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| 1 | Factors associated with residual gastroesophageal reflux disease symptoms in patients receiving proton pump inhibitor maintenance therapy显示文摘AIM To elucidate the factors associated with residual gastroesophageal reflux disease(GERD) symptoms in patients receiving proton pump inhibitor(PPI) maintenance therapy in clinical practice.METHODS The study included 39 GERD patients receiving maintenance PPI therapy. Residual symptoms were assessed using the Frequency Scale for Symptoms of GERD(FSSG) questionnaire and the Gastrointestinal Symptom Rating Scale(GSRS). The relationships between the FSSG score and patient background factors, including the CYP2C19 genotype, were analyzed.RESULTS The FSSG scores ranged from 1 to 28 points(median score: 7.5 points), and 19 patients(48.7%) had a score of 8 points or more. The patients' GSRS scores were significantly correlated with their FSSG scores(correlation coefficient = 0.47, P < 0.005). In erosive esophagitis patients, the FSSG scores of the CYP2C19 rapid metabolizers(RMs) were significantly higher than the scores of the poor metabolizers and intermediate metabolizers(total scores: 16.7 ± 8.6 vs 7.8 ± 5.4, P < 0.05; acid reflux-related symptom scores: 12 ± 1.9 vs 2.5 ± 0.8, P < 0.005). In contrast, the FSSG scores of the CYP2C19 RMs in the non-erosive reflux disease patients were significantly lower than those of the other patients(total scores: 5.5 ± 1.0 vs 11.8 ± 6.3, P < 0.05; dysmotility symptom-related scores: 1.0 ± 0.4 vs 6.0 ± 0.8, P < 0.01). CONCLUSION Approximately half of the GERD patients receiving maintenance PPI therapy had residual symptoms associated with a lower quality of life, and the CYP2C19 genotype appeared to be associated with these residual symptoms. | Fumiaki Kawara Tsuyoshi Fujita Yoshinori Morita Atsushi Uda Atsuhiro Masuda Masaya Saito Makoto Ooi Tsukasa Ishida Yasuyuki Kondo Shiei Yoshida Tatsuya Okuno Yoshihiko Yano Masaru Yoshida Hiromu Kutsumi Takanobu Hayakumo Kazuhiko Yamashita Takeshi Hirano Midori Hirai Takeshi Azuma | 2017 | World Journal of Gastroenterology2017，23，11： | 5 |
| 2 | Retrospective study of technical aspects and complications of endoscopic submucosal dissection for laterally spreading tumors of the colorectum显示文摘 | T. Toyonaga M. Man-i T. Fujita J. East E. Nishino W. Ono Y. Morita T. Sanuki M. Yoshida H. Kutsumi H. Inokuchi T. Azuma | 2010 | Endoscopy2010，，09： | 3 |
| 3 | Serodiagnosis of alveolar hydatid disease by Western blotting显示文摘 | Ito A Nakao M Kutsumi H et aI | 1993 | Trans Roy Soc Trop Med Hyg1993，87，2： | 1 |
| 4 | Relation of angiographically defined coronary heart disease and plasma concentration of insulin,lipid,and apolipoprotein in normolipidemic subjects with varing degrees of glucose tolerance显示文摘 | Fujiwara R Kutsumi Y Hayashi T | 1995 | AmJ Cardiol1995，1575，： | 1 |
| 5 | Diagnostic endoscopic retrograde cholangiopancreatography显示文摘 | Shimizu S Kutsumi H Fujimoto S | 1998 | Endoscopy1998，30，2： | 1 |
| 6 | Rabeprazole reduces the recur- rence risk of peptic ulcers associated with low-dose aspirin in pa- tients with cardiovascular or cerebrovascular disease :a prospective randomized active-controlled trim 显示文摘 | Sannki T Fujita T Kutsumi H | 2012 | J Gastroenterol2012，47，11： | 1 |
