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| 1 | Chromoendoscopy of gastric adenoma using an acetic acid indigocarmine mixture显示文摘AIM:To investigate the usefulness of chromoendoscopy,using an acetic acid indigocarmine mixture(AIM),for gastric adenoma diagnosed by forceps biopsy.METHODS:A total of 54 lesions in 45 patients diagnosed as gastric adenoma by forceps biopsy were prospectively enrolled in this study and treated by endoscopic submucosal dissection(ESD)between January 2011 and January 2012.AIM-chromoendoscopy(AIMCE)was performed followed by ESD.AIM solution was sprinkled and images were recorded every 30 s for 3min.Clinical characteristics such as tumor size(<2cm,≥2 cm),surface color in white light endoscopy(WLE)(whitish,normochromic or reddish),macroscopic appearance(flat or elevated,depressed),and reddish change in AIM-CE were selected as valuables.RESULTS:En bloc resection was achieved in all 54 cases,with curative resection of fifty two lesions(96.3%).Twenty three lesions(42.6%)were diagnosed as welldifferentiated adenocarcinoma and the remaining 31lesions(57.4%)were gastric adenoma.All adenocarcinoma lesions were well-differentiated tubular adenocarcinomas and were restricted within the mucosal layer.The sensitivity of reddish color change in AIM-CE is significantly higher than that in WLE(vs tumor size≥2 cm,P=0.016,vs normochromic or reddish surface color,P=0.046,vs depressed macroscopic type,P=0.0030).On the other hand,no significant differences were found in the specificity and accuracy.In univariate analysis,normochromic or reddish surface color in WLE(OR=3.7,95%CI:1.2-12,P=0.022)and reddish change in AIM-CE(OR=14,95%CI:3.8-70,P<0.001)were significantly related to diagnosis of early gastric cancer(EGC).In multivariate analysis,only reddish change in AIM-CE(OR=11,95%CI:2.3-66,P=0.0022)was a significant factor associated with diagnosis of EGC.CONCLUSION:AIM-CE may have potential for screening EGC in patients initially diagnosed as gastric adenoma by forceps biopsy. | Yoshiyasu Kono Ryuta Takenaka Yoshiro Kawahara Hiroyuki Okada Keisuke Hori Seiji Kawano Yasushi Yamasaki Koji Takemoto Takayoshi Miyake Shigeatsu Fujiki Kazuhide Yamamoto | 2014 | World Journal of Gastroenterology2014，20，17： | 12 |
| 2 | Tolerability of magnifying narrow band imaging endoscopy for esophageal cancer screening显示文摘AIM:To compare the tolerability of magnifying narrow band imaging endoscopy for esophageal cancer screening with that of lugol chromoendoscopy.METHODS:We prospectively enrolled and analyzed 51 patients who were at high risk for esophageal cancer.All patients were divided into two groups:a magnifying narrow band imaging group,and a lugol chromoendoscopy group,for comparison of adverse symptoms.Esophageal cancer screening was performed on withdrawal of the endoscope.The primary endpoint was a score on a visual analogue scale for heartburn after the examination.The secondary endpoints were scale scores for retrosternal pain and dyspnea after the examinations,change in vital signs,total procedure time,and esophageal observation time.RESULTS:The scores for heartburn and retrosternal pain in the magnifying narrow band imaging group were significantly better than those in the lugol chromoendoscopy group(P =0.004,0.024,respectively,ANOVA for repeated measures).The increase in heart rate after the procedure