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| 1 | Cyclooxygenase-2 expression after preoperative chemoradiotherapy correlates with more frequent esophageal cancer recurrence显示文摘AIM: To investigate the relationship between cycloo- xygenase-2 (COX-2), and vascular endothelial growth factor (VEGF), and to determine the clinical significance of this relationship in esophageal cancer patients undergoing chemoradiotherapy (CRT). METHODS: Immunohistochemical staining was used to evaluate COX-2 and VEGF expression in 40 patients with histologically-confirmed esophageal squamous carcinoma (ESCC) who were undergoing preoperative CRT. RESULTS: Fourteen out of 40 ESCC patients showed a pathological complete response (CR) after CRT. COX-2 and VEGF protein expressions were observed in the cytoplasm of 17 and 13 tumors, respectively, with null expression in 9 and 13 tumors, respectively. COX-2 expression was strongly correlated with VEGF expression (P < 0.05). There were also significant associations between COX-2 expression, tumor recurrence, and lymph-node involvement (P = 0.0277 and P = 0.0095, respectively). COX-2 expression and VEGF expression had significant prognostic value for disease-free survival (log-rank test; P = 0.0073 and P = 0.0341, respectively), but not for overall survival, as assessed by univariate analysis. CONCLUSION: Our results suggest that COX-2 expression correlates with VEGF expression and might be a useful prognostic factor for more frequent tumor recurrence in ESCC patients undergoing neoadjuvant CRT. These findings support the use of anti-angiogenic COX-2 inhibitors in the treatment of ESCC. | Reigetsu Yoshikawa Yoshinori Fujiwara Kenji Koishi Syoudou Kojima Tomohiro Matsumoto Hidenori Yanagi Takehira Yamamura Tomoko Hashimoto-Tamaoki Takashi Nishigami Tohru Tsujimura | 2007 | World Journal of Gastroenterology2007，13，16： | 9 |
| 2 | Persistent CXCR4 expression after preoperative chemoradiotherapy predicts early recurrence and poor prognosis in esophageal cancer显示文摘AIM: To study the effect of CXC chemokine receptor-4 (CXCR4) expression on disease progression and prognosis in esophageal cancer. METHODS: CXCR4 expression was evaluated in 37 patients with histologically confirmed esophageal squamous carcinomas (ESCC) undergoing preoperative chemoradiotherapy (CRT) by immunohistochemical staining. RESULTS: Eleven out of 37 ESCC patients showed a pathological complete response (CR) after CRT. CXCR4 protein expression was observed in cell cytoplasms of 13 tumors, and null expression was seen in 13 tumors. Distant recurrence was significantly more common in patients with positive CXCR4 expression (P = 0.0318). After a median follow-up time of 31.6 mo, 19 patients progressed (12 of 19 expressed positive CXCR4) and 11 died (10 of 11 expressed positive CXCR4). Overall survival was significantly correlated with lymph node metastasis (952.1 ± 53.8 d in negative group vs 475.1 ± 56.2 d in positive group, P = 0.023), distant metastasis (874.0 ± 60.4 d in negative group vs 434.9 ± 75.2 d in positive group, P = 0.014) and CRT (811.5 ± 51.2 d in responder group vs 459.6 ± 94.0 d in non-responder group, P = 0.00038) and further with an absence ofCXCR4 expression or no residual tumor (959.8 ± 51.0 d in null expression or no tumor group vs 412.0 ± 57.1 d in positive expression group, P = 0.0001). CONCLUSION: Persistent positive CXCR4 expression is implicated in tumor aggressiveness and poor prognosis in ESCC after CRT, and preoperative CRT may improve the prognosis of ESCC via CXCL12-CXCR4 signaling pathway. | Kenji Koishi Reigetsu Yoshikawa Tohru Tsujimura Tomoko Hashimoto-Tamaoki Syoudou Kojima Hidenori Yanagi Takehira Yamamura Yoshinori Fujiwara | 2006 | World Journal of Gastroenterology2006，12，47： | 9 |
