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| 1 | Immunological Effects of Silica and Asbestos显示文摘Silicosis patients(SILs) and patients who have been exposed to asbestos develop not only respiratory diseases but also certain immunological disorders. In particular,SIL sometimes complicates autoimmune diseases such as systemic scleroderma,rheumatoid arthritis(known as Caplan syndrome) ,and systemic lupus erythematoses. In addition,malignant complications such as lung cancer and malignant mesothelioma often occurr in patients exposed to asbestos,and may be involved in the reduction of tumor immunity. Although silica-induced disorders of autoimmunity have been explained as adjuvant-type effects of silica,more precise analyses are needed and should reflect the recent progress in immunomolecular findings. A brief summary of our investigations related to the immunological effects of silica/asbestos is presented. Recent advances in immunomolecular studies led to detailed analyses of the immunological effects of asbestos and silica. Both affect immuno-competent cells and these effects may be associated with the pathophysiological development of complications in silicosis and asbestos-exposed patients such as the occurrence of autoimmune disorders and malignant tumors,respectively. In addition,immunological analyses may lead to the development of new clinical tools for the modification of the pathophysiological aspects of diseases such as the regulation of autoimmunity or tumor immunity using cell-mediated therapies,various cytokines,and molecule-targeting therapies. In particular,as the incidence of asbestos-related malignancies is increasing and such malignancies have been a medical and social problem since the summer of 2005 in Japan,efforts should be focused on developing a cure for these diseases to eliminate nationwide anxiety. | Takemi Otsuki Megumi Maeda Shuko Murakami Hiroaki Hayashi Yoshie Miura Masayasu Kusaka Takashi Nakano Kazuya Fukuoka Takumi Kishimoto Fuminori Hyodoh Ayako Ueki Yasumitsu Nishimura | 2007 | Cellular & Molecular Immunology2007，4，4： | 9 |
| 2 | Preparation and mechanical properties of bacterial cellulose nanocomposites loaded with silica nanoparticles显示文摘 | Shoichiro Yano Hideaki Maeda Megumi Nakajima | 2008 | Cellulose2008，15，： | 1 |
| 3 | Bread quality of frozen dough substituted with modiWed tapioca starches 显示文摘 | Megumi Miyazaki Tomoko Maeda Naofumi Morita | 2008 | Eur Food Res Technol2008，227，： | 1 |
| 4 | Recent advances in application of modified starches for breadmaking显示文摘 | Megumi Miyazaki Pham Van Hung Tomoko Maeda Naofumi Morita | 2006 | Trends in Food Science & Technology2006，，11： | 1 |
| 5 | Usefulness of the thread‐traction method in esophageal endoscopic submucosal dissection: Randomized controlled trial显示文摘 | Yoshiki Koike Dai Hirasawa Naotaka Fujita Yuki Maeda Tetsuya Ohira Yoshihiro Harada Kenjiro Suzuki Taku Yamagata Megumi Tanaka | 2015 | Digestive Endoscopy2015，，3： | 1 |
| 6 | Bread quality of frozen dough substituted with modiWed tapioca starches显示文摘 | Megumi Miyazaki Tomoko Maeda Naofumi Morita | 2008 | Eur Food Res Technol2008，，227： | 1 |
| 7 | Incremental Prognostic Significance of Peripheral Endothelial Dysfunction in Patients With Heart Failure With Normal Left Ventricular Ejection Fraction显示文摘 | Eiichi Akiyama Seigo Sugiyama Yasushi Matsuzawa Masaaki Konishi Hiroyuki Suzuki Toshimitsu Nozaki Keisuke Ohba Junichi Matsubara Hirofumi Maeda Yoko Horibata Kenji Sakamoto Koichi Sugamura Megumi Yamamuro Hitoshi Sumida Koichi Kaikita Satomi Iwashita Kuni | 2012 | Journal of the American College of Cardiology2012，，18： | 1 |
| 8 | Dough and Baking Properties of High-Amylose and Waxy Wheat Flours显示文摘 | Naofumi Morita Tomoko Maeda Megumi Miyazaki Makoto Yamamori Hideho Miura and Ichiro Ohtsuka | 2002 | Cereal Chem2002，79，4： | 1 |
| 9 | Recent advances in application of modified starches forbreadmaking显示文摘 | Megumi Miyazaki Pham Van Hung Tomoko Maeda | 2006 | Trends in Food Science & Technology2006，17，11： | 1 |
| 10 | Involvement of IL-10 and Bcl-2 in resistance against an asbestos-induced apoptosis of T cells显示文摘 | Yoshie Miura Yasumitsu Nishimura Hironobu Katsuyama Megumi Maeda Hiroaki Hayashi Maolong Dong Fuminori Hyodoh Masafumi Tomita Yoshinobu Matsuo Ayuko Uesaka Kozo Kuribayashi Takashi Nakano Takumi Kishimoto Takemi Otsuki | 2006 | Apoptosis2006，，10： | 1 |