was significantly greater in the lugol chromoendoscopy group.There was no significant difference between the two groups with respect to othervital sign.The total procedure time and esophageal observation time in the magnifying narrow band imaging group were significantly shorter than those in the lugol chromoendoscopy group(450 ± 116 vs 565 ± 174,P =0.004,44 ± 26 vs 151 ± 72,P < 0.001,respectively).CONCLUSION:Magnifying narrow band imaging endoscopy reduced the adverse symptoms compared with lugol chromoendoscopy.Narrow band imaging endoscopy is useful and suitable for esophageal cancer screening periodically. | Yasushi Yamasaki Ryuta Takenaka Keisuke Hori Koji Takemoto Seiji Kawano Yoshiro Kawahara Hiroyuki Okada Shigeatsu Fujiki Kazuhide Yamamoto | 2015 | World Journal of Gastroenterology2015，21，9： | 5 |
| 3 | ADCP application for long-term monitoring of coastal water显示文摘Three kind of application of ADCP is reported for long-term monitoring in coastal sea.(1)The rourine monitoring of water qualities.The water quality and ADCP echo data (600 kHz) observed in the long-term are analgzed at MT (Marine Tower) Station of Kansai International Airport in the Osaka Bay, Japan. The correlation between the turbidity and echo intensity in the surface layer is not good because air bubbles generated by breaking wave are not detected by the turbidity meter, but detected well by ADCP. When estimating the turbidity consists of plankton population from echo intensity, the effect ofbubbles have to be eliminated. (2) Monitoring stirring up of bottom sediment. The special observation was carded out by using following two ADCP in the Osaka Bay, One ADCP was installed upward on the sea. The other ADCP was hanged downward at the gate type stand about 3 m above from the bottom. At the spring tide, high echo intensities indicating the stirring up of bottom sediment were observed. (3) The monitoring for the boundary condition of water mixing at an estuary. In summer season, the ADCP was set at the mouth of Tanabe Bay in Wakayama Prefecture, Japan.During the observation, water temperature near the bottom showed remarkable falls with interval of about 5~7 d. When the bottom temperature fell, the inflow current with low echo intensity water appears at the bottom layer in the ADCP record. It is concluded that when occasional weak northeast wind makes weak coastal upwelling at the mouth of the bay, the combination of upwelling with internal tidal flow causes remarkable water exchange and dispels the red tide. | YOSHIOKA Hiroshi TAKAYAMA Tomotsuka SERIZAWA Shigeatsu | 2005 | Acta Oceanologica Sinica2005，24，1： | 4 |
| 4 | A multicenter, prospective validation of disseminated intravascular coagulation diagnostic criteria for critically ill patients: Comparing current criteria*显示文摘 | Satoshi Gando Toshiaki Iba Yutaka Eguchi Yasuhiro Ohtomo Kohji Okamoto Kazuhide Koseki Toshihiko Mayumi Atsuo Murata Toshiaki Ikeda Hiroyasu Ishikura Masashi Ueyama Hiroshi Ogura Shigeki Kushimoto Daizoh Saitoh Shigeatsu Endo Shuji Shimazaki | 2006 | Critical Care Medicine2006，，3： | 2 |
| 5 | Endoscopic submucosal dissection for cancers of the remnant stomach after distal gastrectomy显示文摘 | Ryuta Takenaka Yoshiro Kawahara Hiroyuki Okada Takao Tsuzuki Satoru Yagi Jun Kato Nobuya Ohara Tadashi Yoshino Atsushi Imagawa Shigeatsu Fujiki Rie Takata Masahiro Nakagawa Motowo Mizuno Tomoki Inaba Tatsuya Toyokawa Kohsaku Sakaguchi | 2008 | Gastrointestinal Endoscopy2008，，2： | 2 |
