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| 1 | Insulin-like growth factor-1, IGF binding protein-3, and the risk of esophageal cancer in a nested case-control study显示文摘AIM To assess the relationship between serum levels of insulin-like growth factor-1(IGF1)/IGF-binding protein-3(IGFBP3)and the risk of esophageal carcinoma.METHODS We assessed the relationship between the serum levels of these molecules and the risk of esophageal cancer in a prospective,nested case-control study of participants from the Japan Collaborative Cohort Study.A baseline survey was conducted from 1988 to 1990.Of the 110585 enrolled participants,35%donated blood samples.Those who had been diagnosed with esophageal cancer were considered cases for nested case-control studies.A conditional logistic model was used to estimate odds ratios for the incidence of esophageal cancer associated with serum IGF1 and IGFBP3 levels.RESULTS Thirty-one cases and 86 controls were eligible for the present assessment.The molar ratio of IGF1/IGFBP3,which represents the free and active form of IGF1,was not correlated with the risk of esophageal carcinoma.A higher molar difference between IGFBP3and IGF1,which estimates the free form of IGFBP3,was associated with a decreased risk of esophageal carcinoma(P=0.0146),and people in the highest tertile had the lowest risk(OR=0.107,95%CI:0.017-0.669).After adjustment for body mass index,tobacco use,and alcohol intake,the molar difference of IGFBP3-IGF1 was inversely correlated with the risk of esophageal carcinoma(P=0.0150).CONCLUSION The free form of IGFBP3,which is estimated by this molar difference,may be inversely associated with esophageal cancer incidence. | Yasushi Adachi Masanori Nojima Mitsuru Mori Kentaro Yamashita Hiro-o Yamano Hiroshi Nakase Takao Endo Kenji Wakai Kiyomi Sakata Akiko Tamakoshi | 2017 | World Journal of Gastroenterology2017，23，19： | 4 |
| 2 | Risk factors for retinopathy associated with interferonα-2b and ribavirin combination therapy in patients with chronic hepatitis C显示文摘AIM: To elucidate the frequency and risk factors for retinopathy in patients with chronic hepatitis C who are treated by interferon-ribavirin combination therapy. METHODS: We prospectively analyzed 73 patients with histologically confirmed chronic hepatitis C, who underwent combination therapy for 24 wk. Optic fundi were examined before, and 2, 4, 12 and 24 wk after the start of combination therapy. RESULTS: Fourteen patients (19%) developed retinopathy, which was initially diagnosed by the appearance of a cotton wool spot in 12 patients. Retinal hemorrhage was observed in 5 patients. No patient complained of visual disturbance. Retinopathy disappeared in 9 patients (64%) despite the continuation of combination therapy. However, retinopathy persisted in 5 patients with retinal hemorrhage. A comparison of the clinical background between the groups with and without retinopathy showed no significant differences in age, gender, viral genotype, RNA level, white blood cell count, platelet count, prothrombin time, complications by diabetes mellitus or hypertension, or pretreatment arteriosclerotic changes in the optic fundi. However, multiple logistic regression analysis revealed that complication by hypertension was observed with a high frequency in the group with retinopathy (P = 0.004, OR=245.918, 95% CI=5.6-10786.2). CONCLUSION: Retinopathy associated with combination therapy of interferon a-2b and ribavirin tends to develop in patients with hypertension. | Chiaki Okuse Hiroshi Yotsuyanagi Yoshihiko Nagase Yuhtaro Kobayashi Kiyomi Yasuda Kazuhiko Koike Shiro Iino Michihiro Suzuki Fumio Itoh | 2006 | World Journal of Gastroenterology2006，12，23： | 4 |
