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| 1 | Optimization of groove texture profile to improve hydrodynamic lubrication performance:Theory and experiments显示文摘It is well known that groove texture with a careful design can be used to enhance the load‐carrying capacity of oil film under the conditions of hydrodynamic lubrication.In this study,a general parametric model was developed,and agenetic algorithm‐sequential quadratic programming hybrid method was adopted to obtain the global‐optimum profile of the groove texture.The optimized profiles at different rotating speeds are all chevrons.The numerical analysis results verified the effect of the optimization.In addition to the numerical optimization,experiments were conducted to validate the superiority of the optimized results.The experimental results show that the optimized groove texture can efficiently reduce the coefficient of friction(COF)and the temperature rise of the specimen.In particular,the optimized groove textures can achieve stable ultra‐low COF values(COF<0.01)under certain conditions. | Wei WANG Yongyong HE Jun ZHAO Junyuan MAO Yutong HU Jianbin LUO | 2020 | Friction2020，8，1： | 13 |
| 2 | Clinical characteristics and survival of 5283 esophageal cancer patients: A multicenter study from eighteen hospitals across six regions in China显示文摘Objective:This study aimed to investigate the potential determining epidemiological and clinical risk factors affecting the survival of esophageal cancer(EC)patients across multiple hospitals in China.Methods:This was a multicenter study comprising of newly diagnosed EC cases from Beijing,Hebei,Henan,Hubei,Zhejiang,and Guangdong Province of China.Their baseline characteristics and treatment methods data were collected from their medical records.The EpiData software was used for data quality control.The Kaplan-Meier method was used to estimate their overall survival(OS),and the Cox’s proportional hazard regression model was used to estimate hazard ratios(HR)and 95%confidence interval(CI).Results:The 3-and 5-year OS rates of the 5283 investigated EC patients were 49.98%and 39.07%,respectively.Their median survival was 36.00 months.The median survival time of females was longer than that of males(females vs.males:45.00 vs.33.00,P<0.001).The 5-year OS rate of patients who never-smoked was higher than that of smokers(never-smokers vs smokers:40.73%vs.37.84%,P=0.001).There was no significant difference in the 5-year OS rate between drinkers and never-drinkers(drinkers vs never-drinkers:34.22%vs.29.65%,P=0.330).In multivariate analysis,pathological stage(stage II:HR=1.80,95%CI=1.40-2.31;stage III:HR=2.62,95%CI=2.06-3.34;stage IV:HR=3.90,95%CI=2.98-5.09),poor differentiation/undifferentiated(HR=1.34,95%CI=1.11-1.63),not married status(HR=2.45,95%CI=1.49-4.04),production and service personnel(HR=1.36,95%CI=1.01-1.83)and farming/fishing(HR=1.40,95%CI=1.12-1.76)were independent prognostic risk factors for poor EC survival.Tumors in the thoracic or abdominal part of the esophagus,female and family history of any cancer were independent factors predictive of a good EC OS.Conclusion:Gender,marital status,occupation,family history of any cancer,tumor topographical site,differentiation status,and pathological stage were associated with the survival rate of EC.This study reveals important clinical characteristics of esophageal cancer patients in China and provides helpful information for their clinical management and surveillance. | Yutong He Di Liang Lingbin Du Tiantian Guo Yanyu Liu Xibin Sun Ning Wang Min Zhang Kuangrong Wei Baoen Shan Wanqing Chen | 2020 | Cancer Communications2020，40，10： | 8 |
| 3 | Medical expenditures for colorectal cancer diagnosis and treatment: A 10-year high-level-hospital-based multicenter retrospective survey in China, 2002-2011显示文摘Objective: Colorectal cancer(CRC) causes a substantial burden of disease in China and the evidence of economic burden triggered is fundamental for priority setting. The aim of this survey was to quantify medical expenditures and the time trends for CRC diagnosis and treatment in China.Methods: From 2012 to 2014, a hospital-based multicenter retrospective survey was conducted in 13 provinces across China. For each eligible CRC patient diagnosed from 2002 to 2011, clinical information and expenditure data were extracted using