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| 1 | Antimicrobial activity of Sapindus mukorossi and Rheum emodi extracts against H pylori: In vitro and in vivo studies显示文摘AIM: To evaluate the antibacterial activity of Sapindus mukorossi (S. mukorossi) and Rheum emodi (R. emodi). METHODS: Powders of S. mukorossi and R. emodi were extracted successively with petroleum ether, benzene, chloroform and ethanol and were concentrated in vacuum. The disk diffusion method was used for in vitro studies and in vivo studies were performed on male Wister rats. Thirty resistant clinical isolates of H pylori, as determined by their antibiotic sensitivity patterns by E-test, along with two Gram +ve (S. aureus, B. subtilis) and two Gram -ve (E. coli, P. vugaris) organisms were screened for their susceptibility patterns against these extracts. RESULTS: In our screening, all 30 resistant isolates and the other four organisms (two Gram +ve S. aureus, B. subtilis and two Gram -ve, E. coli, P. vugaris) were sensitive to the test compounds. It was found that ethanol and chloroform extracts of S. mukorossi and ethanol and benzene extracts of R. emodi inhibited H pylori at very low concentrations. In the in vitro study, the isolates showed a considerable zone of inhibition at very low concentrations (10 μg/mL) for both the extracts. In the in vivo study, the H pylori infection was cleared with minimal doses of extracts of S. mukorossi (2.5 mg/mL) and R. emodi (3.0 mg/mL) given orally for seven days. CONCLUSION: We can conclude from this study that the extracts of S. mukorossi and R. emodi inhibited the growth of pylori in vitro and, in in vivo studies, the H pylori infection cleared within seven days at very low concentrations. We also found that H pylori did not acquire resistance against these herbal extracts even after 10 consecutive passages. | Mohammed Ibrahim Aleem A Khan Santosh K Tiwari Mohammed Aejaz Habeeb MN Khaja CM Habibullah | 2006 | World Journal of Gastroenterology2006，12，44： | 46 |
| 2 | Hepatoprotective activity of Sapindus mukorossi and Rheum emodi extracts: In vitro and in vivo studies显示文摘AIM: To study the hepatoprotective capacity of Sapindus mukorossi (S. mukorossi) and Rheum emodi (R. emodi) extracts in CCl4 treated male rats. METHODS: The dried powder of S. mukorossi and R. emodi was extracted successively with petroleum ether, benzene, chloroform, and ethanol and concentrated in vacuum. Primary rat hepatocyte monolayer cultures were used for in vitro studies. In vivo, the hepatoprotective capacity of the extract of the fruit pericarp of S. mukorossi and the rhizomes of R. emodi was analyzed in liver injured CCl4-treated male rats. RESULTS: In vitro: primary hepatocytes monolayer cultures were treated with CCl4 and extracts of S. mukorossi & R. emodi. A protective activity could be demonstrated in the CCl4 damaged primary monolayer culture. In vivo : extracts of the fruit pericarp of S. mukorossi (2.5 mg/mL) and rhizomes of R. emodi (3.0 mg/mL) were found to have protective properties in rats with CCl4 induced liver damage as judged from serum marker enzyme activities. CONCLUSION: The extracts of S. mukorossi and R. emodi do have a protective capacity both in vitro on primary hepatocytes cultures and in in vivo in a rat model of CCl4 mediated liver injury. | Mohammed Ibrahim Mohammed Nane Khaja Anjum Aara Aleem Ahmed Khan Mohammed Aejaz Habeeb Yalavarthy Prameela Devi Mangamoori Lakshmi Narasu Chitoor Mohammed Habibullah | 2008 | World Journal of Gastroenterology2008，14，16： | 24 |
| 3 | Role of ATG16L,NOD2 and IL23R in Crohn's disease pathogenesis显示文摘Inflammatory bowel disease is a group of diseases that includes Crohn's disease (CD) and ulcerative colitis.CD is characterized as a chronic inflammatory disease of the gastrointestinal tract,ranging from the mouth to the anus.Although there are gross pathological and histological similarities between CD and Johne's disease of cattle,the cause of CD remains controversial.It is vital to understand fully the cause of this disease because it affects approximately 500 000 people in North America and Europe.It ranges from 27 to 48 cases per 100 000 people.There are many theories on the cause of CD ranging from possible association with environmental factors including microorganisms to imbalance in the intestinal normal flora of the patients.Regardless of the environmental trigger,there is strong evidence that a genetic disposition is a major key in acquiring CD.Many studies have proven the link between mutations in the ATG16L,NOD2/CARD15,IBD5,CTLA4,TNFSF15 and IL23R genes,and CD.The purpose of this review is to examine all genetic aspects and theories of CD,including up to date multiple population studies performed worldwide. | Saleh A Naser Melissa Arce Anam Khaja Marlene Fernandez Najih Naser Sammer Elwasila Saisathya Thanigachalam | 2012 | World Journal of Gastroenterology2012，18，5： | 5 |
