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| 1 | Lipid-polymer hybrid nanoparticles with rhamnolipid-triggered release capabilities as anti-biofilm drug delivery vehicles显示文摘In lung biofilm infection therapies, the use of lipid-polymer hybrid nanoparticles to encapsulate drugs has emerged as a promising alternative to using liposomes because they have superior physicochemical stability and still possess the biofilm affinity and sputum-penetrating ability of liposomes. To be deemed equally efficacious as liposomes against bacterial biofilms, however, the capability of hybrid nanoparticles to target-release encapsulated drugs at biofilm colonies must be demonstrated. This communication details our investigations into the trigger-release characteristics of hybrid nanoparticles in response to encountering rhamnolipids, which are ubiquitously present in biofilm colonies of Pseudomonas aeruginosa, a major respiratory pathogen. Poly(lactic-co-glycolic acid) and phosphatidylcholine were used as the polymer nanoparticle core and lipid coat, respectively. These investigations were performed using compounds from various biopharmaceutical classification systems (BCS) that differ in their lipid-membrane perme- abilities. The release of BCS Class III compounds, which have poor lipid-membrane permeabilities, was successfully triggered by rhamnolipids at a concentration approximately equal to their clinically observed value, and this release was attributed to the disruption of lipid coats by rhamnolipid micelles. Not unexpectedly, BCS Class I compounds, which have high lipid-membrane permeabilities, were released freely whether or not rhamnolipids were present. The rate of the triggered release can be controlled by incor-porating an additional lipid layer on the hybrid nanoparticles via the electrostatically driven adsorption of lipid vesicles. | Wean Sin Cheow Kunn Hadinoto | 2012 | Particuology2012，10，3： | 5 |
| 2 | Modeling fluid–particle interaction in dilute-phase turbulentliquid–particle flow simulation显示文摘The present work examines the predictive capability of a two-fluid CFD model that is based on the kinetic theory of granular flow in simulating dilute-phase turbulent liquid–particle pipe flows in which the interstitial fluid effect on the particle fluctuating motion is significant. The impacts of employing different drag correlations and turbulence closure models to describe the fluid–particle interactions (i.e. drag force and long-range interaction) are examined at both the mean and fluctuating velocity levels. The model predictions are validated using experimental data of turbulent liquid–particle flows in a vertical pipe at different particle Reynolds numbers (Re P > 400 and Re P < 400), which characterize the importance of the vortex shedding phenomenon in the fluid-phase turbulence modulation. The results indicate that (1) the fluctuating velocity level predictions at different Re P are highly sensitive to the drag correlation selection and (2) different turbulence closure models must be employed to accurately describe the long-range fluid–particle interaction in each phase. In general, good agreement is found between the model predictions and the experimental data at both the mean and fluctuating velocity levels provided that appropriate combinations of the drag correlation and the turbulence closure model are selected depending on Re P . | Kunn Hadinoto Jia Wei Chew | 2010 | Particuology2010，8，2： | 3 |
| 3 | Panda X-III: Searching for neutrinoless double beta decay with high pressure ^(136)Xe gas time projection chambers显示文摘Searching for the neutrinoless double beta decay(NLDBD)is now regarded as the topmost promising technique to explore the nature of neutrinos after the discovery of neutrino masses in oscillation experiments.Panda X-III(particle and astrophysical xenon experiment III)will search for the NLDBD of136Xe at the China Jin Ping Underground Laboratory(CJPL).In the first phase of the experiment,a high pressure gas Time Projection Chamber(TPC)will contain 200 kg,90%136Xe enriched gas operated at10 bar.Fine pitch micro-pattern gas detector(Microbulk Micromegas)will be used at both ends of the TPC for the charge readout with a cathode in the middle.Charge signals can be used to reconstruct the electron tracks of the NLDBD events and provide good energy and spatial resolution.The detector will be immersed in a large water tank to ensure~5 m of water shielding in all directions.The second phase,a ton-scale experiment,will