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| 1 | Uncoupling neurotrophic function from nociception of nerve growth factor: what can be learned from a rare human disease?显示文摘Nerve growth factor(NGF) is a powerful trophic factor that provides essential support for the survival and differentiation of sympathetic and sensory neurons during development. However, NGF also activates nociceptors contributing significantly to inflammatory pain and neuropathic pain after tissue injury. As such anti-NGF based therapies represent a promising strategy for pain management. Because of dose-dependent serious side effects such as back pain, injection site hyperalgesia, clinical trials of using NGF to treat various disorders such as diabetic neuropathies, chemotherapy-induced and human immunodeficiency virus-associated peripheral neuropathies were all discontinued. Thus far, worldwide clinical applications of NGF in treating patients are very limited except in China. Hereditary sensory autonomic neuropathy type V(HSAN V) is an extremely rare disease. Genetic analyses have revealed that HSAN V is associated with autosomal recessive mutations in NGF. One of the mutations occurred at the 100^(th) position of mature NGF resulting in a change of residue from arginine to tryptophan(R100W). Although those HSAN V patients associated with the NGF^(R100W) mutation suffer from severe loss of deep pain, bone fractures and joint destruction, interestingly patients with the NGF^(R100W) mutation do not show apparent cognitive deficits, suggesting important trophic support function is preserved. We believe that NGF^(R100W) provides an ideal tool to uncouple the two important functions of NGF: trophic versus nociceptive. Studies from investigators including ourselves have indeed confirmed in animal testing that the NGF^(R100W) no longer induced pain. More importantly, the trophic function seemed to be largely preserved in NGF harboring the R100W mutation. On the mechanistic level, we found that the NGF^(R100W) mutation was capable of binding to and signaling through the tyrosine receptor kinase A receptor. But its ability to bind to and activate the 75 kDa neurotrophic factor was significantly diminished. The significance of these findings is at least two folds: 1) the NGF^(R100W) mutation can be used as an alternative to the wildtype NGF to treat human conditions without eliciting pain; and 2) the 75 kDa neurotrophic factor may serve as a novel target for pain management. We will discuss all the details in this mini-review. | Kijung Sung Wanlin Yang Chengbiao Wu | 2019 | Neural Regeneration Research2019，14，4： | 5 |
| 2 | Effect of Damper between Maglev Vehicles on Curve Negotiation 显示文摘 | KIM KiJung HAN Hyungsuk | 2013 | Transactions of the Korean Society of Mechanical Engineers2013，37，4： | 1 |
| 3 | Homogeneously distributed magnetite in the polystyrene spherical particles us ing the miniemulsion polymerization显示文摘 | Junhyeong Ban Kijung Kim Hyejun Jung | 2010 | Journal of Industrial and Engineering Chemistry2010，16，： | 1 |
| 4 | Structural characterization of β -SiC nanowires synthesized by direct heating method显示文摘 | YUNBO BAEK YONGHWAN RYU KIJUNG YONG | 2006 | Materials Science and Engineering:C2006，，26： | 1 |
| 5 | Road pricing and bus service policies 显示文摘 | Kijung A | 2009 | Journal of Transport Economics and Policy2009，43，1： | 1 |
| 6 | Structural eharaeteri-zation of β-SiC nanowires synthesized by direct heating method 显示文摘 | Yunho Baek YongHwan Ryu Kijung Yong | 2006 | Materials Science and Engineering: C2006，，26： | 1 |
| 7 | Optimum conditions for preparing micron-sized PMMA beads in the dispersion polymerization using PVA显示文摘 | Ok Hyung Kim Kangseok Lee Kijung Kim Byung H. Lee Soonja Choe | 2006 | Colloid and Polymer Science2006，，8： | 1 |
| 8 | Upregulation of RIN3 induces endosomal dysfunction in Alzheimer’s disease显示文摘Background In Alzheimer’s Disease(AD),about one-third of the risk genes identified by GWAS encode proteins that function predominantly in the endocytic pathways.Among them,the Ras and Rab Interactor 3(RIN3)is a guanine nucleotide exchange factor(GEF)for the Rab5 small GTPase family and has been implicated to be a risk factor for both late onset AD(LOAD)and sporadic early onset AD(sEOAD).However,how RIN3 is linked to AD pathogenesis is currently undefined.Methods Quantitative PCR and immunoblotting were used to measure the RIN3 expression level in mouse brain tissues and cultured basal forebrain cholinergic neuron(BFCNs).Immunostaining was used to define subcellular localization of RIN3 and to visualize endosomal changes in cultured primary BFCNs and PC12 cells.Recombinant flag-tagged RIN3 protein was purified from HEK293T cells and was used to define RIN3-interactomes by mass spectrometry.RIN3-interacting partners were validated by co-immunoprecipitation,immunofluorescence and yeast two hybrid assays.Live imaging of primary neurons was used to examine axonal transport of amyloid precursor protein(APP)andβ-secretase 1(BACE1).Immunoblotting was used to detect protein