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| 1 | 墨西哥野生马铃薯Solanum pinnatisectum抗晚疫病及抗马铃薯甲虫新基因的遗传分析与分子标记(英文)显示文摘马铃薯晚疫病(Phytophthora infestans)和科罗拉多马铃薯甲虫(CPB)是马铃薯生产中最为严重的病虫害。培育高抗晚疫病和甲虫的马铃薯品种是加拿大马铃薯育种工作的重要组成部分。目前,我们实验室在二倍体1EBN墨西哥野生种中已鉴定出抗马铃薯晚疫病和甲虫的新基因,并利用原生质体融合技术成功的将其转移到栽培品种中。但是,培育出抗晚疫病和抗甲虫的马铃薯新品种仍然是一项艰难而繁杂的工作。为了加快分离抗性基因,建立与抗性基因紧密关联的DNA分子标记至关重要。本研究以感病的二倍体马铃薯品种S.cardiophyllum作为父本,与带有抗性基因的墨西哥野生种S.pinnatisectum杂交。用叶片离体鉴定的方法测试F1和BC1代群体的抗病性,从而筛选抗晚疫病和抗甲虫的植株。US-8/A2交配型病菌测试显示所有的F1代植株都表现出抗晚疫病,而在BC1群体中抗病与感病植株的比例为1:1。这个结果证明,在墨西哥野生种S.pinnatisectum中存在一个抗晚疫病的单显性基因Rpi1。马铃薯甲虫抗性检测中,BC1群体的抗虫性分离比例为1:3.这表明其对甲虫的抗性是由多基因遗传控制的。在F1和BC1群体中利用分子标记结合集团分离分析法(BSA)对S.pinnatisectum中的晚疫病抗性基因Rpi1进行精细作图。根据马铃薯第7条染色体上RFLP标记TG20A和CP56之间的EST和STS标记的序列信息,合成了27对特异性PCR引物。获得一些与抗晚疫病基因Rpi1相关联的新的DNA标记。对BC1群体中大量的个体植株进行的分析表明,在马铃薯第7条染色体上位于抗晚疫病基因Rpi1两侧的两个标记S1c9和GP127-300,它们与Rpi1基因的遗传距离分别为1.17cM和3.89cM。这些标记被用来筛选两个细菌人工染色体(BAC)文库,并分离出与晚疫病抗性相关的90-125kb的BAC克隆,这些克隆将在后续的工作中通过图位克隆的方法而用于分离晚疫病抗性基因。同时分离与甲虫抗性紧密相关的分子标记的工作正在进行中。 | 陈勤 孙慧生 杨继良 李海燕 Sanjib Nandy Debbie Beasley 王冬冬 Mark Goettel | 2009 | 中国马铃薯2009，23，5： | 4 |
| 2 | Effects of Toxic Levels of Aluminium on Seedling Parameters of Rice under Hydroponic Culture显示文摘The presence of Al in the rhizosphere of rice in acid soil restricts root growth and significantly reduces crop productivity.In this study,the effects of Al(30,60 and 90μg/mL)on seedling root growth,number of primary roots per seedling,seedling shoot length,number of leaves per seedling,seedling fresh weight,and seedling dry weight were studied.Rice genotypes were classified into three different classes,namely,tolerant,moderately tolerant,and susceptible,based on root tolerance index.The method of hydroponic culture was modified,and elaborated in the text.Toxic levels of Al in nutrient solution significantly decreased seedling root growth,number of primary roots,seedling shoot length,number of leaves per seedling,seedling fresh weight,and seedling dry weight.Few genotypes showed longer root length at 30μg/mL Al in nutrient solutions compared with the control.High levels of Al in nutrient solutions were highly toxic for rice seedlings.Based on root tolerance index,Radhunipagal,Gobindobhog,Badshabhog,Kalobhog,UBKVR-11,UBKVR-16,UBKVR-18,Khasha and IVT4007-B were classified as tolerant genotypes,and these genotypes may be used as donors for breeding of Altoxicity tolerance. | Bidhan ROY Sanjib BHADRA | 2014 | Rice science2014，21，4： | 3 |
| 3 | Use of Biotic Community Structure as a Measure of Ecological Degradation显示文摘The benthic macroinvertebrate communities of two lotic aquatic habitats,namely,the Churni River(C-R)and the Jalangi River(J-R)were compared in this study.One lotic aquatic system(C-R)was polluted by organic pollutants due to discharge of unprocessed sewage water,while the other(J-R)was not affected by such pollution.Evaluations of various physico-chemical properties of water,sediment and different macroinvertebrate communities of the two tropical lotic systems were done in a period from January,2002 to December,2003.A long term temporal change in the macroinvertebrate communities was recorded due to increase in sediment rH value.Sediment redox potential affected by the anthropogenic activities was found to be an important factor for alteration of macroinvertebrate communities in these aquatic ecosystems.A positive correlation has been established between rH and Margalef index in this study.Potassium and the total count of coliform bacteria in water showed significantly higher values for the polluted Churni River than those for the Jalangi River.Fig 3,Tab 4,Ref | SANJIB Kumar Das DIBYENDU Biswas SUDIPTO Roy | 2007 | 应用与环境生物学报2007，13，5： | 3 |
