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| 1 | Relationship between petroleum hydrocarbon and plankton in a mesocosm experiment显示文摘A mesocosm experiment was carried out from May 26 to June 1, 1998 at the location of 30’52’N, 122’36’E, the Changjiang Estuary, in order to measure the influence of petroleum hydrocar- bon to the ecosystem, furthermore, to estimate the environmental capacity. In the experiment, it is found that the petroleum hydrocarbon can, in some degree, enhance the growth of diatom, but inhibit the growth of dinoflagellate. In general, the petroleum hydrocarbon can inhibit the growth of both Phytoplankton and zooplankton, and can the inhibit the growth of total plankton (including phytoplankton and zooplankton) as well. A kinetic model was presented to estimate the uptake/release rate constants of petroleum hydrocarbon by plankton, and thereafter, the uptake and release rate constants (k1, k2), bioconcentration factor (BCF) as well as the petroleum bydrocarbon influenced influenced uptake and release rate constants of nutrients by phytoplankton (kup, krel) were obtained. The results imply that the bioconcentration of petroleum hydrocarbon by plankton is fairly large and petroleum hydrocarbon caused no significant influence on the uptake of N- NO3, but significant influence on that of P -PO4. In addition, the application of kinetic model for the bioconcentration of volatile organic toxic compound by organism suggests that the uptake of petroleum hydrocarbon by plankton was an important process for the environmental capacity of petroleum hydrocarbon. | Shi Xiaoyong, Wang Xiulin, Han Xiurong, Jiang Yu Zhu Mingyuan, Chen Shang, Koshikawa Hiroshi (1. Ocean University of Qingdao, Qingdao 266003, China 2. First Institute of Oceanology, Qingdao 266061, China 3. National Institute for Environmental Studies, Ja | 2001 | Acta Oceanologica Sinica2001，20，2： | 12 |
| 2 | Magnifying narrow-band imaging with acetic acid to diagnose early colorectal cancer显示文摘AIM:To evaluate the diagnostic characteristics of magnifying endoscopy with acetic acid spray and narrowband imaging(MA-NBI)for early colorectal cancer.METHODS:We conducted a prospective study to evaluate the diagnostic characteristics of MA-NBI in differentiating early colorectal adenocarcinomas from adenomas.To compare the results,we used magnifying endoscopy with NBI(M-NBI)and magnifying endoscopy with crystal violet staining(M-CV).The study was performed in 2 phases.In phase 1,10 colonoscopists at our institution were shown still photographs of 35colorectal polyps(24 adenocarcinomas and 11 adenomas)in M-NBI,MA-NBI,and M-CV.They made diagnostic predictions using a five-grade scoring evaluation.We plotted receiver operating characteristic curves and compared the areas under the curves(AUCs).In phase2,colorectal polyps measuring≥8 mm were prospectively enrolled.During real-time colonoscopy,one ofthe 7 colonoscopists scored the lesion as an adenocarcinoma or an adenoma and assigned a level of confidence to the prediction(high or low).We calculated the accuracy,sensitivity,specificity,positive predictive value(PPV),and negative