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| 1 | Peroxisome proliferator-activated receptor-delta agonist ameliorated inflammasome activation in nonalcoholic fatty liver disease显示文摘AIM: To evaluate the inflammasome activation and the effect of peroxisome proliferator-activated receptors(PPAR)-δ agonist treatment in nonalcoholic fatty liver disease(NAFLD) models.METHODS: Male C57BL/6J mice were classified according to control or high fat diet(HFD) with or without PPAR-δ agonist(GW) over period of 12 wk [control, HFD, HFD + lipopolysaccharide(LPS), HFD + LPS + GW group]. Hep G2 cells were exposed to palmitic acid(PA) and/or LPS in the absence or presence of GW.RESULTS: HFD caused glucose intolerance and hepatic steatosis. In mice fed an HFD with LPS, caspase-1 and interleukin(IL)-1β in the liver were significantly increased. Treatment with GW ameliorated the steatosis and inhibited overexpression of pro-inflammatory cytokines. In Hep G2 cells, PA and LPS treatment markedly increased m RNA of several nucleotide-binding andoligomerization domain-like receptor family members(NLRP3, NLRP6, and NLRP10), caspase-1 and IL-1β. PA and LPS also exaggerated reactive oxygen species production. All of the above effects of PA and LPS were reduced by GW. GW also enhanced the phosphorylation of AMPK-α.CONCLUSION: PPAR-δ agonist reduces fatty acidinduced inflammation and steatosis by suppressing inflammasome activation. Targeting the inflammasome by the PPAR-δ agonist may have therapeutic implication for NAFLD. | Hyun Jung Lee Jong Eun Yeon Eun Jung Ko Eileen L Yoon Sang Jun Suh Keunhee Kang Hae Rim Kim Seoung Hee Kang Yang Jae Yoo Jihye Je Beom Jae Lee Ji Hoon Kim Yeon Seok Seo Hyung Joon Yim Kwan Soo Byun | 2015 | World Journal of Gastroenterology2015，21，45： | 9 |
| 2 | 硝胺的静电火花感度与爆速的关系(英文)显示文摘通过测定12 种硝胺50 % 发火概率下的静电火花能EES,建立了EES与爆速平方值( D2) 的线性关系,以此可预估尚未合成的硝胺化合物,尤其是那些对硝胺化学有重要意义的化合物,如1硝基1氮杂乙烯、1,3二硝基1 ,3二氮杂环丁烷、1,3 ,5 ,7 ,9五硝基1 ,3 ,5 ,7,9五氮杂环癸烷等的EES。 | Vladimír ZEMAN, Ji rˇ í KO C ˇ?, Svatopluk ZEMAN (Department of Theory and Technology of Explosives,University of Pardubice, CZ-532 10 Pardubice, the Czech Republic) | 1999 | 含能材料1999，7，4： | 8 |
| 3 | A case of ascending colon variceal bleeding treated with venous coil embolization显示文摘A 38-year-old female with a history of alcoholic liver cirrhosis visited our hospital with a massive hematochezia.An esophagogastroduodenoscopy did not demonstrate any bleeding source,and a colonoscopy showed a massive hemorrhage in the ascending colon but without an obvious focus.The source of the bleeding could not be found with a mesenteric artery angiography.We performed an enhanced abdominal computed tomography,which revealed a distal ascending colonic varix,and assumed that the varix was the source of the bleeding.We performed a venous coil embolization and histoacryl injection to obliterate the colon varix.The intervention appeared to be successful because the vital signs and hemoglobin laboratory data remained stable and because the hematochezia was no longer observed.We report here on a rare case of colonic variceal bleeding that was treated with venous coil embolization. | Bong Suk Ko Woo Tae Kim Su Sun Chang Eun Hye Kim Seung Woo Lee Won Seok Park Yeon Soo Kim Soon Woo Nam Dong Soo Lee Ji Chang Kim Sang Bum Kang | 2013 | World Journal of Gastroenterology2013，19，2： | 4 |
| 4 | OsIDD2, a zinc finger and INDETERMINATE DOMAIN protein, regulates secondary cell wall formation显示文摘Previously, we found 123 transcription factors(TFs) as candidate regulators of secondary cell wall(SCW)formation in rice by using phylogenetic and co-expression network analyses. Among them, we examined in this work the role of OsIDD_2, a zinc finger and indeterminate domain(IDD) family TF. Its overexpressors showed dwarfism, fragile leaves, and decreased lignin content, which are typical phenotypes of plants defective in SCW formation, whereas its knockout plants showed slightly increased lignin content.The RNA-seq and quantitative reverse transcription