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| 1 | Matrix metalloproteinases and gastrointestinal cancers: Impacts of dietary antioxidants显示文摘The process of carcinogenesis is tightly regulated by antioxidant enzymes and matrix degrading enzymes, namely, matrix metalloproteinases(MMPs). Degradation of extracellular matrix(ECM) proteins like collagen, proteoglycan, laminin, elastin and fibronectin is considered to be the prerequisite for tumor invasion and metastasis. MMPs can degrade essentially all of the ECM components and, most MMPs also substantially contribute to angiogenesis, differentiation, proliferation and apoptosis. Hence, MMPs are important regulators of tumor growth both at the primary site and in distant metastases; thus the enzymes are considered as important targets for cancer therapy. The implications of MMPs in cancers are no longer mysterious; however, the mechanism of action is yet to be explained. Herein, our major interest is to clarify how MMPs are tied up with gastrointestinal cancers. Gastrointestinal cancer is a variety of cancer types, including the cancers of gastrointestinal tract and organs, i.e., esophagus, stomach, biliary system, pancreas, small intestine, large intestine, rectum and anus. The activity of MMPs is regulated by its endogenous inhibitor tissue inhibitor of metallopro-teinase(TIMP) which bind MMPs with a 1:1 stoichiometry. In addition, RECK(reversion including cysteinerich protein with kazal motifs) is a membrane bound glycoprotein that inhibits MMP-2,-9 and-14. Moreover, α2-macroglobulin mediates the uptake of several MMPs thereby inhibit their activity. Cancerous conditions increase intrinsic reactive oxygen species(ROS) through mitochondrial dysfunction leading to altered protease/anti-protease balance. ROS, an index of oxidative stress is also involved in tumorigenesis by activation of different MAP kinase pathways including MMP induction. Oxidative stress is involved in cancer by changing the activity and expression of regulatory proteins especially MMPs. Epidemiological studies have shown that high intake of fruits that rich in antioxidants is associated with a lower cancer incidence. Evidence indicates that some antioxidants inhibit the growth of malignant cells by inducing apoptosis and inhibiting the activity of MMPs. This review is discussed in six subchapters, as follows. | Sugreev Verma Kousik Kesh Nilanjan Ganguly Sayantan Jana Snehasikta Swarnakar | 2014 | World Journal of Biological Chemistry2014，5，3： | 10 |
| 2 | Development of a mass model in estimating weight-wise particle size distribution using digital image processing显示文摘Particle size distribution of coarse aggregates through mechanical sieving gives results in terms of cumulative mass percent. But digital image processing generated size distribution of particles, while being fast and accurate, is often expressed in terms of area function or number of particles. In this paper, a mass model is developed which converts the image obtained size distribution to mass-wise distribution, making it readily comparable to mechanical sieving data. The concept of weight/particle ratio is introduced for mass reconstruction from 2D images of particle aggregates. Using this mass model, the effects of several particle shape parameters(such as major axis, minor axis, and equivalent diameter) on sieve-size of the particles is studied. It is shown that the sieve-size of a particle strongly depend upon the shape parameters, 91% of its variation being explained by major axis, minor axis, bounding box length and equivalent diameter. Furthermore, minor axis gives an overall accurate estimate of particle sieve-size, error in mean size(D-50) being just 0.4%. However, sieve-size of smaller particles(<20 mm) strongly depends upon the length of the smaller arm of the bounding box enclosing them and sieve-sizes of larger particles(>20 mm) are highly correlated to their equivalent diameters. Multiple linear regression analysis has been used to generate overall mass-wise particle size distribution, considering the influences of all these shape parameters on particle sieve-size. Multiple linear regression generated overall mass-wise particle size distribution shows a strong correlation with sieve generated data. The adjusted R-square value of the regression analysis is found to be 99 percent(w.r.t cumulative frequency). The method proposed in this paper provides a time-efficient way of producing accurate(up to 99%) mass-wise PSD using digital image processing and it can be used effectively to replace the mechanical sieving. | Maiti Abhik Chakravarty Debashish Biswas Kousik Halder Arpan | 2017 | International Journal of Mining Science and Technology2017，27，3： | 3 |
| 3 | Behavior of braced excavation in sand under a seismic condition: experimental and numerical studies显示文摘The behavior of braced excavation in dry sand under a seismic condition is investigated in this paper.A series of shake table tests on a reduced scale model of a retaining wall with one level of bracing were conducted to study the effect of different design parameters such as excavation depth,acceleration amplitude and wall stiffness.Numerical analyses using FLAC 2D were also performed considering one level of bracing.The strut forces,lateral displacements and bending moments in the wall at the end of earthquake motion were compared with experimental results.The study showed that in a post-seismic condition,when other factors were constant,lateral displacement,bending moment,strut forces and maximum ground surface displacement increased with excavation depth and the amplitude of base acceleration.The study also showed that as wall stiffness decreased,the lateral displacement of the wall and ground surface displacement increased,but the bending moment of the wall and strut forces decreased.The net earth pressure behind the walls was influenced by excavation depth and the peak acceleration amplitude,but did not change significantly with wall stiffness.Strut force was the least affected parameter when compared with others under a seismic condition. | Sanku Konai Aniruddha Sengupta Kousik Deb | 2018 | Earthquake Engineering and Engineering Vibration2018，17，2： | 2 |