| 7 | Endoscopic Pancreatic Duct Stents Reduce the Incidence of Post–Endoscopic Retrograde Cholangiopancreatography Pancreatitis in High-Risk Patients显示文摘 | Atsushi Sofuni Hiroyuki Maguchi Tsuyoshi Mukai Hiroshi Kawakami Atsushi Irisawa Kensuke Kubota Shinji Okaniwa Masataka Kikuyama Hiromu Kutsumi Keiji Hanada Toshiharu Ueki Takao Itoi | 2011 | Clinical Gastroenterology and Hepatology2011，，10： | 1 |
| 8 | Relation of angiongraphy defimed coronary disease and plasma concentrations insulin, lipid and apolipoprotein in norrnolipidernic subjects with varying degrees of glucose tolerance显示文摘 | Fujiwara R Kutsumi Y Mayashi T | 1995 | Am J Cardio1995，75，2： | 1 |
| 9 | Serodiagnosis of alveolar hydatid disease by Western blotting显示文摘 | ho A Nakao M Kutsumi H | 1993 | Trans Roy Soc Trop Med Hyg1993，87，2： | 1 |
| 10 | Rabeprazole reduces the recur-rence risk of peptic ulcers associated with low-dose aspirin in pa-tients with cardiovascular or cerebrovascular disease: A prospectiverandomized active-controlled trial显示文摘 | Sanuki T Fujita T Kutsumi H | 2012 | J Gastroenterol2012，47，11： | 1 |
| 11 | Relation of angiographically defined coronary artery disease and plasma concentrations of insulin, lipid, and apolipoprotein in normolipidemic subjects with varying degrees of glucose tolerance显示文摘 | Fujiwara R Kutsumi Y Hayashi T | 1995 | Am J Cardiol1995，75，2： | 1 |
| 12 | Relation of angiographically defined coronary artery disease and plasma concentration of insulin,lipid and apolipoprotein in normolipidemic subjects with varying degrees of glucose tolerance显示文摘 | Fujiwara R Kutsumi Y Havashi T | 1995 | Am J Cardiol1995，75，： | 1 |
| 13 | Relation of augionraphecally defined coronry artery disease and plasma concentration of insulin,lipid,and apolipoprotein in normolipidemic subjects with varying degrecs of glucose tolerance显示文摘 | Fujiwara R Kutsumi Y Havashi T | 1995 | Am J Cardilo1995，75，： | 1 |
| 14 | The effect of neutrophil depletion on reperfusion arrhythmias during intracoronary thrombolysis using the leukocyte removal filter显示文摘 | Kutsumi Y Misawa T Tada H | 1989 | ASAIO Trans1989，35，： | 1 |
| 15 | Serodiagnosis of alveolar hydatid disease by Western blotting显示文摘 | Ito A Nakao M Kutsumi H | 1993 | Trans R Soc Trop Med Hyg1993，87，2： | 1 |
| 16 | Late fracture of vascularized fibular graft显示文摘 | Kasashima T Minami A Kutsumi K | 1998 | Microsurgery1998，18，5： | 1 |
| 17 | Relation of angiographically defined coronary artery disease and plasma concentration of insulin,lipid,and apolipoprotein in normolipidemic subjects with varying degree of gluclose tolerance显示文摘 | Fujiwara R Kutsumi Y Hayashi T | 1995 | Am J Cardiol1995，75，2： | 1 |
| 18 | The relationship between pancreatic atrophy after steroid therapy and diabetes mellitus in patients with autoimmune pancreatitis显示文摘 | Atsuhiro Masuda Hideyuki Shiomi Tomokazu Matsuda Mamoru Takenaka Yoshifumi Arisaka Takeshi Azuma Hiromu Kutsumi | 2014 | Pancreatology2014，，5： | 1 |
| 19 | Rabeprazole reduces the recurrence risk of peptic ulcers associated with low-dose aspirin in patients with cardiovascular or eerebrovascular disease: a prospec- tive randomized active-controlled trial显示文摘 | Sanuki T Fujita T Kutsumi H | 2012 | J Gastroenterol2012，47，11： | 1 |
| 20 | Relation of augionraphecally defined coronary artery disease and plasma concentration of insulin,lipid,and apolipoprotein in normolipidemic subjects with varying degrees of glucose tolerance显示文摘 | Fujiwara R Kutsumi Y Havashi T | 1995 | Am J Cardilo1995，75，： | 1 |
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