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| 1 | Mechanosignaling activation of TGFβmaintains intervertebral disc homeostasis显示文摘Intervertebral disc(IVD) degeneration is the leading cause of disability with no disease-modifying treatment.IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal(NC) cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin α_vβ_6-mediated activation of transforming growth factor beta(TGFβ), decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease(DDD). Knockout of TGFβ type II receptor(TβRII) or integrin α_v in the NC cells inhibited functional activity of postnatal NC cells and also resulted in DDD under mechanical loading.Administration of RGD peptide, TGFβ, and α_vβ_6-neutralizing antibodies attenuated IVD degeneration. Thus,integrin-mediated activation of TGFβ plays a critical role in mechanical signaling transduction to regulate IVD cell function and homeostasis. Manipulation of this signaling pathway may be a potential therapeutic target to modify DDD. | Qin Bian Lei Ma Amit Jain Janet L Crane Khaled Kebaish Mei Wan Zhengdong Zhang X Edward Guo Paul D Sponseller Cheryle A Seguin Lee H Riley Yongjun Wang Xu Cao | 2017 | Bone Research2017，5，1： | 9 |
| 2 | Study on the sensitivity to cadmium of marine fish Salaria basilisca(Pisces: Blennidae)显示文摘The present study tested the sensitivity of Salaria basilisca to water-cadmium (Cd) contamination. For this purpose, liver somatic index (LSI), Cd concentrations and the activities of antioxidant enzymes such as catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were measured in the liver of S. basilisca exposed to Cd-contaminated water (2 mg Cd/L as CdCl2) for 14 and 28 d. The results showed that the LSI decreased significantly after 14 and 28 d of Cd-exposure. Cd bioaccumulation in the liver resulted in an increasing uptake up to 42 μg/g dry weight after 28 d of exposure. Activities of CAT and SOD were significantly increased with increasing exposure time. A significant increase in GSH-Px activity, under Cd influence, was observed during 14-day exposure period (p < 0.0001). However, a significant decrease (p < 0.05) in this activity with respect to control fish was registered after 28 d of Cd-exposure. These results showed that Cd accumulation in the liver of S. basilisca could induce oxidative stress as demonstrated by changes in the antioxidant enzyme activities. Results also emphasized that S. basilisca may considered as a sensitive species to Cd exposure. | Imed Messaoudi Sana Barhoumi Khaled Sd Abdelhamid Kerken | 2009 | Journal of Environmental Sciences2009，21，11： | 7 |
| 3 | Cadmium bioaccumulation in three benthic fish species, Salaria basilisca, Zosterisessor ophiocephalus and Solea vulgaris collected from the Gulf of Gabes in Tunisia显示文摘To select a marine teleost fish which can be used as a bioindicator of cadmium (Cd) pollution in the Gulf of Gabes in Tunisia, Cd concentrations in liver and gill were compared in three benthic fish species including Salaria basilisca, Zosterisessor ophiocephalus and Solea vulgaris. Fish samples were collected from three selected sites in the Gulf of Gabes, with di?erent degrees of Cd contamination: the industrialized coast of Sfax (S1), the coast of Douar Chatt (S2) and the coast of Luza (S3). The results shows that Cd concentrations in both sediment and water collected from S1 were significantly higher (p < 0.0001) than those from S2 and S3. For each species, Cd concentrations, in both liver and gill, showed the decreasing order: S1 > S2 > S3. The highest concentration of Cd was detected in the liver of S. basilisca, and only S. basilisca showed bioaccumulation factors (BAF) greater than 1 in all studied sites. In S1 and S2, BAF values respect the following order: S. basilisca > Z. ophiocephalus > S. vulgaris. These results of significant bioaccumulation of Cd, in terms of hepatic concentrations and bioaccumulation factors, indicated that S. basilisca can be used as bioindicator to evaluate the evolution of Cd pollution in the Gulf of Gabes. | BARHOUMI Sana MESSAOUDI Imed DELI Tmim SAD Khaled KERKENI Abdelhamid | 2009 | Journal of Environmental Sciences2009，21，7： | 4 |