| 6 | Usefulness of procalcitonin serum level for the discrimination of severe sepsis from sepsis: a multicenter prospective study显示文摘 | Shigeatsu Endo Naoki Aikawa Seitaro Fujishima | 2008 | Journal of infec- tion and chemotherapy official journal of the Japan Society of Chemotherapy2008，14，3： | 1 |
| 7 | SIRS-ASSOCIATED COAGULOPATHY AND ORGAN DYSFUNCTION IN CRITICALLY ILL PATIENTS WITH THROMBOCYTOPENIA显示文摘 | Hiroshi Ogura Satoshi Gando Toshiaki Iba Yutaka Eguchi Yasuhiro Ohtomo Kohji Okamoto Kazuhide Koseki Toshihiko Mayumi Atsuo Murata Toshiaki Ikeda Hiroyasu Ishikura Masashi Ueyama Shigeki Kushimoto Daizoh Saitoh Shigeatsu Endo Shuji Shimazaki | 2007 | Shock2007，，4： | 1 |
| 8 | Endoscopic Submucosal Dissection for a Superficial Esophageal Squamous Cell Carcinoma within the Parabronchial Diverticula显示文摘 | Tatsuhiro Gotoda Ryuta Takenaka Toshihiro Inokuchi Shigeatsu Fujiki | 2012 | Digestive Endoscopy2012，，1： | 1 |
| 9 | Usefulness of presepsin in the diagnosis of sepsis in a multicenter prospective study显示文摘 | Shigeatsu Endo Yasushi Suzuki Gaku Takahashi Tatsuyori Shozushima Hiroyasu Ishikura Akira Murai Takeshi Nishida Yuhei Irie Masanao Miura Hironobu Iguchi Yasuo Fukui Kimiaki Tanaka Tsuyoshi Nojima Yoshikazu Okamura | 2012 | Journal of Infection and Chemotherapy2012，，6： | 1 |
| 10 | Regulating migration of esophageal stents-management using a Sengstaken-Blakemore tube:A case report and review of literature显示文摘Stent migration, which causes issues in stent therapy for esophageal perforations, can counteract the therapeutic effects and lead to complications. Therefore, techniques to regulate stent migration are important and lead to effective stent therapy. Here, in these cases, we placed a removable fully covered self-expandable metallic stent(FSEMS) in a 52-year-old man with suture failure after surgery to treat Boerhaave syndrome, and in a 53-yearold man with a perforation in the lower esophagus due to acute esophageal necrosis. At the same time, we nasally inserted a Sengstaken-Blakemore tube(SBT), passing it through the stent lumen. By inflating a gastric balloon, the lower end of the stent was supported. When the stent migration was confirmed, the gastric balloon was lifted slightly toward the oral side to correct the stent migration. In this manner, the therapy was completed for these two patients. Using a FSEMS and SBT is a therapeutic method for correcting stent migration and regulating the complete migration of the stent into the stomach without the patient undergoing endoscopic rearrangement of the stent. It was effective for positioning a stent crossing the esophagogastric junction. | Hisaho Sato Kaoru Ishida Shusaku Sasaki Masahiro Kojika Shigeatsu Endo Yoshihiro Inoue Akira Sasaki | 2018 | World Journal of Gastroenterology2018，24，28： | 1 |
| 11 | Risk factors associated with local recurrence of early gastric cancers after endoscopic submucosal dissection显示文摘 | Ryuta Takenaka Yoshiro Kawahara Hiroyuki Okada Keisuke Hori Masafumi Inoue Seiji Kawano Daisuke Tanioka Takao Tsuzuki Satoru Yagi Jun Kato Masayuki Uemura Nobuya Ohara Tadashi Yoshino Atsushi Imagawa Shigeatsu Fujiki Rie Takata Kazuhide Yamamoto | 2008 | Gastrointestinal Endoscopy2008，，5： | 1 |
