|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Immunological Effects of Silica and Asbestos显示文摘Silicosis patients(SILs) and patients who have been exposed to asbestos develop not only respiratory diseases but also certain immunological disorders. In particular,SIL sometimes complicates autoimmune diseases such as systemic scleroderma,rheumatoid arthritis(known as Caplan syndrome) ,and systemic lupus erythematoses. In addition,malignant complications such as lung cancer and malignant mesothelioma often occurr in patients exposed to asbestos,and may be involved in the reduction of tumor immunity. Although silica-induced disorders of autoimmunity have been explained as adjuvant-type effects of silica,more precise analyses are needed and should reflect the recent progress in immunomolecular findings. A brief summary of our investigations related to the immunological effects of silica/asbestos is presented. Recent advances in immunomolecular studies led to detailed analyses of the immunological effects of asbestos and silica. Both affect immuno-competent cells and these effects may be associated with the pathophysiological development of complications in silicosis and asbestos-exposed patients such as the occurrence of autoimmune disorders and malignant tumors,respectively. In addition,immunological analyses may lead to the development of new clinical tools for the modification of the pathophysiological aspects of diseases such as the regulation of autoimmunity or tumor immunity using cell-mediated therapies,various cytokines,and molecule-targeting therapies. In particular,as the incidence of asbestos-related malignancies is increasing and such malignancies have been a medical and social problem since the summer of 2005 in Japan,efforts should be focused on developing a cure for these diseases to eliminate nationwide anxiety. | Takemi Otsuki Megumi Maeda Shuko Murakami Hiroaki Hayashi Yoshie Miura Masayasu Kusaka Takashi Nakano Kazuya Fukuoka Takumi Kishimoto Fuminori Hyodoh Ayako Ueki Yasumitsu Nishimura | 2007 | Cellular & Molecular Immunology2007，4，4： | 9 |
| 2 | Arc Power Limit and Distribution on the Large Negative Ion Source Based on JT-60 NNBI | LEI Guangjiu N. Umeda M. Kawai T. Yamamoto M. KuriyamaT. Ohga N. Ebisawa T. Yamazaki M. Kusaka K. KikuchiS. Hikida K. Usui M. Kazawa S. Numazawa K. MogakiA.Honda F. Satoh S. Norio K. Ooshima 1) Naka Fusion Research Establishment, Japan Atomic Energy Research Institute, Naka-gun, Ibraraki-ken 311-0193, Japan. | 2002 | 中国核科技报告2002，，1： | 7 |
| 3 | Magnifying narrow-band imaging with acetic acid to diagnose early colorectal cancer显示文摘AIM:To evaluate the diagnostic characteristics of magnifying endoscopy with acetic acid spray and narrowband imaging(MA-NBI)for early colorectal cancer.METHODS:We conducted a prospective study to evaluate the diagnostic characteristics of MA-NBI in differentiating early colorectal adenocarcinomas from adenomas.To compare the results,we used magnifying endoscopy with NBI(M-NBI)and magnifying endoscopy with crystal violet staining(M-CV).The study was performed in 2 phases.In phase 1,10 colonoscopists at our institution were shown still photographs of 35colorectal polyps(24 adenocarcinomas and 11 adenomas)in M-NBI,MA-NBI,and M-CV.They made diagnostic predictions using a five-grade scoring evaluation.We plotted receiver operating characteristic curves and compared the areas under the curves(AUCs).In phase2,colorectal polyps measuring≥8 mm were prospectively enrolled.During real-time colonoscopy,one ofthe 7 colonoscopists scored the lesion as an adenocarcinoma or an adenoma and assigned a level of confidence to the prediction(high or low).We calculated the accuracy,sensitivity,specificity,positive predictive value(PPV),and negative predictive value(NPV)for each method and compared the proportions of highconfidence predictions.RESULTS:In phase 1,the mean±SD AUCs were 0.64±0.031 in