a uniform questionnaire. All expenditure data were reported in Chinese Yuan(CNY)using 2011 values.Results: Of the 14,536 CRC patients included, the average age at diagnosis was 58.2 years and 15.8% were stageI cases. The average medical expenditure per patient was estimated at 37,902 CNY [95 % confidence interval(95%CI): 37,282-38,522], and the annual average increase rate was 9.2% from 2002 to 2011(P for trend <0.001), with a cumulative increase of 2.4 times(from 23,275 CNY to 56,010 CNY). The expenditure per patient in stages Ⅰ, Ⅱ, Ⅲ and Ⅳ were 31,698 CNY, 37,067 CNY, 38,918 CNY and 42,614 CNY, respectively(P<0.001). Expenditure significantly differed within various subgroups. Expenses for drugs contributed the largest proportion(52.6%).Conclusions: These conservative estimates illustrated that medical expenditures for CRC diagnosis and treatment in tertiary hospitals in China were substantial and increased rapidly over the 10 years, with drugs continually being the main expense by 2011. Relatively, medical expenditures are lower for CRC in the earlier stages. These findings will facilitate the economic evaluation of CRC prevention and control in China. | Jufang Shi Guoxiang Liu Hong Wang Ayan Mao Chengcheng Liu Lanwei Guo Huiyao Huang Jiansong Ren Xianzhen Liao Yana Bai Xiaojie Sun Xinyu Zhu Jialin Wang Bingbing Song Jinyi Zhou Lin Zhu Haike Lei Yuqin Liu Yunyong Liu Lingbin Du Yutong He Kai Zhang Ni Li Wanqing Chen Min Dai Jie He | 2019 | Chinese Journal of Cancer Research2019，31，5： | 8 |
| 4 | Generation and manipulation of chiral terahertz waves in the three-dimensional topological insulator Bi2Te3显示文摘Arbitrary manipulation of broadband terahertz waves with flexible polarization shaping at the source has great potential in expanding numerous applications,such as imaging,information encryption,and all-optical coherent control of terahertz nonlinear phenomena.Topological insulators featuring unique spinmomentum-locked surface state have already exhibited very promising prospects in terahertz emission,detection,and modulation,which may lay a foundation for future on-chip topological insulator-based terahertz systems.However,polarization-shaped terahertz emitters based on topological insulators with an arbitrarily manipulated temporal evolution of the amplitude and the electric-field vector direction have not yet been explored.We systematically investigated the terahertz radiation from topological insulator Bi2Te3 nanofilms driven by femtosecond laser pulses and successfully realized the generation of efficient chiral terahertz waves with controllable chirality,ellipticity,and principal axis.The convenient engineering of the chiral terahertz waves was interpreted by a photogalvanic effect(PGE)-induced photocurrent,while the linearly polarized terahertz waves originated from linear PGE-induced shift currents.Our work not only provides further understanding of femtosecond coherent control of ultrafast spin currents but also describes an effective way to generate spin-polarized terahertz waves at the source. | Haihui Zhao Xinhou Chen Chen Ouyang Hangtian Wang Deyin Kong Peidi Yang Baolong Zhang Chun Wang Gaoshuai Wei Tianxiao Nie Weisheng Zhao Jungang Miao Yutong Li Li Wang Xiaojun Wu | 2020 | Advanced Photonics2020，2，6： | 6 |
| 5 | Hierarchical-structure anatase TiO2 with conductive network for high-rate and high-loading lithium-ion battery显示文摘Titanium dioxides have been extensively investigated as promising anodes for Lithium ion batteries(LIBs)because of the high–rate capacity and cyclability,as well as the improved safety over graphite anode(1,2)However,as a typical insertion–type anode,anatase TiO2 exhibits low conductivity(10–12S cm-1 for electron conductivity[3]and 10–17–10–10 cm2 s1 for Li+ion diffusion coefficient[4])and poor specific capacity(only accommodate<0.5 Li per bulk TiO2 unit[5]),severely limiting its practical applications. | Xinghua Liu Lijiang Zhao Shitong Wang Meng Chao Yutong Li Jin Leng Junying Zhang Zilong Tang | 2019 | Science Bulletin2019，64，16： | 6 |
