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| 1 | Serum and urine metabolomic fingerprinting in diagnostics of inflammatory bowel diseases显示文摘AIM:To evaluate the utility of serum and urine metabolomic analysis in diagnosing and monitoring of inflammatory bowel diseases(IBD).METHODS:Serum and urine samples were collected from 24 patients with ulcerative colitis(UC),19 patients with the Crohn’s disease(CD)and 17 healthy controls.The activity of UC was assessed with the Simple Clinical Colitis Activity Index,while the activity of CD was determined using the Harvey-Bradshaw Index.The analysis of serum and urine samples was performed using proton nuclear magnetic resonance(NMR)spectroscopy.All spectra were exported to Matlab for preprocessing which resulted in two data matrixes for serum and urine.Prior to the chemometric analysis,both data sets were unit variance scaled.The differences in metabolite fingerprints were assessed using partial least-squaresdiscriminant analysis(PLS-DA).Receiver operating characteristic curves and area under curves were used to evaluate the quality and prediction performance of the obtained PLS-DA models.Metabolites responsible for separation in models were tested using STATISTICA10 with the Mann-Whitney-Wilcoxon test and the Student’s t test(α=0.05).RESULTS:The comparison between the group of patients with active IBD and the group with IBD in remission provided good PLS-DA models(P value 0.002for serum and 0.003 for urine).The metabolites that allowed to distinguish these groups were:N-acetylated compounds and phenylalanine(up-regulated in serum),low-density lipoproteins and very low-density lipoproteins(decreased in serum)as well as glycine(increased in urine)and acetoacetate(decreased in urine).The significant differences in metabolomic profiles were also found between the group of patients with active IBD and healthy control subjects providing the PLS-DA models with a very good separation(P value<0.001 for serum and 0.003 for urine).The metabolites that were found to be the strongest biomarkers included in this case:leucine,isoleucine,3-hydroxybutyric acid,N-acetylated compounds,acetoacetate,glycine,phenylalanine and lactate(increased in serum),creatine,dimethyl sulfone,histidine,choline and its derivatives(decreased in serum),as well as citrate,hippurate,trigonelline,taurine,succinate and 2-hydroxyisobutyrate(decreased in urine).No clear separation in PLS-DA models was found between CD and UC patients based on the analysis of serum and urine samples,although one metabolite(formate)in univariate statistical analysis was significantly lower in serum of patients with active CD,and two metabolites(alanine and N-acetylated compounds)were significantly higher in serum of patients with CD when comparing jointly patients in the remission and active phase of the diseases.Contrary to the results obtained from the serum samples,the analysis of urine samples allowed to distinguish patients with IBD in remission from healthy control subjects.The metabolites of importance included in this case up-regulated acetoacetate and down-regulated citrate,hippurate,taurine,succinate,glycine,alanine and formate.CONCLUSION:NMR-based metabolomic fingerprinting of serum and urine has the potential to be a useful tool in distinguishing patients with active IBD from those in remission. | Tomasz Dawiskiba Stanislaw Deja Agata Mulak Adam Zabek Ewa Jawień Dorota Pawelka Miroslaw Banasik Agnieszka Mastalerz-Migas Waldemar Balcerzak Krzysztof Kaliszewski Jan Skóra Piotr Bar Krzysztof Korta Kornel Pormańczuk Przemyslaw Szyber Adam Litarski Piotr Mlynarz | 2014 | World Journal of Gastroenterology2014，20，1： | 15 |
