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| 1 | Clinical use of bone-targeting radiopharmaceuticals with focus on alpha-emitters显示文摘Various single or multi-modality therapeutic options are available to treat pain of bone metastasis in patients with prostate cancer.Different radionuclides that emitβ-rays such as 153Samarium and 89Strontium and achieve palliation are commercially available.In contrast toβ-emitters,223Radium as a a-emitter has a short path-length.The advantage of the a-emitter is thus a highly localized biological effect that is caused by radiation induced DNA double-strand breaks and subsequent cell killing and/or limited effectiveness of cellular repair mechanisms.Due to the limited range of the a-particles the bone surface to red bone marrow dose ratio is also lower for 223Radium which is expressed in a lower myelotoxicity.The a emitter 223Radium dichloride is the first radiopharmaceutical that significantly prolongslife in castrate resistant prostate cancer patients with wide-spread bone metastatic disease.In a phaseⅢ,randomized,double-blind,placebo-controlled study 921patients with castration-resistant prostate cancer and bone metastases were randomly assigned.The analysis confirmed the 223Radium survival benefit compared to the placebo(median,14.9 mo vs 11.3 mo;P<0.001).In addition,the treatment results in pain palliation and thus,improved quality of life and a delay of skeletal related events.At the same time the toxicity profile of223Radium was favourable.Since May 2013,223Radium dichloride(Xofigo?)is approved by the US Food and Drug Administration. | Hinrich A Wieder Michael Lassmann Martin S Allen-Auerbach Johannes Czernin Ken Herrmann | 2014 | World Journal of Radiology2014，6，7： | 4 |
| 2 | Early Neurobehavioral Outcome After Stroke Is Related to Release of Neurobiochemical Markers of Brain Damage显示文摘 | Michael T. Wunderlich Anne D. Ebert Torsten Kratz Michael Goertler Stefan Jost Manfred Herrmann | 1999 | Stroke: A Journal of Cerebral Circulation1999，，6： | 2 |
| 3 | Generation and detection of terahertz pulsed radiation with photoconductive antennas and its application to imaging显示文摘 | Masahiko Tani Michael Herrmann Kiyomi Sakai | 2002 | Measurement Science & Technology2002，13，11： | 1 |
| 4 | Homozygosity for the CARD15 frameshift mutation 1007fs is predictive of early onset of Crohn’s disease with ileal stenosis, entero-enteral fistulas, and frequent need for surgical intervention with high risk of re-stenosis显示文摘 | Julia Seiderer Fabian Schnitzler Stephan Brand Tanja Staudinger Simone Pfennig Karin Herrmann Katrin Hofbauer Julia Dambacher Cornelia Tillack Michael Sackmann Burkhard G?ke Peter Lohse Thomas Ochsenkühn | 2006 | Scandinavian Journal of Gastroenterology2006，，12： | 1 |
| 5 | Trough in- tegration into power plants-a study on the performance and econo- my of integrated solar combined cycle systems 显示文摘 | Jfirgen Dersch Michael Geyer Ulf Herrmann | 2004 | Energy2004，29，： | 1 |
| 6 | Trough integration into power plants-A study on the performance and economy of integrated solar combined cycle systems显示文摘 | Dersch Jtirgen Michael Geyer Ulf Herrmann | 2004 | Energy2004，29，5： | 1 |
| 7 | The Acute Hemodynamic Effects of MitraClip Therapy显示文摘 | Robert J. Siegel Simon Biner Asim M. Rafique Michael Rinaldi Scott Lim Peter Fail James Hermiller Richard Smalling Patrick L. Whitlow Howard C. Herrmann Elyse Foster Ted Feldman Donald Glower Saibal Kar | 2011 | Journal of the American College of Cardiology2011，，16： | 1 |
| 8 | Trough integration into power plants-A study on the performance and economy of integrated solar combined cycle systems显示文摘 | Dersch Jiirgen Geyer Michael Herrmann Ulf | 2004 | Energy2004，29，56： | 1 |
| 9 | Trough in- tegration into power plants-a study on the performance and econo- my of integrated solar combined cycle systems 显示文摘 | Jurgen Derseh Michael Geyer Ulf Herrmann | 2004 | Energy2004，29，： | 1 |
| 10 | Trough integration into power plants-a study on the performance and economy of int-egrated solar combined cycle systems显示文摘 | Jurgen Dersch Michael Geyer Ulf Herrmann | 2004 | Energy2004，29，： | 1 |
| 11 | The role of epigenetics in the regulation of apoptosis in myelodysplastic syndromes and acute myeloid leukemia显示文摘 | Heidrun Karlic Harald Herrmann Franz Varga Roman Thaler Rene Reitermaier Silvia Spitzer Viviane Ghanim Katharina Blatt Wolfgang R. Sperr Peter Valent Michael Pfeilst?cker | 2013 | Critical Reviews in Oncology / Hematology2013，，： | 1 |
| 12 | Trough integration into power plants-a study on the performance and economy of integrated solar combined cycle systems 显示文摘 | JUrgen D Michael G Herrmann U | 2004 | Energy2004，29，56： | 1 |
| 13 | Higher nitrate-reducer diversity in macrophyte-colonized compared to unvegetated freshwater sediment显示文摘 | Michael V.W. Kofoed Peter Stief Sandra Hauzmayer Andreas Schramm Martina Herrmann | 2012 | Systematic and Applied Microbiology2012，，7： | 1 |
| 14 | 5-year outcomes of transcatheter aortic valve replacement compared with standard treatment for patients with inoperable aortic stenosis (PARTNER 1): a randomised controlled trial显示文摘 | Samir R Kapadia Martin B Leon Raj R Makkar E Murat Tuzcu Lars G Svensson Susheel Kodali John G Webb Michael J Mack Pamela S Douglas Vinod H Thourani Vasilis C Babaliaros Howard C Herrmann Wilson Y Szeto Augusto D Pichard Mathew R Williams Gregory P Fontan | 2015 | The Lancet . 2015 (9986)2015，，： | 1 |
| 15 | Dicationic chelating N-heterocyclic carbene complexes of palladium:new catalysts for the copolymerisation of C2H4 and CO 显示文摘 | Michael G G Herrmann W A | 1999 | J Organometal Chem1999，572，： | 1 |
| 16 | 显示文摘 | Boberski C Michael G Putzky G Hermel W | 1993 | J Mater Sci Lett1993，12，： | 1 |
| 17 | Functional consequences of frizzled-7 receptor overexpression in human hepatocellular carcinoma显示文摘 | Philippe Merle Suzanne de la Monte Miran Kim Marc Herrmann Shinji Tanaka Annette Von Dem Bussche Michael C. Kew Christian Trepo Jack R. Wands | 2004 | Gastroenterology2004，，4： | 1 |
| 18 | Percutaneous Mitral Repair With the MitraClip System显示文摘 | Ted Feldman Saibal Kar Michael Rinaldi Peter Fail James Hermiller Richard Smalling Patrick L. Whitlow William Gray Reginald Low Howard C. Herrmann Scott Lim Elyse Foster Donald Glower | 2009 | Journal of the American College of Cardiology2009，，8： | 1 |
| 19 | Population Aging and Economic Development: Anxieties and Policy Responses 显示文摘 | Michael Herrmann | 2012 | Popnlation Ageing2012，，5： | 1 |
| 20 | Systematic expression profiling of the gastric H+/K+ ATPase in human tissue显示文摘 | Michael Herrmann Jens Selige Sandra Raffael George Sachs Andrea Brambilla Thomas Klein | 2007 | Scandinavian Journal of Gastroenterology2007，，11： | 1 |
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