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| 1 | Treatment of hepatocellular carcinoma with portal venous tumor thrombosis: A comprehensive review显示文摘The natural history of hepatocellular carcinoma(HCC)with portal vein tumor thrombosis(PVTT)is dismal(approximately 2-4 mo),and PVTT is reportedly found in 10%-40%of HCC patients at diagnosis.According to the Barcelona Clinic Liver Cancer(BCLC)Staging System(which is the most widely adopted HCC management guideline),sorafenib is the standard of care for advanced HCC(i.e.,BCLC stage C)and the presence of PVTT is included in this category.However,sorafenib treatment only marginally prolongs patient survival and,notably,its therapeutic efficacy is reduced in patients with PVTT.In this context,there have been diverse efforts to develop alternatives to current standard systemic chemotherapies or combination treatment options.To date,many studies on transarterial chemoembolization,3-dimensional conformal radiotherapy,hepatic arterial chemotherapy,and transarterial radioembolization report better overall survival than sorafenib therapy alone,but their outcomes need to be verified in future prospective,randomized controlled studies in order to be incorporated into current treatment guidelines.Additionally,combination strategies have been applied to treat HCC patients with PVTT,with the hope that the possible synergistic actions among different treatment modalities would provide promising results.This narrative review describes the current status of the management options for HCC with PVTT,with a focus on overall survival. | Kichang Han Jin Hyoung Kim Gi-Young Ko Dong Il Gwon Kyu-Bo Sung | 2016 | World Journal of Gastroenterology2016，22，1： | 29 |
| 2 | A Comparison of Brain Activity between Healthy Subjects and Stroke Patients on fMRI by Acupuncture Stimulation显示文摘目的将在击病人在针灸期间调查大脑活动模式,并且用功能的磁性的回声成像(fMRI ) 把结果与正常题目作比较。有马达软弱和 10 个健康题目的 11 个击病人全部的方法 A 被学习。fMRI 在点 Quchi (LI11 ) 和 Zusanli (ST36 ) 在左边上在针灸期间被执行。数据用针灸刺激导致的大脑激活的统计参量的地图被分析。结果显示出的结果 LI11 和 ST36 的刺激生产了在二之间的显著地不同的大脑激活模式,这组织。正常的组比击组显示出更大的全面激活。在正常的组,正面的脑叶的部分,顶骨脑叶,亚 lobar,小脑和中脑,区域被针灸在左 LI11 激活。在另一方面,仅仅劣等的顶骨腹片区域的右边在击病人被激活。当左 ST36 在正常的组被刺激时,正面的脑叶,顶骨脑叶,时间的脑叶,和亚 lobar 的双方,和枕骨的脑叶的左边,和小脑和中脑区域的右边被激活。为在击组的一样的刺激,仅仅劣等的顶骨腹片和小脑区域的双方被激活(P < 0.05,簇水平) 。释放模式没在两个组在任何针灸刺激期间被注意。结论大脑信号激活在一样的针灸期间是不同的在之间健康并且击病人,和效果显示出不同针灸点的关联。 | Seung-Yeon Cho Mia Kim Jong Joo Sun Geon-Ho Jahng Hengjun J Kim Seong-Uk Park Woo-Sang Jung Chang-Nam Ko Jung-Mi Park | 2013 | Chinese Journal of Integrative Medicine2013，19，4： | 25 |
| 3 | Plant ABC Transporters Enable Many Unique Aspects of a Terrestrial Plant's Lifestyle显示文摘陆上的植物有更多的 ATP 有约束力的盒子(ABC ) 二~四次 transporter 基因比另外的有机体,包括他们的祖先的 microalgae。最近的研究发现在这些 transporters 怀有变化的植物展出戏剧的显型,许多哪个与发展过程和为干燥土地上的生活必要的功能有关。这些结果建议在进化期间乘并且假定允许植物适应陆上的环境条件的新奇功能的那 ABC transporters。从这个观点在植物 ABC transporters 上检验文学导致了我们建议多样的 ABC transporters 启用了陆上的植物的生活方式的许多唯一、必要的方面,由搬运越过植物的特定的膜的各种各样的混合物。 | Jae-Ung Hwang Won-Yong Song Daewoong Hong Donghwi Ko Yasuyo Yamaoka Sunghoon Jang Sojeong Yim Eunjung Lee Deepa Khare Kyungyoon Kim Michael Palmgren Hwan Su Yoon Enrico Martinoia Youngsook Lee | 2016 | Molecular Plant2016，9，3： | 20 |
| 4 | Helicobacter pylori and interleukin-8 in gastric cancer显示文摘Helicobacter pylori(H.pylori)is a major etiological factor in the development of gastric cancer.Large-scale epidemiological studies have confirmed the strong association between H.pylori infection and both cancer development and progression.Interleukin-8(IL-8)is overexpressed in gastric mucosa exposed to H.pylori.The expression of IL-8 directly correlates with a poor prognosis in gastric cancer.IL-8 is multifunctional.In addition to its potent chemotactic activity,it can induce proliferation and migration of cancer cells.In this review,we focus on recent insights into the mechanisms of IL-8 signaling associated with gastric cancer.The relationship between IL-8 and H.pylori is discussed.We also summarize the current therapeutics against IL-8 in gastric cancer. | Ko Eun Lee Pham Ngoc Khoi Yong Xia Jung Sun Park Young Eun Joo Kyung Keun Kim Seok Yong Choi Young Do Jung | 2013 | World Journal of Gastroenterology2013，19，45： | 15 |
