|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | S phase-dependent interaction with DNMT1 dictates the role of UHRF1 but not UHRF2 in DNA methylation maintenance显示文摘最近的研究证明 UHRF1 被指向 DNMT1 到 DNA 复制 foci 为 DNA methylation 维护要求,大概通过它的唯一的半甲醇化物有 DNMT1 的 DNA 有约束力的活动和相互作用。UHRF2, UHRF 家庭蛋白质的另一个成员,高度类似于在顺序和结构的 UHRF1,关于它在 DNA methylation 的角色的涨的问题。在这研究,我们证明 UHRF2 象 UHRF1 一样,也优先地绑在 methylated histone H3 离氨酸 9 (H3K9 ) 通过它的保存 tudor,通过 SET 和戒指的领域和半甲醇化物 DNA 联系了领域。象 UHRF1 一样, UHRF2 在 pericentric heterochromatin 被充实。heterochromatin 本地化取决于到大程度它的 methylated H3K9 有约束力的活动并且到它的 methylated 上的更少的程度 DNA 有约束力的活动。Coimmunoprecipitation 实验证明 UHRF1 和 UHRF2 与 DNMT1, DNMT3a, DNMT3b 和 G9a 交往。尽管有所有这些保存功能,我们发现 UHRF2 不能在 Uhrf1 空老鼠救 DNA methylation 缺点胚胎的干细胞。这个罐头在房间周期的 S 阶段期间为 UHRF2 被归因于无能到成员 DNMT1 到复制 foci。确实,我们发现当 UHRF1 在房间以一种 S 阶段依赖者方式与 DNMT1 交往时, UHRF2 不做。因此,我们的学习证明 UHRF2 和 UHRF1 不在 DNA methylation 维护是机能上地冗余的并且作为为 DNA methylation 指向 DNMT1 的关键规章的机制揭示在 UHRF1 和 DNMT1 之间的 cell-cycle-dependent 相互作用。 | Jiqin Zhang Qinqin Gao Pishun Li Xiaoli Liu Yuanhui Jia Weicheng Wu Jiwen Li Shuo Dong Haruhiko Koseki Jiemin Wong | 2011 | Cell Research2011，21，12： | 12 |
| 2 | 用米卡芬净治疗恶性血液系统疾病可引起毛孢子菌感染显示文摘背景:米卡芬净(micafungin)是新一代的棘白菌素类抗真菌药物,它对念珠菌和曲霉感染的治疗十分有效。然而,这种新药对于某些真菌(包括毛孢子菌)的作用不大。我们观察到4例患者在使用米卡芬净的过程中发生了毛孢子菌感染。我院2001年开始使用该药,但直罕2003年1月才发现使用该药过程中会发生毛孢子菌感染。 | Matsue K Urvu H Koseki M 邓妍(编译) | 2006 | 中国处方药2006，，3： | 4 |
| 3 | PCL2 regulates p53 stability and functions as a tumor suppressor in breast cancer显示文摘Polycomblike2(PCL2) is a well-known component of polycomb repressive complex 2(PRC2) and plays important roles in H3 K27 methylation and homeotic gene silencing.However,the involvement of PCL2 in breast cancer development remains unclear.Here,we established PCL2 as a tumor suppressor gene in breast cancer.Expression level of PCL2 was significantly downregulated in breast cancer tissue samples observed at different TNM stages.Ectopic expression of PCL2 could significantly inhibit cell proliferation and promoted apoptosis.PCL2 also remarkably elevated levels of p53 and its targets by increasing p53 stability.Mechanistically,PCL2 protected p53 proteins from MDM2-mediated ubiquitination and degradation by sequestering MDM2 into the nucleolus.Overexpression of PCL2 also suppressed migration and invasion by inhibiting epithelial-mesenchymal transition.PCL2 expression was correlated with Ecadherin expression and was inversely correlated with vimentin expression.Furthermore,PCL2 knockdown could attenuate anti-tumor effect of MLN4924.Taken together,our findings indicated that PCL2 played a tumor suppressor role in development and progression of breast cancer and may be a prognostic and predictive marker for breast cancer. | Yiran Liang Yang Yang Renbo Guo Shuang Gao Xinghong Guo Danyang Li Meng Wang Haruhiko Koseki Xiangzhi Li | 2018 | Science Bulletin2018，63，10： | 4 |
| 4 | A multicenter, prospective validation of disseminated intravascular coagulation diagnostic criteria for critically ill patients: Comparing current criteria*显示文摘 | Satoshi Gando Toshiaki Iba Yutaka Eguchi Yasuhiro Ohtomo Kohji Okamoto Kazuhide Koseki Toshihiko Mayumi Atsuo Murata Toshiaki Ikeda Hiroyasu Ishikura Masashi Ueyama Hiroshi Ogura Shigeki Kushimoto Daizoh Saitoh Shigeatsu Endo Shuji Shimazaki | 2006 | Critical Care Medicine2006，，3： | 2 |
