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| 1 | Potential of four marine-derived fungi extracts as anti-proliferative and cell death-inducing agents in seven human cancer cell lines显示文摘Objective:To evaluate the in vitro anticancer activity of crude ethyl acetate extracts of the culture of four marine-derived fungi Aspergillus similanensis KUFA 0013(E1),Neosartorya paulistemis KUFC 7897(E2),Neosartorya siamensis KUFA 0017(E4) and Talaromyces trachyspermus KUFC 0021(E3) on a panel of seven human cancer cell lines.Methods:Effects on cell proliferation,induction of DNA damage and cell death were assessed by MTT and clonogenic assays,comet assay and nuclear condensation assay,respectively.Results:The proliferation of HepG2,HCTl 16 and A375 cells decreased after incubation with the extracts E2 and E4.The anti-proliterative effect was confirmed by morphologic alterations and by clonogenic assay.Both extracts also induced cell death in HepG2 and HCT116 cells.Doxorubicin was used as a positive control and showed in vitro anticancer activity.Conclusions:This study demonstrated,for the first time,that extracts of Neosartorya paulistensis and Neosartorya siamensis have selective anti-proliferative and cell death activities in HepG2,HCT16 and A375 cells.The bioactivity of these extracts suggests a potential for biotechnological applications and substantiates that both should be further considered for the elucidation of the molecular targets and signal transduction pathways involved. | Alice Abreu Ramos Maria Prata-Sena Bruno Castro-Carvalho Tida Dethoup Suradet Buttachon Anake Kijjoa Eduardo Rocha | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，10： | 2 |
| 2 | Further constituents of Achillea ageratum显示文摘 | Kijjoa A Vieira LM Pereira JA | 1999 | Phytochemistry1999，51，： | 1 |
| 3 | Polyoxygenated cyclohexene derivatives from Ellipeiopsis cherrevensis 显示文摘 | Kijjoa A Bessa J Pinto M M | 2002 | Phytochemistry2002，59，5： | 1 |
| 4 | Cytotoxicity of prenylated xanthones and other constituents from the wood of Garcinia mer guensis显示文摘 | Kijjoa A Gonzalez M J Pinto M M | 2008 | P lanta Med2008，74，8： | 1 |
| 5 | Drugs and Cosmetics from the Sea显示文摘 | Kijjoa A Sawangwong P | | 0，，： | 1 |
| 6 | Cytotoxic activi ty of lupane-type triterpenes from Glachidion sphaerogynum and Glachidion eriocarpum 显示文摘 | Puapairoj P Naengchomong W Kijjoa A | 2004 | Planta Med2004，70，6： | 1 |
| 7 | Naturally-occurring xanthones: Recentdevelopments 显示文摘 | Vieira LMM Kijjoa A | 2005 | Current Medicinal Chemistry2005，12，21： | 1 |
| 8 | Drugs and cosmetics from the sea 显示文摘 | Kijjoa A Sawangwong P | 2004 | MarDrugs2004，2，1： | 1 |
| 9 | Merodrimanes and other constituents from Talaromyces thailandiasis显示文摘 | DETHOUP T MANOCH L KIJJOA A | 2007 | J Nat Prod2007，70，7： | 1 |
| 10 | Dibromotyrosine derivatives, a maleimide, aplysamine-2 and other constituents of the marine sponge Pseudoceratina purpurea 显示文摘 | Kijjoa A Bessa J Wattanadilok R | 2005 | Z Naturforsch2005，60，： | 1 |
| 11 | Constituents of Polyalthia jucunda . and Their Cytotoxic Effect on Human Cancer Cell Lines显示文摘 | Areerat Suedee Ing-On Mondranondra Anake Kijjoa Madalena Pinto Nair Nazareth Maria S?o José Nascimento Artur M.S. Silva Werner Herz | 2007 | Pharmaceutical Biology2007，，7： | 1 |
| 12 | 5, 7 - Dihydroxychromones and 8 - hydroxytetrahydrochromones from Horsfieldia irya 显示文摘 | GONZALEZ M J PINTO M M KIJJOA A | 2002 | Phytochemistry2002，61，8： | 1 |
| 13 | Arylalkanones from Horsfieldia glabra 显示文摘 | PINTO M M KIJJOA A TANTISEWIET B | 1988 | Phytochemistry1988，27，12： | 1 |
| 14 | A biphenyl type neolignan and a biphenyl ether from Magnolia henryi显示文摘 | Kijjoa A Pinto M M M Tantisewie B | | 0，，04： | 1 |
| 15 | Cytotoxic activity of lupane-type triterpenes from Glochidion sphaerogynum and Glochidion eriocarpum two of which induce apoptosis 显示文摘 | Puapairoj P Naengchomnong W Kijjoa A | 2005 | Planta Med2005，71，： | 1 |
| 16 | Mero- drimanes and other constituents from Talaromyees thai- landiasi显示文摘 | DETHOUP T MANOCH L KIJJOA A | | J Nat Prod0，70，7： | 1 |
| 17 | Sartorymensin, a new indole alkaloid, and new analogues of tryptoquivaline and fiscalins produced by Neosartorya siamensis (KUFC 6349)显示文摘 | Suradet Buttachon Angsumarn Chandrapatya Leka Manoch Artur Silva Luís Gales Céline Bruyère Robert Kiss Anake Kijjoa | 2012 | Tetrahedron2012，，15： | 1 |
| 18 | Cytotoxic Activity of lupine-type triterpenes from Glachidion sphaerogynum and Glachidion ericocarpum显示文摘 | Puapairoj P Naengchomong W Kijjoa A | 2004 | Planta Med2004，70，： | 1 |
| 19 | Cytotoxic Activity of Lupane-Type Triterpenes from Glachidion sphaerogynum and Glachidion eriocarpum显示文摘 | Puapairoj P Naengchomong W Kijjoa A | 2004 | Planta Med2004，70，6： | 1 |
| 20 | Naturally-occurring xanthones: Recent developments 显示文摘 | Vieira L Kijjoa A | 2005 | Curr Med Chem2005，12，21： | 1 |
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