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| 1 | The vital threat of an upper gastrointestinal bleeding: Risk factor analysis of 121 consecutive patients显示文摘瞄准:在预言死亡的病人风险由于分析重要性上面胃肠(UGI ) 在今天的治疗学的政体下面流血。方法:从 1998 ~ 2001,有 UGI 流血的诊断的 121 个病人在我们的医院里被对待。基于病人的数据,一回顾多变量数据分析与开始,超过 270 个单个因素被执行。随后,下列潜在的风险因素经历了逻辑回归分析:年龄,性,起始的血红素, coumarines ,肝肝硬化,前凝血酶时间(磅),胃溃疡(小弯曲),十二指肠溃疡(灯泡我们背墙),福雷斯特分类,脉管的树桩, variceal 流血, Mallory-Weiss 症候群, RBC 替换,周期性的流血,保守、外科的治疗。结果:七十男性(58%) 和 51 女性(42%) 有 70 的中部的年龄的病人(变化:21-96 ) 年被对待。他们的在里面医院死亡是 14% 。当(11/91 )12% 在保守治疗以后死于病人时,(6/30 )20% 在经历外科的治疗以后死了。流血的 UGI 由于十二指肠溃疡发生了(n = 36;30%) ,胃溃疡(n = 35;29%) ,食道的静脉曲张病(n = 12;10%) , Mallory-Weiss 症候群(n = 8;7%) ,粘膜的腐蚀损害(n = 20;17%) ,癌症(n = 5;4%) , coagulopathy (n = 4;3%) ,淋巴瘤(n = 2;2%) ,良性瘤(n = 2;2%) 并且未知理智(n = 1;1%) 。所有上述的因素的逻辑回归分析揭示了那肝肝硬化和十二指肠溃疡(灯泡我们背墙) 是为在 UGI 流血以后的一堂致命的功课的联系风险因素。在内视镜检查法以前,仅仅肝肝硬化是一个可估价的风险因素。此后,肝肝硬化,流血溃疡的地点(灯泡我们背墙) 并且病人的性(男性) 具有为有流血溃疡的病人的临床的结果(死亡) 的预示的重要性。结论:在今天的临床的常规使用的最预示的参数不在预言一个病人的重要威胁由流血的 UGI 摆姿势是足够可靠的。在另一方面,肝肝硬化更经常显著地与增加的风险被联系在在以后的十二指肠的墙定位的溃疡流血以后死。 | Peter Schemmer Frank Decker Genevieve Dei-Anane Volkmar Henschel Klaus Buhl Christian Herfarth Stefan Riedl | 2006 | World Journal of Gastroenterology2006，12，22： | 16 |
| 2 | 马克斯·普朗克创新与竞争研究所就欧盟委员会“关于构建欧洲数据经济征求意见书”的立场声明显示文摘马克斯·普朗克创新与竞争研究所是一家在马克斯·普朗克学会之下设立的研究机构,自五十一年前设立以来,一直致力于在既已确立的科学原理基础之上对知识产权和竞争法的分析与发展进行研究.马克斯·普朗克创新与竞争研究所承担着该领域内基础问题的研究.基于其卓著的研究贡献,马克斯·普朗克创新与竞争研究所发起并引领着德国、欧洲以及国际层面重要的立法及理论研究。 | Josef Drexl Reto M.Hilty Jure Globocnik Franziska Greiner Daria Kim Heiko Richter Peter R.Slowinski Gintar? Surblyt? Axel Walz Klaus Wiedemann 刘维 张嘉莹 | 2017 | 电子知识产权2017，，7： | 11 |
| 3 | Echo-enhanced ultrasound with pulse inversion imaging: A new imaging modality for the differentiation of cystic pancreatic tumours显示文摘瞄准:在膀胱的胰腺的损害的鉴别诊断描述并且讨论提高回响的 sonography。方法:脉搏倒置技术(与 2.4 mL SonoVue 的静脉注射) 或在第二泛音成像的条件下面的 power-Doppler 模式(与 4 g Levovist 的静脉注射) 被用于提高回响的 sonography。结果:Cystadenomas 经常沿着纤维变性海滨显示出许多容器。在另一方面,包囊腺癌是糟糕并且混乱 vascularized。“年轻假包囊”经常被发现有一面高度脉管的 ised 墙。然而,“旧假包囊”的墙是糟糕 vascularized。从未来的研究的数据证明基于这些成像标准,在膀胱的胰腺的群众的区别的提高回响的 sonography 的敏感和特性是 >90% 。结论:膀胱的胰腺的群众在提高回响的 sonography 有一个不同血管形成模式。这些特征为他们的鉴别诊断是有用的,但是组织学仍然是标准答案。 | Steffen Rickes Klaus Mnkemüller Peter Malfertheiner | 2006 | World Journal of Gastroenterology2006，12，14： | 10 |
| 4 | Capecitabine and irinotecan with and without bevacizumab for advanced colorectal cancer patients显示文摘AIM:To investigate the efficacy and safety of capecitabine plus irinotecan±bevacizumab in advanced or metastatic colorectal cancer patients. METHODS:Forty six patients with previously untreated,locally-advanced or metastatic colorectal cancer(mCRC) were recruited between 2001-2006 in a prospective open-label phaseⅡtrial,in German community-based outpatient clinics.Patients received a standard capecitabine plus irinotecan(CAPIRI) or