| 4 | Identification of arylamine N-acetyltransferase inhibitors as an approach towards novel anti-tuberculars显示文摘New anti-tubercular drugs and drug targets are urgently needed to reduce the time for treatment and also to identify agents that will be effective against Mycobacterium tuberculosis persisting intracellularly.Mycobacteria have a unique cell wall.Deletion of the gene for arylamine N-acetyltransferase(NAT)decreases mycobacterial cell wall lipids,particularly the distinctive mycolates,and also increases antibiotic susceptibility and killing within macrophage of Mycobacterium bovis BCG.The nat gene and its associated gene cluster are almost identical in sequence in M.bovis BCG and M.tuberculosis.The gene cluster is essential for intracellular survival of mycobacteria.We have therefore used pure NAT protein for high-throughput screening to identify several classes of small molecules that inhibit NAT activity.Here,we characterize one class of such molecules—triazoles—in relation to its effects on the target enzyme and on both M.bovis BCG and M.tuberculosis.The most potent triazole mimics the effects of deletion of the nat gene on growth,lipid disruption and intracellular survival.We also present the structure-activity relationship between NAT inhibition and effects on mycobacterial growth,and use ligand-protein analysis to give further insight into the structure-activity relationships.We conclude that screening a chemical library with NAT protein yields compounds that have high potential as anti-tubercular agents and that the inhibitors will allow further exploration of the biochemical pathway in which NAT is involved. | Isaac M.Westwood Sanjib Bhakta Angela J.Russell Elizabeth Fullam Matthew C.Anderton Akane Kawamura Andrew W.Mulvaney Richard J.Vickers Veemal Bhowruth Gurdyal S.Besra Ajit Lalvani Stephen G.Davies Edith Sim | 2010 | Protein & Cell2010，1，1： | 3 |
| 5 | 新型蛋白质中的氨基酸(综述)显示文摘氨基酸(Amino Acid,AA)是所有动物体内蛋白质的基本构架,在细胞中起着多重调节功能。对猪而言,AA分两大类:必需氨基酸(Essential Amino Acid,EAA)和非必需氨基酸(Non-Essential Amino Acid,NEAA)。EAA无法在动物的生理系统内自然合成,因此EAA必须通过日粮提供给动物;而NEAA则可在动物体内合成,因此无需在日粮中额外添加。在单胃动物所需的20种AA中(表1),猪的EAA仅为9种(蛋氨酸、组氨酸、苯丙氨酸、亮氨酸、异亮氨酸、苏氨酸、色氨酸、赖氨酸和缬氨酸)。这种不可缺少的AA因动物物种的不同也有所不同。 | 韩浩月(译) 夏俊花(审) 罗静如(制图) Sanjib Borah Dipankar Paul | 2018 | 国外畜牧学(猪与禽)2018，38，1： | 3 |
| 6 | Hepatitis B vaccination in patients with inflammatory bowel disease显示文摘AIM:To determine the prevalence for hepatitis B virus(HBV) and HBV screening and vaccination practices for inflammatory bowel disease(IBD).METHODS:This study is a retrospective,cross-sectional observational study.A retrospective chart review was performed in 500 patients who have been consecutively treated for IBD between September 2008 and January 2013 at the Rush University Medical Center Gastroenterology section.The patients were identified through the electronic medical record with the criteria that they attended the gastroenterology clinic,and that they had a diagnosis of IBD at the time of visit discharge.Once identified,each record was analyzed to determine whether the subject had been infected with HBV in the past,already been vaccinated against HBV,or advised to get vaccinated and followed through with the recommended vaccination.RESULTS:About 254 out of 500 patients(51%) had HBV screening ordered.Among those ordered to have screening tests,86% followed through with HBV serology.Gastroenterology physicians had significantly different screening ratios from each other(P < 0.001).There were no