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| 1 | Comparison of unenhanced magnetic resonance imaging and ultrasound in detecting very small hepatocellular carcinoma显示文摘BACKGROUND In hepatocellular carcinoma(HCC),detection and treatment prior to growth beyond 2 cm are important as a larger tumor size is more frequently associated with microvascular invasion and/or satellites.In the surveillance of very small HCC nodules(≤2 cm in maximum diameter,Barcelona clinical stage 0),we demonstrated that the tumor markers alpha-fetoprotein and PIVKA-Ⅱare not so useful.Therefore,we must survey with imaging modalities.The superiority of magnetic resonance imaging(MRI)over ultrasound(US)to detect HCC was confirmed in many studies.Although enhanced MRI is now performed to accurately diagnose HCC,in conventional clinical practice for HCC surveillance in liver diseases,unenhanced MRI is widely performed throughout the world.While,MRI has made marked improvements in recent years.AIM To make a comparison of unenhanced MRI and US in detecting very small HCC that was examined in the last ten years in patients in whom MRI and US examinations were performed nearly simultaneously.METHODS In 394 patients with very small HCC nodules,those who underwent MRI and US at nearly the same time(on the same day whenever possible or at least within 14 days of one another)at the first diagnosis of HCC were selected.The detection rate of HCC with unenhanced MRI was investigated and compared with that of unenhanced US.RESULTS The sensitivity of unenhanced MRI for detecting very small HCC was 95.1%(97/102,95%confidence interval:90.9-99.3)and that of unenhanced US was 69.6%(71/102,95%confidence interval:60.7-78.5).The sensitivity of unenhanced MRI for detecting very small HCC was significantly higher than that of unenhanced US(P<0.001).Regarding the location of HCC in the liver in patients in whom detection by US was unsuccessful,S7-8 was identified in 51.7%.CONCLUSION Currently,unenhanced MRI is a very useful tool for the surveillance of very small HCC in conventional clinical follow-up practice. | Kazuo Tarao Akito Nozaki Hirokazu Komatsu Tatsuji Komatsu Masataka Taguri Katsuaki Tanaka Testuo Yoshida Hideki Koyasu Makoto Chuma Kazushi Numata Shin Maeda | 2021 | World Journal of Hepatology2021，13，6： | 3 |
| 2 | Recent advances in understanding the molecular mechanisms of the development and function of T h17 cells显示文摘 | Yutaka Kurebayashi Shigenori Nagai Ai Ikejiri Shigeo Koyasu | 2013 | Genes Cells2013，，4： | 2 |
| 3 | Helicobacter pylori CagA Phosphorylation-Independent Function in Epithelial Proliferation and Inflammation显示文摘 | Masato Suzuki Hitomi Mimuro Kotaro Kiga Makoto Fukumatsu Nozomi Ishijima Hanako Morikawa Shigenori Nagai Shigeo Koyasu Robert H. Gilman Dangeruta Kersulyte Douglas E. Berg Chihiro Sasakawa | 2009 | Cell Host & Microbe2009，，1： | 2 |
| 4 | Bradycardia and cardiac arrest caused by intramyometrial injection of vasopressin during a laparoscopically assisted myomectomy显示文摘 | Hobo R Netsu S Koyasu Y | | 0，，02： | 1 |
| 5 | Role of innate lymphocytes in infection and inflammation 显示文摘 | Koyasu S Moro K | 2012 | Front Immuno12012，3，4： | 1 |
| 6 | PI3 K and negative regulation of TLR signaling显示文摘 | Fukao T S Koyasu | 2003 | Trends Immunol2003，24，7： | 1 |
| 7 | New synthesis route for Mo-V- Nb-Te mixed oxides catalyst for propane ammoxidation 显示文摘 | Watanabe Hiromu Koyasu Yukio | 2000 | Applied Catalysis A: General2000，，： | 1 |
| 8 | Risk factorsfor small for gestational age显示文摘 | Tsukamoto H Fukuoka H Koyasu M | 2007 | Pediatr Int2007，49，6： | 1 |
| 9 | Development, differentiation, and diversity of innate lymphoid cells 显示文摘 | Diefenbach A Colonna M Koyasu S | 2014 | Immunity2014，41，3： | 1 |
| 10 | Mechanisms of action of cyclosporine显示文摘 | Matsuda S Koyasu S | 2000 | Immunopharmacol2000，47，： | 1 |
| 11 | PI3K and negative regulation of TLR signaling显示文摘 | Fukao T Koyasu S | 2003 | Trends Immunol2003，24，3： | 1 |
| 12 | Laparoscopic colpopoiesis using sigmoid colon显示文摘 | Ikuma K Ohashi S Koyasu Y | 1997 | Surg Laparosc Endosc1997，7，1： | 1 |
| 13 | The role of PI3K in immune cells显示文摘 | Koyasu S | 2003 | Nature Immun2003，4，： | 1 |
| 14 | Distribution among tissues and intracellular localization of cofilin,a 21 kDa actinbindingprotein显示文摘 | Yonezawa N Nishida E Koyasu S | 1987 | Cell Struct Funct1987，12，5： | 1 |
| 15 | T lymphocyte activation signals for interleukin-2 production involve activation of MKK6-p38 and MKK7-SAPK/JNK signaling pathways sensitive to cyclosporin A显示文摘 | Matsuda S Moriguchi T Koyasu S | 1998 | J Biol Chem1998，273，12： | 1 |
| 16 | Hepatic arterial perfusion increases inthe early stage of severe acute pancreatitis patients:evaluation by perfusioncomputed tomography显示文摘 | Koyasu S Isoda H Tsuji Y | 2012 | European Journal of Radiology2012，81，1： | 1 |
| 17 | Role of innate lymphocytes in infection and in- flammation显示文摘 | Koyasu S Moro K | 2012 | Front lmmunol2012，3，： | 1 |
| 18 | PI3K and negative regulation of TLR signaling显示文摘 | Fukao T Koyasu S | 2003 | Trends Immunol2003，24，7： | 1 |
| 19 | Development of high fatigue strength spring steel显示文摘 | Yoshirou Koyasu | 1996 | Wire journal international1996，，5： | 1 |
| 20 | T lymphocyte activation signals for interleukin-2 production involve activation of MKK6-p38 and MKK7-SAPK/JNK signaling pathways sensitive to cyclosporin A显示文摘 | Matsuda S Moriguchi T Koyasu S | 1998 | J Biol Chem1998，20，12： | 1 |
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