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| 1 | 2018 update of expert consensus statement on antiplatelet therapy in East Asian patients with ACS or undergoing PCI显示文摘East Asians are the most populous race in the world and their health status is an important global issue.Compared with Caucasian populations, East Asian patients have a different benefit/risk ratio when using antithrombotic treatment. Despite this observation, treatment strategies in East Asian patients are mostly based on the American and European guidelines. Despite a lower platelet inhibitory response to clopidogrel, East Asian patients show a similar or even a lower rate of ischemic event occurrence and higher bleeding risk compared with Caucasian patients. For potent P2Y_(12) inhibitors(ticagrelor and prasugrel),East Asian patients have shown less favorable net clinical benefits compared with Caucasian patients,which may be related to differences in pharmacokinetic/pharmacodynamic profiles and therapeutic zone of antiplatelet effect. This updated consensus mainly focuses on state-of-the-art and current controversies in the East Asian population. In addition, when East Asian patients are administered potent P2Y_(12) receptor inhibitors, the strategies and ongoing trials to overcome the related hurdles are discussed. | Yong Huo Young-Hoon Jeong Yanjun Gong Daowen Wang Ben He Jiyan Chen Guosheng Fu Yundai Chen Jianping Li Yi Li Shinya Goto Udaya S.Tantry Paul A.Gurbel Jong-Hwa Ahn Hyo-Soo Kim Myung Ho Jeong Yaling Han Sidney C.Smith Jr. Junbo Ge | 2019 | Science Bulletin2019，64，3： | 12 |
| 2 | Effect of electroacupuncture on glial fibrillary acidic protein and nerve growth factor in the hippocampus of rats with hyperlipidemia and middle cerebral artery thrombus显示文摘Electroacupuncture(EA)has been shown to reduce blood lipid level and improve cerebral ischemia in rats with hyperlipemia complicated by cerebral ischemia.However,there are few studies on the results and mechanism of the effect of EA in reducing blood lipid level or promoting neural repair after stroke in hyperlipidemic subjects.In this study,EA was applied to a rat model of hyperlipidemia and middle cerebral artery thrombosis and the condition of neurons and astrocytes after hippocampal injury was assessed.Except for the normal group,rats in other groups were fed a high-fat diet throughout the whole experiment.Hyperlipidemia models were established in rats fed a high-fat diet for 6 weeks.Middle cerebral artery thrombus models were induced by pasting 50%FeCl3 filter paper on the left middle cerebral artery for 20 minutes on day 50 as the model group.EA1 group rats received EA at bilateral ST40(Fenglong)for 7 days before the thrombosis.Rats in the EA1 and EA2 groups received EA at GV20(Baihui)and bilateral ST40 for 14 days after model establishment.Neuronal health was assessed by hematoxylin-eosin staining in the brain.Hyperlipidemia was assessed by biochemical methods that measured total cholesterol,triglyceride,low-density lipoprotein and high-density lipoprotein in blood sera.Behavioral analysis was used to confirm the establishment of the model.Immunohistochemical methods were used to detect the expression of glial fibrillary acidic protein and nerve growth factor in the hippocampal CA1 region.The results demonstrated that,compared with the model group,blood lipid levels significantly decreased,glial fibrillary acidic protein immunoreactivity was significantly weakened and nerve growth factor immunoreactivity was significantly enhanced in the EA1 and EA2 groups.The repair effect was superior in the EA1 group than in the EA2 group.These findings confirm that EA can reduce blood lipid,inhibit glial fibrillary acidic protein expression and promote nerve growth factor expression in the hippocampal CA1 region after hyperlipidemia and middle cerebral artery thrombosis.All experimental procedures and protocols were approved by the Animal Use and Management Committee of Beijing University of Chinese Medicine,China(approval No.BUCM-3-2018022802-1002)on April 12,2018. | Na-Ying Xue Dong-Yu Ge Rui-Juan Dong Hyung-Hwan Kim Xiu-Jun Ren Ya Tu | 2021 | Neural Regeneration Research2021，16，1： | 9 |
