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| 1 | Role of myeloid-derived suppressor cells in autoimmune disease显示文摘Myeloid-derived suppressor cells(MDSCs) represent an important class of immunoregulatory cells that can be activated to suppress T cell functions. These MDSCs can inhibit T cell functions through cell surface interactions and the release of soluble mediators. MDSCs accumulate in the inflamed tissues and lymphoid organs of patients with autoimmune diseases. Much of our knowledge of MDSC function has come from studies involving cancer models, however many recent studies have helped to characterize MDSC involvement in autoimmune diseases. MDSCs are a heterogeneous group of immature myeloid cells with a number of different functions for the suppression of T cell responses. However, we have yet to fully understand their contributions to the development and regulation of autoimmune diseases. A number of studies have described beneficial functions of MDSCs during autoimmune diseases, and thus there appears to be a potential role for MDSCs in the treatment of these diseases. Nevertheless, many questions remain as to the activation, differentiation, and inhibitory functions of MDSCs. This review aims to summarize our current knowledge of MDSC subsets and suppressive functions in tissue-specific autoimmune disorders. We also describe the potential of MDSC-basedcell therapy for the treatment of autoimmune diseases and note some of hurdles facing the implementation of this therapy. | Kristen R Crook Peng Liu | 2014 | World Journal of Immunology2014，4，1： | 9 |
| 2 | Neuroimaging the brain-gut axis in patients with irritable bowel syndrome显示文摘AIM:To summarize and synthesize current literature on neuroimaging the brain-gut axis in patients with irritable bowel syndrome(IBS).METHODS:A database search for relevant literature was conducted using Pub Med,Scopus and Embase in February 2015.Date filters were applied from the year2009 and onward,and studies were limited to those written in the English language and those performed upon human subjects.The initial search yielded 797articles,out of which 38 were pulled for full text review and 27 were included for study analysis.Investigations were reviewed to determine study design,methodology and results,and data points were placed in tabular format to facilitate analysis of study findings across disparate investigations.RESULTS:Analysis of study data resulted in the abstraction of four key themes:Neurohormonal differences,anatomic measurements of brain structure and connectivity,differences in functional responsiveness of the brain during rectal distention,and confounding/correlating patient factors.Studies in this review noted alterations of glutamate in the left hippocampus(HIPP),commonalities across IBS subjects in terms of brain oscillation patterns,cortical thickness/gray matter volume differences,and neuroanatomical regions withincreased activation in patients with IBS:Anterio cingulate cortex,mid cingulate cortex,amygdala anterior insula,posterior insula and prefrontal cortex.A striking finding among interventions was the substantia influence that patient variables(e.g.,sex,psychologica and disease related factors)had upon the identification of neuroanatomical differences in structure and con nectivity.CONCLUSION:The field of neuroimaging can provide insight into underlying physiological differences that distinguish patients with IBS from a healthy population. | Kristen R Weaver Lee Anne B Sherwin Brian Walitt Gail D'Eramo Melkus Wendy A Henderson | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，2： | 8 |
| 3 | Maintaining clarity:Review of maintenance therapy in nonsmall cell lung cancer显示文摘The purpose of this article is to review the role of maintenance therapy in the treatment of advanced nonsmall cell lung cancer(NSCLC). A brief overview about induction chemotherapy and its primary function in NSCLC is provided to address the basis of maintenance therapies foundation. The development of how maintenance therapy is utilized in this population is discussed and current guidelines for maintenance therapy are reviewed. Benefits and potential pitfalls of maintenance therapy are addressed, allowing a comprehensive review of the achieved clinical benefit that maintenance therapy may or may not have on NSCLC patient population. A review of current literature was conducted and a table is provided comparing the results of various maintenance therapy clinical trials. The table includes geographical location of each study, the number of patients enrolled, progression free survival and overall survival statistics, post-treatment regimens and if molecular testing was conducted. The role of molecular testing in relation to therapeutic treatment options foradvanced NSCLC patients is discussed. A treatment algorithm clearly depicts first line and second line treatment for management of NSCLC and includes molecular testing, maintenance therapy and the role clinical trials have in treatment of NSCLC. This treatment algorithm has been specifically tailored and developed to assist clinicians in the management of advanced NSCLC. | Kristen R Dearing Ashish Sangal Glen J Weiss | 2014 | World Journal of Clinical Oncology2014，5，2： | 3 |
