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| 1 | Organic chloramines in chlorine-based disinfected water systems: A critical review显示文摘This paper is a critical review of current knowledge of organic chloramines in water systems,including their formation, stability, toxicity, analytical methods for detection, and their impact on drinking water treatment and quality. The term organic chloramines may refer to any halogenated organic compounds measured as part of combined chlorine(the difference between the measured free and total chlorine concentrations), and may include N-chloramines,N-chloramino acids, N-chloraldimines and N-chloramides. Organic chloramines can form when dissolved organic nitrogen or dissolved organic carbon react with either free chlorine or inorganic chloramines. They are potentially harmful to humans and may exist as an intermediate for other disinfection by-products. However, little information is available on the formation or occurrence of organic chloramines in water due to a number of challenges. One of the biggest challenges for the identification and quantification of organic chloramines in water systems is the lack of appropriate analytical methods. In addition, many of the organic chloramines that form during disinfection are unstable, which results in difficulties in sampling and detection. To date research has focussed on the study of organic monochloramines.However, given that breakpoint chlorination is commonly undertaken in water treatment systems, the formation of organic dichloramines should also be considered. Organic chloramines can be formed from many different precursors and pathways. Therefore, studying the occurrence of their precursors in water systems would enable better prediction and management of their formation. | Zuo Tong How Ina Kristiana Francesco Busetti Kathryn L.Linge Cynthia A.Joll | 2017 | Journal of Environmental Sciences2017，29，8： | 11 |
| 2 | Formation and control of nitrogenous DBPs from Western Australian source waters: Investigating the impacts of high nitrogen and bromide concentrations显示文摘We studied the formation of four nitrogenous DBPs(N-DBPs) classes(haloacetonitriles,halonitromethanes, haloacetamides, and N-nitrosamines), as well as trihalomethanes and total organic halogen(TOX), after chlorination or chloramination of source waters. We also evaluated the relative and additive toxicity of N-DBPs and water treatment options for minimisation of N-DBPs. The formation of halonitromethanes, haloacetamides, and N-nitrosamines was higher after chloramination and positively correlated with dissolved organic nitrogen or total nitrogen. N-DBPs were major contributors to the toxicity of both chlorinated and chloraminated waters. The strong correlation between bromide concentration and the overall calculated DBP additive toxicity for both chlorinated and chloraminated source waters demonstrated that formation of brominated haloacetonitriles was the main contributor to toxicity. Ozone–biological activated carbon treatment was not effective in removing N-DBP precursors. The occurrence and formation of N-DBPs should be investigated on a case-by-case basis, especially where advanced water treatment processes are being considered to minimise their formation in drinking waters, and where chloramination is used for final disinfection. | Ina Kristiana Deborah Liew Rita K.Henderson Cynthia A.Joll Kathryn L.Linge | 2017 | Journal of Environmental Sciences2017，29，8： | 7 |
| 3 | The therapeutic potential of nerve growth factor combined with blood-brain barrier modulation by focused ultrasound for neurodegenerative disorders显示文摘Nerve growth factor(NGF) is a neurotrophic factor critical for cholinergic neuronal survival, phenotypic maintenance and plasticity in the mammalian brain. NGF has been implicated in the pathogenesis of neurodegenerative disorders, with direct administration of NGF into the brain capable of facilitating neuroprotection and repair. | Kristiana Xhima Isabelle Aubert | 2021 | Neural Regeneration Research2021，16，9： | 4 |
| 4 | Electrochemical oxidation of reverse osmosis concentrate on boron-doped diamond anodes at circumneutral and acidic pH显示文摘 | Arseto Y. Bagastyo Damien J. Batstone Ina Kristiana Wolfgang Gernjak Cynthia Joll Jelena Radjenovic | 2012 | Water Research2012，，18： | 2 |
