and PyFlexU2^(TM) are subjects covered by pending U.S.Patent Applications assigned to FCI Holdings Delaware, LLC. | Kevin Jinrong Ma John Stankus Dakota Faulkner | 2018 | International Journal of Mining Science and Technology2018，28，1： | 3 |
| 6 | Role of C11-FDG dual-tracer PET-CT scan in metastatic screening of hepatocellular carcinoma-a cost-effectiveness analysis显示文摘Background:We aimed to identify predictive factors for positron emission tomography(PET)-detected hepatocellular carcinoma(HCC)metastasis and a cost-effective approach to preoperative PET-computed tomography(CT)for detecting metastasis.Methods:Clinicopathological and survival data of HCC patients having PET-CT with 18F-fludeoxyglucose(FDG)and 11C-acetate(ACT)following contrast-enhanced CT/magnetic resonance imaging(MRI)for preoperative tumor staging were reviewed.Binary logistic regression was performed to identify predictive factors for PET-detected metastasis.A cost-benefit analysis model was built for the incurred costs and the impact of PET-CT findings on treatment strategy was studied.Results:Totally 152 patients were analyzed.Dual-tracer PET-CT detected metastasis in 17 patients(11%).By multivariate analysis,alpha-fetoprotein(AFP)≥400 ng/mL[relative risk(RR):4.30,95%confidence interval(CI):1.41-13.15,P=0.011]and bilobar disease(RR:3.94,95%CI:1.24-12.52,P=0.014)were independent predictive factors for PET-detected metastasis.PET-CT findings altered the treatment strategy for 12 patients(7.9%);three partial hepatectomies,eight episodes of transarterial chemoembolization(TACE)and one episode of ablation were avoided,with an estimated cost-saving of US$91,000,$150,000 and$10,600 respectively.Had the PET-CT been performed only for patients with AFP≥400 ng/mL or bilobar disease(n=74),metastasis would have been confirmed in 14 patients(18.9%),and the cost-saving per patient was estimated at US$1,070.Conclusions:Dual-tracer PET-CT is cost-effective and useful for preoperative HCC staging in patients with AFP≥400 ng/mL or bilobar disease.Its routine use in preoperative workup for all HCC patients is not recommended.Unilobar disease with AFP<400 ng/mL can achieve good negative predictive value for PET-detected metastasis.Screening patients with either factor can avoid unnecessary procedures and is thus cost-effective for preoperative HCC workup. | Kevin K.W.Chu Albert C.Y.Chan Ka Wing Ma Wong Hoi She Wing Chiu Dai Kenneth S.H.Chok Tan To Cheung Chung Mau Lo | 2021 | Hepatobiliary Surgery and Nutrition2021，10，3： | 2 |
| 7 | Highly reactive multilayer-assembled TiO2 coating on electrospun polymer nanofibers显示文摘 | Jung Ah Lee Kevin C Krogman Ma Minglin | 2009 | Adv Mater2009，21，12： | 1 |
| 8 | Deformation twinning in nanocrystalline aluminum 显示文摘 | Chen M W Ma E Hemker Kevin J | 2003 | Science2003，300，5623： | 1 |
| 9 | Contribution of Vitreous Cytology to Final Clinical Diagnosis显示文摘 | Leah A. Wittenberg David A. Maberley Patrick E. Ma N. Kevin Wade Harpreet Gill Valerie A. White | 2008 | Ophthalmology2008，，11： | 1 |
| 10 | Electrochemical behavior of vanadium-substituted Keggin-type polyoxometalates in aqueous solution显示文摘 | Chunxiang Li Yan Zhang Kevin P. O’Halloran Jiawei Zhang Huiyuan Ma | 2009 | Journal of Applied Electrochemistry2009，，3： | 1 |
| 11 | VSL #3<sup>?</sup> probiotic therapy does not reduce portal pressures in patients with decompensated cirrhosis显示文摘 | Saumya Jayakumar Michelle Carbonneau Naomi Hotte A. Dean Befus Chris St. Laurent Richard Owen Mairin McCarthy Karen Madsen Robert J. Bailey Mang Ma Vince Bain Kevin Rioux Puneeta Tandon | 2013 | Liver Int2013，，10： | 1 |
| 12 | Facial asymmetry: three - dimensional analysis using laser surface scanning 显示文摘 | Kevin OG Oleh MA | 1999 | Plastic & Reconstructive Surgery1999，104，4： | 1 |