CAPIRI plus bevacizumab(CAPIRI-BEV) regimen every 3 wk. Dose reductions were mandatory from the first cycle in cases of>grade 2 toxicity.The treatment choice of bevacizumab was at the discretion of the physician.Theprimary endpoints were response and toxicity and secondary endpoints included progression-free survival and overall survival. RESULTS:In the CAPIRI group vs the CAPRI-Bev group there were more female than male patients(47% vs 24%) ,and more patients had colon as the primary tumor site(58.8%vs 48.2%) with fewer patients having sigmoid colon as primary tumor site(5.9%vs 20.7%) .Grade 3/4 toxicity was higher with CAPIRI than CAPIRI-Bev:82%vs 58.6%.Partial response rates were 29.4%and 34.5%,and tumor control rates were 70.6%and 75.9%,respectively.No complete responses were observed.The median progression-free survival was 11.4 mo and 12.8 mo for CAPIRI and CAPIRI-Bev,respectively.The median overall survival for CAPIRI was 15 mo(458 d) and for CAPIRI-Bev 24 mo(733 d) .These differences were not statistically different.In the CAPIRI-Bev,group,two patients underwent a full secondary tumor resection after treatment,whereas in the CAPIRI group no cases underwent this procedure. CONCLUSION:Both regimens were well tolerated and offered effective tumor growth control in this outpatient setting.Severe gastrointestinal toxicities and thromboembolic events were rare and if observed were never fatal. | Markus Moehler Martin F Sprinzl Murad Abdelfattah Carl C Schimanski Bernd Adami Werner Godderz Klaus Majer Dimitri Flieger Andreas Teufel Juergen Siebler Thomas Hoehler Peter R Galle Stephan Kanzler | 2009 | World Journal of Gastroenterology2009，15，4： | 10 |
| 5 | 地球化学与环境样品分析标准物质和GeoReM数据库显示文摘在地球化学和环境样品分析中,标准物质发挥着越来越重要的作用。尽管通常要求分析者必须提供量值溯源的测量过程的信息;但大多数论著都未给出标准物质的数据。文章强调标准物质在地球化学分析工作中的重要性,同时将地球化学与环境样品分析标准物质数据库GeoReM介绍给中国的地质分析工作者。GeoReM数据库收录了1880个地球化学和环境样品分析标准物质的定值数据、汇编数据、分析数据及其他相关信息,其中包括156个由中国制备的标准物质的数据。GeoReM数据库还给出了所收录标准物质推荐使用的首选值及其不确定度。尽管这些首选值大多都不是按照国际标准化组织的有关规定而确定的,但是它们的置信度高,因而被广泛应用于仪器校准和分析数据的质量监控。文章还指出要将中国研制的、发表在中文期刊上的标准物质也收录到GeoReM数据库中,这对于促进中国的相关研究,增加国际认可度具有重要意义。 | JOCHUM Klaus Peter 王晓红 | 2009 | 岩矿测试2009，28，4： | 10 |
| 6 | Drug treatment of functional dyspepsia显示文摘有在药治疗以后的机能性消化不良的病人的征兆的改进经常在不超过 60% 病人不完全、获得。因为机能性消化不良是异构的疾病,这是可能的。尽管大进展与罗马的一致定义被完成了我和 II 标准,仍然关于机能性消化不良的定义有一些方面要求澄清。罗马标准明确地认识到腹上部的疼痛或不快 must 是在作为受不了机能性消化不良标记的病人的占优势的抱怨。然而,这个严格的定义能在每天主要的照顾创造问题临床的实践,有机能性消化不良的病人在此与多重症状介绍。在开始药治疗前,向病人提供疾病过程和安慰的解释被建议。彻底的体格检查和实验室数据和内视镜检查法的明智的使用也被显示。一般来说,基于他们的主要症状与机能性消化不良对待病人的途径实际、有效。通常,病人们应该与如果占优势的症状是腹上部的,使用质子泵禁止者的镇压治疗伤害的酸或胃的食道的倒流症状被对待。尽管在机能性消化不良的 Helicobacter pylori (H pylori ) 的角色继续是争论的一件事,最近的数据显示有在有机能性消化不良的病人的 H pylori 的根除的谦虚却清楚的利益。另外, H pylori 是胃的致癌物,如果发现,它应该被消除。尽管为有 FD 的病人没有特定的食谱,在健康锻练和吃的习惯指导病人可能是有用的。 | Klaus Mnkemüller Peter Malfertheiner | 2006 | World Journal of Gastroenterology2006，12，17： | 9 |