significant differences in the ratios of HBV screening when IBD specialists were compared to other gastroenterology physicians(0.505 ± 0.023 vs 0.536 ± 0.066,P = 0.66).Of those 220 patients screened,51% of IBD patients were found not to be immune against HBV.Approximately 50% of gastroenterology physicians recommended HBV vaccinations to their patients in whom serology was negative for antibodies against HBV.IBD specialists recommended vaccinations to a higher percentage of their patients compared to other gastroenterology physicians(0.168 ± 0.019 vs 0.038 ± 0.026,P = 0.015).Present and/or past HBV infection was found in 3.6% of the patients who had serology checked.There was no statistically significant difference in the prevalence of hepatitis B surface antigen(HBsAg) between our study and that reported in previous studies done in Spain(4/220 vs 14/2076 respectively,P = 0.070); and in France(4/220 vs 3/315 respectively,P = 0.159).But,the prevalence of anti-HBcAb in this study was less than that reported in the study in Spain(7/220 vs 155/2076 respectively,P = 0.006); and was not sig-nificantly different from that reported in the study in France(7/220 vs 8/315 respectively,P = 0.313).CONCLUSION:The prevalence of HBsAg in our IBD patients was not higher than previously reported European studies.Most IBD patients are not routinely screened or vaccinated against HBV at a tertiary referral center in the United States. | Ruwaida Ben Musa Anuhya Gampa Sanjib Basu Ali Keshavarzian Garth Swanson Michael Brown Rana Abraham Keith Bruninga John Losurdo Mark DeMeo Sohrab Mobarhan David Shapiro Ece Mutlu | 2014 | World Journal of Gastroenterology2014，20，41： | 2 |
| 7 | 锌在猪营养上的六种不同作用显示文摘微量元素锌正以各种方式用于猪的饲料中——均是作为一种重要的营养物质使用,并且它还以药用剂量的添加方式用于防治腹泻.本文将阐述锌在猪营养中的六个不同作用. | 何晓芳(译) 张配配(校) 韩浩月(制图) sanjib borah dipankar paul | 2018 | 国外畜牧学(猪与禽)2018，38，5： | 2 |
| 8 | GDF15 promotes prostate cancer bone metastasis and colonization through osteoblastic CCL2 and RANKL activation显示文摘Bone metastases occur in patients with advanced-stage prostate cancer(PCa). The cell-cell interaction between PCa and the bone microenvironment forms a vicious cycle that modulates the bone microenvironment, increases bone deformities, and drives tumor growth in the bone. However, the molecular mechanisms of PCa-mediated modulation of the bone microenvironment are complex and remain poorly defined. Here, we evaluated growth differentiation factor-15(GDF15) function using in vivo preclinical PCa-bone metastasis mouse models and an in vitro bone cell coculture system. Our results suggest that PCa-secreted GDF15 promotes bone metastases and induces bone microarchitectural alterations in a preclinical xenograft model. Mechanistic studies revealed that GDF15 increases osteoblast function and facilitates the growth of PCa in bone by activating osteoclastogenesis through osteoblastic production of CCL2 and RANKL and recruitment of osteomacs. Altogether, our findings demonstrate the critical role of GDF15 in the modulation of the bone microenvironment and subsequent development of PCa bone metastasis. | Jawed Akhtar Siddiqui Parthasarathy Seshacharyulu Sakthivel Muniyan Ramesh Pothuraju Parvez Khan Raghupathy Vengoji Sanjib Chaudhary Shailendra Kumar Maurya Subodh Mukund Lele Maneesh Jain Kaustubh Datta Mohd Wasim Nasser Surinder Kumar Batra | 2022 | Bone Research2022，10，1： | 2 |
| 9 | Improving reinforcement of natural rubber by networking of activated carbon nanotubes显示文摘 | Sanjib Bhattacharyya Christophe Sinturel Ouziyine Bahloul | 2008 | Carbon2008，46，7： | 1 |