| 6 | Deciphering impacts of climate extremes on Tibetan grasslands in the last fifteen years显示文摘Climate extremes have emerged as a crucial driver of changes in terrestrial ecosystems. The Tibetan Plateau, facing a rapid climate change, tends to favor climate extremes. But we lack a clear understanding of the impacts of such extremes on alpine grasslands. Here we show that extreme events(drought,extreme wet, extreme cold and extreme hot) occurred at a frequency of 0.67–4 months decade^(-1) during2001–2015, with extreme precipitation predominantly occurring in June-to-August and extreme temperatures in May. Drought and extreme wet cause opposite and asymmetric effects on grassland growth,with drought-induced reductions greater than increases due to extreme wet. Grassland responses to extreme temperatures, which predominantly occur in May, show a dipole-like spatial pattern, with extreme hot(cold) events enhanced(reduced) growth in the eastern plateau but slightly reduced(enhanced) growth in the western plateau. These opposite responses to extreme temperatures over the eastern plateau are explained by the possibility that the occurrence of extreme cold slows the preseason temperature accumulation, delaying the triggering of spring phenology, while extreme hot hastens the accumulation. In the western plateau, in contrast, positive responses to extreme cold are induced by accompanying high precipitation. Furthermore, high extremeness of climate events generally led to a much lower extremeness in growth response, implying that the Tibetan grasslands have a relatively high resistance to climate extremes. The ecosystem models tested could not accurately simulate grassland responses to drought and extreme temperatures, and require re-parameterization before trust can be placed in their output for this region. | Dan Liu Tao Wang Tao Yang Zhengjie Yan Yongwen Liu Yutong Zhao Shilong Piao | 2019 | Science Bulletin2019，64，7： | 5 |
| 7 | Synergistic Effect between Zr-MOF and Phosphotungstic Acid for Oxidative Desulfurization显示文摘PTA/UiO-66 composites were successfully synthesized by the hydrothermal method.The results showed that the synergistic effect between phosphotungstic acid(PTA)and UiO-66 could enhance the oxidative desulfurization(ODS)activity.The XRD results proved that UiO-66 retained its structure in the PTA/UiO-66 composites.The SEM results showed that the PTA/UiO-66 catalysts exhibited regular octahedral shape.The Raman spectra revealed that PTA in the composites retained the Keggin structure.The XPS results showed that the electron transfer occurred from Zr-MOF to PTA.The ODS reaction mechanism was discussed.Electrons transfer from Zr-MOF to PTA can promote the generation of active species(·OH)and thus enhance the ODS activity.This explanation can be confirmed by the formation of oxygen vacancy and W0 as revealed by the XPS analysis. | Zong Mengya Zhao Yutong Fan Cunzheng Wang Danhong | 2020 | China Petroleum Processing & Petrochemical Technology2020，22，4： | 5 |
| 8 | Computer-based Creativity Enhanced Conceptual Design Model for Non-routine Design of Mechanical Systems显示文摘Computer-based conceptual design for routine design has made great strides, yet non-routine design has not been given due attention, and it is still poorly automated. Considering that the function-behavior-structure(FBS) model is widely used for modeling the conceptual design process, a computer-based creativity enhanced conceptual design model(CECD) for non-routine design of mechanical systems is presented. In the model, the leaf functions in the FBS model are decomposed into and represented with fine-grain basic operation actions(BOA), and the corresponding BOA set in the function domain is then constructed. Choosing building blocks from the database, and expressing their multiple functions with BOAs, the BOA set in the structure domain is formed. Through rule-based dynamic partition of the BOA set in the function domain, many variants of regenerated functional schemes are generated. For enhancing the capability to introduce new design variables into the conceptual design process, and dig out more innovative physical structure schemes, the indirect function-structure matching strategy based on reconstructing the combined structure schemes is adopted. By adjusting the tightness of the partition rules and the granularity of the divided BOA subsets, and making full use of the main function and secondary functions of each basic structure in the process of reconstructing of the physical structures, new design variables and variants are introduced into the physical structure scheme reconstructing process, and a great number of simpler physical structure schemes to accomplish the overall function organically are figured out. The creativity enhanced conceptual design model presented has a dominant capability in introducing new deign variables in function domain and digging out simpler physical structures to accomplish the overall function, therefore it can be utilized to solve non-routine conceptual design problem. | LI Yutong WANG Yuxin DUFFY Alex H B | 2014 | Chinese Journal of Mechanical Engineering2014，27，6： | 5 |