| 7 | Endoscopic closure of a gastrocolic fistula using the over-the-scope-clip-system显示文摘Gastrointestinal (GI) defects such as fistulas and leaks can be potentially closed endoscopically using hemo-clips and loops. However, hemoclips may not allow for closure of large defects and they do not exert enough tensile force to keep fibrotic defects larger than 5 mm approximated. Herein we present a case of successful endoscopic closure of a gastrocolic fistula in a severely malnourished patient with complex post-surgical upper GI anatomy. We strongly believe that this device is a major breakthrough for the management of various types of discontinuity defects or fistulas. In addition, we show the usefulness of placing a direct jejunostomy using the double balloon enteroscopy (DBE) technique during the same procedure. The concept of providing direct jejunal feedings while allowing for upper gas-trointestinal bowel rest to promote the healing of the minimally invasive endoscopic operation is novel. Thus, our case is unique and exemplifies the utility of mini-mally invasive endoscopic endoluminal surgery. | Klaus Mnkemüller Shajan Peter Basem Alkurdi Jayapal Ramesh Daniel Popa C Mel Wilcox | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，8： | 5 |
| 8 | The contribution of Chinese exports to climate change显示文摘 | Christopher L. Weber Glen P. Peters Dabo Guan Klaus Hubacek | 2008 | Energy Policy2008，，9： | 4 |
| 9 | Multipurpose use of the ‘bear claw’ (over‐the‐scope‐clip system) to treat endoluminal gastrointestinal disorders显示文摘 | Klaus M?nkemüller Shajan Peter Jay Toshniwal Daniel Popa Marzena Zabielski Richard D. Stahl Jayapal Ramesh C. Mel Wilcox | 2014 | Digestive Endoscopy2014，，3： | 4 |
| 10 | Multiple gastrointestinal stromal tumors and bilateral pheochromocytoma in neurofibromatosis显示文摘The coincidence of a gastrointestinal stromal tumor (GIST) and a neuroendocrine tumor (NET) in neurofibromatosis type 1 (NF1) is described only five times within the literature. We report on a 63 year old Caucasian female with the rare condition of neurofibromatosis type 1 coinciding with recurrent gastrointestinal stromal tumor plus bilateral pheochromocytoma (PCC). After a history of palpitations and dizziness that lasted for years, a left adrenal mass was detected by CT. Laparotomy revealed a pheochromocytoma of the left adrenal gland while an ileoterminal GIST was found incidentally intraoperatively. After six months contralateral PCC and multiple recurrent GIST were resected again. After four years the patient is doing well without any signs of further recurrent tumors. Discussion includes review of the literature. | Klaus Kramer Cornelia Hasel Andrik J Aschoff Doris Henne-Bruns Peter Wuerl | 2007 | World Journal of Gastroenterology2007，13，24： | 3 |