| 3 | 采用Dytran软件进行轮胎水滑特性研究显示文摘 | Toshihiko Okano Masataka Koishi 高明 梁洪军 丁海峰(摘译) 冯希金(校) | 2007 | 轮胎工业2007，27，5： | 5 |
| 4 | Angptl3 regulates lipid metabolism in mice显示文摘 | Koishi R Ando Y Ono M | 2002 | Nat Genet2002，30，2： | 1 |
| 5 | Angptl3 regulates lipid metabolism in mice 显示文摘 | Koishi R Ando Y Ono M | 2002 | Nat Genet2002，30，2： | 1 |
| 6 | Cell heterogeneity upon myogenic differentiation: down-regulation of MyoD and Myf-5 generates reserve cells显示文摘 | Naoko Yoshida Shosei Yoshida Kyoko Koishi | 1998 | Journal of Cell Science1998，111，181： | 1 |
| 7 | MyoD protein accumulates in satellite cells and its neurally regulated in regenerating myotubes and skeletal muscle fibers显示文摘 | Koishi K Zhang M McLennan IS | 1995 | Dev Dyn1995，202，3： | 1 |
| 8 | Angptl3 regulates lipid metabolism in mice显示文摘 | Koishi R Ando Y Ono M | 2002 | Nat Genet2002，30，2： | 1 |
| 9 | Angptl3 regulates lipid metabolism in mice显示文摘 | Koishi R Ando Y YasunaquK | 2002 | Nat Genet2002，30，2： | 1 |
| 10 | Nanoscale hydrophobic interaction and nanobubble nucleation显示文摘 | Koishi T Yoo S Yasuoka K | 2004 | Physical Review Letters2004，93，18： | 1 |
| 11 | Angptl3 regulates lipid metabolism in mice 显示文摘 | Koishi R Ando Y Ono M | 2002 | Nat Genet2002，30，2： | 1 |
| 12 | Angptl3 regulates lipid metabolism in mice 显示文摘 | Koishi R Ando Y Ono M | 2002 | Nat Genet2002，30，2： | 1 |
| 13 | Intracellular target for photosensitization in cancer antiangiogenic photodynamic therapy mediated by polycation liposome显示文摘 | Yoshito Takeuchi Kanae Ichikawa Sei Yonezawa Kohta Kurohane Takayuki Koishi Mamoru Nango Yukihiro Namba Naoto Oku | 2004 | Journal of Controlled Release2004，，2： | 1 |
| 14 | The type 2 anti-Müllerian hormone receptor has splice variants that are dominant-negative inhibitors显示文摘 | Floriane M. Imhoff Dee Yang Suneeth F. Mathew Andrew N. Clarkson Yui Kawagishi Warren P. Tate Kyoko Koishi Ian S. McLennan | 2013 | FEBS Letters2013，，12： | 1 |
| 15 | Angptl3 regulates lipid metabolism in mice显示文摘 | KOISHI R ANDO Y ONO M | 2002 | Nat Genet2002，30，2： | 1 |
| 16 | Notch4 gene polymorphisms are not associated with autism in Japanese population显示文摘 | Koishi S Yamazaki K Yamamoto K | 2004 | Am J Med Genet B Neuropsychiatr Genet2004，125，： | 1 |
| 17 | Fundamental properties of powder,paste and mortar of surface modified cement and process of the surface modification显示文摘 | TANAKA I KOISHI M | 1999 | Construction and Building Materials1999，13，5： | 1 |
| 18 | MyoD protein accumulates in satellite cells and is neurally regulated in regenerating myotubes and skeletal muscle fibers显示文摘 | Koishi K Zhang M McLennan IS | 1995 | Dev Dyn1995，202，2： | 1 |
| 19 | Angptl 3 Regulates Lipid Metabolism in Mice显示文摘 | Koishi R Ando Y Ono M | 2002 | Nat Genet(S1061-4036)2002，30，： | 1 |
| 20 | Angptl3 regulates lipid metabolism in mice显示文摘 | Koishi R Ando Y Ono M | 2002 | Nat Genet2002，30，2： | 1 |
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