| 9 | Integrated Inspection of QoM, QoP, and QoS for AOI Industries in Metaverses显示文摘With the rapid development of information technologies such as digital twin, extended reality, and blockchain,the hype around 'metaverse' is increasing at astronomical speed. However, much attention has been paid to its entertainment and social functions. Considering the openness and interoperability of metaverses, the market of quality inspection promises explosive growth. In this paper, taking advantage of metaverses, we first propose the concept of Automated Quality Inspection(Auto QI), which performs integrated inspection covering the entire manufacturing process, including Quality of Materials, Quality of Manufacturing(Qo M), Quality of Products, Quality of Processes(Qo P), Quality of Systems, and Quality of Services(Qo S). Based on the scenarios engineering theory, we discuss how to perform interactions between metaverses and the physical world for virtual design instruction and physical validation feedback. Then we introduce a bottomup inspection device development workflow with productivity tools offered by metaverses, making development more effective and efficient than ever. As the core of quality inspection,we propose Quality Transformers to complete detection task,while federated learning is integrated to regulate data sharing.In summary, we point out the development directions of quality inspection under metaverse tide. | Yutong Wang Yonglin Tian Jiangong Wang Yansong Cao Shixing Li Bin Tian | 2022 | IEEE/CAA Journal of Automatica Sinica2022，9，12： | 5 |
| 10 | Effect of Doped Vanadium Dioxide on Oxidative Desulfurization Reaction显示文摘VO2(M) doped with different metals(Ti, Ce, Nb, Zr, W, and Mo) was successfully synthesized by the hydrothermal reduction process using oxalic acid as the reductant. The results showed that doping metals in the VO2(M) lattice could enhance the oxidative desulfurization(ODS) activity. The DSC and Raman spectra revealed that VO2(M) retained its monoclinic structure after doping. Mechanism for the improvement of ODS activity by doping was investigated. Electron transfer to V(V) atom occurs upon doping, and then V(V) changes into V(IV), which can promote the ODS reaction. This explanation can be confirmed by the fact that doping can promote the proportion of V(Ⅳ) after doping as revealed by the XPS analysis. | Zhao Yutong Zong Mengya Fan Cunzheng Chen Kun Wang Danhong Zhang Minghui | 2019 | China Petroleum Processing & Petrochemical Technology2019，21，4： | 4 |
| 11 | The ChatGPT After: Building Knowledge Factories for Knowledge Workers with Knowledge Automation显示文摘Briefing: This perspective introduces the concept and framework of knowledge factories with knowledge machines for knowledge workers to achieve knowledge automation for Industry 5.0 and intelligent industries.Introduction The big hit of Chat GPT makes it imperative to contemplate the practical applications of big or foundation models [1]-[5]. However, as compared to conventional models, there is now an increasingly urgent need for foundation intelligence of foundation models for real-world industrial applications. | Yutong Wang Xiao Wang Xingxia Wang Jing Yang Oliver Kwan Lingxi Li Fei-Yue Wang | 2023 | IEEE/CAA Journal of Automatica Sinica2023，10，11： | 4 |