| 5 | Noninvasive Parameters and hepatic fibrosis scores in children with nonalcoholic fatty liver disease显示文摘AIM:To evaluate the noninvasive parameters and hepatic fibrosis scores in obese children with nonalcoholic fatty liver disease(NAFLD).METHODS:A total of 77 children diagnosed with NAFLD via liver biopsy were included and divided into 2 subgroups according to the histopathologic staging of hepatic fibrosis:mild(stage 0-1)vs significant fibrosis(stage 2-4).Clinical and laboratory parameters were evaluated in each patient.The aspartate aminotransferase(AST)/alanine aminotransferase(ALT)ratio,AST/platelet ratio index(APRI),PGA index,Forns index,FIB-4,NAFLD fibrosis score,and pediatric NAFLD fibrosis index(PNFI)were calculated.RESULTS:No clinical or biochemical parameter exhibited a significant difference between patients with mild and significant fibrosis.Among noninvasive hepatic fibrosis scores,only APRI and FIB4 revealed a significant difference between patients with mild and significant fibrosis(APRI:0.67±0.54 vs 0.78±0.38,P=0.032 and FIB4:0.24±0.12 vs 0.31±0.21,P=0.010).The area under the receiving operating characteristic curve of FIB4 was 0.81,followed by Forns index(0.73),APRI(0.70),NAFLD fibrosis score(0.58),AST/ALT ratio(0.53),PGA score(0.45),and PNFI(0.41).CONCLUSION:APRI and FIB4 might be useful noninvasive hepatic fibrosis scores for predicting hepatic fibrosis in children with NAFLD. | Hye Ran Yang Hae Ryoung Kim Myung Jin Kim Jae Sung Ko Jeong Kee Seo | 2012 | World Journal of Gastroenterology2012，18，13： | 15 |
| 6 | Safety and efficacy of tenofovir in chronic hepatitis B-related decompensated cirrhosis显示文摘AIM To evaluate the safety and efficacy of tenofovir disoproxil fumarate(TDF) as a first-line therapy in decompensated liver disease. METHODS We enrolled 174 chronic hepatitis B-related liver cirrhosis patients treated with 300 mg/d TDF at six Korean centers. Of the 174 cirrhosis patients, 57 were assigned to the decompensated cirrhosis group and 117 were assigned to the compensated cirrhosis group. We followed the patients for 12 mo and evaluated clinical outcomes, including biochemical, virological, and serological responses. We also evaluated changes in hepatic and renal function and compared the decompensated and compensated cirrhosis groups. RESULTS The 1-year complete virological response(CVR) and Hepatitis B e antigen(HBe Ag) seroconversion were seen in 70.2% and 14.2% in the decompensated cirrhosis group, respectively. The rates of HBe Ag seroconversion/loss and ALT normalization at month 12 were similar in both groups. TDF treatment was also effective for decreasing the level of hepatitis B virus(HBV) DNA in both groups, but CVR was higher in the compensated group(88.9% vs 70.2%, P = 0.005). Tenofovir treatment for 12 mo resulted in improved Child-Turcotte-Pugh(CTP) and model for end-stage liver disease(MELD) scores in decompensated group(P < 0.001). Of the 57 decompensated patients, 39(68.4%) achieved CTP class A and 27(49.1%) showed improvement in the CTP score of 2 points after 12 mo of TDF. The observed rate of confirmed 0.5 mg/d L increases in serum levels of creatinine in the decompensated and compensated cirrhosis group were 7.0% and 2.5%, respectively(P < 1.000).CONCLUSION TDF therapy in decompensated cirrhosis patients was effective for decreasing HBV DNA levels and improving hepatic function with relatively lower CVR than in compensated cirrhosis. Thus, physicians should carefully monitor not only renal function but also treatment responses when using TDF in decompensated cirrhosis patients. | Soon Kyu Lee Myeong Jun Song Seok Hyun Kim Byung Seok Lee Tae Hee Lee Young Woo Kang Suk Bae Kim Il Han Song Hee Bok Chae Soon Young Ko Jae Dong Lee | 2017 | World Journal of Gastroenterology2017，23，13： | 14 |
