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| 1 | Current research and treatment for gastrointestinal stromal tumors显示文摘Gastrointestinal stromal tumors(GISTs) are the most common mesenchymal tumors of the gastrointestinal tract and have gained considerable research and treatment interest,especially in the last two decades. GISTs are driven by mutations commonly found in the KIT gene and less commonly in the platelet-derived growth factor receptor alpha gene,BRAF gene and succinate dehydrogenase gene. GISTs behave in a spectrum of malignant potential,and both the tumor size and mitotic index are the most commonly used prognostic criteria. Whilst surgical resection can offer the best cure,targeted therapy in the form of tyrosine kinase inhibitors(TKIs) has revolutionized the management options. As the first-line TKI,imatinib offers treatment for advanced and metastatic GISTs,adjuvant therapy in high-risk GISTs and as a neoadjuvant agent to downsize large tumors prior to resection. The emergence of drug resistance has altered some treatment options,including prolonging the first-line TKI from 1 to 3 years,increasing the dose of TKI or switching to second-line TKI. Other newer TKIs,such as sunitinib and regorafenib,may offer some treatment options for imatinib-resistant GISTs. New molecular targeted therapies are being evaluated,such as inhibitors of BRAF,heat shock protein 90,glutamine and mitogenactivated protein kinase signaling,as well as inhibitors of apoptosis proteins antagonist and even immunotherapy. This editorial review summarizes the recent research trials and potential treatment targets that may influence our future patient-specific management of GISTs. The current guidelines in GIST management from Europe,North America and Asia are highlighted. | Kheng Tian Lim Kok Yang Tan | 2017 | World Journal of Gastroenterology2017，23，27： | 23 |
| 2 | 柚木离体快速繁殖技术显示文摘从优良柚木林段选取3~4 a生优良单株,从中选取无病虫害的幼嫩侧芽,经表面消毒后接种到无菌培养基上,侧芽萌发率达70%~80%.切取新芽进行增殖,30~40 d为一周期,增殖系数为2~3倍.当侧芽增殖到足够数量时,转移到生根培养基上,生根率超过80%~90%.植株移栽成活率达80%~90%.几个月后植株便可种植到大田. | 陈雄庭 Chee Kheng Hoy 郑学勤 Emilia Farida | 2001 | 热带作物学报2001，22，3： | 5 |
| 3 | 从菠萝薄细胞层切片直接诱导体细胞胚显示文摘以菠萝(Ananas comosus L. Merrill)杂交种MD1无菌苗为材料,通过培养薄细胞层切片(Thin cell layer,TCL)的方法,研究直接再生胚的固体培养体系。结果证明,预培养的设计2(在预培养基PT上黑暗预培养无菌苗1周后,从预培养苗茎顶端切取TCL,在MS+2,4-D2mg·L-1或1mg·L-1胚诱导培养基EI2上黑暗培养1周,然后转到光照条件下继续诱导胚1周,再在成熟胚培养基EM上培养2周,最后转入幼苗培养基PL上培养)是直接诱导获得体胚的最佳途径;诱导的体胚最初均来自于薄细胞层上微管束附近的细胞;picloram有利于芽的诱导,2,4-D有利于直接再生胚,但如果球形胚形成后一直培养在较高浓度的2,4-D培养基中,将阻碍球形胚和心形胚进一步发育为成熟胚,反而促进芽的生成。 | 梁雪莲 陈晓玲 Kheng Cheah Diane M Sether Qi Li John Hu | 2009 | 园艺学报2009，36，11： | 3 |
| 4 | Metabolic disturbances associated with antipsychotic drug treatment in patients with schizophrenia:State-of-the-art and future perspectives显示文摘Metabolic disturbances and obesity are major cardiovascular risk factors in patients with schizophrenia,resulting in a higher mortality rate and shorter life expectancy compared with those in the general population.Although schizophrenia and metabolic disturbances may share certain genetic or pathobiological risks,antipsychotics,particularly those of second generation,may further increase the risk of weight gain and metabolic disturbances in patients with schizophrenia.This review included articles on weight gain and metabolic disturbances related to antipsychotics and their mechanisms,monitoring guidelines,and interventions.Nearly all antipsychotics are associated with weight gain,but the degree of the weight gain varies considerably.Although certain neurotransmitter receptorbinding affinities and hormones are correlated with weight gain and specific metabolic abnormalities,the precise mechanisms underlying antipsychoticinduced weight gain and metabolic disturbances remain unclear.Emerging evidence indicates the role of genetic polymorphisms associated with antipsychotic-induced weight gain and antipsychotic-induced metabolic disturbances.Although many guidelines for screening and monitoring antipsychotic-induced metabolic disturbances have been developed,they are not routinely implemented in clinical care.Numerous studies