| 11 | 七氟醚在不停跳冠脉搭桥病人心肌保护效果优于异丙酚显示文摘大量的离体和在体动物实验都证实卤代吸入麻醉药对缺血心肌具有保护作用。吸入麻醉药可促进缺血后心肌功能的恢复和减少心肌梗死面积。其机制有模拟缺血预处理的作用。静脉麻醉药如异丙酚无此种心肌保护作用的特性。其机制尚未阐明。 | Peter F.Conzen Susanne Fischer Christian Detter Klaus Peter 朱珊珊 曾因明 | 2004 | 国外医学(麻醉学与复苏分册)2004，25，1： | 3 |
| 12 | A lexicon for endoscopic adverse events: report of an ASGE workshop显示文摘 | Peter B. Cotton Glenn M. Eisen Lars Aabakken Todd H. Baron Matt M. Hutter Brian C. Jacobson Klaus Mergener Albert Nemcek Bret T. Petersen John L. Petrini Irving M. Pike Linda Rabeneck Joseph Romagnuolo John J. Vargo | 2010 | Gastrointestinal Endoscopy2010，，3： | 3 |
| 13 | Contrast-enhanced harmonic endoscopic ultrasound is able to discriminate benign submucosal lesions from gastrointestinal stromal tumors显示文摘 | Klaus Kannengiesser Reiner Mahlke Frauke Petersen Anja Peters Matthias Ross Torsten Kucharzik Christian Maaser | 2012 | Scandinavian Journal of Gastroenterology2012，，12： | 3 |
| 14 | A multicenter, prospective, randomized comparison of a novel signal transmission capsule endoscope to an existing capsule endoscope显示文摘 | Eric H. Choi Klaus Mergener Carol Semrad Laurel Fisher David R. Cave Milan Dodig Carol Burke Jonathan A. Leighton David Kastenberg Peter Simpson James Sul Kanishka Bhattacharya Roger Charles Lauren Gerson Luke Weber Glenn Eisen Warren Reidel John J. Vargo | 2013 | Gastrointestinal Endoscopy2013，，2： | 2 |
| 15 | The drivers of Chinese CO 2 emissions from 1980 to 2030显示文摘 | Dabo Guan Klaus Hubacek Christopher L. Weber Glen P. Peters David M. Reiner | 2008 | Global Environmental Change2008，，4： | 2 |
| 16 | NeoGemOx: Gemcitabine and oxaliplatin as neoadjuvant treatment for locally advanced, nonmetastasized pancreatic cancer显示文摘 | Klaus Sahora Irene Kuehrer Axel Eisenhut Belgin Akan Claus Koellblinger Peter Goetzinger Bela Teleky Raimund Jakesz Markus Peck-Radosavljevic Ahmed Ba’ssalamah Christoph Zielinski Michael Gnant | 2011 | Surgery2011，，3： | 2 |
| 17 | Establishment of Intestinal Identity and Epithelial-Mesenchymal Signaling by Cdx2显示文摘 | Nan Gao Peter White Klaus H. Kaestner | 2009 | Developmental Cell2009，，4： | 2 |
| 18 | Ten-Microsecond Molecular Dynamics Simulation of a Fast-Folding WW Domain显示文摘 | Peter L. Freddolino Feng Liu Martin Gruebele Klaus Schulten | 2008 | Biophysical Journal2008，，10： | 2 |
| 19 | Reactive wetting during hot-dip galvanizing of high manganese alloyed steel显示文摘 | Marc Blumenau Martin Norden Frank Friedel Klaus Peters | 2010 | Surface & Coatings Technology2010，，10： | 2 |
| 20 | Benign Liver Tumors: Differential Diagnosis and Indications for Surgery显示文摘 | Arved Weimann Burckhardt Ringe Jürgen Klempnauer Peter Lamesch Klaus F. Gratz Mathias Prokop Hansj?rg Maschek Günter Tusch Rudolf Pichlmayr | 1997 | World Journal of Surgery1997，，9： | 2 |
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