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| 1 | Hepatocellular carcinoma with child Pugh-A Cirrhosis treated with stereotactic body radiotherapy显示文摘AIM To evaluate the control, survival, and hepatic function for Child Pugh(CP)-A patients after Stereotactic body radiotherapy(SBRT) in hepatocellular carcinoma(HCC).METHODS From 2009 to 2016, 40 patients with Barcelona Liver Clinic(BCLC) stages 0-B HCC and CP-A cirrhosis completed liver SBRT. The mean prescription dose was 45 Gy(40 to 50 Gy in 4-5 fractions). Local relapse, defined as recurrence within the planning target volume was assessed with intravenous multiphase contrast computed tomography or magnetic resonance imaging every 4-6 mo after completion of SBRT. Progression of cirrhosis was evaluated by CP and Model for End Stage Liver Disease scores every 3-4 mo. Toxicities were graded per the Common Terminology Criteria for Adverse Events(v4.03). Median follow-up was 24 mo.RESULTS Forty-nine HCC lesions among 40 patients were analyzed in this IRB approved retrospective study. Median tumor diameter was 3.5 cm(1.5-8.9 cm). Six patients with tumors ≥ 5 cm completed planned selected transarterial chemoembolization(TACE) in combination with SBRT. Eight patients underwent orthotropic live transplant(OLT) with SBRT as a bridging treatment(median time to transplant was 12 mo, range 5 to 23 mo). The Pathologic complete response(PCR) rate in this group was 62.5%. The 2-year in-field local control was 98%(1 failure). Intrahepatic control was 82% and 62% at 1 and 2 years, respectively. Overall survival(OS) was 92% and 60% at 1 and 2 years, with a median survival of 41 mo per Kaplan Meier analysis. At 1 and 2 years, 71% and 61% of patients retained CPA status. Of the patients with intrahepatic failures, 58% developed progressive cirrhosis, compared to 27% with controlled disease(P = 0.06). Survival specific to hepatic failure was 92%, 81%, and 69% at 12, 18, and 24 mo. There was no grade 3 or higher toxicity. On univariate analysis, gross tumor volume(GTV) < 23 cc was associated with freedom from CP progression(P = 0.05), hepatic failure-specific survival(P = 0.02), and trended with OS(P = 0.10).CONCLUSION SBRT is safe and effective in HCC with early cirrhosis and may extend waiting time for transplant in patients who may not otherwise be immediate candidates. | Shaakir Hasan Ngoc Thai Tadahiro Uemura Vijay Kudithipudi Paul Renz Stephen Abel Alexander V Kirichenko | 2017 | World Journal of Gastrointestinal Surgery2017，9，12： | 2 |
| 2 | Novel syntheses of chiral beta- and gamma-amino acid derivatives utilizing Nprotected (aminoacyl)benzotriazoles from aspartic and glutamic acids显示文摘 | Katritzky A R Tao H Jiang R Suzuki K Kirichenko K | 2007 | J Org Chem2007，72，： | 1 |
| 3 | Asymptotic radius of a slightly conducting liquid jet in an electric field显示文摘 | KIRICHENKO V N PETRYANOV Sokolov I V SUPRUN N N | 1986 | Soy Phys Dokl1986，31，1： | 1 |
| 4 | Synthesis of mono-and N,N-disubstituted thioureas and N-acylthioureas显示文摘 | Katritzky A R Kirichenko N Rogovoy Boris V | 2004 | Synthesis2004，，11： | 1 |
| 5 | On nearly-Kahlerian structures induced by means of 3-vector cross products on six-dimensionalsubmanifolds of Cayley aigebm显示文摘 | Kirichenko V F | 1973 | Vestnik MGU1973，3，： | 1 |
| 6 | Effect of coprecipitation conditions on the surface area,phase composition,and reducibility of CeO2-ZrO2-Y2O3 materials for automotive three-way catalysts显示文摘 | Kirichenko O A Gramham G W Chun W | 1998 | Stud Surf Sci Catal1998，118，： | 1 |
| 7 | High pressure transformation of single-crystal graphite to form molecular car bon-onions 显示文摘 | Blank V Denisov V Kirichenko A | 2007 | Nanotechnology2007，18，34： | 1 |
| 8 | Effect of coprecipitation conditions on the surface area,phase composition,and reducivility of CeO2-ZrO2-Y2-O3 materials for automotive three-way catalysts显示文摘 | Kirichenko O A Gramham G W Chun W | 1998 | Stud Surf Sci Catal1998，118，： | 1 |
| 9 | A study of the boiling of cryogenic liquids 显示文摘 | Kirichenko Y A Dolgoy M L Levchenko N M | 1976 | Heat Transfer - Soviet Research1976，8，4： | 1 |
| 10 | Analysis of quasi - static conditions of boiling onset and bubble departure显示文摘 | Kirichenko Y A Slobozhanin L A Shcherbakova N S | 1983 | Cryogenics1983，23，2： | 1 |
| 11 | Multi-band digital-RF receiver显示文摘 | SARWANA S KIRICHENKO D E DETSENKO V V eta l | 2011 | IEEE Transactions onApplied Superconductivity2011，21，3： | 1 |
| 12 | Asymptotic radius of a slightly conducting liquid jet in an electric field 显示文摘 | Kirichenko V N Sokolov P Suprun N N | 1986 | Soviet Physics Doklady1986，31，： | 1 |
| 13 | Mechanistic basis for inflammation and tumor promotion in lungs of 2,6-di-tert-butyl- 4-methylphenol-treated mice:electrophilic metabolites alkylate and inactivate antioxidant enzymes 显示文摘 | Meier B W Gomez J D Kirichenko O V | 2007 | Chem Res Toxicol2007，20，2： | 1 |
| 14 | In search of ionic liquids incorporating azolate anions显示文摘 | Katritzky A R Singh S Kirichenko K | 2006 | Chemistry-A European Journal2006，12，： | 1 |
| 15 | Analysis of quasi-static conditions of boiling onset and bubble departure 显示文摘 | KIRICHENKO Y A SLOBOZHANIN L A SHCHERBAKOVA N S | 1983 | Cryogenics1983，23，2： | 1 |
| 16 | A study of the boiling of cryogenic liquids 显示文摘 | Kirichenko Yu A Dolgoy M L Levchenko N M et al | 1976 | Heat Transfer - Soviet Research1976，8，4： | 1 |
| 17 | 1-Butyl-3 methylimidazolium 3,5-dinitro-1,2,4-triazolate : A no vel ionic liquid containing a rigid, planar energetic ani on显示文摘 | Katritzky A Singh S Kirichenko K | 2005 | Chemical Communication2005，5，： | 1 |
| 18 | Analysis of quasi - static conditions of boiling onset and bubble departure 显示文摘 | Kirichenko Yu A Slobozhanin L A Shcherbakova N S | 1983 | Cryogenics1983，23，2： | 1 |
| 19 | Studying Genetic Diversity in Inbred Sunflower Lines by RAPD and Isozyme Analyses显示文摘 | V. N. Popov O. Yu. Urbanovich V. V. Kirichenko | 2002 | Russian Journal of Genetics2002，，7： | 1 |
| 20 | Self-dual geometry of generalized Hermitian surfaces显示文摘 | Arsen'eva O E Kirichenko V F | 1998 | Mat Sbomik1998，189，1： | 1 |
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