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| 1 | Target identification of natural medicine with chemical proteomics approach:probe synthesis,target fishing and protein identification显示文摘Natural products are an important source of new drugs for the treatment of various diseases.However,developing natural productbased new medicines through random moiety modification is a lengthy and costly process,due in part to the difficulties associated with comprehensively understanding the mechanism of action and the side effects.Identifying the protein targets of natural products is an effective strategy,but most medicines interact with multiple protein targets,which complicate this process.In recent years,an increasing number of researchers have begun to screen the target proteins of natural products with chemical proteomics approaches,which can provide a more comprehensive array of the protein targets of active small molecules in an unbiased manner.Typically,chemical proteomics experiments for target identification consist of two key steps:(1)chemical probe design and synthesis and(2)target fishing and identification.In recent decades,five different types of chemical proteomic probes and their respective target fishing methods have been developed to screen targets of molecules with different structures,and a variety of protein identification approaches have been invented.Presently,we will classify these chemical proteomics approaches,the application scopes and characteristics of the different types of chemical probes,the different protein identification methods,and the advantages and disadvantages of these strategies. | Xiao Chen Yutong Wang Nan Ma Jing Tian Yurou Shao Bo Zhu Yin Kwan Wong Zhen Liang Chang Zou Jigang Wang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 2 |
| 2 | CD24 + Liver Tumor-Initiating Cells Drive Self-Renewal and Tumor Initiation through STAT3-Mediated NANOG Regulation显示文摘 | Terence Kin Wah Lee Antonia Castilho Vincent Chi Ho Cheung Kwan Ho Tang Stephanie Ma Irene Oi Lin Ng | 2011 | Cell Stem Cell2011，，1： | 2 |
| 3 | miR-130b Promotes CD133 + Liver Tumor-Initiating Cell Growth and Self-Renewal via Tumor Protein 53-Induced Nuclear Protein 1显示文摘 | Stephanie Ma Kwan Ho Tang Yuen Piu Chan Terence K. Lee Pak Shing Kwan Antonia Castilho Irene Ng Kwan Man Nathalie Wong Ka-Fai To Bo-Jian Zheng Paul B.S. Lai Chung Mau Lo Kwok Wah Chan Xin-Yuan Guan | 2010 | Cell Stem Cell2010，，： | 2 |
| 4 | Leptin Signaling Protects NK Cells from Apoptosis During Development in Mouse Bone Marrow显示文摘增加的证据在有免疫力的反应显示 leptin 的一个角色,但是发信号的 leptin 是否涉及在骨头髓(BM ) 调整 NK 房间开发,仍然保持大部分不清楚。在这研究,我们在在 prediabetic 的缺乏的 db/db 老鼠上演的 leptin 受体的 BM 描绘了 NK 房间区别和成熟。尽管 BM 细胞质类似于控制值, NK 房间的全部的数字严重地在变异的鼠标被减少。db/db BM 房间的流动 cytometric 分析揭示了在区别的各种各样的阶段开发 NK 房间的显著地减少的频率。显著地显示的 BM db/db NK 房间增加了 apoptosis,但是维持了正常房间骑车地位和 proliferative 能力。而且, recombinant leptin 能显著地在文化从野类型的老鼠提高 NK 房间的幸存。NK 房间上的进一步的检查功能的活动证明 db/db NK 房间与显著地增加的 IL-10 展出了正常内在的 cytotoxicity 生产。一起拿,我们的调查结果建议发信号的 leptin 经由在老鼠 BM 提高不成熟的 NK 房间的幸存调整 NK 房间开发。 | Cherry Kam Chun Lo Queenie Lai Kwan Lam Min Yang King-Hung Ko Lingyun Sun Rui Ma Shengjun Wang Huaxi Xu Sidney Tam Chang-You Wu Bo-Jiang Zheng Liwei Lu | 2009 | Cellular & Molecular Immunology2009，6，5： | 2 |
