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| 1 | p53 antibodies,metallothioneins,and oxidative stress markers in chronic ulcerative colitis with dysplasia显示文摘AIM:To investigate the role of p53 antibodies (p53Abs),metallothioneins (MTs) and oxidative stress markers in the early detection of dysplasia in chronic ulcerative colitis (UC).METHODS:The study included 30 UC patients,15 without dysplasia (group Ⅱ) and 15 with dysplasia (group Ⅲ),in addition to 15 healthy volunteers (group Ⅰ,control subjects).The enzyme-linked immunosorbent assay technique was used to measure serum p53Abs and MTs,while advanced oxidation protein products (AOPPs),and reduced glutathione (GSH) levels were measured by spectrophotometric method in all subjects.RESULTS:In group Ⅱ and group Ⅲ compared to group Ⅰ,there were significant increases in serum levels of AOPPs (145.94 ± 29.86 μmol/L and 192.21 ± 46.71 μmol/L vs 128.95 ± 3.06 μmol/L,P < 0.002 and P <0.001,respectively),MTs (8.18 ± 0.35 μg/mL and 9.20 ± 0.58 μg/mL vs 6.12 ± 0.25 μg/mL,P < 0.05 and P < 0.05,respectively),and p53Abs (20.19 ± 3.20 U/mL and 34.66 ± 1.34 U/mL vs 9.42 ± 1.64 U/mL,P < 0.001 and P < 0.001,respectively).There were significantly higher levels of AOPPs (P < 0.05) and p53Abs (P < 0.001) in UC patients with dysplasia compared to those without dysplasia,while MTs showed no significant difference between the 2 groups (P > 0.096).In contrast,GSH levels showed a significant decrease in both patients' groups (1.87 ± 0.02 μmol/mL and 1.37 ± 0.09 μmol/mL vs 2.49 ± 0.10 μmol/mL,P < 0.05 and P < 0.05 in groups Ⅱ and Ⅲ,respectively) compared with group Ⅰ,and the levels were significantly lower in group Ⅲ than group Ⅱ (P < 0.05).There was a positive correlation between AOPPs and both MTs (r=0.678,P < 0.001) and p53Abs (r=0.547,P < 0.001),and also between p53Abs and MTs (r=0.739,P < 0.001).There was a negative correlation between AOPPs and GSH (r =-0.385,P < 0.001),and also between GSH and both MTs (r=-0.662,P < 0.001) and p53Abs (r=-0.923,P < 0.001).CONCLUSION:Oxidative stress and oxidative cellular damage play an important role in the pathogenesis of chronic UC and the associated carcinogenetic process.p53Abs levels could help in early detection of dysplasia in these conditions. | Hala E Hamouda Soha S Zakaria Saber A Ismail Mahmoud A Khedr Wael W Mayah | 2011 | World Journal of Gastroenterology2011，17，19： | 5 |
| 2 | Hydrophobic polyethersulfone porous membranes for membrane distillation显示文摘膜蒸馏 MD 是通过逐渐地被用于海水和盐水脱盐过程的微多孔的恐水病的膜的一个热、蒸汽驱动的交通过程。也就是,恐水病的多微孔的 polyethersulfone 公寓表膜的二种类型退火了 polyethersulfone 和 polyethersulfone/tetraethoxysilane PES/TEOS 混合被一个阶段倒置过程准备。膜被描绘,他们的表演用一个水的 NaCl 答案的真空膜蒸馏被调查。准备的膜的表演也与二商业地可得到的恐水病的膜, polytetrafluorethylene 和 polyvinylidene 氟化物相比。运作的参数例如的影响喂温度 2565 敢 ? 牤癩湩?? | Heba ABDALLAH Ayman EL-GENDI Maaly KHEDR Elham EL-ZANATI | 2015 | Frontiers of Chemical Science and Engineering2015，9，1： | 3 |
| 3 | Optimized extraction method for LC–MS determination of bisphenol A, melamine and di(2-ethylhexyl) phthalate in selected soft drinks, syringes, and milk powder显示文摘 | Alaa Khedr | 2013 | Journal of Chromatography B2013，，： | 2 |