| 12 | A Predictive 6G Network with Environment Sensing Enhancement:From Radio Wave Propagation Perspective显示文摘In order to support the future digital society,sixth generation(6G)network faces the challenge to work efficiently and flexibly in a wider range of scenarios.The traditional way of system design is to sequentially get the electromagnetic wave propagation model of typical scenarios firstly and then do the network design by simulation offline,which obviously leads to a 6G network lacking of adaptation to dynamic environments.Recently,with the aid of sensing enhancement,more environment information can be obtained.Based on this,from radio wave propagation perspective,we propose a predictive 6G network with environment sensing enhancement,the electromagnetic wave propagation characteristics prediction enabled network(EWave Net),to further release the potential of 6G.To this end,a prediction plane is created to sense,predict and utilize the physical environment information in EWave Net to realize the electromagnetic wave propagation characteristics prediction timely.A two-level closed feedback workflow is also designed to enhance the sensing and prediction ability for EWave Net.Several promising application cases of EWave Net are analyzed and the open issues to achieve this goal are addressed finally. | Gaofeng Nie Jianhua Zhang Yuxiang Zhang Li Yu Zhen Zhang Yutong Sun Lei Tian Qixing Wang Liang Xia | 2022 | China Communications2022，19，6： | 4 |
| 13 | Impact of gas pressure on particle feature in Fe-based amorphous alloy powders via gas atomization:Simulation and experiment显示文摘Gas atomization is now an important production technique for Fe-based amorphous alloy powders used in additive manufacturing,particularly selective laser melting,fabricating large-sized Fe-based bulk metallic glasses.Using the realizable k-εmodel and discrete phase model theory,the flow dynamics of the gas phase and gas-melt two-phase flow felds in the close-wake condition were investigated to establish the correlation between high gas pressure and powder particle characteristics.The locations of the recirculation zones and the shapes of Mach disks were analyzed in detail for the type of discrete-jet closed-coupled gas atomization nozzle.In the gas-phase flow feld,the vortexes,closed to the Mach disk,are found to be a new deceleration method.In the two-phase flow feld,the shape of Mach disk changes from“S”-shape to“Z”-shape under the impact of the droplet flow.As predicted by the wave model,with the elevation of gas pressure,the size of the particle is found to gradually decrease and its distribution becomes more concentrated.Simulation results were compliant with the Fe-based amorphous alloy powder preparation tests.This study deepens the understanding of the gas pressure impacting particle features via gas atomization,and contributes to technological applications. | Yutong Shi Weiyan Lu Wenhai Sun Suode Zhang Baijun Yang Jianqiang Wang | 2022 | Journal of Materials Science & Technology2022，，10： | 4 |
| 14 | Steps Toward Industry 5.0:Building“6S”Parallel Industries With Cyber-Physical-Social Intelligence显示文摘Very recently,intensive discussions and studies on Industry 5.0 have sprung up and caused the attention of researchers,entrepreneurs,and policymakers from various sectors around the world.However,there is no consensus on why and what is Industry 5.0 yet.In this paper,we define Industry 5.0from its philosophical and historical origin and evolution,emphasize its new thinking on virtual-real duality and human-machine interaction,and introduce its new theory and technology based on parallel intelligence(PI),artificial societies,computational experiments,and parallel execution(the ACP method),and cyber-physical-social systems(CPSS).Case studies and applications of Industry 5.0 over the last decade have been briefly summarized and analyzed with suggestions for its future development.We believe that Industry 5.0 of virtual-real interactive parallel industries has great potentials and is critical for building smart societies.Steps are outlined to ensure a roadmap that would lead to a smooth transition from CPS-based Industry 4.0 to CPSS-based Industry 5.0 for a better world which is Safe in physical spaces,S ecure in cyberspaces,Sustainable in ecology,Sensitive in individual privacy and rights,Service for all,and Smartness of all. | Xingxia Wang Jing Yang Yutong Wang Qinghai Miao Fei-Yue Wang Aijun Zhao Jian-Ling Deng Lingxi Li Xiaoxiang Na Ljubo Vlacic | 2023 | IEEE/CAA Journal of Automatica Sinica2023，10，8： | 4 |