| 3 | Rapid acupuncture for musculoskeletal pain in the emergency room of the Hospital Servidor Publico Estadual, Brazil: A quasi-experimental study显示文摘Objective:To compare differences in self-reported musculoskeletal pain before and after receiving rapid acupuncture for pain at an outpatient emergency department.Methods:Exactly 102 patients presenting to the emergency room of the Hospital Servidor Publico Estadual in Sao Paulo,Brazil,participated in this before-and-after study.All participants had musculoskeletal pain and were treated with the technique proposed by Marques Filho.This emergency acupuncture involved inserting a needle at a point defined by traditional Chinese medicine and applying intense stimulation for 10 s;no more than two points were used on any individual patient.Pain was measured using a numerical visual scale before and immediately after the procedure.Results:Participants in this study were mostly women(78%),had a college degree(47%)and were below the age of 60(56%).The most common region of pain was the lower back(31%),and the most common type of pain was acute and exacerbated chronic pain.The meridians most commonly involved were the eight extra meridians(40%),and the points most often used for treatment were Houxi(SI3),Shenmai(BL62)and Zulinqi(GB41).Almost all participants reported a decrease in pain intensity,independent of sex,education level,pain site and pain type(acute/chronic;P<0.05).At the end of the session,only4%of the participants reported a desire for allopathic medication.Conclusion:This emergency acupuncture technique for analgesia appears to reduce musculoskeletal pain.Trial registration:Brazilian Registry of Clinical Trials(http://www.ensaiosclinicos.gov.br/)with No.RBR-8 dmfjf. | Luciana Aikawa Alexandre Massao Yoshizumi Mirian Matsura Shirassu Marcia Kiyomi Koike | 2020 | Journal of Integrative Medicine2020，18，4： | 3 |
| 4 | 改进燃烧以降低非直喷式柴油机的排放显示文摘探讨了降低涡流室燃烧室柴油机颗粒排放物(PM)的方法,利用一台可用光学仪器观察的发动机,研究了降低PM的机理。本研究阐明了以下一些要点:(1)在低负荷时,抑制初始喷油率使PM降低,因为改变着火点降低了可溶性有机成分(SOF)和延迟浓碳粒流出涡流室降低了烟度。(2)在中和高负荷工况下,排气烟度的主要成因是喷束严重撞击燃烧室壁,从而导致燃油粘附在壁上和浓燃油-空气混合气的滞止。(3)加大涡流室的容积比抑制了在涡流室内浓碳粒的形成。然而在主燃室内由于燃烧室深度有相当大的减小,使混合效果下降,碳粒的氧化作用变得不够充分。(4)为使碳粒-空气在主燃室内得到充分混合的效果,最有效的方法是保持活塞顶部的沟槽区有足够的深度,以阻止从燃烧室通道喷出的火焰流扩宽而因此保证形成双涡流。 | Yoshihiro Hotta Kiyomi Nakakita Minaji Inayoshi 杜任方 | 1999 | 国外内燃机1999，31，5： | 3 |
| 5 | Change in Expression of GBP28/Adiponectin in Carbon Tetrachloride-Administrated Mouse Liver显示文摘 | Madoka Yoda-Murakami Michiko Taniguchi Katsuhiko Takahashi Sakura Kawamata Kiyomi Saito Nam-Ho Choi-Miura Motowo Tomita | 2001 | Biochemical and Biophysical Research Communications2001，，： | 2 |
| 6 | Precore and core promoter mutations, hepatitis B virus DNA levels and progressive liver injury in chronic hepatitis B显示文摘 | Hiroshi Yotsuyanagi Kunihiko Hino Eiichi Tomita Joji Toyoda Kiyomi Yasuda Shiro Iino | 2002 | Journal of Hepatology2002，，3： | 2 |
| 7 | Cancer immunotherapy for pancreatic cancer utilizing α-gal epitope/natural anti-Gal antibody reaction显示文摘Pancreatic ductal adenocarcinoma(PDAC) has the poorest prognosis of all malignancies and is largely resistant to standard therapy. Novel treatments against PDAC are desperately needed. Anti-Gal is the most abundant natural antibody in humans,comprising about 1% of immunoglobulins and is also naturally produced in apes and Old World monkeys. The anti-Gal ligand is a carbohydrate antigen called 'α-gal epitopes' with the structure Galα1-3Galβ1-4Glc NAc-R. These epitopes are expressed as major carbohydrate antigens in non-primate mammals,prosimians,and New World monkeys. Anti-Gal is exploited in cancer vaccines to increase the immunogenicity