| 7 | Comparative analysis of radiofrequency ablation and resection for resectable colorectal liver metastases显示文摘AIM:To evaluate the therapeutic efficacy of radiofrequency ablation(RFA)for resectable colorectal liver metastases(CRLM)compared with that of resection.METHODS:Between June 2004 and June 2009,we retrospectively analyzed 29 patients with resectable CRLMs;17 patients underwent RFA,and 12 underwent hepatic resection.All of the patients were informed about the treatment modalities and were allowed to choose either of them.RFA including an intraoperative approach was performed by a radiologist;otherwise,hepatic resection was performed by a surgeon.Comparative analysis of the two groups was performed,including comparisons of gender,age,and clinical outcomes,such as primary tumor stage and survival rates.RESULTS:The mean tumor size was significantly larger in the resection group(3.59 cm vs 2.02 cm,P<0.01),and the 5-year overall survival(OS)rate for all patients was 44.7%.There was no difference in the 5-year OS rates between the RFA and resection groups(37.8%vs66.7%).Univariate analysis indicated significantly lower5-year OS rates for patients with a tumor size>3cm.The 5-year disease-free survival(DFS)rates were17.6%and 22.2%in the RFA and resection groups,respectively(P=0.119).Univariate analysis revealed that in cases of male gender,age>65 years,T stage<Ⅳ,absence of lymphatic metastasis,and tumor size>3 cm,RFA resulted in significantly inferior 5-year DFS rates compared with surgical resection.CONCLUSION:Surgical resection revealed superior outcomes in the treatment of resectable CRLMs,particularly in cases with a hepatic tumor size>3 cm. | Sanghwa Ko Hongjae Jo Seongpil Yun Eunyoung Park Suk Kim Hyung-Il Seo | 2014 | World Journal of Gastroenterology2014，20，2： | 12 |
| 8 | Genetically confirmed Wilson disease in a 9-month old boy with elevations of aminotransferases显示文摘Wilson disease (WD) is an autosomal recessive disorder of copper transport caused by alteration of the adenosine triphosphatase 7B gene. It is rare to diagnose WD below the age of three years. Molecular genetic testing is one of the most important diagnostic methods and may confirm the diagnosis in equivocal cases. We report a case of a 9-mo old boy with WD who presented as chronic hepatitis. Genetic analysis showed compound heterozygotes of p.G1186S and c.4006delA. | Joo Whee Kim Jong Hyun Kim Jeong Kee Seo Jae Sung Ko Ju Young Chang Hye Ran Yang Kyung Hoon Kang | 2013 | World Journal of Hepatology2013，5，3： | 11 |
| 9 | Clinicopathological features and prognosis of combined hepatocellular carcinoma and cholangiocarcinoma after surgery显示文摘BACKGROUND: Combined hepatocellular carcinoma and cholangiocarcinoma (cH CC-CC) is a rare subtype of primary liver cancer consisting of both hepatocellular carcinoma (HCC)and cholangiocarcinoma (CC). Because of the rarity of this tumor its feature is poorly understood. The present study aimed to evaluate the clinicopathological features and long-term prognosis of patients with cH CC-CC after surgery and to compare with those of the patients with stage-matched HCC and CC.METHODS: The clinicopathological features of the patients who underwent surgery for cH CC-CC at our center during the period of 2001-2010 were retrospectively analyzed and compared with those of stage-matched HCC and CC patients Cancer staging was performed according to the AJCC Cancer Staging Manual (6th ed.). Overall survival and