| 15 | Establishment and Verification of An Efficient Virus-induced Gene Silencing System in Forsythia显示文摘To understand the functional identification of large-scale genomic sequences in Forsythia,tobacco rattle virus(TRV)-mediated virus-induced gene silencing(VIGS),suitable for the plant,was explored in this study.The results showed that the TRV-mediated VIGS system could be successfully used in Forsythia for silencing the reporter gene FsPDS(Forsythia phytoene desaturase)using stem infiltration and leaf infiltrationmethods.All the treated plants were pruned below the injection site after 7–15 d infection;the FsPDS was silenced and typical photobleaching symptoms were observed in newly sprouted leaves at the whole-plant level.Meanwhile,this system has been successfully tested and verified through virus detection and qRT-PCR analysis.After the optimization,Forsythia magnesium chelatase subunit H(FsChlH)was silenced successfully in Forsythia using this system,resulting in yellow leaveswith decreased chlorophyll content.The system was stable,highly efficient and had greater rapidity and convenience,which made it suitable to study the function of genes related to physiological pathways such as growth and development,and metabolic regulation in Forsythia. | Jianshuang Shen Weijia Si Yutong Wu Yang Xu Jia Wang Tangren Cheng Qixiang Zhang Huitang Pan | 2021 | Horticultural Plant Journal2021，7，1： | 3 |
| 16 | Phosphorylated E2F1 ts stabilized by nuclear USPll to drive PeglO gene expression and activate lung epithelial cells显示文摘 | Dan Wang Jing Zhao Shuang Li Jianxin Wei Ling Nan Rama K. Mallampalli Nathaniel M. Weathington Haichun Ma Yutong Zhao | 2018 | Journal of Molecular Cell Biology2018，10，1： | 3 |
| 17 | Application of Human Adenovirus Genotyping by Phylogenetic Analysis in an Outbreak to Identify Nosocomial Infection显示文摘Nosocomial infections are common in pediatric patients and can be fatal in infants and immunocompromised patients. In September 2018, a high positive rate of human adenovirus HAdV was occurred among hospitalized children in the Children's Hospital Affiliated to the Capital Institute of Paediatrics in Beijing. To investigate whether this outbreak of HAdV was related to nosocomial infections or the result of community infections, we collected respiratory specimens from patients with acute respiratory infections in a respiratory ward during June to December 2018, and screened for respiratory viruses. Among 1,840 cases included, 95(5.2%, 95/1840) were positive for HAdV and 81 were genotyped based on phylogenetic analysis, including seven as HAdV-1(8.6%), 30 HAdV-3(37.0%), two HAdV-6(2.5%), and 42 HAdV-7(51.9%). More HAdV-positive samples were collected in August(4.7%, 12/255), September(15.0%, 41/274) and October(6.9%, 17/247), with a peak in September 2018. By combining the results of HAdV phylogenetic analysis with clinical data of patients, there were 77 cases(4.2%, 77/1840;81.1%, 77/95) excluded from nosocomial infections, eight cases representing possible infections transmitted by visitors or attending parents, three cases without sequences that might have been due to infection transmitted by roommates positive for HAdV, one case of a roommate without an HAdV sequence, and six cases that shared highly homologous sequences with those of their roommates, for which nosocomial infections might be considered. In conclusion, genotyping of HAdVs based on phylogenetic analysis combined with clinical information provides a powerful method to distinguish nosocomial infections from community acquired infection, especially when tracing the origins of nosocomial infections. | Chuanyu Yang Chunmei Zhu Yuan Qian Jie Deng Baoyuan Zhang Runan Zhu Fang Wang Yu Sun Dongmei Chen Qi Guo Yutong Zhou Lei Yu Ling Cao Linqing Zhao | 2021 | Virologica Sinica2021，36，3： | 3 |
| 18 | A Novel Artificial Neuron-Like Gas Sensor Constructed from CuS Quantum Dots/Bi2S3 Nanosheets显示文摘Real-time rapid detection of toxic gases at room temperature is particularly important for public health and environmental monitoring.Gas sensors based on conventional bulk materials often suffer from their poor surface-sensitive sites,leading to a very low gas adsorption ability.Moreover,the charge transportation efficiency is usually inhibited by the low defect density of surface-sensitive area than that in the interior.In this work,a gas sensing structure model based on CuS quantum dots/Bi_(2)S_(3) nanosheets(CuS QDs/Bi_(2)S_(3) NSs)inspired by artificial neuron network is constructed.Simulation analysis by density functional calculation revealed that CuS QDs and Bi_(2)S_(3) NSs can be used as the main adsorption