| 5 | Analysis of halonitriles in drinking water using solid-phase microextraction and gas chromatography-mass spectrometry 显示文摘 | Ina Kristiana Cynthia JoU Anna Heitz | 2012 | Journal of Chromatography A2012，1125，： | 1 |
| 6 | Cholesterol homeostasis in two commonly used human prostate cancer cell-lines,LNCaP and PC-3显示文摘 | Krycer JR Kristiana I Brown AJ | 2009 | PLoS One2009，4，12： | 1 |
| 7 | Electrochemical oxidation of reverse osmosis concentrate on borondoped diamond anodes at circumneutral and acidic p H显示文摘 | Bagastyo A Y Batstone D J Kristiana I | 2012 | Water Research2012，46，18： | 1 |
| 8 | Halogen-specific total organic halogen analysis: Assessment by recovery of total bromine显示文摘Determination of halogen-specific total organic halogen(TOX) is vital for studies of disinfection of waters containing bromide, since total organic bromine(TOBr) is likely to be more problematic than total organic chlorine. Here, we present further halogen-specific TOX method optimisation and validation, focusing on measurement of TOBr. The optimised halogen-specific TOX method was validated based on the recovery of model compounds covering different classes of disinfection by-products(haloacetic acids, haloacetonitriles,halophenols and halogenated benzenes) and the recovery of total bromine(mass balance of TOBr and bromide concentrations) during disinfection of waters containing dissolved organic matter and bromide. The validation of a halogen-specific TOX method based on the mass balance of total bromine has not previously been reported. Very good recoveries of organic halogen from all model compounds were obtained, indicating high or complete conversion of all organic halogen in the model compound solution through to halide in the absorber solution for ion chromatography analysis. The method was also successfully applied to monitor conversion of bromide to TOBr in a groundwater treatment plant. An excellent recovery(101%)of total bromine was observed from the raw water to the post-chlorination stage. Excellent recoveries of total bromine(92%–95%) were also obtained from chlorination of a synthetic water containing dissolved organic matter and bromide, demonstrating the validity of the halogen-specific TOX method for TOBr measurement. The halogen-specific TOX method is an important tool to monitor and better understand the formation of halogenated organic compounds, in particular brominated organic compounds, in drinking water systems. | Markus Langsa Sebastien Allard Ina Kristiana Anna Heitz Cynthia A.Joll | 2017 | Journal of Environmental Sciences2017，29，8： | 1 |
| 9 | LASIK World Literature Review显示文摘 | Kerry D. Solomon Luis E. Fernández de Castro Helga P. Sandoval Joseph M. Biber Brian Groat Kristiana D. Neff Michelle S. Ying John W. French Eric D. Donnenfeld Richard L. Lindstrom | 2009 | Ophthalmology2009，，4： | 1 |
| 10 | Antipsychotic drugs upregulate lipogenic gene expression by disrupting intracellular trafficking of lipoprotein-derived cholesterol 显示文摘 | Kristiana I Sharpe LJ Catts VS | 2010 | Pharmacogeno- mics J2010，10，5： | 1 |
| 11 | Signaling regulates activity of DHCR24, the final enzyme in cholesterol synthesis显示文摘 | Luu W Zerenturk E J Kristiana I | 2014 | J Lipid Res2014，55，3： | 1 |
| 12 | Cholesterol homeosta- sis in two commonly used human prostate cancer cell-lines, LNCaP and PC-3显示文摘 | KRYCER JR KRISTIANA I BROWN AJ | 2009 | PLoS One2009，4，12： | 1 |
| 13 | Formation of N-nitrosarnines from chloramination of molecular weight fractions of natural organic matter显示文摘 | Kristiana I Tan J Joll CA | 2013 | Water Research2013，47，2： | 1 |
| 14 | Qualitative and quantitative analysis of flavor additives on tobacco products using SPME-GC-Mass spectroscopy显示文摘 | Kristiana I Joll C Heitz A | 1997 | J Agric Food Chem1997，45，3： | 1 |
| 15 | Analysis of halonitriles in drinking water using solid-phase microextraction and gas chromatography-mass spectrometry显示文摘 | Kristiana I Joll C Heitz A | 2012 | Journal of Chromatography A2012，1225，： | 1 |
| 16 | The endogenous regulator 24( S ),25-epoxycholesterol inhibits cholesterol synthesis at DHCR24 (Seladin-1)显示文摘 | Eser J. Zerenturk Ika Kristiana Saloni Gill Andrew J. Brown | 2011 | BBA - Molecular and Cell Biology of Lipids2011，，9： | 1 |
