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| 1 | Perceived risk as a barrier to appropriate diagnosis of irritable bowel syndrome显示文摘AIM:To evaluate perceived risk,diagnostic testing,and acceptance of a diagnosis of irritable bowel syndrome(IBS)among the Korean laypersons.METHODS:We designed a conceptual framework to evaluate the health-seeking behavior of subjects based on a knowledge,attitude,and practice model.We developed a vignette-based questionnaire about IBS based on a literature review and focused group interviews.The vignette described a 40-year-old woman who meets the RomeⅢcriteria for IBS without red-flag signs.It was followed by questions about demographic characteristics,health behaviors,IBS symptoms,risk perception,perceived need for diagnostic tests,and acceptance of a positive diagnosis of IBS.Weplanned a nationwide survey targeting laypersons without IBS and between the ages of 20 and 69 years.Survey participants were selected by quota sampling stratified by gender,age,and nationwide location.A multivariate logistic model was constructed based on literature reviews,univariate analysis,and a stepwise selection method to investigate correlations between the perceived risk,need for diagnostic tests,and acceptance of a positive diagnosis.RESULTS:Of 2354 eligible households,1000 subjects completed the survey and 983 subjects were analyzed,excluding those who met symptom criteria for IBS.After reading the IBS vignette,the majority of subjects(86.8%)responded that the patient was at increased risk of severe disease.The most frequent concern was colon cancer(59.8%),followed by surgical condition(51.5%).Most subjects responded the patient needs diagnostic tests(97.2%).Colonoscopy was the most commonly required test(79.5%).Less than half of the respondents requested a stool examination(45.0%),blood test(40.7%),abdominal ultrasound(36.0%),or computed tomography(20.2%).The subjects who felt increased risk were more likely to see a need for colonoscopy[adjusted odds ratio(a OR)=2.10,95%CI:1.38-3.18].When asked about the positive diagnosis,the most frequent response was that'the patient would not be reassured'(65.7%).The increased risk perception group was less likely to be reassured by a positive diagnosis of IBS,compared to the other respondents(a OR=0.52,95%CI:0.34-0.78).CONCLUSION:For IBS diagnosis,increased risk perception is a possible barrier to the appropriate use of diagnostic tests and to the patient’s acceptance of a positive diagnosis. | Eunmi Ahn Ki Young Son Dong Wook Shin Min Kyu Han Hyejin Lee Ah Reum An Eun Ho Kim Be Long Cho | 2014 | World Journal of Gastroenterology2014，20，48： | 2 |
| 2 | Catheter=directed thrombolysis with percutaneous rheolytic thrombectomy versus thrombolysis alone in upper and lower extremity deep vein thrombosis 显示文摘 | Kim HS Patra A Paxton BE | 2006 | Cardiovasc Intervant Radiol2006，29，6： | 1 |
| 3 | Air pollution exposure and health effects in fetus 显示文摘 | Lee BE Park HS Kim YJ | 2004 | J Prev Med Public Health2004，37，4： | 1 |
| 4 | Comparison of propofol and fentanyladministered at the end of anaesthesia for prevention of emergenceagitation after sevoflurane anaesthesia in children 显示文摘 | Kim MS Moon BE Kim H | 2013 | Br JAnaesth2013，，2： | 1 |
| 5 | Catheter-directed thmmbolysis with percutaneous rheolytie thrombectomy versus thrombolysis alone in upper and lower extremity deep vein thrombosis显示文摘 | Kim HS Patra A Paxton BE | 2006 | Cardiovasc Intervent Radiol2006，29，6： | 1 |
| 6 | A damage model for the fatigue life of elastomertic materials显示文摘 | WANG Be LU Hongbing KIM Gyu-Ho | 2002 | Meeh Mat2002，34，8： | 1 |
| 7 | Recent clinical overview of renal and perirenal abscesses in 56 consecutive cases显示文摘 | Lee BE Seol HY Kim TK | 2008 | Kore- an J Intern Med2008，23，3： | 1 |
| 8 | Cytokine modulation of atopic dermatitis filaggrin skin expression 显示文摘 | Howell MD Kim BE Gao P | 2007 | J Allergy ClinIm- munol2007，120，1： | 1 |
| 9 | Th2 cytokines act on S100/All to downregulate keratinocyte differentiation显示文摘 | Howell MD Fairchild HR Kim BE | 2008 | J Invest Dermatol2008，128，9： | 1 |
| 10 | Catheter-directed thrombolysis with percutaneous rheolytie thrombeetomy versus thrombolysis alone in upper and lower extremity deep vein thrombosis显示文摘 | Kim HS Patra A Paxton BE | 2006 | Cardiovase Intervent Radiol2006，29，6： | 1 |
| 11 | Prognostic implications of alpha-fetoprotein response during treatment of hepatoblastoma 显示文摘 | Koh KN Park M Kim BE | 2011 | Pediatr Blood Cancer2011，57，4： | 1 |
| 12 | IL-25 enhances HSV-1 replication by inhibiting filaggrin expression, and acts synergistically with Th2 cytokines to enhance HSV-1 replication 显示文摘 | Kim BE Bin L Ye YM | 2013 | J Invest Dermatol2013，133，12： | 1 |
| 13 | Power generation using differentcation,anion and ultrafiltration membranes in microbial fuel cells显示文摘 | Kim J R Cheng S Oh SE Logan BE | 2007 | Environment Science and Technology2007，41，3： | 1 |
| 14 | Loricrin and involu- crin expression is down-regulated by Th2 cytokines through STAT-6显示文摘 | Kim BE Leung DY Boguniewicz M | 2008 | Clin hnnmnol2008，126，3： | 1 |
| 15 | Adjunctive percuta-neous mechanical thrombectomy for lower-extremity deep vein thrombosis:clinical and economic outcomes显示文摘 | Kim HS Patra A Paxton BE | 2006 | J Vasc Interv Radiol2006，17，7： | 1 |
| 16 | Changes in symptom clusters in patients undergoing radiation therapy 显示文摘 | Kim E Jahan T Aouizerat BE | 2009 | Support Care Cancer2009，17，11： | 1 |
| 17 | Catheter-directed thrombolysis with percutaneous rheolytic thrombectomy versus thrombolysis alone in upper and lower extremity deep vein thrombosis显示文摘 | Kim HS Patrs A Paxton BE | 2006 | Cardiovasc Intervent Radiol2006，29，6： | 1 |
| 18 | Comparable efficacy of silk fi- broin with the collagen membranes for guided bone regeneration in rat calvarial defects显示文摘 | Kim JY Yang BE Ahn JH | 2014 | J Adv Prosthodont2014，6，6： | 1 |
| 19 | Acrodermatitis en- teropathica mutations affect transport activity, localization and zinc-responsive trafficking of the mouse ZIP4 zinc transporter显示文摘 | Wang F Kim BE Dufner-Beattie J | 2004 | Hum Mol Genet2004，13，5： | 1 |
| 20 | A review of the prevalence and impact of multiple symptoms in oncology patients显示文摘 | Kim J Dodd M J Aouizerat BE | 2009 | J Pain Symptom Manage2009，37，4： | 1 |
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