expression,processing of APP and phosphorylated forms of Tau.Results We have shown that RIN3 mRNA level was significantly increased in the hippocampus and cortex of APP/PS1 mouse brain.Basal forebrain cholinergic neurons(BFCNs)cultured from E18 APP/PS1 mouse embryos also showed increased RIN3 expression accompanied by early endosome enlargement.In addition,via its proline rich domain,RIN3 recruited BIN1(bridging integrator 1)and CD2AP(CD2 associated protein),two other AD risk factors,to early endosomes.Interestingly,overexpression of RIN3 or CD2AP promoted APP cleavage to increase its carboxyl terminal fragments(CTFs)in PC12 cells.Upregulation of RIN3 or the neuronal isoform of BIN1 increased phosphorylated Tau level.Therefore,upregulation of RIN3 expression promoted accumulation of APP CTFs and increased phosphorylated Tau.These effects by RIN3 was rescued by the expression of a dominant negative Rab5(Rab5S34N)construct.Our study has thus pointed to that RIN3 acts through Rab5 to impact endosomal trafficking and signaling.Conclusion RIN3 is significantly upregulated and correlated with endosomal dysfunction in APP/PS1 mouse.Through interacting with BIN1 and CD2AP,increased RIN3 expression alters axonal trafficking and procession of APP.Together with our previous studies,our current work has thus provided important insights into the role of RIN3 in regulating endosomal signaling and trafficking. | Ruinan Shen Xiaobei Zhao Lu He Yongbo Ding Wei Xu Suzhen Lin Savannah Fang Wanlin Yang Kijung Sung Brian Spencer Robert A.Rissman Ming Lei Jianqing Ding Chengbiao Wu | 2020 | Translational Neurodegeneration2020，9，2： | 1 |
| 9 | Optimum fin density of low fin tubes for the condensers of building chillers with HCFC123 显示文摘 | Park Kijung Dongsoo Jung | 2008 | Energy Conversion and Management2008，49，8： | 1 |
| 10 | Journal of Industrial and Engineering Chemistry显示文摘 | Junhyeong Ban Kijung Kim Hyejun Jung | 2010 | 16: 1040-10492010，16，： | 1 |
| 11 | Boiling heat transfer enhancement with carbon nanotubes for refrigerants used in building air-conditioning 显示文摘 | Park KiJung Jung Dongsoo | 2007 | Energy and Buildings2007，，： | 1 |
| 12 | A study on the dynamic behaviors of water droplets impacting nanostructured surfaces 显示文摘 | Kwak Geunjae Lee Dong Woog Kang In Seok Yong Kijung | 2011 | AIP Advances2011，1，04： | 1 |
| 13 | Overview of emerging catalytic materials for electrochemical green ammonia synthesis and process显示文摘The concept of“green-ammonia-zero-carbon emission”is an emerging research topic in the global community and many countries driving toward decarbonizing a diversity of applications dependent on fossil fuels.In light of this,electrochemical nitrogen reduction reaction(ENRR)received great attention at ambient conditions.The low efficiency(%)and ammonia(NH_(3))production rates are two major challenges in making a sustainable future.Besides,hydrogen evolution reaction is another crucial factor for realizing this NH_(3)synthesis to meet the large-scale commercial demand.Herein,the(i)importance of NH_(3)as an energy carrier for the next future,(ii)discussion with ENRR theory and the fundamental mechanism,(iii)device configuration and types of electrolytic systems for NH_(3)synthesis including key metrics,(iv)then moving into rising electrocatalysts for ENRR such as single-atom catalysts(SACs),MXenes,and metal–organic frameworks that were scientifically summarized,and(v)finally,the current technical contests and future perceptions are discussed.Hence,this review aims to give insightful direction and a fresh motivation toward ENRR and the development of advanced electrocatalysts in terms of cost,efficiency,and technologically large scale for the synthesis of green NH_(3). | Venkata Thulasivarma Chebrolu Daehee Jang Gokana Mohana Rani Chaeeun Lim Kijung Yong Won Bae Kim | 2023 | Carbon Energy2023，5，12： | 0 |
| 14 | Design and roles of RGO-wrapping in charge transfer and surface passivation in photoelectrochemical enhancement of cascade-band photoanode显示文摘快电荷转移和 anti-photocorrosion 是为为 photoelectrochemical (PEC ) 开发有效、持久的 photoanodes 的二个关键因素房间。减少的 graphene 氧化物(RGO ) 是能提供的一个有希望的 photoanode 元素这两。在这研究,我们阐明了在电荷转移和由包 RGO 的 photoanode 的精确设计和它的 PEC 性质的检查的 photoanodes 的表面钝化的 RGO 的角色。有三个不同图案的 hetero-nanorods (HNR ) 的数组作为积木用 RGO, CdSe nanoparticles (NP ) ,和 ZnO nanorods (NR ) 作为 photoanodes 被制作。CdSe@ZnO HNR 被与 CdSe NP 装饰 ZnO NR 准备。有限元素的分析和试验性的研究证明在 CdSe@ZnO HNR,真希望, ZnO NR 被 RGO 包,在 CdSe 和 ZnO 之间的电导率被 RGO 提高到梭费用。如果 RGO 仅仅包围了 CdSe@ZnO HNR 的外面,腐蚀由于 RGO 的钝化效果被减缓,它增加了 photoanode 的电子一生。如果 CdSe 和 ZnO 被 RGO 充分包,二个上述的盒子的优点两个都被获得。有控制位置的图案的包 RGO 的 CdSe@ZnO HNR 与高 PEC 效率,和发达合成正在答应 photoanode 材料过程能被使用作为一块积木用 RGO 探索下一代的 photoanodes 的设计和制造。 | Zhuo Zhang Mingi Choi Minki Baek Insung Hwang Changshin Cho Zexiang Deng Jinwoo Lee Kijung Yong | 2017 | Nano Research2017，10，7： | 0 |
| 15 | Exploring the Regional Spatial Structure of the Seoul Metropolitan Area to Reduce Car Travel显示文摘 | Lee Seungil An Youngsoo Kim Kijung | 2015 | 北京规划建设2015，，B06： | 0 |
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