| 5 | Uplift behavior of underground structures caused by liquefaction of surrounding soil during earthquake 显示文摘 | KOSEKI J MATSUO O KOGA Y | 1997 | Soils and Foundations1997，37，1： | 1 |
| 6 | Prediction of microbial growth in freshcut vegetables treated with acidic electrolyzed water during storage under various temperature conditions显示文摘 | KOSEKI S ITOH K | 2001 | J Food Prot2001，64，12： | 1 |
| 7 | Shaking and tilt table tests of geosynthetic-reinforced soil and conventional- type retaining walls 显示文摘 | KOSEKI J MUNAF Y TASTSUOKA F | 1998 | Geosynthetics Intemational Industral Fabrics Assoc Int1998，5，1： | 1 |
| 8 | Prediction of microbial growth in fresh cut vegetables treated with acidic electrolyzedwater during storage under various temperature conditions显示文摘 | KOSEKI S ITOH K | 2001 | Journal of Food Protection2001，64，12： | 1 |
| 9 | Evaluation on thermal hazard of methyl ethyl ketone peroxide by using adiabatic method显示文摘 | FU Zhi-min LI Xin-rui Koseki H | 2003 | Journal of Loss Prevention in the Process Industries2003，16，5： | 1 |
| 10 | Adipanectinp revents atherosclerosis by increasing cholesterol efflux from macrophages显示文摘 | Tsubakio-Yamamoto K Matsuura F Koseki M | 2008 | Biochem Biophys Res Commun2008，375，3： | 1 |
| 11 | Intraocular pressure and central visual field of normal tension glaucoma 显示文摘 | Araie M Kitazawa M Koseki N | 1997 | Br J Ophthalmol1997，81，： | 1 |
| 12 | Giant adrenal myelolipoma: report of a case 显示文摘 | AKAMATSU H KOSEKI M NAKABA H | 2004 | Surg Today2004，34，： | 1 |
| 13 | Effect of mild heat pretreatment with alkaline electrolyzed water on the efficacy of acidic electrolyzed water against Escherichia coli O157 : H7 and Salmonella on Lettuce显示文摘 | KOSEKI S YOSHIDA K KAMITANI Y | 2004 | Food Microbiology2004，21，5： | 1 |
| 14 | Numerical simulation of equiaxed grain formation in weld solidification 显示文摘 | Koseki T Inoue H Fukudac Y | 2003 | Science and Technology of Advanced Materials2003，4，： | 1 |
| 15 | Aerodynamic Performance of a Centrifugal Compressor With Vaned Diffusers显示文摘 | Yoshinaga Y Gyobu I Mishina H Koseki F | 1980 | ASME Journal of Fuids Engineering1980，102，12： | 1 |
| 16 | Estimation of thermal balance in heptane pool fire显示文摘 | Hiroshi Koseki and Hiroshi Hayasaka | 1989 | Journal of Fire Science1989，，7： | 1 |
| 17 | Nitric oxide mediates excitotoxic and anoxic damage in rat retinal ganglion cells cocultured with astroglia显示文摘 | Morgan J Caprioli J Koseki Y | 1999 | Arch Ophthalmol1999，117，11： | 1 |
| 18 | Predicting the self-accelerating decomposition temperature (SADT) of organic peroxides based on non-isothermal decomposition behavior显示文摘 | Dong Y Hiroshi Koseki Kazutoshi Hasegawa | 2003 | Journal of Loss Prevention in the Process Industries2003，16，： | 1 |
| 19 | Analysis of polyethylene particles isolated from periprosthetic tissue of loosened hip arthroplasty and comparison with radiographic appearance 显示文摘 | Koseki H Matsumoto T Ito S | 2005 | J Orthop Sci2005，10，3： | 1 |
| 20 | Prediction of microbical groth in fresh-cut vegetables treated with acidic electrolyzed water during storage under various temperature conditions显示文摘 | KOSEKI S ITOH K | 2001 | Journal of Food Protection2001，64，12： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员