| 3 | Real earnings management and the cost of new corporate bonds显示文摘 | Wenxia Ge Jeong-Bon Kim | 2013 | Journal of Business Research2013，，： | 2 |
| 4 | Antigen-specific Tregs control T cell responses against a limited repertoire of tumor antigens in patients with colorectal carcinoma显示文摘 | Bonertz Andreas Weitz Jürgen Pietsch Dong-Ho Kim Rahbari Nuh N Schlude Christoph Ge Yingzi Juenger Simone Vlodavsky Israel Khazaie Khashayarsha Jaeger Dirk Reissfelder Christoph Antolovic Dalibor Aigner Maximilian Koch Moritz Beckhove Phili | 2009 | Journal of Clinical Investigation2009，，11： | 2 |
| 5 | DNA methyltransferase 1 -associ ated protein ( DMAP1 ) is a co-repressor that stimulates DNA methy lation globally and locally at sites of double strand bread repair显示文摘 | Lee GE Kim JH Taylor M | 2010 | Biol Chen2010，285，37： | 1 |
| 6 | Immunocytochemical panelfor distinguishing between adenocarcinomas and reactive mesothe-lial cells in effusion cell blocks显示文摘 | Kim JH Kim GE Choi YD | 2009 | Diagn Cytopathol2009，37，4： | 1 |
| 7 | Transarterial chemoembolization can be safely performed in patients with hepatocellular carcinoma Invading the main portal vein and may improve the overall survival显示文摘 | Chung GE Lee JH Kim HY | 2011 | Radiology2011，258，2： | 1 |
| 8 | Malignant renal cysts: diagnostic performance and strong predictors at MDCT显示文摘 | Kim DY Kim JK Min GE | 2010 | Acta Radiol2010，51，5： | 1 |
| 9 | Non-alcoholic fatty liverdisease across the spectrum of hypothyroidism显示文摘 | Chung GE Kim D Kim W | 2012 | J Hepatol2012，57，1： | 1 |
| 10 | Risk factors for postoperative ile- us after urologic laparoscopic surgery 显示文摘 | Kim M J Min GE Yoo KH | 2011 | J Korean Surg Soc2011，80，6： | 1 |
| 11 | Combined chemotherapy and radiation versus radiation alone in the management of localized angiocentric lymphoma of the head and neck显示文摘 | Kim GE Lee SW Chang SK | 2001 | Radiother Oncol2001，61，3： | 1 |
| 12 | Quantitative assessment of DNA methylation for the detection of cervical and endometrial adenocarcinomas in liquid-based cytology specimens显示文摘 | Kim GE Kweon SS Lee JS | 2012 | Anal Quant Cytol Histo12012，34，4： | 1 |
| 13 | Transformation of ginsenosides Rb2 and Rc from Panax ginseng by food microorganisms显示文摘 | Chi H Kim DH Ji GE | 2005 | Biol Pharm Bull2005，28，： | 1 |
| 14 | Non-alcoholic fatty liver disease across the spectrum of hypothyroidism显示文摘 | Chung GE Kim D Kim W | 2012 | J Hepatol2012，57，： | 1 |
| 15 | Internal governance, legal institutions and bank loan contracting around the world显示文摘 | Wenxia Ge Jeong-Bon Kim Byron Y. Song | 2012 | Journal of Corporate Finance2012，，3： | 1 |
| 16 | Sonographic appearance of a free-floating at heromatous plaque in a patient with acute stroke显示文摘 | Cho YP Kwon TW Kim GE | 2002 | J Clin Ultrasound2002，30，： | 1 |
| 17 | Effect of oral probiotics (Bifidobacterium lactis AD011 and Laetobacillus acidophilus AD031) administration on ovalbumin-induced food allergy mouse model显示文摘 | Kim JY Choi YO Ji GE | 2008 | J Microbiol Biotechnol2008，18，8： | 1 |
| 18 | Coupling of cell migration with neurogenesis by proneural bHLH factors 显示文摘 | Ge W He F Kim K J | 2006 | Proc Natl Acad Sci USA2006，103，5： | 1 |
| 19 | Differential cyclooxygenase - 2 expression in squamous cell and adenocarcinoma of the uterine cervix显示文摘 | Kim YB Kim GE Pyo FIR | 2004 | Int J Radiat Oncol Biol Phys2004，0，3： | 1 |
| 20 | Radiation treatment in patients with recurrent Kimura's disease显示文摘 | Kim GE Kirn WC Yang WI | 1997 | Int J Radiat Oncol Biolphys1997，38，： | 1 |
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