| 12 | Predicting the Severity of Systemic Inflammatory Response Syndrome (SIRS)-Associated Coagulopathy With Hemostatic Molecular Markers and Vascular Endothelial Injury Markers显示文摘 | Toshiaki Iba Satoshi Gando Atsuo Murata Shigeki Kushimoto Daizoh Saitoh Yutaka Eguchi Yasuhiro Ohtomo Kohji Okamoto Kazuhide Koseki Toshihiko Mayumi Toshiaki Ikeda Hiroyasu Ishhikura Masashi Ueyama Yuji Ogura Shigeatsu Endo Shuji Shimazaki | 2007 | The Journal of Trauma: Injury, Infection, and Critical Care2007，，5： | 1 |
| 13 | Effect of linezolid on cytokine production capacity and plasma endotoxin levels in response to lipopolysaccharide stimulation of whole blood显示文摘 | Gaku Takahashi Nobuhiro Sato Yasunori Yaegashi Masahiro Kojika Naoya Matsumoto Tomohiro Kikkawa Tatsuyori Shozushima Shinji Akitomi Kiichi Aoki Naoko Ito Koichi Hoshikawa Yasushi Suzuki Yoshihiro Inoue Go Wakabayashi Shigeatsu Endo | 2010 | Journal of Infection and Chemotherapy2010，，： | 1 |
| 14 | CASE REPORT: Acute Pancreatitis Induced by Diffuse Pancreatic Invasion of Adult T-cell Leukemia/Lymphoma Cells显示文摘 | Akinori Mori Yasuharu Kikuchi Shigeatsu Motoori Jun’ichiro Watanabe Masami Shinozaki Masanobu Eguchi | 2003 | Digestive Diseases and Sciences2003，，10： | 1 |
| 15 | Diagnostic role of 18F-fluorodeoxyglucose positron emission tomography for follicular lymphoma with gastrointestinal involvement显示文摘AIM:To investigate the capacity for 18F-fluorodeoxyglucose(18F-FDG) positron emission tomography(PET) to evaluate patients with gastrointestinal lesions of follicular lymphoma.METHODS:This retrospective case series consisted of 41 patients with follicular lymphoma and gastrointestinal involvement who underwent 18F-FDG-PET and endoscopic evaluations at ten different institutions between November 1996 and October 2011.Data for endoscopic,radiological,and biological examinations performed were retrospectively reviewed from clinical records.A semi-quantitative analysis of 18F-FDG uptake was performed for each involved area by calculating the maximum standardized uptake value(SUVmax).Based on the positivity of 18F-FDG uptake in the gastrointestinal lesions analyzed,patients were subdivided into two groups.To identify potential predictive factors for 18F-FDG positivity,these two groups were compared with respect to gender,age at diagnosis of lymphoma,histopathological grade,pattern of follicular dendritic cells,mitotic rate,clinical stage,soluble interleukin-2 receptor levels detected by 18F-FDG-PET,lactate dehydrogenase(LDH) levels,hemoglobin levels,bone marrow involvement,detectability of gastrointestinal lesions by computed tomography(CT) scanning,and follicular lymphoma international prognostic index(FLIPI) risk.RESULTS:Involvement of follicular lymphoma in the stomach,duodenum,jejunum,ileum,cecum,colon,and rectum was identified in 1,34,6,3,2,3,and 6 patients,respectively.No patient had esophageal involvement.In total,19/41(46.3%) patients exhibited true-positive 18F-FDG uptake in the lesions present in their gastrointestinal tract.In contrast,false-negative 18F-FDG uptake was detected in 24 patients(58.5%),while false-positive 18F-FDG uptake was detected in 5 patients(12.2%).In the former case,2/19 patients had both 18F-FDG-positive lesions and 18F-FDGnegative lesions in the gastrointestinal tract.In patients with 18F-FDG avidity,the SUVmax value of the involved gastrointestinal tract