predictive value(NPV)for each method and compared the proportions of highconfidence predictions.RESULTS:In phase 1,the mean±SD AUCs were 0.64±0.031 in M-NBI,0.71±0.066 in MA-NBI,and 0.76±0.059 in M-CV(P<0.05 for M-NBI vs MA-NBI,P<0.001 for M-NBI vs M-CV,and not significant for MANBI vs M-CV).In phase 2,84 patients with 91 lesions(46 adenocarcinomas and 45 adenomas)were enrolled.The diagnostic characteristics were as follows:73%accuracy,85%sensitivity,60%specificity,68%PPV,and 79%NPV in M-NBI;73%accuracy,80%sensitivity,64%specificity,70%PPV,and 76%NPV in MA-NBI;and 73%accuracy,83%sensitivity,62%specificity,69%PPV,and 78%NPV in M-CV.The proportions of high-confidence predictions were 57%in M-NBI,75%in MA-NBI,and 76%in M-CV(P<0.005 for M-NBI vs MA-NBI,P<0.0005 for M-NBI vs M-CV,and P=1.0 for MA-NBI vs M-CV).CONCLUSION:MA-NBI is useful for differentiating early colorectal adenocarcinomas from adenomas. | Norihiro Goto Toshihiro Kusaka Yumi Tomita Hideyuki Tanaka Yoshio Itokawa Yorimitsu Koshikawa Daisuke Yamaguchi Yoshitaka Nakai Shigehiko Fujii Hiroyuki Kokuryu | 2014 | World Journal of Gastroenterology2014，20，43： | 4 |
| 3 | Bacterioplankton production in dilution zone of the Changjiang (Yangtze) Estuary显示文摘The bacterioplankton production and bacterioplankton abundance were surveyed in dilution zone of the Changjiang Estuary and a mesocosm experimental device for enriched phosphate experiment and oil contaminated experiment was placed in the waters nearby Luhua Island during October 1997 and May 1998. The results showed that the average bacterioplankton production in spring was higher than that in autumn, the production at the surface water was higher than that at the bottom in the surveyed area; the higher values appeared in the middle of the area. The results from mesocosm experiment with adding phosphate and oil contaminated showed that the bacterioplankton production increased rising trend day by day during the experiment period. | Liu Zilin 1,2 , Koshikawa Hiroshi 3, Ning Xiuren 1,2 , Shi Junxian 2, Cai Yuming 1,21.KeyLaboratoryofSubmarineGeosciences,StateOceanicAdministration,China2.SecondInstituteofOceanography,StateOceanicAdministration,Hangzhou310012,China3.Nationa | 2001 | Acta Oceanologica Sinica2001，20，1： | 3 |
| 4 | Endoscopic ultrasound-guided fine-needle aspiration biopsy for the diagnosis of gastrointestinal stromal tumors in the stomach显示文摘 | Kenji Okubo Kenji Yamao Tsuneya Nakamura Masahiro Tajika Akira Sawaki Kazuo Hara Hiroki Kawai Yoshitaka Yamamura Yoshinari Mochizuki Takashi Koshikawa Ken-ichi Inada | 2004 | Journal of Gastroenterology2004，，8： | 2 |
| 5 | 从营养扰动实验看原绿球藻在近海分布的制约因素(英文)显示文摘地球上细胞最小、丰度最大的放氧光合自养原核生物原绿球藻 (Prochlorococcus)发现于热带大洋 ,并被证实可在某些近海甚至近岸水域大量分布。但除温度之外 ,原绿球藻自然分布的控制因子尚不明了。从近海和大洋生态条件的主要差别考虑 ,在南海进行了主要营养盐———氮、磷和微量元素———铁、钴扰动的现场培养实验 ,并应用流式细胞技术监测原绿球藻及聚球藻 (Synechococcus)、超微型真核浮游植物 (pico_eukaryotes)的细胞丰度和单细胞色素含量的响应以及细菌的影响。结果表明 ,磷和钴的添加有利于原绿球藻 ,而氮和铁的添加更有利于聚球藻和超微型真核浮游植物。同时 ,由环境条件引起的生物响应又间接地导致超微型生物之间的相互作用。因而 ,原绿球藻在近海的分布 。 | 焦念志 杨燕辉 Hiroshi KOSHIKAWA Shigeki HARADA Masataka WATANABE | 2002 | Acta Botanica Sinica2002，44，6： | 2 |
