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| 1 | Keratinocytes costimulate naive human T cells via CD2: a potential target to prevent the development of proinflammatory Th1 cells in the skin显示文摘The interplay between keratinocytes and immune cells,especially T cells,plays an important role in the pathogenesis of chronic inflammatory skin diseases.During psoriasis,keratinocytes attract T cells by releasing chemokines,while skin-infiltrating selfreactive T cells secrete proinflammatory cytokines,e.g.,IFN γand IL-17A,that cause epidermal hyperplasia.Similarly,in chronic graftversus-host disease,allogenic IFN γ-producing Th1/Tc1 and IL-17-producing Th17/Tc17 cells are recruited by keratinocyte-derived chemokines and accumulate in the skin.However,whether keratinocytes act as nonprofessional antigen-presenting cells to directly activate naive human T cells in the epidermis remains unknown.Here,we demonstrate that under proinflammatory conditions,primary human keratinocytes indeed activate naive human T cells.This activation required cell contact and costimulatory signaling via CD58/CD2 and CD54/LFA-1.Naive T cells costimulated by keratinocytes selectively differentiated into Th1 and Th17 cells.In particular,keratinocyte-initiated Th1 differentiation was dependent on costimulation through CD58/CD2.The latter molecule initiated STAT1 signaling and IFN γproduction in T cells.Costimulation of T cells by keratinocytes resulting in Th1 and Th17 differentiation represents a new explanation for the local enrichment of Th1 and Th17 cells in the skin of patients with a chronic inflammatory skin disease.Consequently,local interference with T cell–keratinocyte interactions may represent a novel strategy for the treatment of Th1 and Th17 cell-driven skin diseases. | Christian Orlik Daniel Deibel Johanna Küblbeck Emre Balta Sabina Ganskih Jüri Habicht Beate Niesler Jutta Schröder-Braunstein Knut Schäkel Guido Wabnitz Yvonne Samstag | 2020 | Cellular & Molecular Immunology2020，17，4： | 4 |
| 2 | A way to higher reso lution: spherical-aberration correction in a 200 kV transmis- sion electron microscope 显示文摘 | KNUT U BERND K MAX H | 1998 | Ultramicroscopy1998，75，1： | 1 |
| 3 | Identification of Bacteria Infecting Ixodes ricinus Ticks by 16SrDNA amplification and denaturing gradient gel electrophoresis显示文摘 | Tveten A K Knut K S | 2011 | Vector Borne Zoonotic Dis2011，11，10： | 1 |
| 4 | Contingent claims valuation when the security price is combination of an Ito process and a random point process 显示文摘 | Knut K A | 1988 | Stochastic process and their applications1988，28，2： | 1 |
| 5 | Contingent Claims Valuation when the Security Price is Combination of an Ito Process and a Random Point Process显示文摘 | Aase | 1988 | Stochastic Process and Their Applications1988，28，2： | 1 |
| 6 | Contingent claims valuation when the security price is combination of an ito process and a random point process显示文摘 | Knut K Aase | 1988 | Stochastic processes and their Applications1988，28，2： | 1 |
| 7 | Development and innovation potential in the Slovene manufacturing industry:Analysis of an industrial innovation survey显示文摘 | Knut K Ulrike B Peter S | 2001 | Technovation2001，21，3： | 1 |
| 8 | IL-12 enhances the generation of tumour antigen-specific Thl CD4 T cells during ex vivo expansion 显示文摘 | Knuts on K L Disis M L | 2004 | Clin Exp Immunol2004，135，2： | 1 |
| 9 | Sleep loss:A novel risk factor for insulin resistance and type 2 diabetes显示文摘 | Spiegel K Knut son K Leproult R | 2005 | J Appl Physiol2005，99，： | 1 |
| 10 | Contingent claims valuation when the security price is combination of an its process and a random point process显示文摘 | Knut K AASE | 1988 | Stochastic processes and their Applications1988，28，2： | 1 |
| 11 | Contingent claims valuation when the security price is combination of an ito process and a random point process显示文摘 | AASE | 1988 | Stochastic processes and their Applications1988，28，2： | 1 |
| 12 | Randomized comparison of effects of suture-based and collagen-based vascular closure devices on post-procedural leg perfusion显示文摘 | Hagen I. M. K?lsch MD Holger Eggebrecht MD Susanne Mayringer Thomas Konorza MD B. Sievers MD Stefan Sack MD Raimund Erbel MD Knut Kroeger MD | 2008 | Clinical Research in Cardiology2008，，1： | 1 |
| 13 | Contingent claims valuation when the security price is combination of an It(o) process and a random point procss显示文摘 | KNUT K A | 1988 | Stochastic Processes and Their Applications1988，28，2： | 1 |
| 14 | Contingent claims valuation when the security price is combination of an Ito process and a random point process显示文摘 | KNUT K AASE | 1988 | Stochastic Processes and Their Applications1988，28，2： | 1 |
| 15 | Roundup ready soybean event-specific real-time quantitative PCR assay and estimation of the practical detection and quantification limits in GMO analyses显示文摘 | Knut G Berdal K Holst-Jensen A | 2001 | Eur Food Res Techuol2001，213，： | 1 |
| 16 | Very low levels of microalbuminuria are associated with increased risk of coronary heart disease and death independently of renal function hypertension and diabetes显示文摘 | Klaus K Knut B J Bo FR | 2004 | Circulation2004，110，： | 1 |
| 17 | Observations of microcracking in cement paste upon drying and rewetting by environmental scanning electron microscopy显示文摘 | KNUT 0 K HAMLIN M J | 1996 | Adv Cem Based Mater1996，3，： | 1 |
| 18 | Lipopolysaccharide-binding protein: A new biomarker for infectious endocarditis 显示文摘 | Tania V Cornelia P Knut K | 2009 | Clin Chem2009，55，： | 1 |
| 19 | Soil amino acid turnover dominates the nitrogen flux in permafrost-dominated taiga forest soils 显示文摘 | DAVID L J KNUT K | 2002 | Soil Biology and Biochemistry2002，34，： | 1 |
| 20 | Quartz cementation in sedimentary basins 显示文摘 | Knut Bjorlykke Egeberg P K | 1993 | AAPG Bulletin1993，77，： | 1 |
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