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| 1 | Comparative analysis of open and laparoscopic colectomy for malignancy in a developing country显示文摘AIM: To compare the short-term, including oncologic, outcomes of open vs laparoscopic colectomy for cancer in a developing country. METHODS: The records of patients who underwent elective open and laparoscopic colectomies for cancer at the University Hospital of the West Indies between January 2005 and December 2010 were retrospectively reviewed. Demographic(age, gender, Charlson comorbidity index score), peri-operative, post-operative and oncologic data were collected for each patient. Specific oncologic variables included lymph node yield, pathologic stage, grade, proximal, distal and circumferential margin involvement. Fisher's exact, Mann-Whitney, and binary logistic regression tests were used for analysis. Significance level was set atP < 0.05. RESULTS: There were 87 cases for open colectomy(OC) and 17 cases for laparoscopic colectomy(LC). Demographics did not significantly differ between OC and LC groups. Intra-operative blood loss and postoperative analgesic requirements did not significantly differ between groups. There was a trend towards longer operating times in OC group and shorter hospital stay in the LC group. Lymph node yield(14 vs 14, P = 0.619), proximal(10 cm vs 7 cm, P = 0.353) and distal(8 cm vs 8 cm, P = 0.57) resection margin distance and circumferential margin involvement(9 vs 0, P = 0.348) did not significantly differ between groups. Thirty-day morbidity was equivalent between groups(22 vs 6, P = 0.774). There were 6 deaths within 30 d of initial procedure, all in the OC group(6.9%). CONCLUSION: Laparoscopic colectomy in a developing country is oncologically safe and represents a option for colonic malignancies in these regions. Such data encourage the continued laparoscopic development. | Pierre-Anthony Leake Kristen Pitzul Patrick O Roberts Joseph M Plummer | 2013 | World Journal of Gastrointestinal Surgery2013，5，11： | 8 |
| 2 | Efficacy and safety of liquid nitrogen cryotherapy for treatment of Barrett's esophagus显示文摘AIM To evaluate the efficacy and safety of liquid nitrogen cryotherapy as a primary or rescue treatment for BE,with and without dysplasia,or intramucosal adenocarcinoma (IMC).METHODS This was a retrospective,single-center study carried out in a tertiary care center including 45 patients with BE who was treatment-na?ve or who had persistent intestinal metaplasia(IM),dysplasia,or IMC despite prior therapy.Barrett's mucosa was resected via EMR when clinically appropriate,then patients underwent cryotherapy until eradication or until deemed to have failed treatment.Surveillance biopsies were taken at standard intervals.RESULTS From 2010 through 2014,33 patients were studied regarding the efficacy of cryotherapy.Overall,29 patients (88%) responded to cryotherapy,with 84% having complete regression of all dysplasia and cancer.Complete eradication of cancer and dysplasia was seen in 75% of subjects with IMC; the remaining two subjects did not respond to cryotherapy.Following cryotherapy,15 patients with high-grade dysplasia (HGD) had 30% complete regression,50% IM,and 7% low-grade dysplasia (LGD); one subject had persistent HGD.Complete eradication of dysplasia occurred in all 5 patients with LGD.In 5 patients with IM,complete regression occurred in 4,and IM persisted in one.In 136 cryotherapy sessions amongst 45 patients,adverse events included chest pain (1%),stricture (4%),and one gastrointestinal bleed in a patient on dual antiplatelet therapy who had previously undergone EMR.CONCLUSION Cryotherapy is an efficacious and safe treatment modality for Barrett's esophagus with and without dysplasia or intramucosal adenocarcinoma. | Kristen Suchniak-Mussari Charles E Dye Matthew T Moyer Abraham Mathew Thomas J McGarrity Eileen M Gagliardi Jennifer L Maranki John M Levenick | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，9： | 4 |