sites and charge transport pathways,respectively.Thus,the high-sensitivity sensing of NO_(2) can be realized by designing the artificial neuron-like sensor.The experimental results showed that the CuS QDs with a size of about 8 nm are highly adsorbable,which can enhance the NO_(2) sensitivity due to the rich sensitive sites and quantum size effect.The Bi_(2)S_(3) NSs can be used as a charge transfer network channel to achieve efficient charge collection and transmission.The neuron-like sensor that simulates biological smell shows a significantly enhanced response value(3.4),excellent responsiveness(18 s)and recovery rate(338 s),low theoretical detection limit of 78 ppb,and excellent selectivity for NO_(2).Furthermore,the developed wearable device can also realize the visual detection of NO2 through real-time signal changes. | Xinwei Chen Tao Wang Jia Shi Wen Lv Yutong Han Min Zeng Jianhua Yang Nantao Hu Yanjie Su Hao Wei Zhihua Zhou Zhi Yang Yafei Zhang | 2022 | Nano-Micro Letters2022，14，1： | 3 |
| 19 | The role of dendritic cells derived osteoclasts in bone destruction diseases显示文摘The bone is previously considered as a dominant organ involved in the processes of locomotion.However,in the past two decades,a large number of studies have suggested that the skeletal system closely coordinated with the immune system so as to result in the emerging area of'osteoimmunology'.In the evolution of many kinds of bone destruction-related dis-eases,osteoclasts could differentiate from dendritic cells,which contributed to increased expression of osteoclast-related membrane receptors and relatively higher activity of bone destruction,inducing sewere bone destruction under inflammatory conditions.Numerous fac-tors could influence the interaction between osteoclasts and dendritic cells,contributing to the pathogenesis of several bone diseases in the context of inflammation,including both im-munocytes and a large number of cytokines.In addition,the products of osteoclasts released from bone destruction area serve as important signals for the differentiation and activation of immature dendritic cells.Therefore,the border between the dendritic cell-rela ted immune response and osteoclast-related bone destruction has gradually unravelled.Dendritic cells and osteoclasts cooperate with each other to mediate bone destruction and bone remodelling under inflammatory conditions.In this review,we will pay attention to the interactions be-tween dendritic cells and osteoclasts in physiological and pathological conditions to further understand the skeletal system and identifty potential new therapeutic targets for the future by summarizing their significant roles and molecular mechanisms in bone destruction. | Bo Wang Yutong Dong Zhansong Tian Yueqi Chen Shiwu Dong | 2021 | Genes & Diseases2021，8，4： | 2 |
| 20 | Fault protection method of single-phase break for distribution network considering the influence of neutral grounding modes显示文摘With the rapid development of modern distribution network and the access of distributed generation,the network structure is becoming increasingly complex.Frequent single-phase break faults have seriously affected equipment and personal safety and stable operation of the power system.However,with the development and application of the composite neutral grounding modes,the protection of single-phase break fault is facing new challenges.This paper proposes a protection method of single-phase break fault for distribution network considering the influence of neutral grounding modes.The characteristics of neutral voltage and sequence current are analyzed under normal operation and single-phase break fault with different grounding modes.Following this,the protection criterion based on neutral voltage and sequence current variation is constructed.The protection method of singlephase break fault for distribution network is proposed,which is applicable for various neutral grounding modes.Theoretical analysis and simulation results show that the protection method is less affected by system asymmetry,fault location and load distribution.The method has higher sensitivity,reliability and adaptability. | Yang Xiao Jinxin Ouyang Xiaofu Xiong Yutong Wang Yongjie Luo | 2020 | Protection and Control of Modern Power Systems2020，5，1： | 2 |
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