consist of five TPCs in the same water tank,with improved energy resolution and better control over backgrounds. | Xun Chen Chang Bo Fu Javier Galan Karl Giboni Franco Giuliani Ling Hui Gu Ke Han Xiang Dong Ji Heng Lin Jiang Lai Liu Kai Xiang Ni Hiroki Kusano Xiang Xiang Ren Shao Bo Wang Yong Yang Dan Zhang Tao Zhang Li Zhao Xiang Ming Sun Shou Yang Hu Si Yu Jian Xing Long Li Xiao Mei Li Hao Liang Huan Qiao Zhang Ming Rui Zhao Jing Zhou Ya Jun Mao Hao Qiao Si Guang Wang Ying Yuan Meng Wang Amir N.Khan Neill Raper Jian Tang Wei Wang Jia Ning Dong Chang Qing Feng Cheng Li Jian Bei Liu Shu Bin Liu Xiao Lian Wang Dan Yang Zhu Juan F.Castel Susana Cebri'an Theopisti Dafni Javier G.Garza Igor G.Irastorza Francisco J.Iguaz Gloria Luz ′on Hector Mirallas Stephan Aune Eric Berthoumieux Yann Bedfer Denis Calvet Nicole d'Hose Alain Delbart Maria Diakaki Esther Ferrer-Ribas Andrea Ferrero Fabienne Kunne Damien Neyret Thomas Papaevangelou Franck Sabatie Maxence Vanderbroucke AnDi Tan Wick Haxton Yuan Mei Chinorat Kobdaj Yu-Peng Yan | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，6： | 2 |
| 4 | Development of gaskets on the basis of new PTFE microfibres显示文摘 | KEMPE Gerlinde KuNNE Hans-Joachim LaiSSIG Gunther | 1998 | Chem Eng Technol1998，21，11： | 1 |
| 5 | Biosynthesis of phosphatidic acid, lysophosphatidic acid, diglyceride, and triglyceride by fatty acyltransferase pathways in Escherichia coli 显示文摘 | Pieringer RA Bonner H Kunnes RS | 1967 | J Biol Chem1967，242，11： | 1 |
| 6 | The mechanism of ABCG5/ ABCG8 in biliary cholesterol secretion in mice显示文摘 | KOSTERS A KUNNE C LOOUE N | 2006 | J Lipid Res2006，47，： | 1 |
| 7 | Activity of the bilesalt export pump(ABCB11)is critically dependent on canalicularmembrane cholesterol content显示文摘 | Paulusma CC De Waart DR Kunne C | 2009 | Biol Chem2009，284，15： | 1 |
| 8 | An enzyme additive for corn si- lage: Effects on silage composition and animal performance 显示文摘 | Sheperd A C Kunn L J R | 1996 | Journal of Dairy Science1996，79，10： | 1 |
| 9 | Acquisition of myogenic specificity through replacement of one amino acid of MASH21 and introduction of an additional alphahelical turn显示文摘 | Dezan C Mcierhans D Kunne A G | 1999 | Biol Chem1999，380，6： | 1 |
| 10 | Altered dispos-ition of acetaminophen in mice with adisruption of the Mrp3 gene 显示文摘 | Manautou JE de Waart DR Kunne C | 2005 | Hepatology2005，42，5： | 1 |
| 11 | A pyruvate-buffered dialysis fluid induces less peritoneal angiogenesis and fibrosis than a conventional solution显示文摘 | van Westrhenen R Zweers MM Kunne C | 2008 | Perit Dial Int2008，28，5： | 1 |
| 12 | CRISPR immunity relies on the consecutive binding and degradation of negatively supercoiled invader DNA by Cascade and Cas3显示文摘 | Westra ER van ErPPB Kunne T | 2012 | Mol Cell2012，46，5： | 1 |
| 13 | Direct Intestinal Cholesterol Secretion Contributes Significantly to Total Fecal Neutral Sterol Excretion in Mice显示文摘 | Astrid E. van der Velde Carlos L.J. Vrins Karin van den Oever Cindy Kunne Ronald P.J. Oude Elferink Folkert Kuipers Albert K. Groen | 2007 | Gastroenterology2007，，3： | 1 |
| 14 | Predicting turbulence modulations at different Reynolds numbers in dilute-phase turbulentliquid-particle flow simulations显示文摘 | KUNN H | 2010 | Chemical Engineering Science2010，65，19： | 1 |
| 15 | Atp8b1 deficiency in mice reduces resistance of the canalicular membrane to hydrophobic bile salts and impairs bile salt transport显示文摘 | PAULUSMA CC GROEN A KUNNE C | 2006 | Hepatology2006，44，： | 1 |
| 16 | Spray dry- ing formulation of hollow spherical aggregates of silica nanoparticles by experimental design 显示文摘 | Wean Sin Cheow Selina Li Kunn I-Iadinoto | 2010 | Chemical En-gineering Research and Design2010，88，56： | 1 |
| 17 | Lipotoxieity and steatohepatitis in an overfed mouse model for non-alcoholic fatty liver disease显示文摘 | Gaemers I C Stallen J M Kunne C | 2011 | Biochim Biophys Acta2011，1812，4： | 1 |
| 18 | Atp8b1 deficiency in mice reduces resistance of the canalicular membrane to hydrophobic bile salts and impairs bile salt transport显示文摘 | Paulusma CC Groen A Kunne C | 2006 | Hepatology2006，44，1： | 1 |
| 19 | Statins and chronic heart failure:do we neck a large-scale outcome trial 显示文摘 | Kunn H Mcmurray JJ | 2002 | J Am Coll Cardiol2002，39，： | 1 |
| 20 | CRISPR immunity relies on the consecutive binding and degradation of negatively supercoiled invader DNA by Cascade and Cas3 显示文摘 | Westra E R van Erp P B KUnne T | 2012 | Mol Cell2012，46，5： | 1 |
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