| 3 | Drosophila nemo is an essential gene involved in the regulation of programmed cell death显示文摘 | Ivana Mirkovic Kristi Charish Sharon M Gorski Kristen McKnight Esther M Verheyen | 2002 | Mechanisms of Development2002，，1： | 1 |
| 4 | Cadmium uptake by barley as affected by Cd sources and pH levels显示文摘 | SINGH R B KRISTEN M | 1998 | Geoderma1998，84，： | 1 |
| 5 | Atypical language lateralisation associated with right fronto-temporal grey matter increases-a combined fMRI and VBM study in left-sided mesial temporal lobe epilepsy patients 显示文摘 | Kristen L Markus M Jozsef J | 2012 | NeuroImage2012，59，1： | 1 |
| 6 | Late Enhancement in Cardiac Amyloidosis:Correlation of MRI Enhancement Pattern with Histopathological Findings显示文摘 | Hosch W Kristen AV Libicher M | 2008 | Amyloid2008，15，3： | 1 |
| 7 | The GANA Program : A Tailoring Approach to Adapting Parent Child Interaction Therapy for Mexican Americans显示文摘 | Kristen M McCabe May Yeh Ann F Garland | 2005 | Education and Treatment of Children2005，28，2： | 1 |
| 8 | Reaction kinetics and optimization of the copper-catalyzed oxidation of ApoA-1M 显示文摘 | Sa V H Joseph K M Kristen E T | 2009 | Chemical Engineering Science2009，64，： | 1 |
| 9 | 4-1BB is superior to CD28 costimulation for generating CD8^+ cytotoxic lymphocytes for adoptive immunotherapy 显示文摘 | Hua Zhang Kristen M Marcela V | 2007 | The Journal of Immunology2007，17，9： | 1 |
| 10 | DNA sequence of the skeletal muscle calcium release channel cDNA and verification of the Arg 615-Cys 615 mutation associated with porcine malignant hyperthermia in Norwegian Landrace pigs 显示文摘 | Harbitz I Kristen T Bosnes M | 1992 | Animal Genetics1992，23，： | 1 |
| 11 | From safety analysis to software requirements显示文摘 | Kristen M Hansen Anders P Ravn | 1998 | IEEE Transaction on Software Engineering1998，24，7： | 1 |
| 12 | Presentation and outcome of hepatocellular carcinoma in HIV-infected patients: A U.S.–Canadian multicenter study显示文摘 | Norbert Br?u Rena K. Fox Peiying Xiao Kristen Marks Zeenat Naqvi Lynn E. Taylor Anita Trikha Morris Sherman Mark S. Sulkowski Douglas T. Dieterich Michael O. Rigsby Teresa L. Wright Maria D. Hernandez Mamta K. Jain Gajendra K. Khatri Richard K. Sterling M | 2007 | Journal of Hepatology2007，，4： | 1 |
| 13 | The anthropometric verification of corrective surgery outcome in clett secondary deformities 显示文摘 | Duskova M Kristen M Smahel Z | 2006 | Craniofac Surg2006，17，3： | 1 |
| 14 | 查看详情显示文摘 | Kristen M | | 0，，1： | 1 |
| 15 | Baseline obesity status modifies effectiveness of adapted diabetes prevention program lifestyle interventions for weight management in primary care 显示文摘 | Kristen MJ Azar-Lan X Jun M | 2013 | BioMed Research International2013，1155，11： | 1 |
| 16 | Utility of area curve ratio electrocochleography in early Meniere disease显示文摘 | ANAND K DEVAIAH M D KRISTEN L | 2003 | Arch Otolaryngol Head Neck Surg2003，129，： | 1 |
| 17 | Spin-offs from research centres at a research university 显示文摘 | Morten Steffensen Everett M Rogfrs Kristen Speakman | 1999 | Journal of Business Venturing1999，15，1： | 1 |
| 18 | Structure of Ca 2+-Bound S100A4and its interaction with peptides derived from non-muscle myosin-IIA显示文摘 | Vladimir N Kristen M Sarah C | 2008 | Biochemistry2008，47，18： | 1 |
| 19 | Post-transcriptional regulation of glucose transporter-1 by an AU-rich element in the 3 ′ UTR and by hnRNP A2显示文摘 | Mary E Griffin B.JoNell Hamilton Kristen M Roy Min Du Alicia M Willson Benjamin J Keenan Xiao Wei Wang Ralph C Nichols | 2004 | Biochemical and Biophysical Research Communications2004，，4： | 1 |
| 20 | Glutamine's protection against cellular injury is dependent on heat shock factor-1 显示文摘 | Angela L M Martin D Kristen D S | 2006 | Cell Physiology2006，290，6： | 1 |
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