| 17 | The formation of halogen-specific TOX from chlorination and chloramination of natural organic matter iso- lates显示文摘 | Kristiana I Gallard H Joll C | 2009 | Water Research2009，43，： | 1 |
| 18 | IL-10, an inflammatory/inhibitory cytokine, but not always 显示文摘 | Pio C Duraisamy K Kristiana K | 2003 | Immunology Letters2003，86，： | 1 |
| 19 | Powdered activated car- bon coupled with enhanced coagulation for natural organic matter removal and disinfection by-product control: application in a Western Australian water treatment plant 显示文摘 | Kristiana I Joll C Heitz A | 2011 | Chemosphere2011，83，5： | 1 |
| 20 | Mixed-Charge,pH-Responsive Nanoparticles for Selective Interactions with Cells,Organelles,and Bacteria显示文摘CONSPECTUS:Charged interfaces are ubiquitous in biology,from proteins,to membranes enclosing cells and organelles,to bacterial cell walls.For nanomaterials to interact with these biological entities effectively and selectively,their electrostatic properties must be fine-tuned.To date,charged nanomaterials have had their surfaces decorated with a single type of charged ligands(positive,negative,or zwitterionic),sometimes“diluted”with additional uncharged/hydrophobic ligands.Although such materials have shown some promise,they can be nonselectively cytotoxic or membrane-permeable,and can nonspecifically adsorb serum proteins or display limited cellular uptake.In this Account,we review a decade of our work on pH-responsive nanoparticles(NPs)covered with mixtures of oppositely charged ligands.These so-called mixed-charge nanoparticles(MCNPs)comprise d∼4−12 nm Au cores protected with mixed monolayers comprising positively charged N,N,N-trimethyl(11-mercaptoundecyl)ammonium chloride(TMA,[+])and negatively charged mercaptoundecanoic acid(MUA,[−])ligands at varying and precisely adjustable proportions.The MCNPs are pH-responsive because MUA ligands can be protonated at a lower pH and,instead of interacting electrostatically,can engage in hydrogen bonding.Importantly,by adjusting the proportion of TMA and MUA functional groups on the particles’surfaces,(χTMA:χMUA)NP,and/or particle sizes,the relative balance between electrostatic,hydrogen bonding,and van der Waals forces can be tuned,translating into pH-dependent stability versus aggregation of the MCNPs.In this way,MCNPs resist aggregation at the pH of healthy tissues and blood,but they precipitate or even crystallize at a narrow range of acidic pHs,characteristic of extracellular space surrounding tumors as well as intracellular endolysosomal compartments.We harnessed this propensity of MCNPs to aggregate at the desired pH to target low-pH lysosomes in cancer cells.As we showed,MCNPs with compositions around(χTMA:χMUA)NP=80:20 are noncytotoxic to normal cells and do not present adverse effects in mice but kill multiple different cancer cell types through a pH-dependent assembly of micron-sized crystals inside cancer lysosomes.Due to impaired transport and clearance mechanisms,this crystallization leads to an increase in osmotic pressure and lysosome swelling,which permeabilizes lysosomal membranes triggering lysosomal cell death only in cancer cells.The same NPs display only limited aggregation in higher-pH autolysosomes of noncancerous cells.MCNPs can also selectively interact with and disrupt differentially charged bacterial cell walls,leading to Gram-selective antibiotic activity.The most effective ligand composition against Gram-negative bacteria is(χTMA:χMUA)NP=80:20,while for Gram-positive bacteria it is 48:52.Mechanistically,cationic ligands help to attach the particles to Gram-negative cell walls,while partly protonated MUA ligands compete for hydrogen bonds with cell surface lipopolysaccharides and peptidoglycans.As for Gram-positive bacteria,in addition to hydrogen bonding,deprotonated MUAs may contribute to the disruption of the cell wall by coordinating metal cations.Although MCNPs can be nowadays prepared in various and precisely controlled compositions,their properties and in vivo fates merit further study.In this spirit,we conclude this Account by outlining several unresolved problems important for the application of mixed-charge nanoconstructs in vivo and in the clinic. | Marta Siek Kristiana Kandere-Grzybowska Bartosz A.Grzybowski | 2020 | Accounts of Materials Research2020，1，3： | 0 |
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