| 4 | Load Balancing in Cloud Computing using Stochastic Hill Climbing-A Soft Computing Approach显示文摘 | Brototi Mondal Kousik Dasgupta Paramartha Durra | 2012 | Procedia Technology2012，4，： | 1 |
| 5 | Combining reflective mulchand hos t plant resistance for sweetpotato whitefly (Hemiptera:Aleyrodidae) management in watermelon 显示文摘 | Simmons A M Kousik C S Levi A | 2010 | Crop protection2010，29，8： | 1 |
| 6 | Combining reflective mulch and host plant resistance for sweetpotato whitefly (Hemiptera:Aleyrodidae) management in watermelon显示文摘 | Simmons A M Kousik C S Levi A | | 0，，： | 1 |
| 7 | 3D finite-element dy- namic analysis of rigid pavement using infinite elements 显示文摘 | Patil V A SawanV A t Deb Kousik | 2013 | International Journal of Geomechanics2013，10，3： | 1 |
| 8 | Upcycling end of lithium cobalt oxide batteries to electrocatalyst for oxygen reduction reaction in direct methanol fuel cell via sustainable approach显示文摘Recycling spent lithium-ion batteries(SLIBs)has become essential to preserve the environment and reclaim vital resources for sustainable development.The typical SLIBs recycling concentrated on separating valuable components had limitations,including high energy consumption and complicated separation processes.This work suggests a safe hydrometallurgical process to recover usable metallic cobalt from depleted LiCoO_(2)batteries by utilizing citric acid as leachant and hydrogen peroxide as an oxidizing agent,with ethanol as a selective precipitating agent.The anode graphite was also recovered and converted to graphene oxide(GO).The above components were directly resynthesized to cobaltintegrated nitrogen-doped graphene(Co@NG).The Co@NG showed a decent activity towards oxygen reduction reaction(ORR)with a half-wave potential of 0.880 V vs.RHE,almost similar to Pt/C(0.888 V vs.RHE)and with an onset potential of 0.92 V vs.RHE.The metal-nitrogen-carbon(Co-N-C)having the highest nitrogen content has decreased the barrier for ORR since the reaction was enhanced for Co@NG-800,as confirmed by density functional theory(DFT)simulations.The Co@NG cathode catalyst coupled with commercial Pt-Ru/C as anode catalyst exhibits excellent performance for direct methanol fuel cell(DMFC)with a peak power density of 34.7 mW cm^(-2)at a discharge current density of120 m A cm^(-2)and decent stability,indicating the promising utilization of spent battery materials in DMFC applications.Besides,lithium was recovered from supernatant as lithium carbonate by coprecipitation process.This work avoids sophisticated elemental separation by utilizing SLIBs for other renewable energy applications,lowering the environmental concerns associated with recycling. | Keyru Serbara Bejigo Kousik Bhunia Jungho Kim Chaehyeon Lee Seoin Back Sang-Jae Kim | 2023 | Journal of Energy Chemistry2023，，7： | 1 |
| 9 | Laboratory model studies on unreinforced and geogrid-reinforced sand bed over stone column-improved soit clay显示文摘 | KOUSIK D NARENDRA K S JAGTAP B N | 2011 | Geotextiles and Geomembranes2011，29，2： | 1 |
| 10 | Laboratory Model Studies on Unreinforced and Geogrid-Reinforced Sand Bed over Stone Column-Improved Soft Clay显示文摘 | Kousik D Narendra K S Jagtap B N | 2011 | Geotextiles and Geomembranes2011，29，： | 1 |
| 11 | Electrochemical characterization of polythiophene-coated steel显示文摘 | KOUSIK G PITCH S RENGANATHANN G | 2001 | Prog Org Coat2001，43，4： | 1 |
| 12 | Improved genetic algorithm for channel allocation with channel borrowing in mobile computing显示文摘 | Somnath Sinha Maha Patra Kousik Roy Sarthak Banerjee etc | 2006 | IEEE Transactions on Mobile Computing2006，5，7： | 1 |
| 13 | Optical and nonlinear electrical properties of SnO2-polyaniline nanocopomsites 显示文摘 | Kousik Dutta S K De | 2007 | Material Letters2007，61，27： | 1 |
| 14 | Application of nonwovens as acoustic textile in automobiles 显示文摘 | DEBIPRASAD G PALASH P KOUSIK D | 2013 | The Indian Textile Journal2013，123，11： | 1 |
| 15 | Laboratory model studies on unreinforced and geogrid-reinforced sand bed over stone column-improved soft clay显示文摘 | Kousik Deb Narendra Kumar Samadhiya Jagtap Babasaheb Namdeo | 2010 | Geotextiles and Geomembranes2010，，2： | 1 |
| 16 | Disease potential of pepper bacterial spot pathogen races that overcome the Bs2 gene for resistance显示文摘 | Kousik C S Ritchie D F | | 0，，12： | 1 |
| 17 | Empirical Mode Decomposition Analysis of Two Different Financial Time Series and Their Comparison 显示文摘 | KOUSIK G INDRANIL M CHOWDHURY R A | 2008 | Chaos Solitons & Fractals2008，37，4： | 1 |
| 18 | Metallic nanowires from carbon nanotube building blocks:the effect of atomic defects on the nanotube influencing nanowire growth显示文摘 | Panchapakesan B Kousik Sivakumar Shaoxin Lu | 2003 | American Society of Mechanical Engineers EEP2003，3，： | 1 |
| 19 | Empirical Mode Decomposition Analysis of Two Different Financial Time Series and Their Comparison 显示文摘 | KOUSIK G INDRANIL M | 2008 | Chaos Solitons & Fractals2008，37，4： | 1 |
| 20 | Using recurrence plot analysis to distinguish between endogenous and exogenous stock market erashes显示文摘 | Kousik G Basabi B Roy C A | 2010 | Physica A: Statistical Mechanics and its Applica- tions2010，389，9： | 1 |
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