disease-free survival were compared among the groups and prognostic factors of cH CC-CC were evaluated.RESULTS: Significant differences were observed in clinico pathological features among 42 patients with cH CC-CC, 90patients with HCC and 45 patients with CC. Similar to HCC patients, cH CC-CC patients had frequent hepatitis B virus antigen positivity, microscopic vessel invasion, cirrhosis and high level of serum alpha-fetoprotein. Similar to CC patients, cH CC-CC patients showed increased bile duct invasion and decreased capsule. The 1-, 3-, and 5-year overall survival and disease free survival of patients with cH CC-CC were not significantly different from those with stage-matched patients with CC;but significantly poorer than those with HCC. In subanalysis of patients with stage II, the overall survival in patients with cH CC-CC or CC was significantly poorer than that in patients , with HCC. We did not find the difference in patients with other stages. Univariate analysis of overall and disease-free survival of patients with cH CC-CC showed that the vascular invasion and intrahepatic metastasis were the significant predictive factors.CONCLUSION: Patients with cH CC-CC showed similar clinico- pathological features as those with HCC or CC, and patients with cH CC-CC or CC had a poorer prognosis compared with those with HCC, especially at matched stage II.. | Seung Duk Lee Sang-Jae Park Sung-Sik Han Seong Hoon Kim Young-Kyu Kim Soon-Ae Lee Young Hwan Ko Eun Kyung Hong | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，6： | 11 |
| 10 | Bibliometrics: tracking research impact by selecting Lhe appropriate metrics显示文摘 | Ashok Agarwal Damayanthi Durairajanayagam Sindhuja Tatagari Sandro C Esteves Avi Harlev Ralf Henkel Shubhadeep Roychoudhury Sheryl Homa Nicolas Garrido Puchalt Ranjith Ramasamy Ahmad Majzoub Kim Dao Ly Eva Tvrda Mourad Assidi Kavindra Kesai Reecha Sharma Saleem Banihani Edmund Ko Muhammad Abu-Elmagd Jaime Gosalvez Asher Bashiri | 2016 | Asian Journal of Andrology2016，18，2： | 10 |
| 11 | Comparison of postpolypectomy bleeding between epinephrine and saline submucosal injection for large colon polyps by conventional polypectomy:A prospective randomized,multicenter study显示文摘AIM:To evaluate and compare the clinical outcomes of prophylactic submucosal saline-epinephrine injection and saline injection alone for large colon polyps by conventional polypectomy. METHODS:A prospective study was conducted from July 2003 to July 2004 at 11 tertiary endoscopic centers. Large colon polyps (> 10 mm in diameter) wererandomized to undergo endoscopic polypectomy with submucosal saline-epinephrine injection (epinephrine group) or normal saline injection (saline group). Endoscopic polypectomy was performed by the conventional snare method,and early (< 12 h) and late bleeding complications (12 h-30 d) were observed. RESULTS:A total of 561 polyps in 486 patients were resected by endoscopic polypectomy. Overall,bleeding complications occurred in 7.6% (37/486) of the patients,including 4.9% (12/244) in the epinephrine group,and 10.3% (25/242) in the saline group. Early and late postpolypectomy bleeding (PPB) occurred in 6.6% (32/486) and 1% (5/486) of the patients,respectively,including 4.5% (11/244),0.4% (1/244) in the epinephrine group,and 8.7% (21/242),1.7% (4/242) in the saline group. No significant differences in the rates of overall,early and late PPB were observed between the 2 groups. Multivariate stepwise logistic regression analysis revealed that large size (> 2 cm) and neoplastic polyps were independently and significantly associated with the presence of PPB. CONCLUSION:The prophylactic submucosal injection of diluted epinephrine does not appear to provide an additional advantage over the saline injection alone for the prevention of PPB. | Suck-Ho Lee Il-Kwun Chung Sun-Joo Kim Jin-Oh Kim Bong-Min Ko Won-Ho Kim Hyun-Soo Kim Dong-IL Park Hyo-Jong Kim Jeong-Sik Byeon Suk-Kyun Yang Byeong Ik Jang Sung-Ae Jung Yoon-Tae Jeen Jai-Hyun Choi Hwang Choi Dong-Soo Han Jae Suk Song | 2007 | World Journal of Gastroenterology2007，13，21： | 9 |