polymerase chain reaction analyses confirmed that some lignin biosynthetic genes were downregulated in the OsIDD_2-overexpressing plants, and revealed the same case for other genes involved in cellulose synthesis and sucrose metabolism. The transient expression assay using rice protoplasts revealed that OsIDD_2 negatively regulates the transcription of genes involved in lignin biosynthesis, cinnamyl alcohol dehydrogenase 2 and 3(CAD_2 and 3), and sucrose metabolism, sucrose synthase 5(SUS_5), whereas an Alpha Screen assay, which can detect the interaction between TFs and their target DNA sequences, directly confirmed the interaction between OsIDD_2 and the target sequences located in the promoter regions of CAD_2 and CAD_3. Based on these observations, we conclude that OsIDD_2 is negatively involved in SCW formation and other biological events by downregulating its target genes. | Peng Huang Hideki Yoshida Kenji Yano Shunsuke Kinoshita Kyosuke Kawai Eriko Koketsu Masako Hattori Sayaka Takehara Ji Huang Ko Hirano Reynante Lacsamana Ordonio Makoto Matsuoka Miyako Ueguchi-Tanaka | 2018 | Journal of Integrative Plant Biology2018，60，2： | 3 |
| 5 | Safe drug treatment and procedure for herpes zoster in pregnancy:a case report显示文摘To the Editor:A first infection of varicella-zoster virus(VZV)during pregnancy can cause serious systemic disease to both mother and the fetus.Despite this maternal herpes zoster(HZ)does not increase fetal mortality,and the transmission of varicella-zoster virus to the fetus rarely occurs.Although HZ infection has a minimal effect on the fetus,maternal HZ can cause significant complications for the mother. | Ji Yeong Kim You Ri Ko Sung Eun Sim Sua Oh Mi Hyeon Lee Hue Jung Park | 2020 | Chinese Medical Journal2020，，16： | 2 |
| 6 | Interplay between ABA and GA Modulates the Timing of Asymmetric Cell Divisions in the Arabidopsis Root Ground Tissue显示文摘在多细胞的有机体,控制预定和不对称的细胞部门(ACD ) 的程度为正确 patterning 是关键的。在在 Arabidopsis thaliana 的 embryonic 以后根开发期间,地面织物(GT ) 成熟包含内皮的另外的 ACD,它产生二不同纸巾:内皮(内部) 并且中间的外皮(外部) 。这被报导了 abscisic 酸(骆驼毛的织物) 和赤霉素(GA ) 小径涉及中间的外皮(MC ) 形成。然而,在 GT 成熟期间位于在骆驼毛的织物和 GA 之间的相互作用下面的分子的机制仍然保持大部分未知。通过 transcriptome 分析,我们识别了一以前 uncharacterized C 2 H 2-type 锌手指基因,其表情被 GA 和骆驼毛的织物调整,因此命名的 GAZ (GA- 和骆驼毛的织物应答的锌手指) 。幼苗宫外地 overexpressing GAZ (GAZ 公牛) 在 MC 形成期间对骆驼毛的织物和 GA 敏感,而 GAZ-SRDX 和 RNAi 幼苗显示了相反的显型。另外,我们的结果显示 GAZ 涉及骆驼毛的织物和 GA 动态平衡的 transcriptional 规定。与那件骆驼毛的织物和 GA 协调控制预定 MC 形成的以前的研究一致,我们也证实了在骆驼毛的织物和 GA 之间的唯一的相互影响并且识别了在 Arabidopsis 根的 GT 成熟期间衔接二条荷尔蒙小径的因素和规章的网络。 | Shin Ae Lee Sejeong Jang Eun Kyung Yoon Jung-Ok Heo Kwang Suk Chang Ji Won Choi Souvik Dhar Gyuree Kim Jeong-Eun Choe Jae Bok Heo Chian Kwon Jae-Heung Ko Yong-Sic Hwang Jun Lim | 2016 | Molecular Plant2016，9，6： | 2 |
| 7 | Skin diseases in the Da Qing Diabetes Study:a cross-sectional study显示文摘Background:The prevalence of skin diseases and diabetes mellitus(DM)are prominent around the world.The current scope of knowledge regarding the prevalence of skin diseases and comorbidities with type 2 DM(T2DM)is limited,leading to limited recognition of the correlations between skin diseases and T2DM.Methods:We collected 383 subjects from the Da Qing Diabetes Study during the period from July 9th to September 1st,2016.The subjects were categorized into three groups:Normal glucose tolerance(NGT),impaired glucose tolerance(IGT),and T2DM.The prevalence and clinical characteristics of skin diseases were recorded and investigated.Results:In this cross-sectional study,383 individuals with ages ranging from 53 to 89-year-old were recruited.The overall prevalence of skin diseases was 93.5%,and 75.7%of individuals had two or more kinds of skin diseases.Additionally,there were 47 kinds of comorbid skin diseases in patients with T2DM,of which eight kinds of skin diseases had a prevalence>10%.The prevalence of skin diseases in NGT,IGT,and T2DM groups were 93.3%,91.5%,and 96.6%,respectively;stratified analysis by categories showed a statistically significant difference in'disturbances of pigmentation'and'neurological