M-NBI,0.71±0.066 in MA-NBI,and 0.76±0.059 in M-CV(P<0.05 for M-NBI vs MA-NBI,P<0.001 for M-NBI vs M-CV,and not significant for MANBI vs M-CV).In phase 2,84 patients with 91 lesions(46 adenocarcinomas and 45 adenomas)were enrolled.The diagnostic characteristics were as follows:73%accuracy,85%sensitivity,60%specificity,68%PPV,and 79%NPV in M-NBI;73%accuracy,80%sensitivity,64%specificity,70%PPV,and 76%NPV in MA-NBI;and 73%accuracy,83%sensitivity,62%specificity,69%PPV,and 78%NPV in M-CV.The proportions of high-confidence predictions were 57%in M-NBI,75%in MA-NBI,and 76%in M-CV(P<0.005 for M-NBI vs MA-NBI,P<0.0005 for M-NBI vs M-CV,and P=1.0 for MA-NBI vs M-CV).CONCLUSION:MA-NBI is useful for differentiating early colorectal adenocarcinomas from adenomas. | Norihiro Goto Toshihiro Kusaka Yumi Tomita Hideyuki Tanaka Yoshio Itokawa Yorimitsu Koshikawa Daisuke Yamaguchi Yoshitaka Nakai Shigehiko Fujii Hiroyuki Kokuryu | 2014 | World Journal of Gastroenterology2014，20，43： | 4 |
| 4 | A prospective, randomized, double-blind, controlled trial on the efficacy of carbon dioxide insufflation in gastric endoscopic submucosal dissection显示文摘 | Y. Maeda D. Hirasawa N. Fujita T. Obana T. Sugawara T. Ohira Y. Harada T. Yamagata K. Suzuki Y. Koike J. Kusaka M. Tanaka Y. Noda | 2013 | Endoscopy2013，，05： | 4 |
| 5 | 微导通孔的电镀填孔技术显示文摘本文主介绍了电镀填孔技术,并探讨了DC和PPR电镀填孔技术的优缺点和影响填孔效果的相关因素。 | George Allardyce Mark Lefebvre Hideki Tsuchida Masaru Kusaka Shinjiro Hayashi 张伯兴 | 2004 | 印制电路信息2004，，10： | 4 |
| 6 | Case of pediatric traditional serrated adenoma resected via endoscopic submucosal dissection显示文摘Traditional serrated adenoma(TSA)is a type of serrated polyp of the colorectum and is thought to be a precancerous lesion.There are three types of serrated polyps,namely,hyperplastic polyps,sessile serrated adenomas/polyps,and TSAs.TSA is the least common of the three types and accounts for about 5% of serrated polyps.Here we report a pediatric case of TSA that was successfully resected by endoscopic submucosal dissection(ESD).This rare case report describes a pediatric patient with no family history of colonic polyp who was admitted to our hospital with hematochezia.On colonoscopy,we found a polypoid lesion measuring 10 mm in diameter in the lower rectum.We selected ESD as a surgical option for en bloc resection,and histopathological examination revealed TSA.The findings in this case suggest that TSA with precancerous potential can occur in children,and that ESD is useful for treating this lesion. | Sonoko Kondo Hirohito Mori Noriko Nishiyama Takeo Kondo Ryuichi Shimono Hitoshi Okada Takashi Kusaka | 2017 | World Journal of Gastroenterology2017，23，24： | 4 |
| 7 | Two-dimensional optical tomography of hemodynamic changes in a preterm infant brain显示文摘Our preliminary results on two-dimensional(2D)optical tomographic imaging of hemodynamic changes in a preterm infant brain are reported.We use the established 16-channel time-correlated single photon counting system for the detection and generalized pulse spectrum technique based algorithm for the image reconstruction.The experiments demonstrate that diffuse optical tomography may be a potent means for investigating brain functions and neural development of infant brains in the perinatal period. | 高峰 薛媛 赵会娟 Takashi Kusaka Masanori Ueno Yukio Yamada | 2007 | Chinese Optics Letters2007，5，8： | 3 |
| 8 | Effects of statins on the adipocyte maturation and expression of glucose transporter 4 (SLC2A4): implications in glycaemic control显示文摘 | M. Nakata S. Nagasaka I. Kusaka H. Matsuoka S. Ishibashi T. Yada | 2006 | Diabetologia2006，，8： | 2 |