| 12 | Peroxisome proliferator-activated receptor-delta agonist ameliorated inflammasome activation in nonalcoholic fatty liver disease显示文摘AIM: To evaluate the inflammasome activation and the effect of peroxisome proliferator-activated receptors(PPAR)-δ agonist treatment in nonalcoholic fatty liver disease(NAFLD) models.METHODS: Male C57BL/6J mice were classified according to control or high fat diet(HFD) with or without PPAR-δ agonist(GW) over period of 12 wk [control, HFD, HFD + lipopolysaccharide(LPS), HFD + LPS + GW group]. Hep G2 cells were exposed to palmitic acid(PA) and/or LPS in the absence or presence of GW.RESULTS: HFD caused glucose intolerance and hepatic steatosis. In mice fed an HFD with LPS, caspase-1 and interleukin(IL)-1β in the liver were significantly increased. Treatment with GW ameliorated the steatosis and inhibited overexpression of pro-inflammatory cytokines. In Hep G2 cells, PA and LPS treatment markedly increased m RNA of several nucleotide-binding andoligomerization domain-like receptor family members(NLRP3, NLRP6, and NLRP10), caspase-1 and IL-1β. PA and LPS also exaggerated reactive oxygen species production. All of the above effects of PA and LPS were reduced by GW. GW also enhanced the phosphorylation of AMPK-α.CONCLUSION: PPAR-δ agonist reduces fatty acidinduced inflammation and steatosis by suppressing inflammasome activation. Targeting the inflammasome by the PPAR-δ agonist may have therapeutic implication for NAFLD. | Hyun Jung Lee Jong Eun Yeon Eun Jung Ko Eileen L Yoon Sang Jun Suh Keunhee Kang Hae Rim Kim Seoung Hee Kang Yang Jae Yoo Jihye Je Beom Jae Lee Ji Hoon Kim Yeon Seok Seo Hyung Joon Yim Kwan Soo Byun | 2015 | World Journal of Gastroenterology2015，21，45： | 9 |
| 13 | Totally laparoscopic total gastrectomy using the modified overlap method and conventional open total gastrectomy:A comparative study显示文摘BACKGROUND Although several methods of totally laparoscopic total gastrectomy(TLTG)have been reported.The best anastomosis technique for LTG has not been established.AIM To investigate the effectiveness and surgical outcomes of TLTG using the modified overlap method compared with open total gastrectomy(OTG)using the circular stapled method.METHODS We performed 151 and 131 surgeries using TLTG with the modified overlap method and OTG for gastric cancer between March 2012 and December 2018.Surgical and oncological outcomes were compared between groups using propensity score matching.In addition,we analyzed the risk factors associated with postoperative complications.RESULTS Patients who underwent TLTG were discharged earlier than those who underwent OTG[TLTG(9.62±5.32)vs OTG(13.51±10.67),P<0.05].Time to first flatus and soft diet were significantly shorter in TLTG group.The pain scores at all postoperative periods and administration of opioids were significantly lower in the TLTG group than in the OTG group.No significant difference in early,late and esophagojejunostomy(EJ)-related complications or 5-year recurrence free and overall survival between groups.Multivariate analysis demonstrated that body mass index[odds ratio(OR),1.824;95%confidence interval(CI):1.029-3.234,P=0.040]and American Society of Anaesthesiologists(ASA)score(OR,3.154;95%CI:1.084-9.174,P=0.035)were independent risk factors of early complications.Additionally,age was associated with≥3 Clavien-Dindo classification and EJrelated complications.CONCLUSION Although TLTG with the modified overlap method showed similar complication rate and oncological outcome with OTG,it yields lower pain score,earlier bowel recovery,and discharge.Surgeons should perform total gastrectomy cautiously and delicately in patients with obesity,high ASA scores,and older ages. | Chang Seok Ko Nam Ryong Choi Byung Sik Kim Jeong Hwan Yook Min-Ju Kim Beom Su Kim | 2021 | World Journal of Gastroenterology2021，27，18： | 8 |