and psychogenic dermatoses'.The duration of T2DM also significantly associated with the prevalence of'disturbances of pigmentation'and'neurological and psychogenic dermatoses'.Subsequently,the prevalence of'disturbances of pigmentation'was higher in males than females in NGT(P<0.01)and T2DM(P<0.01)groups.In addition,the difference in the prevalence of'disturbances of pigmentation'was also significant in NGT and T2DM groups(P<0.01).Conclusions:There was a high prevalence of skin diseases in the Da Qing Diabetes Study.To address the skin diseases in the Da Qing Diabetes Study,increased awareness and intervention measures should be implemented. | Chang-Bing Shen Xin Qian Rui-Xing Yu Xue-Lei Ji Yin-Juan Shi Jing Gao Cheng-Xu Li Ke-Ke Li Wen-Min Fei Xue Shen Zi-Yi Wang Yang Han Xiao-Li Ning Randy Ko Yi-Hsiang Hsu Xian-Yong Yin Guang-Wei Li Yong Cui | 2021 | Chinese Medical Journal2021，，10： | 2 |
| 8 | Treadmill exercise inhibits apoptotic neuronal cell death with suppressed vascular endothelial growth factor expression in the retinas of the diabetic rats 显示文摘 | JI E S KO I G CHO J W | 2013 | Exerc Rehabil2013，9，3： | 1 |
| 9 | The selection of volume ratio of two-stage rotary compressor and its effects on air-to-water heat pump with flash tank cycle显示文摘 | Younghwan Ko Sangkyoung Park Simon Jin Byungsoon Kim Ji Hwan Jeong | 2013 | Applied Energy2013，，： | 1 |
| 10 | Preparation of size-controlled bovine serum albumin (BSA) nanoparticles by a modified desolvation method显示文摘 | Ji Yeon Jun Hoang Hai Nguyen Sae-Yeol-Rim Paik Hyang Sook Chun Byeong-Cheol Kang Sanghoon Ko | 2011 | Food Chemistry2011，，4： | 1 |
| 11 | Tandem Synthesis of Photoactive Benzodifuran Moieties in the Formation of Microporous Organic Networks显示文摘 | Narae Kang Ji Hoon Park Kyoung Chul Ko Jiseul Chun Eunchul Kim Hee‐Won Shin Sang Moon Lee Hae Jin Kim Tae Kyu Ahn Jin Yong Lee Seung Uk Son | 2013 | Angew. Chem. Int. Ed2013，，24： | 1 |
| 12 | An unusual case of cerebral penetrating injury by a driven bone fragment secondary to blunt head trauma显示文摘 | Lee JI Ko JK Cha SH | 2011 | J Korean Neurosurg Soc2011，12，50： | 1 |
| 13 | An adequate level of training for technical competence in screening and diagnostic colonoscopy: a prospective multicenter evaluation of the learning curve显示文摘 | Suck-Ho Lee Il-Kwun Chung Sun-Joo Kim Jin-Oh Kim Bong-Min Ko Young Hwangbo Won Ho Kim Dong Hun Park Sang Kil Lee Cheol Hee Park Il-Hyun Baek Dong Il Park Seun-Ja Park Jeong-Seon Ji Byung-Ik Jang Yoon-Tae Jeen Jeong Eun Shin Jeong-Sik Byeon Chang-Soo Eun D | 2008 | Gastrointestinal Endoscopy2008，，4： | 1 |
| 14 | The effect of boron on the abrasive wear behavior of austenitic Fe-based hardfacing alloys显示文摘 | Ji Hui Kim Kang Hee Ko Seung Dae Noh Gyung Guk Kim Seon Jin Kim | 2009 | Wear2009，，9： | 1 |
| 15 | Outcome for children treated for relapsed or refractory acute myelogenous leukemia (rAML):a Therapeutic Advances in Childhood Leukemia(TACL) Consortium study显示文摘 | Gorman MF Ji L Ko RH | 2010 | Pediatr Blood Cancer2010，55，3： | 1 |
| 16 | A novel approach for detecting hypercoagulability utilizing thromboelastography 显示文摘 | KO R H JI L YOUNG G | 2013 | Hemorrhage and Hemostasis2013，131，4： | 1 |
| 17 | Measuring balance in the elderly : preliminary development of an instrument 显示文摘 | Berg KO Wood-Dauphinee S William JI | 1989 | Physiother Can1989，41，23： | 1 |
| 18 | Measuring balance in the elderly: validation of an instrument显示文摘 | Berg KO Wood-Dauphinee SL Williams JI | 1992 | Can J Public Health1992，83，2： | 1 |
| 19 | Measuring balance in the eloerly :validation of an instrument显示文摘 | Berg KO Wood Dauphinee SL Williams JI | 1992 | Can J Public Health1992，83，2： | 1 |
| 20 | Changing pattern of antibiotic resistance of H elicobacter pylori in children during 20 years in J inju, S outh K orea显示文摘 | Ji‐Hyun Seo Jin‐Su Jun Jung Sook Yeom Ji Sook Park Hee‐Shang Youn Gyung‐Hyuck Ko Seung‐Chul Baik Woo‐Kon Lee Myung‐Je Cho Kwang‐Ho Rhee | 2013 | Pediatr Int2013，，3： | 1 |
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