| 4 | 抑郁症的非药物治疗:系统性综述与证据图显示文摘背景抑郁症非药物治疗的疗效比较目前仍然不清楚。方法我们对一些系统性综述作了概述,回顾了随机对照试验(RCT),比较抑郁症非药物治疗的有效性和认知行为治疗(CBT)。对多个电子数据库在2016年2月之前发表的所有文献进行了检索,不限制语言。成对的评阅人进行资料纳入、数据提炼并评估偏倚的风险。在适用的时候进行了荟萃分析。结果我们收录了367项RCT,纳入了约2000名患者,进行了11种治疗,导出17项独立的头对头比较。通过标准化的量表评估,发现CBT、自然疗法、行为干预与躯体活动干预可以降低抑郁的严重程度。然而,这些非药物干预的相对疗效仍然缺乏。这些干预对临床缓解和复发的效果不清楚。CBT的发生率比抗抑郁药物更低。局限性由于证据缺乏一致性、证据不清或偏倚风险高,导致证据的质量只是低到中等,限制了我们研究结果的可信度。结论抑郁症的非药物治疗能减少抑郁症状,在轻度到重度抑郁症患者中,应当合并抗抑郁药物治疗,一同进行。对于非药物治疗的选择,应当根据患者的价值观、偏好、临床和社会因素来与患者共同作出决定。 | Wigdan H Farah Mouaz Alsawas Maria Mainou Fares Alahdab Magdoleen H Farah Ahmed T Ahmed Essa A Mohamed Jehad Almasri Michael R Gionfriddo Ana Castaneda-Guarderas Khaled Mohammed Zhen Wang Noor Asi Craig N Sawchuk Mark D Williams Larry J Prokop M Hassan Murad Annie LeBlanc | 2017 | 英国医学杂志中文版2017，20，11： | 2 |
| 5 | Multiverse and the Time State显示文摘 | Khaled (Moh'd Khalaf) Suleiman Alnobani | 2017 | Journal of Energy and Power Engineering2017，11，3： | 2 |
| 6 | Milrinone facilitates resuscitation from cardiac arrest and attenuates posttresuscitation myocardial dysfunction 显示文摘 | Niemann JT Garner D Khaleeli E | 2003 | Circulation2003，108，： | 1 |
| 7 | The Cross Product of Interconnection Networks显示文摘 | Khaled D Abdelelah A A | 1997 | IEEE Transaction on Parallel and Distributed Systems1997，8，2： | 1 |
| 8 | Compressed sensing for real-time energy-efficient ECG compression on wireless body sensor nodes显示文摘 | Mamaghanian H Khaled N Atienza D | | 0，，09： | 1 |
| 9 | Milrinone facilitates resuscitation from cardiac arrest and attenuates postresuscitation myocardial dysfunction 显示文摘 | Niemann JT Garner D Khaleeli E | 2003 | Circulation2003，108，24： | 1 |
| 10 | MITF : Master regula- tor of melanocyte development and melanoma onco- gene显示文摘 | Levy C Khaled M Fisher D E | 2006 | Trends Mol ivied2006，12，9： | 1 |
| 11 | Tethering of tricuspid valve resulting from aberrant tendinous cords mimic Ebstein's anomaly, three-dimensional echocardiography approach 显示文摘 | Khaled H Sebastien H Yves D | 2014 | Echocardiography2014，3，2： | 1 |
| 12 | Biomarkers of systemic in- flammation and depression and fatigue in moderate clinically stable COPD显示文摘 | Khaled A Umme K Rachel D | 2011 | Respir Res2011，12，1： | 1 |
| 13 | Manipulation of colonic bacteria and volatile fatty acids production by dietary high amylose maize (amylomaize) starch granules显示文摘 | Wang X Brown I L Khaled D | | 0，，： | 1 |
| 14 | Reversal of Cadmium-Induced Thyroid Dysfunction by Selenium, Zinc, or Their Combination in Rat显示文摘 | Fatima Hammouda Imed Messaoudi Jihène Hani Tarek Baati Khaled Sa?d Abdelhamid Kerkeni | 2008 | Biological Trace Element Research2008，，1： | 1 |
| 15 | A New Energy Concept显示文摘 | Khaled (Moh'd Khalaf) Suleiman Ainobani | 2016 | Journal of Energy and Power Engineering2016，10，2： | 1 |
| 16 | An efficient procedure for the synthesis of trans-2-,-3-,and -4-pyridalacetones显示文摘 | Morin R D Khaled M A | 1984 | Synthesis1984，，7： | 1 |
| 17 | The conditional node connectivity of the k-ary n-cube显示文摘 | Khaled D | 2004 | Joumal of Interconnection Networks2004，5，1： | 1 |
| 18 | Design and exploration of low-power analog to information conversion based on compressed sensing显示文摘 | MAMAGHANIAN H KHALED N ATIENZA D | 2012 | IEEE Journal on Emerging and Selected Topics in Circuits and Systems2012，2，3： | 1 |
| 19 | On the theory ofconsolidation with double porosity 显示文摘 | KHALED M BESKOS D AIFANTIS E | 1984 | InternationalJournal for Numerical and Analytical Methods inGeomechanics1984，，20： | 1 |
| 20 | Compressed Sensingfor iieal-Tinie Energy-Efficient ECG Compression on WirelessBody Sensor No(ies 显示文摘 | Mamaghanian H Khaled N Atienza D et ai | | IEEE Transactions on Biomedical Engi-neering0，58，9： | 1 |
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