| 10 | Improving reinforce-ment of natural rubber by networking of activated carbon nanotubes 显示文摘 | Sanjib Bhattacharyya Christophe Sinturel Ouziyine Bahloul | 2008 | Carbon2008，46，7： | 1 |
| 11 | Variation of physiological and antioxidative responses in tea cultivars subjected to ele- vated water stress followed by rehydration recovery显示文摘 | Hrishikesh U Sanjib K P Biman K D | 2008 | Acta Physiologiae Plantarum2008，30，： | 1 |
| 12 | Image motion compensation through augmented collinearity equations 显示文摘 | SANJIB K G | 1985 | Optical Engineering1985，24，6： | 1 |
| 13 | Clinical and magnetic resonance imaging findings in patients with Leigh syndrome and SURF1 mutations显示文摘 | Kothari Sonam Nahid Akthar Khan Parayil Sankaran Bindu Arun B. Taly N. Gayathri M.M. Srinivas Bharath C. Govindaraju H.R. Arvinda Madhu Nagappa Sanjib Sinha K. Thangaraj | 2013 | Brain and Development2013，，： | 1 |
| 14 | Torque ripple minimization in PM synchronous motors using iterative learning control显示文摘 | Qian Weizhe Panda Sanjib K Xu JianXin | 2004 | IEEE Transactions on Power Electronics2004，19，2： | 1 |
| 15 | Preparation of biodiesel from crude oil of Pongamia pinnata显示文摘 | Sanjib Kumar Karmee Anju Chadha | 2005 | Bioresource Technology2005，96，13： | 1 |
| 16 | Improving reinforcement of natural rubber by networking of activated carbon nanotubes显示文摘 | Sanjib B Sinturel C Bahloul O | 2008 | Carbon2008，46，7： | 1 |
| 17 | Acute renal failure following multiple wasp stings显示文摘 | Nisha Bhatta Rupa Singh Sanjib Sharma Arvind Sinnha Shiv Raja | 2005 | Pediatric Nephrology2005，，12： | 1 |
| 18 | Gastroprotective effect of the iridoid fraction from Barleria prionitis leaves on experimentally-induced gastric ulceration显示文摘AIM: To study the gastroprotective effect and in vivo antioxidant potential of a standardized iridoid fraction from B. prionitis leaves(BPE) against different gastric ulcer models in rats. METHOD: The standardized iridoid fraction from BPE at 50, 100, and 200 mg/kg body weight was administered orally, twice daily for 5 days for prevention from aspirin, ethanol, cold-restraint stress(CRS), and pylorus ligation(PL)-induced ulcers. Estimation of the antioxidant enzyme activity was carried out in a CRS-induced ulcer model, and various gastric secretion parameters including volume of gastric juice, acid output, and pH value were estimated in the PL-induced ulcer model. RESULTS: BPE showed a dose-dependent ulcer protective effect in PL(18.67%–66.26% protection), aspirin(24.65%–63.25% protection), CRS(20.77%–59.42% protection), and EtOH(16.93%–77.04% protection)-induced ulcers. BPE treatment in PL-rats showed a decrease in acid-pepsin secretion, and enhanced mucin and mucosal glycoproteins. However, BPE reduced the ulcer index with significant decrease in LPO(P < 0.01–0.001), SOD(P < 0.01–0.001), and an increase in CAT(P < 0.01–0.001), activity in the CRS-induced model. CONCLUSION: The data shows that the iridoid fraction from BPE possesses anti-ulcerogenic and antioxidant potential. | Sunil K.Jaiswal Mukesh K.Dubey Sanjib Das Ch.V.Rao | 2014 | Chinese Journal of Natural Medicines2014，12，10： | 1 |
| 19 | Variation of physiological and antioxidative responses in tea cultivars subjected to ele-vated water stress followed by rehydration recovery显示文摘 | Hrishikesh U Sanjib K P Biman K D | | 0，，： | 1 |
| 20 | Indirect Torque Control of Switched Reluctance Motors Using Iterative Learning Control 显示文摘 | Sanjib K Sahoo Sanjib K Panda Xu Jian Xin | 2005 | IEEE Transactions on Power Electron- ics2005，20，1： | 1 |
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