of antigen-presenting cells(APCs). Cancer cells or PDAC tumor lysates are processed to express α-gal epitopes. Vaccination with these components results in in vivo opsonization by anti-Gal Ig G in PDAC patients. The Fc portion of the vaccine-bound anti-Gal interacts with Fcγ receptors of APCs,inducing uptake of the vaccine components,transport of the vaccine tumor membranes to draining lymph nodes,and processing and presentation of tumor-associated antigens(TAAs). Cancer vaccines expressing α-gal epitopes elicit strong antibody production against multiple TAAs contained in PDAC cells and induce activation of multiple tumor-specific T cells. Here,we review new areas of clinical importance related to the α-gal epitope/anti-Gal antibody reaction and the advantages in immunotherapy against PDAC. | Masahiro Tanemura Eiji Miyoshi Hiroaki Nagano Hidetoshi Eguchi Katsuyoshi Matsunami Kiyomi Taniyama Nobutaka Hatanaka Hiroki Akamatsu Masaki Mori Yuichiro Doki | 2015 | World Journal of Gastroenterology2015，21，40： | 2 |
| 8 | Generation of metabolically functioning hepatocytes from human pluripotent stem cells by FOXA2 and HNF1α transduction显示文摘 | Kazuo Takayama Mitsuru Inamura Kenji Kawabata Michiko Sugawara Kiyomi Kikuchi Maiko Higuchi Yasuhito Nagamoto Hitoshi Watanabe Katsuhisa Tashiro Fuminori Sakurai Takao Hayakawa Miho Kusuda Furue Hiroyuki Mizuguchi | 2012 | Journal of Hepatology2012，，3： | 1 |
| 9 | Library construction for next-generation sequencing: overviews and challenges 显示文摘 | HEAD S R KIYOMI K H LAMERE S A | 2014 | Biotechniques2014，56，2： | 1 |
| 10 | Synthesis and Biological Activity of 22,23-Epoxybrassinosteroid 2,3-Diacetates显示文摘 | Fumio Futatsuya Kiyomi Kobayashi Hitoshi Satoh | 1989 | Agric Biol Chem1989，53，1： | 1 |
| 11 | Relationship between the pressure and diameter of the carotid artery in humans显示文摘 | Kiyomi N Motoaki S | 2000 | Heart and Vessels2000，15，1： | 1 |
| 12 | An inter-laboratory collaborative study by the Non-Genotoxic Carcinogen Study Group in Japan, on a cell transformation assay for tumour promoters using Bhas 42 cells 显示文摘 | Kiyomi O Makoto U Noriho T | 2005 | Altern Lab Anim2005，33，6： | 1 |
| 13 | Anovel fine system for masking bitter taste显示文摘 | Yoshimi S Kiyomi S Kazumitsu Y | 1993 | Biol Pharm Bull1993，16，2： | 1 |
| 14 | Generation and detection of terahertz pulsed radiation with photoconductive antennas and its application to imaging显示文摘 | Masahiko Tani Michael Herrmann Kiyomi Sakai | 2002 | Measurement Science & Technology2002，13，11： | 1 |
| 15 | Aberrant promoter methylation profile of prostate cancers and its relationship to clinico pathological features显示文摘 | Riichiroh Maruyama Shinichi Toyooka Kiyomi O | 2002 | Clinical Cancer Research2002，8，： | 1 |
| 16 | The beneficial effects of atrial natriuretic peptide on arrhythmias and myocardial high-energy phosphates after reperfusion 显示文摘 | Takata Y Hirayama Y Kiyomi S | 1996 | Cardiovasc Res1996，32，2： | 1 |
| 17 | High Performance Steel Plate for Tank and Pressure Vessel Use显示文摘 | HAYASHI Kenji ARAKI Kiyomi A B E Takashi | 2005 | JFE Technical Report2005，5，： | 1 |
| 18 | Comparison of the Use of Liver Models for Predicting Drug Clearance Using in Vitro Kinetic Data from Hepatic Microsomes and Isolated Hepatocytes显示文摘 | Kiyomi Ito J. Brian Houston | 2004 | Pharmaceutical Research2004，，5： | 1 |
| 19 | Anovel fine system for masking bitter taste显示文摘 | Yoshimi S Kiyomi S Kazumitsu Y | 1993 | Biol Pharm Bull1993，16，2： | 1 |
| 20 | Limonoids from fruit of Melia toosendan and their cytotoxic activity显示文摘 | Kiyomi Tada Michio Takido Susumu Kitanaka | 1999 | Phytochemistry1999，51，： | 1 |
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