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| 1 | 脑海绵状血管畸形临床诊疗指南概要:血管瘤联盟科学咨询委员会临床专家组基于系统文献评价的共识推荐显示文摘背景尽管脑海绵状血管畸形(cerebral cavernous malformation, CCM)的相关研究文献已相当丰富,但在诊断和治疗策略方面仍存在着争议。目的制订CCM诊疗指南。方法作为代表CCM患者和研究的患者支持团体,血管瘤联盟(www.angioma.org)召集了一个包括CCM临床专家在内的多学科写作组来帮助总结现有的CCM临床诊疗相关文献,重点关注5个主题:(1)流行病学和自然病程;(2)遗传检测和咨询;(3)诊断标准和影像学标准;(4)神经外科注意事项;(5)神经内科注意事项。写作组根据预定方案进行了文献回顾和证据评价,最终制定推荐意见,并且确立了共识、争议和知识空白。结果根据方法学标准从1983年1月1日至2014年9月31日期间公开发表的1 270篇文献中筛选出98篇,并确定了另外38篇近期或相关的文献。各主题作者利用这些文献总结了现有知识并形成了23项共识诊疗推荐,同时根据美国心脏协会/美国卒中协会标准进行了推荐强度(效应量)和证据水平(确定性估计)评级。其中,尚无A级证据(因为缺乏随机对照试验),B级证据11项(48%),C级证据12项(52%);Ⅰ级推荐8项(35%),Ⅱ级推荐10项(43%),Ⅲ级推荐5项(22%)。结论现有证据支持对CCM诊疗的推荐,但这些证据的级别和推荐强度普遍较低,因此需要进一步研究来帮助进行更好的临床实践并更新这些推荐。完整的推荐文档包括引用文献的纳入标准、关于各项推荐更详尽的评判标准以及各种争议和知识空白的总结,同样通过了同行评议并可在线获取(www.angioma.org/CCMGuidelines)。 | Amy Akers Rustam Al-Shahi Salman Issam A. Awad Kristen Dahlem Kelly Flemming Blaine Hart Helen Kim Ignacio Jusue-Torres Douglas Kondziolka Cornelia Lee Leslie Morrison Daniele Rigamonti Tania Rebeiz Elisabeth Toumier-Lasserve Darrel Waggoner Kevin Whitehead 鄂同舟 雷宇 倪伟 顾宇翔 | 2017 | 国际脑血管病杂志2017，25，7： | 4 |
| 2 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 3 | Dietary supplementation of Bacillus subtilis influenced intestinal health of weaned pigs experimentally infected with a pathogenic E. coli显示文摘Background: There is growing evidence to support the beneficial effects of supplementing direct-fed microbials(DFM) on performance, health status, and immune responses of weaned pigs. Therefore, the objective of this study was to investigate dietary supplementation of Bacillus subtilis(DSM 25841) on growth performance, diarrhea, gut permeability and immunity of weaned pigs experimentally infected with a pathogenic F-18 Escherichia coli(E. coli).Results: The F18 E. coli infection reduced(P < 0.05) growth performance and intestinal villi height, whereas increased(P < 0.05) diarrhea and transcellular and paracellular permeability in the jejunum compared with non-challenged control. Supplementation of Bacillus subtilis linearly enhanced average daily gain of E. coli infected pigs from d 0 to 5 post-inoculation(PI)(P < 0.05) and d 0 to 11 PI(P = 0.058). Supplementation of high dose of Bacillus subtilis reduced(P < 0.05) both transcellular and paracellular permeability on d 5 and d11 PI compared with the E. coli infected pigs fed with control diet. E. coli infection up-regulated(P < 0.05)the m RNA expression of SLC5 A10(soluble carrier family 5 member 10) and MUC2(mucin 2) on d 5 PI, but down-regulated(P < 0.05) expression of SLC5 A10, MUC2, and CLDN1 on d 11 PI in jejunal mucosa when pigs were fed with the control diet. Supplementation of Bacillus subtilis linearly up-regulated(P < 0.05) the m RNA expression of CFTR and ZO1 on d 5 PI and SLC5 A10 and MUC2 on d 11 PI in jejunal mucosa of E. coli infected pigs. In addition, E. coli infection increased(P < 0.05) the m RNA expression of several immune genes(IL1 A, IL1 B, and IL7 on d 5 PI, and IL1 B, IL6, IL7, and TNF on d 11 PI) in the ileal mucosa of weaned pigs. Inclusion of Bacillus subtilis to control diet linearly down-regulated gene expression of IL1 A on d 5 PI(P = 0.07) and IL6 on d 11 PI(P < 0.05) in ileal mucosa of E. coli infected pigs.Conclusions: Supplementation of Bacillus subtilis(DSM 25841) enhanced growth rate and improved gut barrier function of weaned pigs experimentally infected with a pathogenic E. coli. | Kwangwook Kim Yijie He Xia Xiong Amy Ehrlich Xunde Li Helen Raybould Edward R.Atwill Elizabeth A.Maga Jens JΦrgensen Yanhong Liu | 2019 | Journal of Animal Science and Biotechnology2019，10，4： | 3 |
| 4 | Influence of Technologic Advances on Outcomes in Patients With Unresectable, Locally Advanced Non–Small-Cell Lung Cancer Receiving Concomitant Chemoradiotherapy显示文摘 | Zhongxing X. Liao Ritsuko R. Komaki Howard D. Thames Helen H. Liu Susan L. Tucker Radhe Mohan Mary K. Martel Xiong Wei Kunyu Yang Edward S. Kim George Blumenschein Waun Ki Hong James D. Cox | 2010 | International Journal of Radiation Oncology Biology Physics2010，，3： | 1 |
| 5 | A Si BiCMOS transimpedance amplifier for 10 Gbit/s SONET receiver显示文摘 | Kim Helen H Chandrasekhar S Burrus Charles A | 2001 | IEEE Journal of Solid-State Circuits2001，36，5： | 1 |