| 9 | Role of nitric oxide in the pathogenesis of Barrett's-associated carcinogenesis显示文摘Barrett's esophagus(BE), a premalignant condition to Barrett's adenocarcinoma(BAC), is closely associated with chronic inflammation due to gastro-esophageal reflux. Caudal type homeobox 2(CDX2), a representative marker of BE, is increased during the metaplastic and neoplastic transformation of BE. Nitric oxide(NO) has been proposed to be a crucial mediator of Barrett's carcinogenesis. We previously demonstrated that CDX2 might be induced directly under stimulation of large amounts of NO generated around the gastroesophageal junction(GEJ) by activating epithelial growth factor receptor in a ligand-independent manner. Thus, we reviewed recent developments on the role of NO in Barrett's carcinogenesis. Notably, recent studies have reported that microbial communities in the distal esophagus are significantly different among groups with a normal esophagus, reflux esophagitis, BE or BAC, despite there being no difference in the bacterial quantity. Considering that microorganism components can be one of the major sources of large amounts of NO, these studies suggest that the bacterial composition in the distal esophagus might play an important role in regulating NO production during the carcinogenic process. Controlling an inflammatory reaction due to gastro-esophageal reflux or bacterial composition around the GEJ might help prevent the progression of Barrett's carcinogenesis by inhibiting NO production. | Gen Kusaka Kaname Uno Katsunori Iijima Tooru Shimosegawa | 2016 | World Journal of Gastrointestinal Pathophysiology2016，7，1： | 2 |
| 10 | Increased RhoA translocation in aorta of diabetic rats显示文摘瞄准:在糖尿病的老鼠的主动脉分析 RhoA 表示和激活。方法:男 SD 老鼠(n=70 ) 被划分成 2 个组:糖尿病的组和控制组。糖尿病被 streptozotocin (55 mg/kg ) 的静脉注射导致。老鼠 3 个星期在糖尿病的正式就职以后被学习。西方的弄污被用来测量 Rho 的表示和激活。结果:心搏率被测量 24 h/d;它在糖尿病的老鼠由 58+/-13 beats/min 减少了。当由 KCl 和血清素刺激了时,等轴的紧张证明糖尿病的主动脉的收缩显著地与控制主动脉的相比被减少。当由醋胆素刺激了时,糖尿病的主动脉的松驰被减少。在糖尿病的老鼠的大动脉的纸巾的提高的 RhoA 易位被膜界限 RhoA 的 90% 增加决定,显示 RhoA 的激活显著地在糖尿病的主动脉被增加。结论:我们的数据在调整 RhoA 上面建议那能涉及糖尿病的老鼠的脉管的机能障碍。 | Jiping TANG Ikuyo KUSAKA Amber R MASSEY Shadon ROLLINS John H ZHANG | 2006 | Acta Pharmacologica Sinica2006，27，5： | 2 |
| 11 | A pilot study to assess mediastinal emphysema after esophageal endoscopic submucosal dissection with carbon dioxide insufflation显示文摘 | Y. Maeda D. Hirasawa N. Fujita T. Obana T. Sugawara T. Ohira Y. Harada T. Yamagata K. Suzuki Y. Koike Y. Yamamoto Z. Kusaka Y. Noda | 2012 | Endoscopy2012，，06： | 2 |
| 12 | Role of AT1 receptors and NAD(P)H oxidase in diabetes-aggravated ischemic brain injury显示文摘 | Kusaka I Kusaka G Zhou C | 2004 | Physiol Heart Circ Physiol2004，286，6： | 1 |
| 13 | A simple single-layer urban canopy model for atmpspherlc models: Comparison with mutil-layer and slab models显示文摘 | Kusaka H Kondo H | 2001 | Boundary Layer Meteorology2001，101，： | 1 |
| 14 | Estimation of trunk muscle pa-rameters for a biomechanical model by age, height and weight显示文摘 | SEO A LEE J H KUSAKA Y | 2003 | J Occupational Health2003，45，4： | 1 |
| 15 | Analysis of K-ras codon 12 mutations and p53 overexpression in colorectal nodule- aggregating tumors 显示文摘 | Kusaka T Fukui H Sano Y | 2000 | J Gastroenterol Hepatol2000，15，10： | 1 |
| 16 | Ciliary body detachment associated with transient myopic shift after pars plana vitrectomy显示文摘 | Kusaka S Okada A A Hayasshi A | 2000 | Retina2000，20，4： | 1 |
| 17 | Prevention of lymphocys-tormation following systematic lymphadenectomy 显示文摘 | Yamamoto R Saitoh T Kusaka T etal | 2000 | Jpn J Cli-nOncol2000，30，9： | 1 |
| 18 | Association of CTLA-4 polymorphism with positive anti-GAD antibody in Japanese subjects with type l diabetes mellitus显示文摘 | Hayashi H Kusaka I Nagasaka S | 1999 | Clin Endocrinol(Oxf)1999，51，： | 1 |
| 19 | Comparative pulmonary responses caused by exposure to standard cobalt and ultrafine cobalt显示文摘 | Zhang Q Kusaka Y Donaldson K | 2000 | J Occup Health2000，42，： | 1 |
| 20 | Measurement of cerebral oxygenation in neonates after vaginal delivery and cesarean section using full spectrum near infrared spectroscopy 显示文摘 | Isobe K Kusaka T Fujikawa Y | 2002 | Comp Biochem Physiol A Mol Integr Physiol2002，132，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员