| 4 | Dopamine levels after repetitive transcranial magnetic stimulation of motor cortex in patients with Parkinson's disease: preliminary results 显示文摘 | Khedr EM Rothwell JC Shawky OA | 2007 | Mov Disord2007，22，7： | 1 |
| 5 | Magnetic nanocomposites: preparation and characterization of Co-ferrite nanopariticles显示文摘 | Khedr M H Omar A A Abdel-Moaty S A | 2006 | Colloids Surf A2006，281，： | 1 |
| 6 | Impact of allergic rhinitis on quality of life in patients with bronchial asthma 显示文摘 | Elkholy MM Khedr MH Halawa A | 2012 | Int J Health Sci (Qassim)2012，6，2： | 1 |
| 7 | Long-term effect of repetitive transcranial magnetic stimulation on motor function recovery after acute ischemic stroke显示文摘 | Khedr EM Etraby AE Hemeda M | 2010 | Acta Neurol Scand2010，121，： | 1 |
| 8 | Management of displaced intra-articular calcaneal fractures using the limited open sinus tarsiapproach and fixation by screws only technique 显示文摘 | Abdelazeem A Khedr A Abousayed M | 2014 | Int Orthop2014，38，3： | 1 |
| 9 | Therapeutic trial of repetitive transcranial magnetic stimulation after acute ischemic stroke显示文摘 | Khedr EM Ahmed MA Fathy N | 2005 | Neurology2005，65，3： | 1 |
| 10 | Impact of allergic rhinitis on quality of life in patients with bronchial asthma显示文摘 | Elkholy MM Khedr MH Halawa A | | 0，，： | 1 |
| 11 | Negotiating context intormation in context-aware systems 显示文摘 | Khedr M Karmouch A | 2004 | IEEE Intelligent Systems2004，19，6： | 1 |
| 12 | Therapeutic effect of repetitive transcranial magnetic stimulation on motor function in Parkinson's disease patients显示文摘 | Khedr EM Farweez HM Islam H | 2003 | Eur J Neurol2003，10，： | 1 |
| 13 | Distribution of aquatic plants in relation to environmental factors in the Nile Deha显示文摘 | Khedr A H A El-Demerdash M A | 1997 | Aquat Bot1997，56，： | 1 |
| 14 | Therapeutic role of rtms on recovery of dysphagia in patients with lateral medullary syndrome and brainstem infarction显示文摘 | Khedr EM Abo-Elfetoh N | | 0，，05： | 1 |
| 15 | Carbothermic reduction kinetics of nanocrystallite Fe 2 O 3 /NiO composites for the production of Fe/Ni alloy显示文摘 | K.S. Abdel-Halim M.H. Khedr M.I. Nasr M.Sh. Abdel-wahab | 2008 | Journal of Alloys and Compounds2008，，1： | 1 |
| 16 | Therapeutic trial of repetitive transcranial magnetic stimulation after acute ischemic stroke显示文摘 | Khedr EM Ahmed MA Fathy N | 2005 | Neurology2005，65，3： | 1 |
| 17 | Role of 1 and 3 Hz repetitive transcranial magnetic stimula- tion on motor function recovery after acute ischaemic stroke显示文摘 | Khedr EM Abdel-Fadeil MR Farghali A | 2009 | Eur J Neurol2009，16，12： | 1 |
| 18 | ACAI:Agent-based Context-aware Infrastructure for Spontaneous Applications显示文摘 | Khedr M Karmouch A | | 0，，01： | 1 |
| 19 | Protective effect of mirtazapine and hesperidin on cyclophosphamide-induced oxidative damage and infertility in rat ovaries显示文摘 | Khedr NF | 2015 | Exp Biol Med(Maywood)2015，240，12： | 1 |
| 20 | Therapeutic trial of repetitive transcranial magnetic stimulation after acute ischemic stroke显示文摘 | Khedr EM Ahmed MA Fathy N etal | 2005 | Neurology2005，65，3： | 1 |
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