| 6 | Assistant Instructors Facilitate Simulation for Medical Students显示文摘 | Yinin Hu Joanna Choi Adela Mahmutovic Helen Kim Ivy A. Le Sara K. Rasmussen | 2014 | Journal of Surgical Research2014，，： | 1 |
| 7 | Repair of medial orbital wall fracture : transcamncular approach 显示文摘 | Kim S Helen Leu M Chung SH | 2005 | Orbit2005，24，1： | 1 |
| 8 | An Efficient Path-generation Method for Vh-tual Colonoscopy 显示文摘 | Jeongjin Lee Helen Hong Yeong Gil Shin Soo-Hong Kim | 2005 | Lecture Notes in Computer Science (S0302-9743)2005，3773，： | 1 |
| 9 | An Efficient Path - generation Method for Virtual Colonoscopy 显示文摘 | Jeongjin Lee Helen Hong Yeong Gil Shin Soo-Hong Kim | 2005 | Lecture Notes in Computer Science2005，3773，： | 1 |
| 10 | A Randomized Phase 3 Trial Comparing Pemetrexed/Carboplatin and Docetaxel/Carboplatin as First-Line Treatment for Advanced, Nonsquamous Non-small Cell Lung Cancer显示文摘 | José Rodrigues-Pereira Joo-Hang Kim Manuel Magallanes Dae Ho Lee Jie Wang Vinod Ganju Luis Martínez-Barrera Helen Barraclough Maximiliano van Kooten Mauro Orlando | 2011 | Journal of Thoracic Oncology2011，，： | 1 |
| 11 | Correlates of ante- and postnatal depression in fathers: A systematic review显示文摘 | Kim Yiong Wee Helen Skouteris Ciaran Pier Ben Richardson Jeannette Milgrom | 2010 | Journal of Affective Disorders2010，，3： | 1 |
| 12 | Yeast, a model organism for iron and copper metabolism studies显示文摘 | Jeane De Freitas Henri Wintz J Hyoun Kim Helen Poynton Tama Fox Chris Vulpe | 2003 | BioMetals2003，，1： | 1 |
| 13 | Evidence that the hexose-to-sucrose ratio does not control the switch to storage product accumulation in oilseeds:analysis of tobacco seed development and effects of overexpressing apoplastic invertase显示文摘 | KIM L T S M HELENE L JOHN L G | 2004 | Journal of Experimental Botany2004，55，： | 1 |
| 14 | Exposure Rate of Hydroxyapatite Orbital Implants显示文摘 | Jin Sook Yoon Helen Lew Sung Joo Kim Sang Yeul Lee | 2008 | Ophthalmology2008，，3： | 1 |
| 15 | Influence of Technologic Advances on Outcomes in Patients With Unresectable, Locally Advanced Non–Small-Cell Lung Cancer Receiving Concomitant Chemoradiotherapy显示文摘 | Zhongxing X. Liao Ritsuko R. Komaki Howard D. Thames Helen H. Liu Susan L. Tucker Radhe Mohan Mary K. Martel Xiong Wei Kunyu Yang Edward S. Kim George Blumenschein Waun Ki Hong James D. Cox | 2010 | International Journal of Radiation Oncology, Biology, Physics2010，，3： | 1 |
| 16 | Liquid chromatography tandem mass spectrometry identification of proanthocyanidins in rat plasma after oral administration of grape seed extract显示文摘 | Jeevan K. Prasain Ning Peng Yanying Dai Ray Moore Alireza Arabshahi Landon Wilson Stephen Barnes J. Michael Wyss Helen Kim Ray L. Watts | 2008 | Phytomedicine2008，，2： | 1 |
| 17 | Elderly Subset Analysis of Randomized Phase III Study Comparing Pemetrexed Plus Carboplatin with Docetaxel Plus Carboplatin as First-Line Treatment for Patients with Locally Advanced or Metastatic Non-Small Cell Lung Cancer显示文摘 | José Rodrigues Pereira Rebecca Cheng Mauro Orlando Joo-Hang Kim Helen Barraclough | 2013 | Drugs in R&D2013，，： | 1 |
| 18 | The neurological manifestations of Nipah virus encephalitis, a novel paramyxovirus显示文摘 | Kim‐EnLee T.Umapathi Chai‐BengTan HelenTjoei‐Lian Tjia Tju‐SiangChua Helen May‐LinOh Kwong‐MingFock AshokKurup AshaDas Adrian Keng‐YewTan Wei‐LingLee | 2001 | Ann Neurol2001，，： | 1 |
| 19 | Markers of survival and metastatic potential in childhood CNS primitive neuro-ectodermal brain tumours: an integrative genomic analysis显示文摘 | Daniel Picard Suzanne Miller Cynthia E Hawkins Eric Bouffet Hazel A Rogers Tiffany SY Chan Seung-Ki Kim Young-Shin Ra Jason Fangusaro Andrey Korshunov Helen Toledano Hideo Nakamura James T Hayden Jennifer Chan Lucie Lafay-Cousin Pingzhao Hu Xing Fan Karin | 2012 | Lancet Oncology2012，，8： | 1 |
| 20 | Empty follicle syndrome in the setting of dramatic weight loss after bariatric surgery: case report and review of available literature显示文摘 | Jennifer Hirshfeld-Cytron Helen H. Kim | 2008 | Fertility and Sterility2008，，4： | 1 |
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