| 13 | A small mobile robot for security and inspection operations显示文摘 | Moore Kevin L Ma Lili | 2002 | Control Engineering Practice2002，10，11： | 1 |
| 14 | Brain-targeting,acid-responsive antioxidant nanoparticles for stroke treatment and drug delivery显示文摘Stroke is the leading cause of death and disability.Currently,there is no effective pharmacological treatment for this disease,which can be partially attributed to the inability to efficiently deliver therapeutics to the brain.Here we report the development of natural compound-derived nanoparticles(NPs),which function both as a potent therapeutic agent for stroke treatment and as an efficient carrier for drug delivery to the ischemic brain.First,we screened a collection of natural nanomaterials and identified betulinic acid(BA)as one of the most potent antioxidants for stroke treatment.Next,we engineered BA NPs for preferential drug release in acidic ischemic tissue through chemically converting BA to betulinic amine(BAM)and for targeted drug delivery through surface conjugation of AMD3100,a CXCR4 antagonist.The resulting AMD3100-conjugated BAM NPs,or A-BAM NPs,were then assessed as a therapeutic agent for stroke treatment and as a carrier for delivery of NA1,a neuroprotective peptide.We show that intravenous administration of A-BAM NPs effectively improved recovery from stroke and its efficacy was further enhanced when NA1 was encapsulated.Due to their multifunctionality and significant efficacy,we anticipate that A-BAM NPs have the potential to be translated both as a therapeutic agent and as a drug carrier to improve the treatment of stroke. | Shenqi Zhang Bin Peng Zeming Chen Jiang Yu Gang Deng Youmei Bao Chao Ma Fengyi Du Wendy C.Sheu W.Taylor Kimberly J.Marc Simard Daniel Coman Qianxue Chen Fahmeed Hyder Jiangbing Zhou Kevin N.Sheth | 2022 | Bioactive Materials2022，7，10： | 1 |
| 15 | Multifunctional Multilayer Films Containing Polyoxometalates and Bismuth Oxide Nanoparticles显示文摘 | LI Chunxiang O’HALLORAN KEVIN P MA Huiyuan | 2009 | Journal of Physical Chemistry B2009，113，23： | 1 |
| 16 | CHOP-like chemotherapy plus rituximab versus CHOP-like chemotherapy alone in young patients with good-prognosis diffuse large-B-cell lymphoma: a randomised controlled trial by the MabThera International Trial (MInT) Group显示文摘 | Michael Pfreundschuh Lorenz Trümper Anders ?sterborg Ruth Pettengell Marek Trneny Kevin Imrie David Ma Devinder Gill Jan Walewski Pier-Luigi Zinzani Rolf Stahel Stein Kvaloy Ofer Shpilberg Ulrich Jaeger Mads Hansen Tuula Lehtinen Armando López-Guillermo C | 2006 | Lancet Oncology2006，，5： | 1 |
| 17 | Facial asymmetry: three-dimensional analysis using laser surface scanning 显示文摘 | Kevin FO Oleh MA Ontario T | 1999 | Plast Reconstr Surg1999，104，4： | 1 |
| 18 | Facial asymmetry:Three-Dimensional analysis using laser surface scanning显示文摘 | Kevin FO Oleh MA | 1999 | Plast Reconstr Surg1999，104，4： | 1 |
| 19 | Dabrafenib in patients with melanoma, untreated brain metastases, and other solid tumours: a phase 1 dose-escalation trial显示文摘 | Gerald S Falchook Georgina V Long Razelle Kurzrock Kevin B Kim Tobias H Arkenau Michael P Brown Omid Hamid Jeffrey R Infante Michael Millward Anna C Pavlick Steven J O’Day Samuel C Blackman C Martin Curtis Peter Lebowitz Bo Ma Daniele Ouellet Richard F Ke | 2012 | The Lancet . 2012 (9829)2012，，9829： | 1 |
| 20 | Four dengue virus serotypes found circulating during an outbreak of dengue fever and dengue haemorrhagic fever in Jakarta, Indonesia, during 2004显示文摘 | Agus Suwandono Herman Kosasih Nurhayati Rita Kusriastuti Syahrial Harun Chairin Ma’roef Suharyono Wuryadi Bambang Herianto Djoko Yuwono Kevin R. Porter Charmagne G. Beckett Patrick J. Blair | 2006 | Transactions of the Royal Society of Tropical Medicine and Hygiene2006，，： | 1 |
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