| 4 | Effect of Annealing Temperature on Film Morphology of Organic–Inorganic Hybrid Pervoskite Solid‐State Solar Cells显示文摘 | Amalie Dualeh Nicolas Tétreault Thomas Moehl Peng Gao Mohammad Khaja Nazeeruddin Michael Gr?tzel | 2014 | Adv. Funct. Mater2014，，21： | 2 |
| 5 | Balloon-occluded retrograde trans- venous obliteration of gastric varices : conception, evolution, and history 显示文摘 | Saad WE Khaja MS Hirota S | 2012 | Tech Vasc Interv Radio12012，15，3： | 1 |
| 6 | Perovskite as Light Harvester: A Game Changer in Photovolta-ics显示文摘 | Samrana Kazim Mohammad Khaja Nazeeruddin Michael Gratzel | 2014 | Angew Chem hat Ed2014，53，： | 1 |
| 7 | Highly Efficient and Stable FAPbI_(3) Perovskite Solar Cells and Modules Based on Exposure of the(011)Facet显示文摘Perovskite crystal facets greatly impact the performance and stability of their corresponding photovoltaic devices.Compared to the(001)facet,the(011)facet yields better photoelectric properties,including higher conductivity and enhanced charge carrier mobility.Thus,achieving(011)facet-exposed films is a promising way to improve device performance.However,the growth of(011)facets is energetically unfavorable in FAPbI_(3) perovskites due to the influence of methylammonium chloride additive.Here,1-butyl-4-methylpyridinium chloride([4MBP]Cl)was used to expose(011)facets.The[4MBP]^(+)cation selectively decreases the surface energy of the(011)facet enabling the growth of the(011)plane.The[4MBP]^(+)cation causes the perovskite nuclei to rotate by 45°such that(011)crystal facets stack along the out-of-plane direction.The(011)facet has excellent charge transport properties and can achieve better-matched energy level alignment.In addition,[4MBP]Cl increases the activation energy barrier for ion migration,suppressing decomposition of the perovskite.As a result,a small-size device(0.06 cm2)and a module(29.0 cm2)based on exposure of the(011)facet achieved power conversion efficiencies of 25.24%and 21.12%,respectively. | Kai Zhang Bin Ding Chenyue Wang Pengju Shi Xianfu Zhang Cheng Liu Yi Yang Xingyu Gao Rui Wang Li Tao Keith G.Brooks Songyuan Dai Paul J.Dyson Mohammad Khaja Nazeeruddin Yong Ding | 2023 | Nano-Micro Letters2023，15，9： | 1 |
| 8 | Detection of Y chromosome-specific DNA in the plasma and urine of pregnant women using nested polymerase chain reaction显示文摘 | A1-Yatama M K Mustafa A S Ali S Abraham S Khan Z Khaja N | 2001 | Prenat Diagn2001，21，： | 1 |
| 9 | Noninvasive evaluation of left ventricular performance based on peak aortic blood accelera- tion measured with a continuous-wave Doppler velocity meter 显示文摘 | Sabbah HN Khaja F Brymer JF | 1986 | Circulation1986，74，2： | 1 |
| 10 | Established treatments for acute is- chemic stroke 显示文摘 | Khaja A M Grotta J C | 2007 | Lancet2007，369，9558： | 1 |
| 11 | Structure-based design: synthesis and biological evaluation of a series of novel cycloamide- derived HIV-1 protease inhibitors 显示文摘 | Arun K Ghosh Lisa M Swanson Hanna Cho Sofiya Leshehenko Khaja Azhar Hussain Stephanie Kay D Eric Walters Yasuhiro Koh Hiroaki Mitsuya | 2005 | Journal of medicinal chemistry2005，48，10： | 1 |
| 12 | Perovskite as Light Harvester: A Game Changer in Photovoltaics显示文摘 | Samrana Kazim Mohammad Khaja Nazeeruddin Michael Gr?tzel Shahzada Ahmad | 2014 | Angew. Chem. Int. Ed2014，，11： | 1 |
| 13 | Prescription writing skills of residents in a family practice residency progTamme in Bah- rain 显示文摘 | A1 Khaja KA Sequeira RP AI-Ansari TM | 2008 | Postgrad Med J2008，84，990： | 1 |
| 14 | Fate and distribution of arsenic in laboratory-scale subsurface horizontal-flow constructed wetlands treating an artificial was- tewater显示文摘 | Khaja Zillur Rahman Arndt Wiessner Peter Kuschk | 2011 | Ecological Engineering2011，37，8： | 1 |
| 15 | Effective use of re- al-life events as tools for teaching-learning clinical phar- macology in a problem-based learning curriculum显示文摘 | James H A1 Khaja KA Sequeira RP | 2015 | In- dian J Pharmacol2015，47，3： | 1 |
| 16 | Immunologic basis and immuno- prophylaxis of RhD induced hemolytic disease of the newborn (HDN) 显示文摘 | Payam Khaja Pasha R Shokri F | 2008 | Iran J Immunol2008，5，4： | 1 |
| 17 | Hemodynamic response to oxygen therapy in chronic obstructive pulmonary disease显示文摘 | Timms RM Khaja FU Williams GW | 1985 | Ann Intern Med1985，102，1： | 1 |
| 18 | Established treatments for acute ischaemic stroke 显示文摘 | Khaja A M Grotta J C | 2007 | Lancet2007，369，： | 1 |
| 19 | Established treatments for acute ischaemic stroke 显示文摘 | Khaja AM Grotta JC | 2007 | The Lancet2007，369，： | 1 |
| 20 | Evaluation of heparin assay for coagulation management in newborns undergoing EC- MO 显示文摘 | Khaja WA Bilen O Lukner RB | 2010 | Anl J Clin Pathol2010，134，6： | 1 |
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