| 2 | 应用微织构刀具的超声椭圆振动辅助切削研究显示文摘采用一种新型椭圆共振模式的振动切削结构,应用带有微观织构的硬质合金刀具对6061铝合金进行椭圆振动辅助切削研究。为了改善刀具前刀面在干切削过程中的摩擦状况以减少粘结,利用激光加工技术在硬质合金刀具前刀面分别生成圆形、交织矩形和并联矩形的微观织构。通过对6061铝合金进行正交干切削实验,对比带有织构刀具和常规刀具的切削效果,仿真分析不同织构对切削性能的影响。主要表征切削参数为切削力、切屑卷曲、刀具粘结和加工表面质量。结果表明:带有织构的刀具可在低速切削时改善切削效果,且矩形织构刀具的改善效果尤为明显。 | 何宇 邹平 王春雨 邢佑强 Kornel F.Ehmann | 2019 | 电加工与模具2019，0，4： | 4 |
| 3 | 面向硬切削的切削区域温度场解析建模及实验研究显示文摘硬切削加工过程中,切削温度及分布是影响刀具使用寿命和加工质量的关键因素之一,其中切削区域温度及分布的精确测量与预测一直是切削加工机理研究的热点和难题,主要问题是现有的温度测量方法很难实现对切削区域温度分布的原位(在接近切削作用区域)测量,其温度测量结果的时间和空间分辨率难以满足要求,因此切削区域温度预测模型的有效性和准确性难以得到验证。论文针对上述难题,在深入分析切削加工过程中材料塑性变形区复杂热力耦合效应的基础上, | 李林文 李斌 Kornel F.Ehmann | 2015 | 机械工程学报2015，51，10： | 3 |
| 4 | Forming and uniformity of shaft parts without a stub bar by axial closed-open-type cross-wedge rolling显示文摘To realize cross-wedge rolling of shaft parts without a stub bar in a short process,an axial closed-open-type cross-wedge rolling technique was proposed.Based on the strain characteristics in the rolling,evaluation indices of deformation uniformity were provided,and the DEFORM-3D software was adopted to conduct numerical simulations of the rolling process.The metal flow and strain distribution in all stages of the rolling process were analyzed.It is shown that the strain value of the rolled piece close to the end is relatively high while the overall strain distribution is uniform in the rolling process.When the percentage reduction in area is smaller,the fluctuation range of the equivalent strain will be lower and the overall uniformity of the rolled piece will be better.A variable angle wedge was implemented to make metal flow inward and eliminate concavity.Finally,rolling experiment was performed,which indicate that the shape of the rolled piece obtained is consistent with the simulation results.Concavity value in the rolling is decreased by 92%as compared to conventional open rolling.The research results lay a theoretical basis for realizing closed-open-type cross-wedge rolling without a stub bar. | Xue-dao Shu Song Zhang Kornel F.Ehmann Zi-xuan Li Yi-lun Wei | 2020 | Journal of Iron and Steel Research(International)2020，27，9： | 2 |
| 5 | Towards atomic and close-to-atomic scale manufacturing显示文摘Human beings have witnessed unprecedented developments since the 1760s using precision tools and manufacturing methods that have led to ever-increasing precision,from millimeter to micrometer,to single nanometer,and to atomic levels.The modes of manufacturing have also advanced from craft-based manufacturing in the Stone,Bronze,and Iron Ages to precisioncontrollable manufacturing using automatic machinery.In the past 30 years,since the invention of the scanning tunneling microscope,humans have become capable of manipulating single atoms,laying the groundwork for the coming era of atomic and close-to-atomic scale manufacturing(ACSM).Close-to-atomic scale manufacturing includes all necessary steps to convert raw materials,components,or parts into products designed to meet the user’s specifications.The processes involved in ACSM are not only atomically precise but also remove,add,or transform work material at the atomic and close-to-atomic scales.This review discusses the history of the development of ACSM and the current state-of-the-art processes to achieve atomically precise and/or atomic-scale manufacturing.Existing and future applications of ACSM in quantum computing,molecular circuitry,and the life and material sciences are also described.To further develop ACSM,it is critical to understand the underlying mechanisms of atomic-scale and atomically precise manufacturing;develop functional devices,materials,and processes for ACSM;and promote high throughput manufacturing. | Fengzhou Fang Nan Zhang Dongming Guo Kornel Ehmann Benny Cheung Kui Liu Kazuya Yamamura | 2019 | International Journal of Extreme Manufacturing2019，1，1： | 2 |
