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| 1 | Effects of icariin on cGMP-specific PDE5 and cAMP-specific PDE4 activities显示文摘Aim:To clarify the mechanism of the therapeutic action of icariin on erectlile dysfunction(ED).Methods:PDE5 was isolated from the human platelet and PDE4 form the rat liver tissue using the FPLC system (Pharmacia,Milton Keynes,UK)and the Mono Q column.The inhibitory effects of icariin on PDE5 and PDE4 activities were investigated by the two-step radioisotope procedure with [^3H]-c GMP/[^3H]-cAMP.Papaverine served as the control drug.Results:Icariin and papaverine showed dose-dependent inhibitory effects on PDE5 and PDE4 activities.The IC50 of Icariin and papaverine on PDE5 were 0.432μ mol/L and 0.680μmol/L,respectively and those on PDE4,73.50μmol/L and 3.07μmol/L,respectively.The potencies of selectivity of icariin and papaverine on PDE5(PDE4/PDE5 of IC50)were 167.67 times and 4.54 times,respectively.Conclusion:Icariin is a cGMP-specific PDE5 inhibitor that may be developed into an oral effective agent for the treatment of ED. | ZC Xin EK Kim CS Lin WJ Liu L Tian YM Yuan J Fu | 2003 | Asian Journal of Andrology2003，5，1： | 38 |
| 2 | 高级别子宫内膜间质肉瘤的分子改变及免疫治疗策略显示文摘高级别子宫内膜间质肉瘤(HG-ESS)为子宫内膜间质肉瘤(EST)的一种组织学亚型,治疗原则以手术为主,内分泌治疗、放疗、化疗为辅,总体预后不良。效果不确切,新的治疗策略如免疫治疗成为当下研究的热点。最新研究表明,HG-ESS可获益于免疫治疗。 | 王星语(编译) 张师前(编译) Kim Y Kim D Sung WJ | 2022 | 中华医学杂志2022，102，20： | 2 |
| 3 | Isolation and Characterization of Marine Bacterial Strain Degrading Fucoidan from Korean Undaria pinnatifida Sporophylls 显示文摘 | Kim WJ Kim SM Lee YH | 2008 | Microbiology and Biotechnology2008，18，4： | 1 |
| 4 | Clinical characteristics and efficacy of bronchoscopic intervention for tracheobronchial leiomyoma显示文摘 | Kwon YS Kim H Koh WJ | 2008 | Respirology2008，13，6： | 1 |
| 5 | Keratocyte apoptosis: implications on corneal wound healing, tissue organization, and disease显示文摘 | Wilson SE Kim WJ | 1998 | Invest Ophthalmol Vls Scl1998，39，： | 1 |
| 6 | Adding posterior lumbar interbody fusion to pedicle screw fixation and posterolateral fusion after decompression in spondylolytic spondylolisthesis显示文摘 | Suk S Lee CK Kim WJ | 1997 | Spine1997，22，2： | 1 |
| 7 | Rise in serum soluble intercellular adhesion molecule-1 levels with vasospasm following aneurysmal subarachnoid hemorrhage显示文摘 | Mocco J Mack WJ Kim GH | 2002 | Neurosurgery2002，97，3： | 1 |
| 8 | Application of minimally invasive treatment for early gastric cancer 显示文摘 | Hyung WJ Cheong JH Kim J | 2004 | J Surg Oncol2004，85，： | 1 |
| 9 | Leakage of cement in percutaneous transpedicular vertebroplasty for painful osteoporotic compression fractures显示文摘 | Yeom JS Kim WJ Choy WS | 2003 | J Bone Joint Surg Br2003，85，1： | 1 |
| 10 | Augmentation of pedicle screw fixation strength using an injectable calcium phosphate cement as a function of injection timing and method 显示文摘 | Renner SM Lim TH Kim WJ | 2004 | Spine (Pbila Pa 1976)2004，29，11： | 1 |
| 11 | Mesoporous silica nanospheres as highly efficient MRI contrast agents显示文摘 | Taylor KM Kim JS Rieter WJ | 2008 | J Am Chem Soc2008，130，7： | 1 |
| 12 | Adding posterior lumbar interbody fusion to pedicle screw fixation and posterolateral fusion after decompression in spondylolytic spondylolisthesis显示文摘 | Suk SI Lee CK Kim WJ | 1997 | spine1997，22，2： | 1 |
| 13 | Gleditsia sinensis thorn extract inhibits proliferation and TNF-α-induced MMP-9 expression in vascular smooth muscle cells显示文摘 | Lee SJ Park SS Kim WJ | | 0，，02： | 1 |
| 14 | Minimally invasive treatment ofobscure gastrointestinal bleeding using laparoscopic ultrasonography 显示文摘 | Hyung WJ Lim JS Kim TI et ai | 2007 | Surg Laparosc Endosc Percutan Tech2007，17，4： | 1 |
| 15 | Moire reduction in digital still camera by using inflection point in frequency domain 显示文摘 | Kim DC Kyung WJ Lee CH | 2014 | J Inst Electr Inform Eng2014，51，1： | 1 |
| 16 | Adding posterior lumbar interbody fusion to pedicle screw fixation and posterolateral fusion after decompression in spondylolytic spondylolisthesis显示文摘 | Suk SI Lee CK Kim WJ | 1997 | Spine1997，22，2： | 1 |
| 17 | Effects of apoE isoforms on beta-amyloid-induced matrix metalloproteinase-9 in rat astrocytes显示文摘 | Wang S Kim WJ | 2006 | Brain Res2006，1111，： | 1 |
| 18 | RUNX3 inactivation by point mutations and aberrant DNA methylation in bladder tumors显示文摘 | Kim WJ Kim EJ Jeong P | 2005 | Cancer Res2005，65，20： | 1 |
| 19 | Adaptive-Neuro-Fuzzy-Based Sens-orless Control of a Smart-Material Actuator 显示文摘 | Sadighi A Kim WJ | 2011 | IEEE/ASME Transactions on Mechatronics2011，16，2： | 1 |
| 20 | Adding posterior lumbar interbody fusion to pedicle screw fixation and posterolateral fusion after decompression in spondylolytic spondylolisthesis显示文摘 | Suk SL Lee CK Kim WJ | 1997 | Spine1997，22，2： | 1 |
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