| 4 | Cadmium uptake by barley as affected by Cd sources and pH levels显示文摘 | SINGH R B KRISTEN M | 1998 | Geoderma1998，84，： | 1 |
| 5 | N-terminal pro-B-type natriuretic peptide is a major predictor of the development of atrial fibrillation显示文摘 | Kristen K Patrick T Susan R | 2009 | Circulation2009，120，： | 1 |
| 6 | Scarf截骨治疗拇外翻的中长期随访结果显示文摘Scarf截骨治疗拇外翻畸形的远期效果和复发率研究甚少。作者对108例行Scarf截骨的拇外翻患者(115足)进行研究,平均随访124个月。结果发现,AOFAS平均评分由术前的57分提高至95分,影像学测量(拇外翻角、跖骨间角和和籽骨位置)显著改善(P〈0.05),复发率为30%。 | Bock P Kluger R Kristen K H 李军 | 2015 | 临床骨科杂志2015，18，6： | 1 |
| 7 | Contemporary outcomes of surgical ventricular septal defect closure 显示文摘 | Brett R Anderson Kristen N | 2013 | The Jour-nal of Thoracic and Cardiovascular Surgery2013，145，3： | 1 |
| 8 | Analytical and clinical performance of a homogeneous enzymatic LDL-cholesterol assay compared with the ultracentrifugation-dextran sulfate-Mg2+ method显示文摘 | Elizabeth I Kristen D | 1998 | Clin Chem1998，44，6： | 1 |
| 9 | Insuring redevelopment at contaminated urban properties显示文摘 | Wernstedt K Meyer P B Kristen R Y | 2003 | Public Works Management & Policy2003，8，2： | 1 |
| 10 | Transtbrmable facultative thermophile Geobacillus stearothermophilus NUB3621 as a host strain for metabolic engineering显示文摘 | Kristen B Srebrenka R lchiro M | 2014 | Applied Microbiology and Biotechnology2014，98，15： | 1 |
| 11 | HIV Testing Frequency Among Men Who Have Sex With Men Attending Sexually Transmitted Disease Clinics: Implications for HIV Prevention and Surveillance显示文摘 | Donna J Helms Hillard S Weinstock Kristen C Mahle Kyle T Bernstein Bruce W Furness Charlotte K Kent Cornelis A Rietmeijer Akbar M Shahkolahi James P Hughes Matthew R Golden | 2009 | JAIDS Journal of Acquired Immune Deficiency Syndromes2009，，3： | 1 |
| 12 | Resistance to three pathogens in the endangered winter-run chinook salmon (Oncorhynchus tshawytscha ) : effects of inbreeding and major histocompatibility complex genotypes显示文摘 | KRISTEN D A GIESE A R HOLLY L M | 2002 | Can J Fish Aquat Sci2002，59，6： | 1 |
| 13 | Spin-offs from rsearch cnters at a rsearch uiversity 显示文摘 | MORTEN S EVERETT M R KRISTEN S | 2000 | Journal of Business Venturing2000，，1： | 1 |
| 14 | Assessment of potential antibiotics contaminants in water and preliminary occurrence analysis显示文摘 | CHING H H JAY E R KRISTEN L S | 2002 | Journal of Environmental Quality2002，11，： | 1 |
| 15 | Brown adipose tissue regulates glucose homeostasis and insulin sensitivity显示文摘 | Stanford Kristin I Middelbeek Roeland J W Townsend Kristy L An Ding Nygaard Eva B Hitchcox Kristen M Markan Kathleen R Nakano Kazuhiro Hirshman Michael F Tseng Yu-Hua Goodyear Laurie J | 2013 | Journal of Clinical Investigation2013，，1： | 1 |
| 16 | Functional food productsmade from fish protein isolate recovered with isoelectricsolubilization/precipitation 显示文摘 | Tahergorabi R Sarah K Kristen E | 2012 | Food Science and Technology2012，42，6： | 1 |
| 17 | Nafopidil inhibits 5-hyfroxytrypta mine-induced platelet aggregation and 5-by drorytryptamine uptake in platelets of healthy volunteers 显示文摘 | Kristen R Breidert M Nelson K | 1994 | Eur olin Pharmacol1994，46，3： | 1 |
| 18 | Recognition of hyaluronan released in sterile injury irrolves a unique receptor complex dependent on Ton-like receptor 4, CD14, and MD2 显示文摘 | Kristen R Taylor Kenshi YamAsaki | 2007 | Biol Chem2007，282，18： | 1 |
| 19 | Assessment of potential anti-biotics contaminants in water and preliminary occurrence analysis显示文摘 | CHING H H JAY E R KRISTEN L S | 2002 | our-nal of Environmental Quality2002，11，： | 1 |
| 20 | Prevalence of transmitted drug resistance associated mutations and HIV-1 subtypes in new HIV-1 diagnoses, U.S.–2006显示文摘 | William H Wheeler Rebecca A Ziebell Helena Zabina Danuta Pieniazek Joseph Prejean Ulana R Bodnar Kristen C Mahle Walid Heneine Jeffrey A Johnson H Irene Hall | 2010 | AIDS2010，，8： | 1 |
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