| 6 | Aldosterone increases transmembrane influx of Na+ in vascular smooth muscle cells through increased synthesis of Na+ channels显示文摘 | Kornel L Smosana KB | 1995 | Steroids1995，60，： | 1 |
| 7 | Intraoperative Endoscopy for the Assessment of Circular-stapled Anastomosis in Laparoscopic Colon Surgery显示文摘 | Andreas Shamiyeh Kornel Szabo Wolfgang Ulf Wayand Joerg Zehetner | 2012 | Surgical Laparoscopy Endoscopy & Percutaneous Techniques2012，，1： | 1 |
| 8 | An analyt-ical model of rotary ultrasonic milling显示文摘 | ErichBertsche Kornel Ehmann Kostyantyn Malukhin | | 0，，65： | 1 |
| 9 | Error model and accuracy analysis of a six-DOF stewart platform 显示文摘 | Wang S M Kornel F E | 2002 | Journal of Manufacturing Science and Engineering2002，124，2： | 1 |
| 10 | Thermophilic bio-hydrogen production from energy plants by Caldicellulosiruptor saccharolyticus and comparison with related studies显示文摘 | Galina i Gabor R Kornel K | 2009 | lnternational Journal of Hydrogen Energy2009，34，9： | 1 |
| 11 | Genetic diversity in sweetpotato [Ipomoea batatas (L.) Lam.] in relationship to geographic sources as assessed with RAPD markers显示文摘 | Simon Templar Gichuki Maria Berenyi Dapeng Zhang Michael Hermann Josef Schmidt Josef Gl?ssl Kornel Burg | 2003 | Genetic Resources and Crop Evolution2003，，4： | 1 |
| 12 | A genetic linkage map of sweetpotato [Ipomoea batatas (L.) Lam.] based on AFLP markers显示文摘 | Albert Kriegner Jim Carlos Cervantes Kornel Burg Robert O.M. Mwanga Dapeng Zhang | 2003 | Molecular Breeding2003，，3： | 1 |
| 13 | Identification and control for micro-drilling productivity enhancement显示文摘 | Cheong Man Sheel Cho Dong Woo Ehmann Kornel F | 1999 | International Journal of Machine Tools & Manufacture1999，39，： | 1 |
| 14 | Stability analysis of chatter on a tandem rolling mill 显示文摘 | Hu Pei-hua Kornel F E | 2000 | Journal of Manufacturing Proces- ses2000，2，4： | 1 |
| 15 | Intraoperative Endoscopy for the Assessment of Circular-stapled Anastomosis in Laparoscopic Colon Surgery显示文摘 | Andreas Shamiyeh Kornel Szabo Wolfgang Ulf Wayand Joerg Zehetner | 2012 | Surgical Laparoscopy, Endoscopy & Percutaneous Techniques2012，，： | 1 |
| 16 | Evidence for the presence in arterial walls of intracellular-molecular mechanism for action of miner alocorticoids 显示文摘 | Kornel L Ramsay C Kanamarlapudi N | 1982 | Clin Exp Hypertens A1982，4，910： | 1 |
| 17 | Identification and control for micro-drilling productivity enhancement 显示文摘 | Cheong Man sheel Cho dong Woo Kornel F ehmann | 1999 | International Journal of Machine Tool & Manufacture1999，，39： | 1 |
| 18 | Development of a virtual machining system, part 1: approximation of the size effect for cutting force prediction显示文摘 | Jeong Hoon Ko Won-Soo Yun Dong-Woo Cho Kornel F. Ehmann | 2002 | International Journal of Machine Tools and Manufacture2002，，15： | 1 |
| 19 | Evaluation of safety and efficacy of radiation-sterilized bone allografts in reconstructive oral surgery显示文摘 | Marta Krasny Kornel Krasny Artur Kamiński Ma?gorzata Zadurska Piotr Piekarczyk Piotr Fiedor | 2013 | Cell and Tissue Banking2013，，： | 1 |
| 20 | Two-dimensional photoacoustic imaging by use of Fourier transform image reconstruction and a detector with an anisotropic response显示文摘 | Kornel P Kostli Paul C Beard | 2003 | Appl Opt2003，42，10： | 1 |
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