| 14 | restosterone replacement therapy for late-onsel lypogonadism: current trends in Korea显示文摘在比 40 年老的人的睾丸激素层次能以 1 % 的率减少; -2%每年,和报告显示出那超过 50 %80 岁的孩子,人们有与性腺机能减退一致的睾丸激素层次。迟了发作的性腺机能减退(LOH ) 是与推进年龄联系并且由浆液睾丸激素缺乏的典型症状描绘了的临床、生物化学的症候群。在最近的十年,在使人变老的 LOH 的概念在欧洲国家和美国变得熟悉。它也在整个朝鲜是利息和争论的一个话题。然而,大多数为 LOH 认为睾丸激素代替治疗(TRT ) 的优点或劣势是处理的数据首先在西方的人口上从研究被获得了;因此,在亚洲人,可以与西方的人相比有不同浆液睾丸激素,的 TRT 的效果的研究被需要。TRT 通常在朝鲜被规定,尽管有在亚洲人口的 TRT 的效果上的研究的少量。从各种各样的 TRT 研究的数据在增加浆液睾丸激素层次并且改进由问询表估计了的主观症状基于朝鲜语显示出它的功效。当前,补丁和短行动的肌内的注射被胶化和长行动的明确的表达代替。然而,阻止 overdiagnosis 和 overtreatment,为 TRT 的指示应该包括性腺机能减退的两低睾丸激素水平和症状和症状。 | Young Hwii Ko Je Jong Kim | 2011 | Asian Journal of Andrology2011，13，4： | 8 |
| 15 | A novel synthetic compound MCAP suppresses LPS- induced murine microglial activation in vitro via inhibiting NF-kB and p38 MAPK pathways显示文摘目的:调查新奇合成混合物的 anti-neuroinflammatory 活动,对在 vitro.Methods 的 导致LPS 的 microglial 激活的 7-methylchroman-2-carboxylic 酸N-( 2-trifluoromethyl ) phenylamide ( MCAP ):主要老鼠 microglia 和 BV2 microglia 房间暴露于 LPS ( 50 或 100 ng/mL )。iNOS 和 COX-2 的表示, proinflammatory cytokines, NF-κ B 和 p38 MAPK 发信号分子被 RT-PCR,西方的污点和 ELISA 分析。microglia 的词法变化和 NF-ĸ 的原子 translocation; B 用阶段对比和荧光显微镜学被设想, respectively.Results : 有 MCAP 的预告的处理(0.1, 1, 10 μ mol/L ) 在 BV2 microglia 房间的 iNOS 和 COX-2 的 dose-dependently 禁止的导致 LPS 的表示。类似的结果与 MCAP 在主要 microglia pretreated 被获得(0.1, 0.5 μ mol/L ) 。MCAP dose-dependently 消除了 TNF-α 的导致 LPS 的版本;, IL-6 和 IL-1β,并且 NF-κ 的减轻的导致 LPS 的激活;由减少 Iκ 的 phosphorylation 的 B; Bα在 BV2 microglia 房间。而且, MCAP 稀释了 p38 MAPK 的 导致LPS 的 phosphorylation SB203580 ,一个 p38 MAPK 禁止者, MEF-2 ( p38 MAPK 下游的一个抄写因素)的表示上的显著地加强的 引起MCAP 的抑制 .Conclusion : MCAP 由禁止 p38 MAPK 和 NF-κ 在 vitro 在鼠科的 microglia 施加反煽动性的效果; B 发信号小径和 proinflammatory 回答。MCAP 可以为治疗包含激活的 microglial 房间的疾病作为一个新奇代理人被开发。 | Byung-Wook KIM Sandeep Vasant MORE Yo-Sep YUN Hyun-Myung KO Jae-Hwan KWAK Heesoon LEE Kyoungho SUK In-Su KIM Dong-Kug CHOI | 2016 | Acta Pharmacologica Sinica2016，37，3： | 8 |
| 16 | Effects of ozonation and coagulation on effluent organic matter characteristics and ultrafiltration membrane fouling显示文摘Effluent organic matter(EfOM) is the major cause of fouling in the low pressure membranes process for wastewater reuse. Coagulation and oxidation of biological wastewater treatment effluent have been applied for the fouling control of microfiltration membranes. However, the change in EfOM structure by pre-treatments has not been clearly identified. The changes of EfOM characteristics induced by coagulation and ozonation were investigated through size exclusion chromatography,UV/Vis spectrophotometry, fluorescence spectrophotometry and titrimetric analysis to identify the mechanisms in the reduction of ultrafiltration(UF) membrane fouling. The results indicated that reduction of flux decline by coagulation was due to modified characteristics of dissolved organic carbon(DOC) content. Total concentration of DOC was not reduced by ozonation. However, the mass fraction of the molecules with molecular weight larger than 5 kDa, fluorescence intensity,aromaticity, highly condensed chromophores, average molecular weight and soluble microbial byproducts decreased greatly after ozonation. These results indicated that EfOM was partially oxidized by ozonation to low molecular weight, highly charged compounds with abundant electronwithdrawing functional groups, which are favourable for alleviating UF membrane flux decline. | Kwon Jeong Dae-Sung Lee Do-Gun Kim Seok-Oh Ko | 2014 | Journal of Environmental Sciences2014，26，6： | 7 |