| 6 | Focal adhesion kinase is overexpressed in hepatocellular carcinoma and can be served as an independent prognostic fator 显示文摘 | FUJU T KOSHIKAWA K NOMOTO S | 2004 | J Hepatol2004，41，2： | 1 |
| 7 | Cooperative interactions of laminin 5 gamma2 chain, matrix metalloproteinase-2, and membrane type1-matrix metalloproteinase are required for mimicry of embryonic vasculogenesis by aggressive melanoma 显示文摘 | Seftor RE Seftor EA Koshikawa N | 2001 | Cancer Res2001，61，17： | 1 |
| 8 | Screening of genes expressed in developing mandibles during soldier differentiation in the termite Hodotermopsis sjostedti 显示文摘 | Koshikawa S Cornette R Hojo M | 2005 | Febs Lett2005，579，6： | 1 |
| 9 | Arteriosclerosis obliterans (ASO)显示文摘 | Koshikawa M Ikeda U | 2010 | Nihon Rinsho2010，68，5： | 1 |
| 10 | Expression of trypsin in vascular endothelial cells显示文摘 | KOSHIKAWA K NAGASHIMA Y MIYAGI Y | 1997 | FEBS Lett1997，409，3： | 1 |
| 11 | Diagnostic utility of EUS-guided FNA in patients with gastric submucosal tumors显示文摘 | Mohamed A. Mekky Kenji Yamao Akira Sawaki Nobumasa Mizuno Kazuo Hara Mohamed A. Nafeh Ashraf M. Osman Takashi Koshikawa Yasushi Yatabe Vikram Bhatia | 2010 | Gastrointestinal Endoscopy2010，，6： | 1 |
| 12 | Anisotropically conducting films consisting of sub-micron copper wires in the ion track membranes of poly (ethylane terephthalate)显示文摘 | MAEKAWA Y KOSHIKAWA H YOSHIDA M | 2004 | Polymer2004，45，： | 1 |
| 13 | Focal adhesion kinase is overexpressed in hepatocellular carcinoma and can be served as an independent prognostic factor 显示文摘 | Tsutomu Fujii Katsumi Koshikawa Shuji Nomoto | 2004 | Journal of Hepatology2004，41，1： | 1 |
| 14 | Angioim-munoblastic T-cell lymphoma (angioimmunoblastic lym-phadenopathy with dysproteinemia -type T-celllymphoma) followed by Hodgkin's disease associated withEpstein-Barr virus显示文摘 | Nakamura S Sasajima Y Koshikawa T | 1995 | Pathol Int1995，45，12： | 1 |
| 15 | Interdigitating cell sarcoma:a morphologic and immunologic study of lymph node lesions in four cases显示文摘 | Koshikawa T Kitoh K | 1994 | Pathol Int1994，44，5： | 1 |
| 16 | A self-reported instrument for prodromal symptoms of psychosis:Testing the clinical validity of the PRIME Screen-Revised (PS-R) in a Japanese population显示文摘 | Kobayashi H Nemoto T Koshikawa H | 2008 | Schizophr Res2008，106，23： | 1 |
| 17 | Fast recovery 3D d fast Spin-Echo MR imaging of the inmer ear at 3T显示文摘 | NAGANAWA S KOSHIKAWA T FUKATSU H | 2002 | AJNR2002，23，2： | 1 |
| 18 | Multi-faceted analyses of a highly metastatic human lung cancer cell line NCI-H460 -LNM35 suggest mimicry of inflammatory cells in metastasis显示文摘 | Kozaki K Koshikawa K Tatematsu Y | 2001 | Oncogene2001，20，31： | 1 |
| 19 | Cleavage of metastasis suppressor gene product KISS-1 protein/metastin by matrix metalloproteinases 显示文摘 | Takino T Koshikawa N Miyamori H | 2003 | Oncogene2003，22，30： | 1 |
| 20 | Cooperative interactions of laminin-5 gamma-2 chain,matrix metalloproteinase-2,and membrane type-1-matrixmetalloproteinase are required for mimicry of embryonic vasculogenesis by aggressive melanoma显示文摘 | Seftor R E Seftor E A Koshikawa N | 2001 | Cancer Res2001，61，17： | 1 |
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