| 5 | CHD1L promotes hepatocellular carcinoma progression and metastasis in mice and is associated with these processes in human patients显示文摘 | Chen Leilei Chan Tim Hon Man Yuan Yun-Fei Hu Liang Huang Jun Ma Stephanie Wang Jian Dong Sui-Sui Tang Kwan Ho Xie Dan Li Yan Guan Xin-Yuan | 2010 | Journal of Clinical Investigation2010，，4： | 2 |
| 6 | TRPC1 associates with BKCa channel to form a signal complex in vascular smooth muscle cells 显示文摘 | Kwan HY Shen B Ma X | 2009 | Circ Res2009，104，5： | 1 |
| 7 | TRPC1 associates with BK(Ca)channel to form a signal complex in vascular smooth muscle cells显示文摘 | Kwan HY Shen B Ma X | 2009 | Circ Res2009，104，5： | 1 |
| 8 | Inhibition of endothelium-dependent vascular relaxation by tetrandrine显示文摘 | KWAN CY MA FM HUI SC | 1999 | Life Sci1999，64，25： | 1 |
| 9 | In-vitro activity of ofloxacin against Mycobacterium tuberculosis and its clinical efficacy in multidrug resistant pulmonary tuberculosis显示文摘 | Yew WW Kwan SY Ma WK | | 0，，： | 1 |
| 10 | The destruct ion of the lower urinary tractby ketamine abuse: a new syndrome? 显示文摘 | PEGGY SAU KWAN CH U WAI KIT MA SIMON CHU NWING WONG | 2008 | Brit J Urol Intern2008，102，： | 1 |
| 11 | Lupeol targets liver tumor‐initiating cells through phosphatase and tensin homolog modulation显示文摘 | Terence Kin Wah Lee Antonia Castilho Vincent Chi Ho Cheung Kwan Ho Tang Stephanie Ma Irene Oi Lin Ng | 2011 | Hepatology2011，，1： | 1 |
| 12 | Inhibition of endothelium-dependent vascular relaxation by tetrandrine显示文摘 | Kwan CY Ma FM Hui SC | 1999 | Life Sci1999，64，25： | 1 |
| 13 | The destruction of the lower urinary tract by Ket- amine absue: a new syndrome 显示文摘 | Peggy Sau - Kwan Chu Wai - Kit Ma Simon Chun - Wing Wang | 2008 | BJU International2008，102，11： | 1 |
| 14 | In-vitro activity of ofloxacin against Mycobacterium tuberculosis and its clinical efficacy in multidrug-resistant tuberculosis显示文摘 | Yew WW Kwan SY Ma WK | 1990 | J antimicrob Chemother1990，26，： | 1 |
| 15 | MicroRNA-616 induces androgen-in- dependent growth of prostate cancer ceils by suppressing expression of tissue factor pathway inhibitor TFPI-2显示文摘 | Ma S Chan YP Kwan PS | 2011 | Cancer Res2011，1571，2： | 1 |
| 16 | Blueberry extract prolongs lifespan of Drosophila melanogaster显示文摘 | Cheng Peng Yuanyuan Zuo Kin Ming Kwan Yintong Liang Ka Ying Ma Ho Yin Edwin Chan Yu Huang Hongjian Yu Zhen-Yu Chen | 2011 | Experimental Gerontology2011，，2： | 1 |
| 17 | Recent Advances in Hardware - Accelerated Volume Rendering 显示文摘 | Ma Kwan Liu Lum Erie B Muraki Shigem | 2003 | Computers and Graphics2003，27，5： | 1 |
| 18 | CNGA2 contributes to ATP-in- duced noncapacitative Ca2 + influx in vascular endothelial cells 显示文摘 | Kwan HY Cheng KT Ma Y | 2010 | J Vasc Res2010，47，2： | 1 |
| 19 | Parallel Volume Visualization on Workstations显示文摘 | Kwan Liu Ma James S Painter | 1993 | Computers & Graphics1993，17，1： | 1 |
| 20 | Prevalence of acute myocardial infarction and other serious diagnoses in patients presenting to an urban emergency department with chest pain显示文摘 | Kohn MA Kwan E Gupta M | 2005 | J Emerg Med2005，29，4： | 1 |
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