| 17 | Identifying Pb-free perovskites for solar cells by machine learning显示文摘Recent advances in computing power have enabled the generation of large datasets for materials,enabling data-driven approaches to problem-solving in materials science,including materials discovery.Machine learning is a primary tool for manipulating such large datasets,predicting unknown material properties and uncovering relationships between structure and property.Among state-of-the-art machine learning algorithms,gradient-boosted regression trees(GBRT)are known to provide highly accurate predictions,as well as interpretable analysis based on the importance of features.Here,in a search for lead-free perovskites for use in solar cells,we applied the GBRT algorithm to a dataset of electronic structures for candidate halide double perovskites to predict heat of formation and bandgap.Statistical analysis of the selected features identifies design guidelines for the discovery of new lead-free perovskites. | Jino Im Seongwon Lee Tae-Wook Ko Hyun Woo Kim YunKyong Hyon Hyunju Chang | 2019 | npj Computational Materials2019，，1： | 6 |
| 18 | Case of inappropriate ADH syndrome:Hyponatremia due to polyethylene glycol bowel preparation显示文摘Colonoscopic screening has been reported to reduce deaths from colorectal cancer.Adequate bowel preparation is essential for this and safety is an important issue in choosing the methods.Polyethylene glycol(PEG)is regarded as a safe method for cleansing,especially compared with oral sodium phosphate.Here,we present a case of hyponatremia caused by the syndrome of inappropriate antidiuretic hormone(ADH)syndrome after PEG precolonoscopic cleansing resulting in generalized tonic-clonic seizures.A 62-year-old women had ingested PEG for precolonoscopic bowel cleansing.While waiting for the colonoscopy,she developed a stuporous mentality and generalized tonic-clonic seizures,which did not correlate with brain magnetic resonance imaging.Her serum sodium level was 113 mEq per liter and laboratory analyses were consistent with inappropriate ADH syndrome.Her thyroid and adrenal functions were normal.There were no malignancies,infections,respiratory disorders or central nervous disorders and she had no history of taking either diuretics or other medications,which might have caused inappropriate ADH syndrome.She was treated with 3%hypertonic saline and showed a complete neurological recovery as her sodium levels recovered.Follow-up visits showed the patient to have a normal sodium level without neurologic deficits.This case shows that inappropriate ADH syndrome can be caused by PEG preparation,which implies that physicians have to be aware of the possible side effects of this colonic cleansing approach and mindful of the possible ensuing symptoms. | Sun-Hye Ko Chul-Hyun Lim Jae-Young Kim Seung Hun Kang Myong Ki Baeg Hyun Jin Oh | 2014 | World Journal of Gastroenterology2014，20，34： | 5 |
| 19 | Anxiety and depression propensities in patients with acute toxic liver injury显示文摘AIM:To investigate anxiety and depression propensities in patients with toxic liver injury.METHODS:The subjects were divided into three groups:a healthy control group(Group 1,n=125),an acute non-toxic liver injury group(Group 2,n=124),and a group with acute toxic liver injury group caused by noncommercial herbal preparations(Group 3,n=126).These three groups were compared and evaluated through questionnaire surveys and using the Hospital Anxiety-Depression Scale(HADS),Beck Anxiety Inventory(BAI),Beck Depression Inventory(BDI),and the hypochondriasis scale.RESULTS:The HADS anxiety subscale was 4.9±2.7,5.0±3.0 and 5.6±3.4,in Groups 1,2,and 3,respectively.The HADS depression subscale in Group 3 showed the most significant score(5.2±3.2,6.4±3.4 and 7.2±3.4in Groups 