| 11 | Acute and delayed psychiatric sequelae among patients hospitalised with COVID-19:a cohort study using LIFE study data显示文摘Background Characterising the psychiatric sequelae of coronavirus disease 2019(COVID-19)can inform the development of long-term treatment strategies.However,few studies have examined these sequelae at different time points after COVID-19 infection.Aims The study aimed to investigate the incidences and risks of acute and delayed psychiatric sequelae in patients hospitalised with COVID-19 in Japan.Methods This retrospective cohort study was conducted using a database comprising healthcare claims data from public health insurance enrollees residing in a Japanese city.We analysed a primary cohort comprising patients hospitalised with COVID-19 between March 2020 and July 2021 and two control cohorts comprising patients hospitalised with influenza or other respiratory tract infections(RTI)during the same period.We calculated the incidences of acute(1–3 months after infection)and delayed(4–6 months after infection)psychiatric sequelae.These sequelae were identified using diagnosis codes and categorised as mood/anxiety/psychotic disorder,mood disorder,anxiety disorder,psychotic disorder or insomnia.Multivariable logistic regression models were used to estimate the odds ratios(ORs)of psychiatric sequelae occurrence after COVID-19 infection compared with influenza and other RTI.Results The study population with acute psychiatric sequela consisted of 662 patients with COVID-19,644 patients with influenza,and 7369 patients with RTI who could be followed for 3 months;the study population with delayed psychiatric sequelae consisted of 371 patients with COVID-19,546 patients with influenza,and 5397 patients with RTI who could be followed for 6 months.In the analysis of acute psychiatric sequelae,COVID-19 had significantly higher odds of mood/anxiety/psychotic disorder(OR:1.39,p=0.026),psychotic disorder(OR:2.13,p<0.001),and insomnia(OR:2.59,p<0.001)than influenza,and significantly higher odds of insomnia(OR:1.44,p=0.002)and significantly lower odds of anxiety disorder(OR:0.56,p<0.001)than other RTI.In the analysis of delayed psychiatric sequelae,COVID-19 had significantly higher odds of psychotic disorder(OR:2.25,p=0.007)than influenza,but significantly lower odds of anxiety disorder(OR:0.55,p=0.011)than other RTI.Conclusions COVID-19 was generally associated with an increased risk of psychiatric sequelae occurring within 3 months after infection,but had a lower risk of new psychiatric sequelae developing 4–6 months after infection. | Fumiko Murata Megumi Maeda Chieko Ishiguro Haruhisa Fukuda | 2022 | General Psychiatry2022，35，3： | 0 |
| 12 | Identification of telomere maintenance gene variations related to lung adenocarcinoma risk by genome-wide association and whole genome sequencing analyses显示文摘Dear editor,Lung carcinoma is responsible for the highest fatal-ity rate among cancer-related deaths globally,with lung adenocarcinoma(LADC)emerging as the prevailing sub-type. | Kouya Shiraishi Atsushi Takahashi Yukihide Momozawa Yataro Daigo Syuzo Kaneko Takahisa Kawaguchi Hideo Kunitoh Shingo Matsumoto Hidehito Horinouchi Akiteru Goto Takayuki Honda Kimihiro Shimizu Masahiro Torasawa Daisuke Takayanagi Motonobu Saito Akira Saito Yuichiro Ohe Shun-ichi Watanabe Koichi Goto Masahiro Tsuboi Katsuya Tsuchihara Sadaaki Takata Tomomi Aoi Atsushi Takano Masashi Kobayashi Yohei Miyagi Kazumi Tanaka Hiroyuki Suzuki Daichi Maeda Takumi Yamaura Maiko Matsuda Yoko Shimada Takaaki Mizuno Hiromi Sakamoto Teruhiko Yoshida Yasushi Goto Tatsuya Yoshida Taiki Yamaji Makoto Sonobe Shinichi Toyooka Kazue Yoneda Katsuhiro Masago Fumihiro Tanaka Megumi Hara Nobuo Fuse Satoshi S.Nishizuka Noriko Motoi Norie Sawada Yuichiro Nishida Kazuki Kumada Kenji Takeuchi Kozo Tanno Yasushi Yatabe Kuniko Sunami Tomoyuki Hishida Yasunari Miyazaki Hidemi Ito Mitsuhiro Amemiya Hirohiko Totsuka Haruhiko Nakayama Tomoyuki Yokose Kazuyoshi Ishigaki Toshiteru Nagashima Yoichi Ohtaki Kazuhiro Imai Ken Takasawa Yoshihiro Minamiya Kazuma Kobayashi Kenichi Okubo Kenji Wakai Atsushi Shimizu Masayuki Yamamoto Motoki Iwasaki Koichi Matsuda Johji Inazawa Yuichi Shiraishi Hiroyoshi Nishikawa Yoshinori Murakami Michiaki Kubo Fumihiko Matsuda Yoichiro Kamatani Ryuji Hamamoto Keitaro Matsuo Takashi Kohno | 2024 | Cancer Communications2024，44，2： | 0 |
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