have also investigated strategies for managing antipsychotic-induced metabolic disturbances.Thus,patients and their caregivers must be educated and motivated to pursue a healthier life through smoking cessation and dietary and physical activity programs.If lifestyle intervention fails,switching to another antipsychotic drug with a lower metabolic risk or adding adjunctive medication to mitigate weight gain should be considered.Antipsychotic medications are essential for schizophrenia treatment,hence clinicians should monitor and manage the resulting weight gain and metabolic disturbances. | Shen-Chieh Chang Kah Kheng Goh Mong-Liang Lu | 2021 | World Journal of Psychiatry2021，11，10： | 3 |
| 5 | Correlation between total phenolic and mineral contents with antioxidant activity of eight Malaysian bananas ( Musa sp.)显示文摘 | Shaida Fariza Sulaiman Nor Adlin Md. Yusoff Ibrahim M. Eldeen Eng Meng Seow Azliana Abu Bakar Sajak Supriatno Kheng Leong Ooi | 2010 | Journal of Food Composition and Analysis2010，，1： | 2 |
| 6 | 香蕉胚性细胞悬浮培养方法的改进显示文摘针对香蕉胚性悬浮细胞培养过程中存在的胚性愈伤组织的诱导率低、周期过长、胚性易丢失等问题,以'苹果蕉'及'威廉斯'香蕉的未成熟雄花为试验材料,对香蕉胚性愈伤组织的诱导、悬浮培养的理化条件进行改进。结果表明:(1)光照条件较暗培养更有利于诱导理想的香蕉胚性愈伤组织;(2)M1培养基中加入酪蛋白和脯氨酸有利于胚性愈伤组织的诱导;(3)用微孔板代替三角瓶悬浮培养,有利于悬浮细胞分裂增殖,而且可减少污染的可能。 | 李敬阳 唐粉玲 John S.Hu Wayne Borth Kheng Cheah 谷会 金志强 | 2012 | 热带作物学报2012，33，5： | 2 |
| 7 | Eosinophilic esophagitis presenting as complete esophageal desquamation :An unusual case of chest pain 显示文摘 | Kheng JL Zhang LJ Anish S | 2014 | N A J Med Sci2014，7，2： | 1 |
| 8 | LBL assembled laminates with hierarchical organization from nano to microscale: high-toughness nanomaterials and deformation imaging显示文摘 | PODSIADLO P ARRUDA E M KHENG E | 2009 | ACS Nano2009，3，6： | 1 |
| 9 | Xylanase production by a local fungal isolate,Aspergillus niger USM AI1 via solid state fermentation using palm kernel cake(PKC) as substrate显示文摘 | KHENG P P IBRAHIM C O | 2005 | Songklanakarin J Sci Technol2005，27，2： | 1 |
| 10 | The Adoption of Electronic Pro-curement in Singapore显示文摘 | Kheng C B Al-Hawamdeh S | 2002 | Electronic Commerce Resecarch2002，2，12： | 1 |
| 11 | The Adoption of Electronic Procurement in Singapore显示文摘 | Chia Boon Kheng Suliman Al-Hawamdeh | | Electronic Commerce Research (-)0，，： | 1 |
| 12 | Intravenous catheter line set of clinical obser- vation and treatment of lacrimal lacrimal duct obstruction 显示文摘 | Lvjin Zhouzhu Sheng Dufu Qin Li Xin Cheng Lee Kheng Wah Hushou Zhi | 2013 | Guiyang Medical College2013，35，2： | 1 |
| 13 | Capsule endoscopy vs. push enteroscopy and enteroclysis in suspected small-bowel Crohn’s disease <ce:link locator='fx1'/>显示文摘 | André Kheng Ho Chong Andrew Taylor Ashley Miller Oliver Hennessy William Connell Paul Desmond | 2005 | Gastrointestinal Endoscopy2005，，2： | 1 |
| 14 | Self-autonomous wireless sensor nodes with wind energy harvesting for remote sensing of wind-driven wildfire spread显示文摘 | Yen Kheng Tan Sanjib Kumar Panda | | 0，，04： | 1 |
| 15 | UV/H202 degradation ki netics of isoprene in aqueous solution 显示文摘 | Elkanzi E M Goh Bee Kheng | 2000 | Journal of Hazardous Materials2000，73，： | 1 |
| 16 | Observation of negatively charged excitons X- in semiconductor quantum wells显示文摘 | K Kheng R T Cox Y Merle | 1993 | Phys Rev Lett1993，71，： | 1 |
| 17 | Self- AutonomousWireless Sensor Nodes With Wind Energy Ha-rvest-ing for Remote Sensing of Wind-Driven WildfireSpread显示文摘 | TAN Yen Kheng PANDA Sanjib Kumar | 2011 | IEEE Journals & Magazines2011，6，4： | 1 |
| 18 | The adoption of electronic procurement in singapore显示文摘 | KHENG C B AI-Hawamdeh S | 2002 | Electronic Commerce Resecarch2002，2，12： | 1 |
| 19 | Optimized wind energy harvesting system using resistance emulator and active rectifier for wireless sensor nodes 显示文摘 | Yen Kheng Tan | 2011 | IEEE Trans Power Electron2011，26，1： | 1 |
| 20 | Energy harvesting from hybrid indoor ambient light and thermal energy sources for enhanced performance of wireless sensor nodes 显示文摘 | Tan Yen Kheng Panda Sanjib Kumar | 2011 | IEEE Transactions on Industrial Electronics2011，58，9： | 1 |
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