ranged from 2.6 to 17.4(median:4.7).For the 18F-FDG-negative(n = 22) and-positive(n = 19) groups,there were no differences in the male to female ratios(10/12 vs 4/15,P = 0.186),patient age(63.6 ± 2.4 years vs 60.1 ± 2.6 years,P = 0.323),presence of histopathological grade 1 vs 2(20/2 and 17/2,P = 1.000),follicular dendritic cell pattern(duodenal/nodal:13/5 vs 10/3,P = 1.000),mitotic rate(low/partly high,14/1 vs 10/3,P = 0.311),clinical stage according to the Ann Arbor system(stages ⅠE and ⅡE/other,15/7 vs 15/4,P = 0.499),clinical stage according to the Lugano system(stages Ⅰ and Ⅱ-1/other,14/8 vs 14/5,P = 0.489),soluble interleukin-2 receptor levels(495 ± 78 vs 402 ± 83,P = 0.884),LDH levels(188 ± 7 vs 183 ± 8,P = 0.749),hemoglobin levels(13.5 ± 0.3 vs 12.8 ± 0.4,P = 0.197),bone marrow involvement(positive/negative,1/8 vs 1/10,P = 1.000),detectability by CT scanning(positive/negative,1/16 vs 4/13,P = 0.335),and FLIPI risk(low risk/other,16/6 vs 13/6,P = 0.763),respectively in each case.CONCLUSION:These findings indicate that it is not feasible to predict 18F-FDG-avidity.Therefore,18FFDG-PET scans represent a complementary modality for the detection of gastrointestinal involvements in follicular lymphoma patients,and surveillance of the entire gastrointestinal tract by endoscopic examinations is required. | Masaya Iwamuro Hiroyuki Okada Katsuyoshi Takata Katsuji Shinagawa Shigeatsu Fujiki Junji Shiode Atsushi Imagawa Masashi Araki Toshiaki Morito Mamoru Nishimura Motowo Mizuno Tomoki Inaba Seiyu Suzuki Yoshinari Kawai Tadashi Yoshino Yoshiro Kawahara Akinobu Takaki Kazuhide Yamamoto | 2012 | World Journal of Gastroenterology2012，18，44： | 1 |
| 16 | The Presence of Large Serrated Polyps Increases Risk for Colorectal Cancer显示文摘 | Sakiko Hiraoka Jun Kato Shigeatsu Fujiki Eisuke Kaji Tamiya Morikawa Takatoshi Murakami Toru Nawa Motoaki Kuriyama Toshio Uraoka Nobuya Ohara Kazuhide Yamamoto | 2010 | Gastroenterology2010，，5： | 1 |
| 17 | Usefulness of procalcitonin serum level for the discrimination of severe sepsis from sepsis: a multicenter prospective study显示文摘 | Shigeatsu Endo Naoki Aikawa Seitaro Fujishima Isao Sekine Kazuhiro Kogawa Yasuhiro Yamamoto Shigeki Kushimoto Hidekazu Yukioka Noboru Kato Kyoichi Totsuka Ken Kikuchi Toshiaki Ikeda Kazumi Ikeda Hiroyuki Yamada Kazuaki Harada Shinji Satomura | 2008 | Journal of Infection and Chemotherapy2008，，3： | 1 |
| 18 | Effects of losartan, a nonpeptide angiotensin Ⅱ receptor antagonist, on cardiac hypertrophy and the tissue angiotensin Ⅱ content in spontaneously hypertensive rats 显示文摘 | Kenji M Makio T Shigeatsu H | 1992 | Life Science1992，51，4： | 1 |
| 19 | Randomized Study of the Benefits of Preoperative Corticosteroid Administration on the Postoperative Morbidity and Cytokine Response in Patients Undergoing Surgery for Esophageal Cancer显示文摘 | Nobuhiro Sato Keisuke Koeda Kenichiro Ikeda Yusuke Kimura Kiichi Aoki Takeshi Iwaya Yuji Akiyama Kaoru Ishida Kazuyoshi Saito Shigeatsu Endo | 2002 | Annals of Surgery2002，，2： | 1 |
| 20 | Sa1667 Reddish Color Change in AIM-Chromoendoscopy in Patients With Early Gastric Cancer显示文摘 | Ryuta Takenaka Yoshiro Kawahara Yoshiyasu Kono Yasushi Yamasaki Daisuke Kawai Koji Takemoto Akihiko Taira Hirofumi Tsugeno Shigeatsu Fujiki | 2013 | Gastrointestinal Endoscopy2013，，5： | 1 |
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