1,2,and 3,respectively)(P<0.01 vs Group 1,P<0.05 vs Group 2).The BAI and BDI in Group 3showed the most significant score(7.0±6.3 and 6.9±6.9,9.5±8.6 and 8.8±7.3,10.7±7.2 and 11.6±8.5in Groups 1,2,and 3,respectively)(BAI:P<0.01 vs Group 1,P<0.05 vs Group 2)(BDI:P<0.01 vs Group1 and 2).Group 3 showed a significantly higher hypochondriasis score(8.2±6.0,11.6±7.5 and 13.1±6.5in Groups 1,2,and 3,respectively)(P<0.01 vs Group 1,P<0.05 vs Group 2).CONCLUSION:Psychological factors that present vulnerability to the temptation to use alternative medicines,such as herbs and plant preparations,are important for understanding toxic liver injury. | Jeong Ill Suh Jeong Kyu Sakong Kwan Lee Yong Kook Lee Jeong Bae Park Dong Joon Kim Yeon Seok SeoDepartment of Internal Medicine Korea University Anam Hospital Korea University College of Medicine Seoul 136-705 South Korea Jae Dong Lee Soon Young Ko Byung Seok Lee Seok Hyun Kim Byung Seok Kim Young Seok Kim Heon Ju Lee In Hee Kim Joo Hyun Sohn Tae Yeob Kim Byung Min Ahn | 2013 | World Journal of Gastroenterology2013，19，47： | 5 |
| 20 | Antioxidative phytoceuticals to ameliorate pancreatitis in animal models: An answer from nature显示文摘Despite enthusiastic efforts directed at elucidating critical underlying mechanisms towards the identification of novel therapeutic targets for severe acute pancreatitis(SAP), the disease remains without a specific therapy to be executed within the first hours to days after onset of symptoms. Although earlier management for SAP should aim to either treat organ failure or reduce infectious complications, the current standard of care for the general management of AP in the first hours to days after onset of symptoms include intravenous fluid replacement, nutritional changes, and the use of analgesics with a close monitoring of vital signs. Furthermore, repeated evaluation of severity is very important, as the condition is particularly unstable in the early stages. In cases where biliary pancreatitis is accompanied by acute cholangitis or in cases where biliary stasis is suspected,an early endoscopic retrograde cholangiopancreatography is recommended.However,practice guidelines regarding the treatment of pancreatitis are suboptimal.In chronic pancreatitis,conservative management strategies include lifestyle modifications and dietary changes followed by analgesics and pancreatic enzyme supplementation.Recently,attention has been focused on phytoceuticals or antioxidants as agents that could surpass the limitations associated with currently available therapies.Because oxidative stress has been shown to play an important role in the pathogenesis of pancreatitis,antioxidants alone or combined with conventional therapy may improve oxidativestress-induced organ damage.Interest in phytoceuticals stems from their potential use as simple,accurate tools for pancreatitis prognostication that could replace older and more tedious methods.Therefore,the use of antioxidative nutrition or phytoceuticals may represent a new direction for clinical research in pancreatitis.In this review article,recent advances in the understanding of the pathogenesis of pancreatitis are discussed and the paradigm shift underway to develop phytoceuticals and antioxidants to treat it is introduced.Despite the promise of studies evaluating the effects of antioxidants/phytoceuticals in pancreatitis,translation to the clinic has thus far been disappointing.However,it is expected that continued research will provide solid evidence to justify the use of antioxidative phytoceuticals in the treatment of pancreatitis. | Jong-Min Park Sooyeon Lee Mi Kyung Chung Sung-Hun Kwon Eun-Hee Kim Kwang Hyun Ko Chang Il Kwon Ki Baik Hahm | 2014 | World Journal of Gastroenterology2014，20，44： | 5 |
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